Chitotriosidase and Alzheimer's disease

Current Alzheimer Research

Volumn 4, Issue 3, 2007, Pages 295-296

  Sotgiu, Stefano ^a   Piras, M R ^a   Barone, Rita ^b,c   Arru, Giannina ^a   Fois, M L ^a   Rosati, Giulio ^a   Musumeci, Salvatore ^a  

^a UNIVERSITY OF SASSARI   (Italy)

^b CNR   (Italy)

^c UNIVERSITY OF SASSARI   (Italy)

Author keywords

Alzheimer's disease; Chitotriosidase; Macrophage

Indexed keywords

AMYLOID BETA PROTEIN; CHITOTRIOSIDASE;

AGED; ALZHEIMER DISEASE; CONTROLLED STUDY; ENZYME ACTIVITY; ENZYME BLOOD LEVEL; ENZYME INDUCTION; FEMALE; HUMAN; LETTER; MACROPHAGE; MALE; MICROGLIA; PATHOGENESIS; PRIORITY JOURNAL;

ADULT; AGE FACTORS; AGED; AGED, 80 AND OVER; ALZHEIMER DISEASE; FEMALE; HEXOSAMINIDASES; HUMANS; MALE; MIDDLE AGED;

EID: 34347377321     PISSN: 15672050     EISSN: None     Source Type: Journal    
DOI: 10.2174/156720507781077232     Document Type: Letter

References (8)

1. Castellani RJ, Siedlak SL, Fortino AE, Perry G, Ghetti B, Smith MA. Chitin-like polysaccharides in Alzheimer's disease brains. Curr Alzheimer Res 2:419-423 (2005).
2. Boot RG, Renkema GH, Verhoek M, Strijland A, Bliek J, de Meulemeester TM, et al. The human chitotriosidase gene. Nature of inherited enzyme deficiency. J Biol Chem 273:25680-25685 (1998).
3. Malaguarnera L, Simpore J, Prodi DA, Angius A, Sassu A, Persico I, et al. A 24-bp duplication in exon 10 of human chitotriosidase gene from the sub-Saharan to the Mediterranean area: role of parasitic diseases and environmental conditions. Genes Immun 4:570-574 (2003).
4. Sotgiu S, Barone R, Arru G, Fois ML, Pugliatti M, Sanna A, et al. Intrathecal chitotriosidase and the outcome of multiple sclerosis. Mult Scler, in press.
5. Sotgiu S, Barone R, Zanda B, Arru G, Fois ML, Arru A, Rosati G, Marchetti B, Musumeci S. Chitotriosidase in patients with acute ischemic stroke. Eur Neurol 54:149-53 (2005).
6. Casal JA, Robles A, Tutor JC. Serum markers of monocyte/macrophage activation in patients with Alzheimer's disease and other types of dementia. Clin Biochem 36:553-556 (2003).
7. Lue LF, Kuo YM, Roher AE, Brachova L, Shen Y, Sue L, et al. Soluble amyloid β peptide concentration as a predictor of synaptic change in Alzheimer's disease. Am J Pathol 155:853-862 (1999).
8. Minagar A, Shapshak P, Fujimura R, Ownby R, Heyes M, Eisdorfer C. The role of macrophage/microglia and astrocytes in the pathogenesis of three neurologic disorders: HIV-associated dementia, Alzheimer disease, and multiple sclerosis. J Neurol Sci 202:13-23 (2002).