Expression and mutation analysis of genes that encode the Myc antagonists Mad1, Mxi1 and Rox in acute leukaemia

Leukemia and Lymphoma

Volumn 48, Issue 6, 2007, Pages 1200-1207

  Guo, Xiao Ling ^a,b   Pan, Ling ^a   Zhang, Xue Jun ^a   Suo, Xiao Hui ^a   Niu, Zhi Yun ^a   Zhang, Jing Yu ^a   Wang, Fuxu ^a   Dong, Zuo Ren ^a   Da, Wanming ^b   Ohno, Ruzo ^c  

^a HEBEI MEDICAL UNIVERSITY   (China)

^b Department of Hematology   (China)

^c AICHI CANCER CENTER HOSPITAL   (Japan)

Author keywords

Leukaemia; Mad1; Mutation; Mxi1; Rox

Indexed keywords

MYC PROTEIN; PROTEIN MAD1; PROTEIN MXI1; PROTEIN ROX; UNCLASSIFIED DRUG;

ACUTE GRANULOCYTIC LEUKEMIA; ACUTE LEUKEMIA; ACUTE LYMPHOBLASTIC LEUKEMIA; ADULT; AGED; ARTICLE; BONE MARROW CELL; CANCER SCREENING; CELL LINE; CLINICAL ARTICLE; CONTROLLED STUDY; FEMALE; GENE EXPRESSION; GENE MUTATION; GENE SEQUENCE; GENETIC ANALYSIS; HEMATOLOGIC MALIGNANCY; HEMATOPOIETIC CELL; HUMAN; HUMAN CELL; LEUKEMOGENESIS; MALE; MISSENSE MUTATION; NUCLEOTIDE SEQUENCE; PERIPHERAL BLOOD MONONUCLEAR CELL; PRIORITY JOURNAL; PROTEIN DOMAIN; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; SINGLE STRAND CONFORMATION POLYMORPHISM; VOLUNTEER;

ACUTE DISEASE; ADOLESCENT; ADULT; AGED; AMINO ACID SEQUENCE; BASE SEQUENCE; BASIC HELIX-LOOP-HELIX LEUCINE ZIPPER TRANSCRIPTION FACTORS; BASIC HELIX-LOOP-HELIX TRANSCRIPTION FACTORS; BONE MARROW CELLS; CELL CYCLE PROTEINS; CELL LINE, TUMOR; DNA MUTATIONAL ANALYSIS; FEMALE; GENE EXPRESSION; HL-60 CELLS; HUMANS; K562 CELLS; LEUKEMIA; MALE; MIDDLE AGED; MOLECULAR SEQUENCE DATA; NUCLEAR PROTEINS; PROTO-ONCOGENE PROTEINS C-MYC; REPRESSOR PROTEINS; SEQUENCE HOMOLOGY, AMINO ACID; TUMOR SUPPRESSOR PROTEINS; U937 CELLS;

EID: 34347351211     PISSN: 10428194     EISSN: 10292403     Source Type: Journal    
DOI: 10.1080/10428190701342018     Document Type: Article

References (28)

1. Henriksson, M. and Luscher, B. (1996) Proteins of the Myc network: essential regulators of cell growth and differentiation. Adv Cancer Res, 68, pp. 109-182.
2. Blackwood, E. M. and Eisenman, R. N. (1991) Max: A helix-loop-helix zipper protein that forms a sequence-specific DNA-binding complex with Myc. Science, 251, pp. 1211-1217.
3. Billin, A. N., Eilers, A. L., Queva, C. and Ayer, D. E. (1999) Mlx, a novel Max-like BHLHZip protein that interacts with the Max network of transcription factors. J Biol Chem, 274, pp. 36344-36350.
4. Gallant, P. (2006) Myc/Max/Mad in invertebrates: The evolution of the Max network. Curr Top Microbiol Immunol, 302, pp. 235-253.
5. Ayer, D. E., Kretzner, L. and Eisenman, R. N. (1993) Mad: A heterodimeric partner for Max that antagonizes Myc transcriptional activity. Cell, 72, pp. 211-222.
6. Zervos, A. S., Gyuris, J. and Brent, R. (1993) Mxi1, a protein that specifically interacts with Max to bind Myc-Max recognition sites. Cell, 72, pp. 223-232.
7. Hurlin, P. J., Queva, C. and Eisenman, R. N. (1997) Mnt, a novel Max-interacting protein is coexpressed with Myc in proliferating cells and mediates repression at Myc binding sites. Genes Dev, 11, pp. 44-58.
8. Edelhoff, S., Ayer, D. E., Zervos, A. S., Steingrimsson, E., Jenkins, N. A. and Copeland, N. G. (1994) Mapping of two genes encoding members of a distinct subfamily of MAX interacting proteins: MAD to human chromosome 2 and mouse chromosome 6, and MXI1 to human chromosome 10 and mouse chromosome 19. Oncogene, 9, pp. 665-668.
9. Roy, B. and Reisman, D. (1995) Inducible expression of Mad accelerates growth arrest of serum deprived human glioblastoma cells. Cell Biol Int, 19, pp. 307-313.
10. Chen, J., Willingham, T., Margraf, L. R., Schreiber-Agus, N., DePinho, R. A. and Nisen, P. D. (1995) Effects of the MYC oncogene antagonist, MAD, on proliferation, cell cycling and the malignant phenotype of human brain tumour cells. Nat Med, 1, pp. 638-643.
11. Prochownik, E. V., Grove, L Eagle, Deubler, D., Zhu, X. L., Stephenson, R. A. and Rohr, L. R. (1998) Commonly occurring loss and mutation of the MXI1 gene in prostate cancer. Genes Chromosomes Cancer, 22, pp. 295-304.
12. Li, X. J., Wang, D. Y., Zhu, Y., Guo, R. J., Wang, X. D. and Lubomir, K. (1999) Mxi1 mutations in human neurofibrosarcomas. Jpn J Cancer Res, 90, pp. 740-746.
13. Sommer, A., Waha, A., Tonn, J., Sorensen, N., Hurlin, P. J. and Eisenman, R. N. (1999) Analysis of the Max-binding protein MNT in human medulloblastomas. Int J Cancer, 82, pp. 810-816.
14. Nigro, C. L., Venesio, T., Reymond, A., Meroni, G., Alberici, P. and Cainarca, S. (1998) The human ROX gene: Genomic structure and mutation analysis in human breast tumors. Genomics, 49, pp. 275-282.
15. Takahashi, T., Konishi, H., Kozaki, K., Osada, H., Saji, S. and Takahashi, T. (1998) Molecular analysis of a Myc antagonist, ROX/Mnt, at 17p13.3 in human lung cancers. Jpn J Cancer Res, 89, pp. 347-351.
16. Ayer, D. E., Lawrence, Q. A. and Eisenman, R. N. (1995) Mad-Max transcriptional repression is mediated by ternary complex formation with mammalian homologs of yeast repressor Sin3. Cell, 80, pp. 767-776.
17. Sommer, A., Hilfenhaus, S., Menkel, A., Kremmer, E., Seiser, C. and Loidl, P. (1997) Cell growth inhibition by the Mad/Max complex through recruitment of histone deacetylase activity. Curr Biol, 7, pp. 357-365.
18. Koskinen, P. J., Ayer, D. E. and Eisenman, R. N. (1995) Repression of Myc-Ras cotransformation by Mad is mediated by multiple protein - protein interactions. Cell Growth Differ, 6, pp. 623-629.
19. Roussel, M. F., Ashmun, R. A., Sherr, C. J., Eisenman, R. N. and Ayer, D. E. (1996) Inhibition of cell proliferation by the Mad1 transcriptional repressor. Mol Cell Biol, 16, pp. 2796-2801.
20. Eilers, A. L., Billin, A. N., Liu, J. and Ayer, D. E. (1999) A 13-amino acid amphipathic alpha-helix is required for the functional interaction between the transcriptional repressor Mad1 and mSin3A. J Biol Chem, 274, pp. 32750-32756.
21. Hara, F., Suzuki, T., Saito, M., Hikino, T., Fukushima, T. and Oyama, T. (1994) Non-isotopic single strand conformation polymorphism (PCR-SSCP) with subsequent direct sequencing after silver staining. Pathol Int, 44, pp. 815-816.
22. Foley, K. P. and Eisenman, R. N. (1999) Two MAD tails: What the recent knockouts of Mad1 and Mxi1 tell us about the MYC/MAX/MAD network. Biochim Biophys Acta, 1423, pp. M37-M47.
23. Kawamata, N., Park, D., Wilczynski, S., Yokota, J. and Koeffler, H. P. (1996) Point mutations of the Mxil gene are rare in prostate cancers. Prostate, 29, pp. 191-193.
24. Bartsch, D., Peiffer, S. L., Kaleem, Z., Wells Jr, S. A. and Goodfellow, P. J. (1996) Mxi1 tumor suppressor gene is not mutated in primary pancreatic adenocarcinoma. Cancer Lett, 102, pp. 73-76.
25. Wechsler, D. S., Shelly, C. A., Petroff, C. A. and Dang, C. V. (1997) MXI1, a putative tumor suppressor gene, suppresses growth of human glioblastoma cells. Cancer Res, 57, pp. 4905-4912.
26. Ferre-D'Amare, A. R., Prendergast, G. C., Ziff, E. B. and Burley, S. K. (1993) Recognition by Max of its cognate DNA through a dimeric b/HLH/Z domain. Nature, 363, pp. 38-45.
27. Schreiber-Agus, N., Meng, Y., Hoang, T., Hou Jr, H., Chen, K. and Greenberg, R. (1998) Role of Mxi1 in aging organ systems and the regulation of normal and neoplastic growth. Nature, 393, pp. 483-487.
28. Magrath, I. (1990) The pathogenesis of Burkitt's lymphoma. Adv Cancer Res, 55, pp. 133-270.