Antispasmodic, analgesic, and sedative effects of Mormodica involucrata aqueous extract in rodents

Pharmaceutical Biology

Volumn 45, Issue 4, 2007, Pages 339-341

  Aziba, P I ^a   Sandahl, J F ^a   Sibandze, G ^a  

^a UNIVERSITY OF SWAZILAND   (Swaziland)

Author keywords

Analgesic; Antispasmodic; Mormodica involucrata; Rat stomach strip; Sedative

Indexed keywords

ACETYLCHOLINE; CHOLINESTERASE INHIBITOR; MEVINPHOS; MORMODICA INVOLUCRATA EXTRACT; ORGANOPHOSPHATE; PARACETAMOL; PLANT EXTRACT; UNCLASSIFIED DRUG;

ANALGESIC ACTIVITY; ANIMAL EXPERIMENT; ANIMAL TISSUE; AQUEOUS SOLUTION; ARTICLE; CONCENTRATION RESPONSE; CONTROLLED STUDY; DRUG EFFECT; DRUG MECHANISM; DRUG MEGADOSE; FEMALE; LETHALITY; MALE; MEDICINAL PLANT; MORMODICA INVOLUCRATA; MOUSE; NONHUMAN; RAT; RODENT; SEDATION; SLEEP INDUCTION; SMOOTH MUSCLE CONTRACTILITY; SPASMOLYSIS; STOMACH MUSCLE; WRITHING TEST;

MORMODICA; MUS; RATTUS; RODENTIA;

EID: 34347372028     PISSN: 13880209     EISSN: 17445116     Source Type: Journal    
DOI: 10.1080/13880200701212957     Document Type: Article

References (10)

1. Aziba PI, Ekor M, Adedeji A (2001): Pharmacological screening of a methanol extract from Mormodica in rodents. Pharm Biol 39: 305-307.
2. Bolton TB (1979): Mechanism of action of transmitter and other substances on smooth muscle. Physiol Rev 59: 607-718.
3. Daziel JM (1987): The Useful Plants of Tropical West Africa. London, Crown Agents, p. 31.
4. Iwu MM (1993): Handbook of Africa Medicinal Plants. Boca Raton, CRCS Press, p. 57.
5. 2+ release and contractile regulation in smooth muscle. Prog Clin Biol Res 327: 167-182.
6. Komori S, Bolton TB (1991): The involvement of rynodine receptors in muscarinic receptor mediated current. J Physiol 433: 495-517.
7. Oliver Beaver B (1986): Medicinal Plants in Tropical. West Africa, London, Cambridge University Press, p. 108.
8. Trease GE, Evans MC (1983): Textbook of Pharmacology. London, Valliere Tindal, pp. 343-383.
9. Vane JR (1957): A sensitive method for assay of 5-hydroxytryptamine. Br J Pharmacol Exp Ther 218: 459-464.
10. Whittle BA (1964): The use of changes in capillary permeability in mice to distinguish between, narcotic and narcotic analgesics. Br J Pharmacol Chem 22: 246-263.