Proteomic identification of a novel Anaplasma phagocytophilum DNA binding protein that regulates a putative transcription factor

Journal of Bacteriology

Volumn 189, Issue 13, 2007, Pages 4880-4886

  Wang, Xueqi ^a   Kikuchi, Takane ^a   Rikihisa, Yasuko ^a  

^a OHIO STATE UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

DNA BINDING PROTEIN; OUTER MEMBRANE PROTEIN; OUTER MEMBRANE PROTEIN P44; RECOMBINANT PROTEIN APXR; TRANSCRIPTION FACTOR; TRANSCRIPTION FACTOR TR1; UNCLASSIFIED DRUG;

AFFINITY CHROMATOGRAPHY; ANAPLASMA PHAGOCYTOPHILUM; ANAPLASMOSIS; ARTICLE; BINDING SITE; MASS SPECTROMETRY; NONHUMAN; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; PROTEIN INTERACTION; PROTEOMICS; REPORTER GENE; TRANSCRIPTION REGULATION;

ANAPLASMA PHAGOCYTOPHILUM; BACTERIAL PROTEINS; BASE SEQUENCE; DNA FOOTPRINTING; DNA, BACTERIAL; DNA-BINDING PROTEINS; ELECTROPHORETIC MOBILITY SHIFT ASSAY; GENE EXPRESSION REGULATION, BACTERIAL; MOLECULAR SEQUENCE DATA; PROMOTER REGIONS (GENETICS); PROTEIN BINDING; PROTEOMICS; TANDEM MASS SPECTROMETRY; TRANSCRIPTION FACTORS; TRANSCRIPTION, GENETIC;

ANAPLASMA PHAGOCYTOPHILUM; BACTERIA (MICROORGANISMS);

EID: 34347388440     PISSN: 00219193     EISSN: None     Source Type: Journal    
DOI: 10.1128/JB.00318-07     Document Type: Article

References (22)

1. Barbet, A. F., J. T. Agnes, A. L. Moreland, A. M. Lundgren, A. R. Alleman, S. M. Noh, K. A. Brayton, U. G. Munderloh, and G. H. Palmer. 2005. Identification of functional promoters in the msp2 expression loci of Anaplasma marginale and Anaplasma phagocytophilum. Gene 353:89-97.
2. Chen, S. M., J. S. Dumler, J. S. Bakken, and D. H. Walker. 1994. Identification of a granulocytotropic Ehrlichia species as the etiologic agent of human disease. J. Clin. Microbiol. 32:589-595.
3. Cheng, Z., Y. Kumagai, M. Lin, C. Zhang, and Y. Rikihisa. 2006. Intra-leukocyte expression of two-component systems in Ehrlichia chaffeensis and Anaplasma phagocytophilum and effects of the histidine kinase inhibitor closantel. Cell. Microbiol. 8:1241-1252.
4. Demma, L. J., R. C. Holman, J. H. McQuiston, J. W. Krebs, and D. L. Swerdlow. 2005. Epidemiology of human ehrlichiosis and anaplasmosis in the United States, 2001-2002. Am. J. Trop. Med. Hyg. 73:400-409.
5. Drlica, K., and J. Rouviere-Yaniv. 1987. Histonelike proteins of bacteria. Microbiol. Rev. 51:301-319.
6. Dumler, J. S. 2005. Anaplasma and ehrlichia infection. Ann. N. Y. Acad. Sci. 1063:361-373.
7. Dunning Hotopp, J. C., M. Lin, R. Madupu, J. Crabtree, S. V. Angiuoli, J. Eisen, R. Seshadri, Q. Ren, M. Wu, T. R. Utterback, S. Smith, M. Lewis, H. Khouri, C. Zhang, H. Niu, Q. Lin, N. Ohashi, N. Zhi, W. Nelson, L. M. Brinkac, R. J. Dodson, M. J. Rosovitz, J. Sundaram, S. C. Daugherty, T. Davidsen, A. S. Durkin, M. Gwinn, D. H. Haft, J. D. Selengut, S. A. Sullivan, N. Zafar, L. Zhou, F. Benahmed, H. Forberger, R. Halpin, S. Mulligan, J. Robinson, O. White, Y. Rikihisa, and H. Tettelin. 2006. Comparative genomics of emerging human ehrlichiosis agents. PLoS Genet. 2:e21.
8. Felsheim, R. F., M. J. Herron, C. M. Nelson, N. Y. Burkhardt, A. F. Barbet, T. J. Kurtti, and U. G. Munderloh. 2006. Transformation of Anaplasma phagocytophilum. BMC Biotechnol. 6:42.
9. Goodman, J. L., C. Nelson, B. Vitale, J. E. Madigan, J. S. Dumler, T. J. Kurtti, and U. G. Munderloh. 1996. Direct cultivation of the causative agent of human granulocytic ehrlichiosis. N. Engl. J. Med. 334:209-215.
10. Gralla, J. D. 1991. Transcriptional control - lessons from an E. coli promoter data base. Cell 66:415-418.
11. Herron, M. J., M. E. Ericson, T. J. Kurtti, and U. G. Munderloh. 2005. The interactions of Anaplasma phagocytophilum, endothelial cells, and human neutrophils. Ann. N. Y. Acad. Sci. 1063:374-382.
12. Koo, I. C., D. Walthers, P. S. Hefty, L. J. Kenney, and R. S. Stephens. 2006. ChxR is a transcriptional activator in Chlamydia. Proc. Natl. Acad. Sci. USA 103:750-755.
13. Lin, Q., Y. Rikihisa, N. Ohashi, and N. Zhi. 2003. Mechanisms of variable p44 expression by Anaplasma phagocytophilum. Infect. Immun. 71:5650-5661.
14. Lohr, C. V., K. A. Brayton, A. F. Barbet, and G. H. Palmer. 2004. Characterization of the Anaplasma marginale msp2 locus and its synteny with the ompl/p30 loci of Ehrlichia chaffeensis and E. canis. Gene 325:115-121.
15. Miller, J. H. 1972. Experiments in molecular genetics. Cold Spring Harbor Laboratory, Cold Spring Harbor, NY.
16. Munderloh, U. G., M. J. Lynch, M. J. Herron, A. T. Palmer, T. J. Kurtti, R. D. Nelson, and J. L. Goodman. 2004. Infection of endothelial cells with Anaplasma marginale and A. phagocytophilum. Vet. Microbiol. 101:53-64.
17. Ohashi, N., Y. Rikihisa, and A. Unver. 2001. Analysis of transcriptionally active gene clusters of major outer membrane protein multigene family in Ehrlichia canis and E. chaffeensis. Infect. Immun. 69:2083-2091.
18. Petrovec, M., S. Lotric Furlan, T. A. Zupanc, F. Strle, P. Brouqui, V. Roux, and J. S. Dumler. 1997. Human disease in Europe caused by a granulocytic Ehrlichia species. J. Clin. Microbiol. 35:1556-1559.
19. Rikihisa, Y., N. Zhi, G. P. Wormser, B. Wen, H. W. Horowitz, and K. E. Hechemy. 1997. Ultrastructural and antigenic characterization of a granulocytic ehrlichiosis agent directly isolated and stably cultivated from a patient in New York State. J. Infect. Dis. 175:210-213.
20. Tapias, A., S. Fernandez, J. C. Alonso, and J. Barbe. 2002. Rhodobacter sphaeroides LexA has dual activity: optimising and repressing recA gene transcription. Nucleic Acids Res. 30:1539-1546.
21. Wang, X., Y. Rikihisa, T.-H. Lai, Y. Kumagai, N. Zhi, and S. M. Reed. 2004. Rapid sequential changeover of expressed p44 genes during the acute phase of Anaplasma phagocytophilum infection in horses. Infect. Immun. 72:6852-6859.
22. Zianni, M., K. Tessanne, M. Merighi, R. Laguna, and F. R. Tabita. 2006. Identification of the DNA bases of a DNase I footprint by the use of dye primer sequencing on an automated capillary DNA analysis instrument. J. Biomol. Tech. 17:103-113.