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Volumn 20, Issue 4, 2007, Pages 163-170
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Engineering of α1-antitrypsin variants selective for subtilisin-like proprotein convertases PACE4 and PC6: Importance of the P2′ residue in stable complex formation of the serpin with proprotein convertase
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Author keywords
1 antitrypsin; Furin; PACE4; PC6; Proprotein convertase
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Indexed keywords
ANTITRYPSIN;
FURIN;
PROTEIN-BASED INHIBITORS;
SUBTILISIN-LIKE PROPROTEIN CONVERTASE (SPC);
COMPLEXATION;
ENZYME ACTIVITY;
FUNCTIONAL GROUPS;
HEAT STABILIZERS;
METASTABLE PHASES;
SUBSTITUTION REACTIONS;
ENZYME INHIBITION;
ALANINE DERIVATIVE;
ALANYLVALYLPROLYLMETHIONINE;
ALPHA 1 ANTITRYPSIN;
AMINO ACID;
ARGINYLARGINYLARGINYLARGININE;
LEUCINE;
SERINE PROTEINASE;
SERINE PROTEINASE INHIBITOR;
SUBTILISIN;
UNCLASSIFIED DRUG;
PCSK6 PROTEIN, RAT;
PROPROTEIN CONVERTASE 5;
AMINO ACID SEQUENCE;
AMINO ACID SUBSTITUTION;
ARTICLE;
COMPLEX FORMATION;
ENZYME ACTIVITY;
EXTRACELLULAR MATRIX;
HUMAN;
HUMAN CELL;
NONHUMAN;
PRIORITY JOURNAL;
PROTEIN ANALYSIS;
PROTEIN DEGRADATION;
PROTEIN ENGINEERING;
PROTEIN LOCALIZATION;
RAT;
THERMOSTABILITY;
ANIMAL;
BINDING SITE;
CHEMISTRY;
DRUG ANTAGONISM;
GENETICS;
METHODOLOGY;
BACTERIA (MICROORGANISMS);
RATTUS;
ALPHA 1-ANTITRYPSIN;
AMINO ACID SEQUENCE;
AMINO ACID SUBSTITUTION;
ANIMALS;
BINDING SITES;
PROPROTEIN CONVERTASE 5;
PROPROTEIN CONVERTASES;
PROTEIN ENGINEERING;
RATS;
SERPINS;
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EID: 34347373105
PISSN: 17410126
EISSN: 17410134
Source Type: Journal
DOI: 10.1093/protein/gzm007 Document Type: Article |
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Times cited : (9)
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References (35)
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