Enantioseparation of S,R-(±)-ketoprofen on plain silica gel layers with achiral mobile phase

Journal of Liquid Chromatography and Related Technologies

Volumn 30, Issue 15, 2007, Pages 2185-2192

  Sajewicz, Mieczysław ^a   Grygierczyk, Gabriela ^a   Gontarska, Monika ^a   Kowalska, Teresa ^a  

^a UNIVERSITY OF SILESIA   (Poland)

Author keywords

Chiral silica gel; Chirality; Racemic mixtures; S,R ( ) Ketoprofen; TLC; Two dimensional enantioseparation

Indexed keywords

COATINGS; DICHROISM; MICROCRYSTALLINE SILICON; PHASE SEPARATION; THIN LAYER CHROMATOGRAPHY;

CHIRAL SILICA GEL; RACEMIC MIXTURES; S,R-(±)-KETOPROFEN; TWO-DIMENSIONAL ENANTIOSEPARATION;

DRUG PRODUCTS;

ACETIC ACID; ACETONITRILE; KETOPROFEN; SILICA GEL; WATER;

ARTICLE; CARBON NUCLEAR MAGNETIC RESONANCE; CRYSTAL; DRUG PURITY; ENANTIOMER; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; LIQUID CHROMATOGRAPHY; PHYSICAL PHASE; PLANAR CHROMATOGRAPHY; PROTON NUCLEAR MAGNETIC RESONANCE; RACEMIC MIXTURE; SEPARATION TECHNIQUE;

EID: 34347371977     PISSN: 10826076     EISSN: 1520572X     Source Type: Journal    
DOI: 10.1080/10826070701451522     Document Type: Article

References (5)

1. Sajewicz, M.; Hauck, H.-E.; Drabik, G.; Namysło, E.; Głód, B.; Kowalska, T. Tracing possible structural asymmetry of silica gel used for precoating thin-layer chromatography plates. J. Planar Chromatogr.-Mod. TLC 2006, 19, 278-281.
2. Sajewicz, M.; Piȩtka, R.; Drabik, G.; Namysło, E.; Kowalska, T. On the stereochemically peculiar two-dimensional separation of 2-arylpropionic acids by chiral TLC. J. Planar Chromatogr.-Mod. TLC 2006, 19, 273-277.
3. Sajewicz, M.; Gontarska, M.; Wróbel, M.; Kowalska, T. Enantioseparation and oscillatory transenantiomerization of S,R- (±)-ketoprofen, as investigated by means of thin layer chromatography with densitometric detection. J. Liq. Chromatogr. Rel. Technol. 2007, 30 (15), 2193-2208.
4. The British Pharmacopoeia; The Pharmaceutical Press: London, 2002, 1003-1004.
5. Liversidge, G.G. Ketoprofen. In Analytical Profiles of Drug Substances; Florey, K., Ed.; Academic Press: London, 1981; 443-471.