Formulation study of oxybutynin patches

Pharmaceutical Development and Technology

Volumn 12, Issue 3, 2007, Pages 239-246

  Minghetti, Paola ^a   Cilurzo, Francesco ^a   Pagani, Stefania ^a   Casiraghi, Antonella ^a   Assandri, Riccardo ^b   Montanari, Luisa ^a  

^a UNIVERSITY OF MILAN   (Italy)

^b Cross Research SA   (Switzerland)

Author keywords

Crystallization inhibitor; Oxybutynin; Patch; Pharmacokinetic; Transdermal delivery

Indexed keywords

COPOLYMER; DIMETICONE; EUDRAGIT; EUDRAGIT RS; METHACRYLIC ACID METHYL ESTER; OXYBUTYNIN; PENETRATION ENHANCING AGENT; POLYETHYLENE;

AREA UNDER THE CURVE; ARTICLE; CRYSTAL; CRYSTALLIZATION; DRUG ADSORPTION; DRUG BLOOD LEVEL; DRUG DETERMINATION; DRUG EFFICACY; DRUG FORMULATION; DRUG HALF LIFE; DRUG TOLERABILITY; FEASIBILITY STUDY; HUMAN; HUMAN EXPERIMENT; IN VIVO STUDY; MAXIMUM PLASMA CONCENTRATION; NORMAL HUMAN; PRIORITY JOURNAL; SINGLE DRUG DOSE; TRANSDERMAL PATCH;

CALORIMETRY, DIFFERENTIAL SCANNING; DRUG COMPOUNDING; FEASIBILITY STUDIES; FEMALE; HUMANS; MANDELIC ACIDS; MUSCARINIC ANTAGONISTS; PERMEABILITY; SKIN; SPECTROSCOPY, FOURIER TRANSFORM INFRARED;

EID: 34347407545     PISSN: 10837450     EISSN: 10979867     Source Type: Journal    
DOI: 10.1080/10837450701212701     Document Type: Article

References (15)

1. Lish, P.M.; Labudde, J.A.; Peters, E.L.; Robbins, S.I. The anticholinergic activity of agents indicated for urinary incontinence is an important property for effective control of bladder dysfunction. J. Pharmacol. Exp. Ther. 1995, 149, 467-488.
2. Versi, E.; Appell, R.; Mobley, D.; Patton, W.; Saltzstein, D. Dry mouth with conventional and controlled release oxybutynin in urinary incontinence: The Ditropan XL Study Group. Obstet. Gynecol. 2000, 29, 718-721.
3. Zobrist, R.H.; Schmid, B.; Feick, A.; Quan, D.; Sander, S.W. Pharmacokinetics of the R- and S-enantiomers of oxybutynin and N-desethyloxybutynin following oral and transdermal administration of the racemate in healthy volunteers. Pharm. Res. 2001, 18 (7), 1029-1033.
4. Zobrist, R.H.; Quan, D.; Thomas, H.M.; Stanworth, S.; Sanders, S.W. Pharmacokinetics and metabolism of transdermal oxybutynin: In vitro and in vivo performance of a novel delivery system. Pharm. Res. 2003, 20 (1), 103-109.
5. Yu, J.J.; Chien, T.; Chien, Y. Transdermal dual-controlled delivery of testosterone and estradiol: (I) Impact of system design, Drug Dev. Ind. Pharm. 1991, 17, 1883-1904.
6. Ma, X.; Taw, J.; Chiang, C.M. Control of drug crystallization in transdermal matrix system, Int. J. Pharm. 1996, 142, 115-119.
7. Kotiyan, P. N.; Vavia, P.R. Eudragits: role as crystallization inhibitors in drug in adhesive transdermal systems of estradiol. Eur. J. Pharm. Biopharm. 2001, 52, 173-180.
8. Cilurzo, F.; Minghetti, P.; Casiraghi, A.; Tosi, L.; Pagani, S.; Montanari, L. Polymethacrylates as crystallization inhibitors in monolayer transdermal patches containing ibuprofen. Eur. J. Pharm. Biopharm. 2005, 60 (1), 61-66.
9. Lipp., R.; Muller-Fahrnow, A. Use of x-ray crystallography for the characterization of single crystal grown in steroid containing transdermal drug delivery systems. Eur. J. Pharm. Biopharm. 1999, 47, 133-138.
10. Minghetti, P.; Casiraghi, A.; Cilurzo, F.; Montanari, L.; Marazzi, M.; Falcone, L.; Donati, V. Comparison of different membranes with cultures of keratinocytes from man for percutaneous absorption of nitroglycerine. J. Pharm. Pharmacol. 1999, 51, 673-678.
11. Lim P.F.C.; Liu X.Y.; Kang L.; Ho P.C.L.; Chan Y.W.; Chan S.Y. Limonene GP1/PG organogel as a vehicle in transdermal delivery of haloperidol. Int. J. Pharm. 2006, 311 (1-2), 157-164.
12. Gerber M.; Breytenbach J.C.; Hadgraft J.; Du Plessis J. Synthesis and transdermal properties of acetylsalicylic acid and selected esters. Int. J. Pharm. 2006, 310 (1-2), 31-36.
13. CTFA technical guidelines III, 1991. "Pharmacology and toxicology, safety testing guidelines. Guidelines for evaluating contact sensitization potential," The Cosmetic, Toiletry and Fragrance Association Inc. Washington D.C., USA G.N. McEwen, Jr and Anita S. Curry Editors, 7-9.
14. Minghetti, P.; Casiraghi, A.; Montanari, L.; Monzani, M.V. In vitro skin permeation of Sinitrodil, a member of a new class of nitrovasodilator drugs. Eur. J. Pharm. Sci. 1999, 7, 231-236.
15. Fukazawa, I.; Uchida, E.; Uchida, N.; Kouda T. Pharmacokinetics data of oxybutynin patch: repeated dose study. Jpn. J. Clin. Ther. 1999, 30 (1), 257-259.