Cytokeratin CK20 is a sensitive marker for Crooke's cells and the early cytoskeletal changes associated with hypercortisolism within pituitary corticotrophs

Endocrine Pathology

Volumn 17, Issue 4, 2006, Pages 365-376

  Eschbacher, Jennifer M ^a   Coons, Stephen W ^a  

^a BARROW NEUROLOGICAL INSTITUTE   (United States)

Author keywords

CK20; Crooke's cell; Cytokeratin; Hypercortisolism; Pituitary

Indexed keywords

BIOLOGICAL MARKER; CORTICOTROPIN; CYTOKERATIN 20; GLUCOCORTICOID; HYDROCORTISONE;

ADENOHYPOPHYSIS; ANTIBODY SPECIFICITY; ARTICLE; AUTOPSY; CLINICAL ARTICLE; CROOKE CELL; CYTOSKELETON; DISEASE ASSOCIATION; EPITHELIUM CELL; HUMAN; HUMAN TISSUE; HYPERCORTISOLISM; HYPOPHYSIS; HYPOPHYSIS CELL; IMMUNOCHEMISTRY; IMMUNOHISTOCHEMISTRY; IMMUNOREACTIVITY; PRIORITY JOURNAL; PROTEIN EXPRESSION; SENSITIVITY AND SPECIFICITY;

BIOLOGICAL MARKERS; CORTICOTROPHS; CUSHING SYNDROME; CYTOSKELETON; HUMANS; KERATIN-20; SENSITIVITY AND SPECIFICITY;

EID: 34347342784     PISSN: 10463976     EISSN: None     Source Type: Journal    
DOI: 10.1007/s12022-006-0008-y     Document Type: Article

References (21)

1. Crooke AC. A change in the basophil cells of the pituitary gland common to conditions which exhibit the syndrome attributed to basophil adenoma. J Path Bacteriol 41:339-349, 1935.
2. Laqueur GL. Cytological changes in human hypophyses after cortisone and ACTH treatment. Science 112:429-430, 1950.
3. Ogawa A, Sugihara S, Nakanishi Y, et al. Intermediate filament expression in non-neoplastic pituitary cells. Virchows Arch B Cell Pathol Incl Mol Pathol 58:331-340, 1990.
4. Halliday WC, Asa SL, Kovacs K, Scheithauer BW. Intermediate filaments in the human pituitary gland: an immunohistochemical study. Canad J Neurol Sci 17:131-136, 1990.
5. Uei Y. Immunohistological study of Crooke's cells. Pathol Res Pract 183:636-637, 1988.
6. Neumann PE, Horoupian DS, Goldman JE, Hess MA. Cytoplasmic filaments of Crooke's hyaline change belong to the cytokeratin class. An immunocytochemical and ultrastructural study. Am J Pathol 116:214-222, 1984.
7. Uei Y, Kanzaki M, Yabana T. Further immunohistochemical study of Crooke's hyalin. Pathol Res Pract 187:539-540, 1991.
8. Kasper M, Kasper M, Kern F, Heitz PU, Gudat F. Immunohistochemical studies on human pituitary gland and adenomas. J Hirnforsch 32:725-734, 1991.
9. Kasper M, Stosiek P, van Muijen GN, Moll R. Cell type heterogeneity of intermediate filament expression in epithelia of the human pituitary gland. Histochemistry 93:93-103, 1989.
10. Moll R, Lowe A, Laufer J, Franke WW. Cytokeratin 20 in human carcinomas. A new histodiagnostic marker detected by monoclonal antibodies. Am J Pathol 140:427-447, 1992.
11. Wildi S, Kleeff J, Maruyama H, et al. Characterization of cytokeratin 20 expression in pancreatic and colorectal cancer. Clin Cancer Res 5:2840-2847, 1999.
12. Miettinen M. Keratin 20 immunohistochemical marker for gastrointestinal, urothelial, and Merkel cell carcinomas. Mod Pathol 8:384-388, 1995.
13. Coons SW, Estrada SI, Gamez R, White WL. Cytokeratin CK 7 and CK 20 expression in pituitary adenomas. Endocr Pathol 16:201-210, 2005.
14. George DH, Scheithauer BW, Kovacs K, et al. Crooke's cell adenoma of the pituitary: an aggressive variant of corticotroph adenoma. Am J Surg Pathol 27:1330-1336, 2003.
15. Dabbs DD. Diagnostic immunochemistry. In: Cerilli LA, Wick MR, eds. Immunohistology of soft tissue and osseous neoplasms. Philadelphia: Churchill Livingstone, 2002; 59-60.
16. Asa SL. Atlas of tumor pathology, tumors of the pituitary gland. Washington, DC: Armed Forces Institute of Pathology, 1998.
17. Kovacs K, Horvath E, Stratmann IE, Ezrin C. Cytoplasmic microfilaments in the anterior lobe of the human pituitary gland. Acta Anat (Basel) 87:414-426, 1974.
18. DeCicco FA, Dekker A, Yunis EJ. Fine structure of Crooke's hyaline change in the human pituitary gland. Arch Pathol 94:65-70, 1972.
19. Wagermark J, Wersall J. Ultrastructural features of Crooke's changes in pituitary basophil cells. Acta Pathol Microbiol Scand 72:367-375, 1968.
20. Flitsch J, Ludecke DK, Knappe UJ, Saeger W. Correlates of long-term hypocortisolism after transsphenoidal microsurgery for Cushing's disease. Exp Clin Endocrinol Diabetes 107:183-189, 1999.
21. Saeger W, Geisler F, Ludecke DK. Pituitary pathology in Cushing's disease. Pathol Res Pract 183:592-595, 1988.