Predictors of tumor downsizing and regression with preoperative radiotherapy alone and with concomitant tegafur/uracil (UFT) for resectable advanced rectal adenocarcinoma

Hepato-Gastroenterology

Volumn 54, Issue 76, 2007, Pages 1107-1112

  Sadahiro, Sotaro ^a   Suzuki, Toshiyuki ^a   Maeda, Yuji ^a   Tanaka, Yoichi ^a   Nakamura, Tomoki ^a   Saguchi, Takeshi ^a   Yasuda, Seiei ^a   Makuuchi, Hiroyasu ^a   Murayama, Chieko ^a   Ohizumi, Yukio ^a  

^a TOKAI UNIVERSITY   (Japan)

Author keywords

Chemoradiotherapy; Radiosensitivity; Radiotherapy; Rectal cancer; Tegafur uracil (UFT)

Indexed keywords

KI 67 ANTIGEN; PROTEIN P21; PROTEIN P53; UFT;

ADULT; ADVANCED CANCER; AGED; ARTICLE; CANCER SURGERY; FEMALE; HISTOPATHOLOGY; HUMAN; HUMAN TISSUE; INTRAOPERATIVE RADIOTHERAPY; MAJOR CLINICAL STUDY; MALE; PREDICTOR VARIABLE; PREOPERATIVE RADIOTHERAPY; PRIORITY JOURNAL; PROTEIN EXPRESSION; RECTUM CARCINOMA; TUMOR BIOPSY; TUMOR REGRESSION;

ADENOCARCINOMA; AGED; ANTINEOPLASTIC COMBINED CHEMOTHERAPY PROTOCOLS; APOPTOSIS; DRUG RESISTANCE, NEOPLASM; FEMALE; HUMANS; MALE; MIDDLE AGED; PREOPERATIVE CARE; PROGNOSIS; RADIATION TOLERANCE; RECTAL NEOPLASMS; TEGAFUR; TREATMENT OUTCOME; TUMOR MARKERS, BIOLOGICAL; URACIL;

EID: 34347339671     PISSN: 01726390     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (28)

1. Gerard A, Buyse M, Nordlinger B, et al: Preoperative radiotherapy as adjuvant treatment in rectal cancer. Final results of a randomized study of the European Organization for Research and Treatment of Cancer (EORTC). Ann Surg 1988; 208:606-614.
2. Goldberg PA, Nicholls RJ, Porter NH, et al: Long-term results of a randomized trial of short-course low-dose adjuvant preoperative radiotherapy for rectal cancer: reduction in local failure. Eur J Cancer 1994; 30A:1602-1606.
3. Marsh PJ, James RD, Schofield PF. Adjuvant preoperative radiotherapy for locally advanced rectal carcinoma: results of a prospective, randomized trial. Dis Colon Rectum 1994; 37:1205-1214.
4. Swedish Rectal Cancer Trial: Improved survival with preoperative radiotherapy in resectable rectal cancer. N Engl J Med 1997; 336: 980-987.
5. Colorectal Cancer Collaborative Group: Adjuvant radiotherapy for rectal cancer: a systematic overview of 8507 patients from 22 randomised trials. Lancet 2001; 358:1291-1304.
6. Janjan NA, Khoo VS, Abbruzzese J, et al: Tumor downstaging and sphincter preservation with preoperative chemoradiation in locally advanced rectal cancer. Int J Radiat Oncol Biol Phys 1999; 44:1027-1038.
7. Crane CH, Skibber JM, Birnbaum EH, et al: The addition of continuous infusion 5-FU to preoperative radiation therapy increases tumor response, leading to increased sphincter preservation in locally advanced rectal cancer. Int J Radiat Oncol Biol Phys 2003; 57:84-89.
8. Berger C, de Muret A, Garaud P, et al: Preoperative radiotherapy (RT) for rectal cancer: predictors of tumor downstsging and residual tumor cell density (RTCD): prognostic implications. Int J Radiat Oncol Biol Phys 1997; 37:619-627.
9. Francois Y, Nemoz CJ, Baulieux J, et al. Influence of the interval between preoperative radiation therapy and surgery on downstaging and on the rate of sphincter-sparing surgery for rectal cancer: the Lyon R90-01 randomized trial. J Clin Oncol 1999; 17:2396-2402.
10. Moore HG, Gittleman AE, Minsky BD, et al: Rate of pathologic complete response with increased interval between preoperative combined modality therapy and rectal cancer resection. Dis Colon Rectum 2004; 47:279-286.
11. Fu CG, Tominaga O, Nagawa H, et al: Role of p53 and P21/WAF1 detectionin patients selection for preoperative radiotherapy in rectal cancer patients. Dis Colon rectum 1998; 41:68-74.
12. Scott N, Hale A, Deakin M, et al: A histopathological assessment of the response of rectal adenocarcinoma to combination chemo-radiotherapy: relationship to apoptotic activity, p53 and bcl-2 expression. Eur J Surg Oncol 1998; 24:169-173.
13. Qiu H, Sirivongs P, Rothenberger M, et al: Molecular prognostic factors in rectal cancer treated by radiation and surgery. Dis Colon Rectum 2000; 43:451-459.
14. Adell G, Zhang H, Jansson A, et al: Decreased tumor cell proliferation as an indicator of the effect of preoperative radiotherapy of rectal cancer. Int J Radiat Oncol Biol Phys 2001; 50:659-663.
15. Rödel C, Grabenbauer GG, Papadopoulos T, et al: Apoptosis as a cellular predictor for histopathologic response to neoadjuvant radiochemotherapy in patients with rectal cancer. Int J Radiat Oncol Biol Phys 2002; 52:294-303.
16. Sadahiro S, Suzuki T, Ishikawa K, et al: Intraoperative radiation therapy for curatively resected rectal cancer. Dis Colon Rectum 2001; 44:1689-1695.
17. Sadahiro S, Suzuki T, Ishikawa K, et al: Preoperative radio/chemoradiotherapy in combination with intraoperative radiotherapy for T3-4Nx Rectal Cancer. Eur J Surg Oncol 2004; 30:750-758.
18. Fujii S, Ikenaka K, Fukushima M, Shirasaka T:. Effect of uracil and its derivatives on antitumor activity of 5-fluorouracil and 1-(2-tetrahydrofuryl)-5-fluorouracil. 1978;69:763-772.
19. Fujii S, Kitano S, Ikenaka K, Shirasaka T: Effect of coadministration of uracil or cytosine on the antitumor activity of clinical doses of 1-(2-tetrahydrofuryl)-5-fluorouracil and level of 5-fluorouracil in rodents. Gann 1979; 70:209-214.
20. Sulkes A, Benner SE, Canetta RM: Uracil-ftorafur: an oral fluoropyrimidine active in colorectal cancer. J Clin Oncol 1998; 16:3461-3475.
21. Ho DH, Pazdur R, Covington W, et al: Comparison of 5-fluorouracil pharmacokinetics in patients receiving continuous 5-fluorouracil infusion and oral uracil plus N1-(2′-tetrahydrofuryl)-5-fluorouracil. Clin Cancer Res 1998; 4:2085-2088.
22. Heald RJ, Husband EM, Ryall RD: The mesorectum in rectal cancer surgery-the clue to pelvic recurrence? Br J Surg 1982; 69:613-616.
23. Mandard AM, Dalibard F, Mandard JC, et al: Pathologic assessment of tumor regression after preoperative chemoradiotherapy of esophageal correlation. Clinicopathologic correlations. Cancer 1994; 73:2680-2686.
24. Sauer R, Fietkau R, Wittekind C, et al: German Rectal Cancer Group. Adjuvant vs. neoadjuvant radiochemotherapy for locally advanced rectal cancer: the German trial CAO/ARO/AIO-94. Colorectal Dis 2003; 5:406-415.
25. Janjan NA, Abbruzzese J, Pazdur R, et al: Prognostic implications of response to preoperative infusional chemoradiation in locally advanced rectal cancer. Radiother Oncol 1999; 51:153-160.
26. Ruo L, Tickoo S, Klimstra DS, et al: Long-term prognostic significance of extent of rectal cancer response to preoperative radiation and chemotherapy. Ann Surg 2002; 236:75-81.
27. Valentini V, Coco C, Picciocchi A, et al: Does downstaging predict improved outcome after preoperative chemoradiation for extraperitoneal locally advanced rectal cancer? A long-term analysis of 165 patients. Int J Radiat Oncol Biol Phys 2002; 53:664-674.
28. García-Aguilar J, Hernandez de Anda E, Sirivongs P, et al: A pathologic complete response to preoperative chemoradiation is associated with lower local recurrence and improved survival in rectal cancer patients treated by mesorectal excision. Dis Colon Rectum 2003; 46:298-304.