Association of suicide and antidepressant prescription rates in Japan, 1999-2003

Journal of Clinical Psychiatry

Volumn 68, Issue 6, 2007, Pages 908-916

  Nakagawa, Atsuo ^a,b,c   Grunebaum, Michael F ^a,b   Ellis, Steven P ^a,b   Oquendo, Maria A ^a,b   Kashima, Haruo ^c   Gibbons, Robert D ^d   Mann, J John ^a,b  

^a NEW YORK STATE PSYCHIATRIC INSTITUTE   (United States)

^b Keio University ^*  (United States)

^c KEIO UNIVERSITY   (Japan)

^d UNIVERSITY OF ILLINOIS AT CHICAGO   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

AMOXAPINE; FLUVOXAMINE; LOFEPRAMINE; MAPROTILINE; MIANSERIN; MILNACIPRAN; PAROXETINE; SAFRAZINE; SEROTONIN UPTAKE INHIBITOR; TECIPTILINE; TRAZODONE; TRICYCLIC ANTIDEPRESSANT AGENT;

ADULT; AGED; ALCOHOL CONSUMPTION; ARTICLE; CONTROLLED STUDY; DEPRESSION; DISEASE ASSOCIATION; DRUG UTILIZATION; FEMALE; HUMAN; JAPAN; MAJOR CLINICAL STUDY; MALE; PRESCRIPTION; PRIORITY JOURNAL; SEX DIFFERENCE; SUICIDAL BEHAVIOR; UNEMPLOYMENT;

EID: 34347325970     PISSN: 01606689     EISSN: None     Source Type: Journal    
DOI: 10.4088/JCP.v68n0613     Document Type: Article

References (88)

1. World Health Organization. Suicide rates (per 100,000) by country, year, and sex. 2004. Available at: http://www.who.int/mental_health/prevention/ suicide/en/Figures_web0604_table.pdf. Accessed Dec 1, 2005
2. Ministry of Health, Labor and Welfare. Cause of death by sex. Vital Statistics of Japan, 2004 Available at: http://wwwdbtk.mhlw.go.jp/toukei/data/ 010/2004/toukeihyou/0004982/t0109010/MC120000_002.html. Accessed Jan 26, 2005
3. National Center for Injury Prevention and Control. 2004, United States suicide injury deaths and rates per 100,000 [CDC Web site]. Available at: http://webapp.cdc.gov/sasweb/ncipc/mortrate.html. Accessed Dec 15, 2005
4. Barraclough B, Bunch J, Nelson B, et al. One hundred cases of suicide: clinical aspects. Br J Psychiatry 1974;125:355-357
5. Hagnell O, Rorsman B. Suicide in the Lundby study: a comparative investigation of clinical aspects. Neuropsychobiology 1979;5:61-73
6. Rich CL, Young D, Fowler RC. San Diego suicide study, pt 1: young vs old subjects. Arch Gen Psychiatry 1986;43:577-582
7. Henriksson MM, Aro HM, Marttunen MJ, et al. Mental disorders and comorbidity in suicide. Am J Psychiatry 1993;150:935-940
8. Isacsson G, Bergman U, Rich CL. Antidepressants, depression and suicide: an analysis of the San Diego study. J Affect Disord 1994;32:277-286
9. Isometsä E, Henriksson M, Heikkinen M, et al. Suicide and the use of antidepressants: drug treatment of depression is inadequate. BMJ 1994;308:915
10. Isacsson G, Holmgren P, Druid H, et al. The utilization of antidepressants: a key issue in the prevention of suicide: an analysis of 5281 suicides in Sweden during the period 1992-1994. Acta Psychiatr Scand 1997;96:94-100
11. Oquendo MA, Malone KM, Ellis SP, et al. Inadequacy of antidepressant treatment for patients with major depression who are at risk for suicidal behavior. Am J Psychiatry 1999;156:190-194
12. Mann JJ, Apter A, Bertolote J, et al. Suicide prevention strategies: a systematic review. JAMA 2005;294:2064-2074
13. McNamus P, Mant A, Mitchell PB, et al. Recent trends in the use of antidepressants in Australia, 1990-1998. Med J Aust 2000;173:458-461
14. Olfson M, Marcus SC, Pincus HA, et al. Antidepressant prescribing practices of outpatient psychiatrists. Arch Gen Psychiatry 1998;55: 310-316
15. Lawrenson RA, Tyrer F, Newson RB, et al. The treatment of depression in UK general practice: selective serotonin reuptake inhibitors and tricyclic antidepressants compared. J Affect Disord 2000;59:149-157
16. Rihmer Z. Can better recognition and treatment of depression reduce suicide rates?: a brief review. Eur Psychiatry 2001;16:406-409
17. Grunebaum MF, Ellis SP, Li S, et al. Antidepressants and suicide risk in the United States, 1985-1999. J Clin Psychiatry 2004;65:1456-1462
18. Gibbons RD, Hur K, Bhaumik DK, et al. The relationship between antidepressant medication use and rate of suicide. Arch Gen Psychiatry 2005;62:165-172
19. Isacsson G. Suicide prevention-a medical breakthrough? Acta Psychiatr Scand 2000;102:113-117
20. Carlsten A, Waern M, Ekedahl A, et al. Antidepressant medication and suicide in Sweden. Pharmacoepidemiol Drug Saf 2001;10:525-530
21. Kelly CB, Ansari T, Rafferty T, et al. Antidepressant prescribing and suicide rare in Northern Ireland. Eur Psychiatry 2003;18:325-328
22. Rihmer Z. Decreasing national suicide rates: fact or fiction? World J Biol Psychiatry 2004;5:55-56
23. Hall WD, Mant A, Mitchell PB, et al. Association between antidepressant prescribing and suicide in Australia, 1991-2000: trend analysis. BMJ 2003;326:1008
24. Ludwig J, Marcotte DE. Anti-depressants, suicide, and drug regulation. J Policy Anal Manage 2005;24:249-272
25. Olfson M, Shaffer D, Marcus SC, et al. Relationship between antidepressant medication treatment and suicide in adolescents. Arch Gen Psychiatry 2003;60:978-982
26. Barbui C, Campomori A, D'Avanzo B, et al. Antidepressant drug use in Italy since the introduction of SSRIs: national trends, regional differences and impact on suicide rates. Soc Psychiatry Psychiatr Epidemiol 1999;34:152-156
27. Guaiana G, Andretta M, Corbari L, et al. Antidepressant drug consumption and public health indicators in Italy, 1955 to 2000. J Clin Psychiatry 2005;66:750-755
28. Helgason T, Tomasson H, Zoega T. Antidepressants and public health in Iceland: time series analysis of national data. Br J Psychiatry 2004;184: 157-162
29. Takahashi Y. Amidst a sudden increase of suicide. In: Suicide in Japan [monograph]. Tokyo, Japan: 2003:1-12
30. Rich CL, Isacsson G. Suicide and antidepressants in South Alabama: evidence for improved treatment of depression. J Affect Disord 1997; 45:135-142
31. Henriksson S, Boethius G, Isacsson G. Suicides are seldom prescribed antidepressants: findings from a prospective prescription database in Jamtland county, Sweden, 1985-95. Acta Psychiatr Scand 2001;103: 301-306
32. Isacsson G, Holmgren P, Ahlner J. Selective serotonin reuptake inhibitor antidepressants and the risk of suicide: a controlled forensic database study of 14,857 suicides. Acta Psychiatr Scand 2005;111:286-290
33. Platt S. Unemployment and suicidal behavior: a review of the literature. Soc Sci Med 1984;19:93-115
34. Takei N, Kawai M, Mori N. Sluggish economics affect health of Japanese 'business warriors.' Br J Psychiatry 2000;176:494-495
35. Hawton K, Harriss L, Hodder K, et al. The influence of the economic and social environment on deliberate self-harm and suicide: an ecological and person-based study. Psychol Med 2001;31:827-836
36. Yamasaki A, Chinami M, Morgenthaler S, et al. Enterprise failures correlate positively with suicide rate for both sexes in Japan. Psychol Rep 2004;95:917-920
37. Fawcett J, Scheftner WA, Fogg L, et al. Time-related predictors of suicide in major affective disorder. Am J Psychiatry 1990;147:1189-1194
38. Carlson GA, Rich CL, Grayson P, et al. Secular trends in psychiatric diagnoses of suicide victims. J Affect Disord 1991;21:127-132
39. Cooper J, Kapur N, Webb R, et al. Suicide after deliberate self-harm: a 4-year cohort study. Am J Psychiatry 2005;162:297-303
40. WHO World Mental Health Survey Consortium. Prevalence, severity, and unmet need for treatment of mental disorders in the World Health Organization World Mental Health Surveys. JAMA 2004;291:2581-2590
41. Ikegami N, Campbell JC. Medical care in Japan. N Engl J Med 1995; 333:1295-1299
42. WHO Collaborating Centre for Drug Statistics Methodology. Guidelines for ATC Classification and DDD Assignment, 2nd ed. Oslo, Norway: World Health Organization; 1998
43. Japanese Labor Force Survey. Statistics Bureau, Japanese Ministry of Internal Affairs and Communications. Available at http://www.stat.go.jp/data/ roudou/longtime/zuhyou/lt01-13.xls. Accessed Feb 4, 2006
44. National Tax Agency. Liquor Tax Statistics of Japan. Available at http://www.nta.go.jp/category/toukei/tokei/jikei/1594/deta/07.xls. Accessed Feb 3, 2006
45. Pinheiro JC, Bates DM. Generalized Least Squares: Mixed-Effects Models and S and S-PLUS. New York, NY: Springer; 2000
46. R Development Core Team. R: A Language and Environment for Statistical Computing. Vienna, Austria: R Foundation for Statistical Computing; 2003
47. Efron B, Tibshirani R. An Introduction to the Bootstrap. New York, NY: Wiley; 1985
48. Rao CR, Wu Y. On model selection. In: Lahiri P, ed. Model Selection, Lecture Notes-Monograph Series. Beachwood, Ohio: Institute of Mathematical Statistics; 2001:1-64
49. Ministry of Health, Labor and Welfare. Method of suicide by sex and age. Vital Statistics of Japan, 2004. Available at: http://wwwdbtk.mhlw.go.jp/toukei/ data/010/2004/toukeihyou/0004982/t0109034/MC36O0O0_001.html. Accessed Aug 29, 2006
50. Moore DS, McCabe GP. Introduction to the Practice of Statistics. New York, NY: W.H. Freeman and Co; 1989:225
51. Potter WZ, Rudorfer MV, Manji H. The pharmacologic treatment of depression. N Engl J Med 1991;325:633-642
52. Geddes JR, Carney SM, Davies C, et al. Relapse prevention with antidepressant drug treatment in depressive disorders: a systematic review. Lancet 2003;361:653-661
53. Fujii S, Kaneko N, Hikawa H, et al. Antidepressant prescribing in Japan. Jpn Bull Soc Psychiatry 2005;14:30-35
54. Sareen J, Cox BJ, Afifi TO, et al. Anxiety disorders and risk for suicidal ideation and suicide attempts: a population-based longitudinal study of adults. Arch Gen Psychiatry 2005;62:1249-1257
55. Kohn R, Saxena S, Levav I, et al. The treatment gap in mental health care. Bull World Health Organ 2004;82:858-866
56. Rothera I, Jones R, Gordon C. An examination of the attitudes and practice of general practitioners in the diagnosis and treatment of depression in older people. Int J Geriatr Psychiatry 2002;17:354-358
57. Hannaford PC, Thompson C, Simpson M. Evaluation of an educational programme to improve the recognition of psychological illness by general practitioners. Br J Gen Pract 1996;46:333-337
58. Butler R, Collins E, Katona C, et al. Does a teaching programme improve general practitioners' management of depression in the elderly? J Affect Disord 1997;46:303-308
59. Rutz W, von Knorring L, Walinder J. Frequency of suicide on Gotland after systematic postgraduate education of general practitioners. Acta Psychiatr Scand 1989;80:151-154
60. Fairman KA, Teitelbaum F, Drevets WC, et al. Course of antidepressant treatment with tricyclic versus selective serotonin reuptake inhibitor agents: a comparison in managed care and fee-for-service environments. Am J Manag Care 1997;3:453-465
61. Croghan TW, Melfi CA, Crown WE, et al. Cost-effectiveness of antidepressant medications. J Ment Health Policy Econ 1998;1:109-117
62. Kapur S, Mieczkowski T, Mann JJ. Antidepressant medications and the relative risk of suicide attempt and suicide. JAMA 1992;268:3441-3445
63. Bruce ML, Ten Have TR, Reynolds CF 3rd, et al. Reducing suicidal ideation and depressive symptoms in depressed older primary care patients: a randomized controlled trial. JAMA 2004;291:1081-1091
64. Brown GK, Ten Have TR, Henriques GR, et al. Cognitive therapy for the prevention of suicide attempts: a randomized controlled trial. JAMA 2005;294:563-570
65. Takahashi K, Naito H, Morita M, et al. Suicide prevention for the elderly in Matsunoyama Town, Higashikubiki County, Niigata Prefecture: psychiatric care for elderly depression in the community. Seishin Shinkeigaku Zasshi 1998;100:469-485
66. Whittington CJ, Kendall T, Fonagy P, et al. Selective serotonin reuptake inhibitors in childhood depression: systematic review of published versus unpublished data. Lancet 2004;363:1341-1345
67. Fergusson D, Doucette S, Glass KC, et al. Association between suicide attempts and selective serotonin reuptake inhibitors: systematic review of randomized controlled trials. BMJ 2005;330:396-399
68. Gunnell D, Saperia J, Ashby D. Selective serotonin reuptake inhibitors (SSRIs) and suicide in adults: meta-analysis of drug company data from placebo controlled, randomized controlled trials submitted to the MHRA's safety review. BMJ 2005;330:385-388
69. Hammad TA, Laughren T, Racoosin J. Suicidality in pediatric patients treated with antidepressant drugs. Arch Gen Psychiatry 2006;63:332-339
70. Hammad TA. Review and evaluation of clinical data. Food and Drug Administration. 2005 Available at: http://www.fda.gov/ohrms/dockets/ac/04/ briefing/2004-4065b1-10-TAB08-Hammads-Review.pdf. Accessed Feb 4, 2006
71. Mann JJ, Emslie G, Baldessarini RJ, et al. ACNP Task Force Report on SSRIs and Suicidal Behavior in Youth. Neuropsychopharmacology 2006;31:473-492
72. Khan A, Warner HA, Brown WA. Symptom reduction and suicide risk in patients treated with placebo in antidepressant clinical trials: an analysis of the Food and Drug Administration database. Arch Gen Psychiatry 2000;57:311-317
73. Khan A, Khan S, Kolts R, et al. Suicide rates in clinical trials of SSRIs, other antidepressants, and placebo: analysis of FDA reports. Am J Psychiatry 2003;160:790-792
74. Beasley CM Jr, Dornseif BE, Bosomworth JC, et al. Fluoxetine and suicide: a meta-analysis of controlled trials of treatment for depression. BMJ 1991;303:685-692
75. Ojima T, Nakamura Y, Detels R. Comparative study about methods of suicide between Japan and the United States. J Epidemiol 2004;14: 187-192
76. Cherek DR, Lane SD, Pietras CJ, et al. Effects of chronic paroxetine administration on measures of aggressive and impulsive responses of adult males with a historv of conduct disorder. Psychopharmacology 2002;159:266-274
77. Reist C, Nakamura K, Sagart E, et al. Impulsive aggressive behavior: open-label treatment with citalopram. J Clin Psychiatry 2003;64:81-85
78. Mozes T, Meiri G, Ben-Amity G, et al. Reboxetine as an optional treatment for hyperkinetic conduct disorder: a prospective open-label trial. J Child Adolesc Psychopharmacol 2005;15:259-269
79. Oquendo MA, Galfalvy H, Russo S, et al. Prospective study of clinical predictors of suicidal acts after a major depressive episode in patients with major depressive disorder or bipolar disorder. Am J Psychiatry 2004;161:1433-1441
80. Dumais A, Lesage AD, Alda M, et al. Risk factors for suicide completion in major depression: a case-control study of impulsive and aggressive behaviors in men. Am J Psychiatry 2005;162:2116-2124
81. Yamasaki A, Sakai R, Shirakawa T. Low income, unemployment, and suicide mortality rates for middle-age persons in Japan. Psychol Rep 2005;96:337-348
82. Iwasaki M, Akechi T, Uchitomi Y, et al. Cigarette smoking and completed suicide among middle-aged men: a population-based cohort study in Japan. Ann Epidemiol 2005;15:286-292
83. Malone KM, Waternaux C, Haas GL, et al. Cigarette smoking, suicidal behavior, and serotonin function in major psychiatric disorders. Am J Psychiatry 2003;160:773-779
84. Yamamoto J. Recent trends of drug abuse in Japan. Ann N Y Acad Sci 2004;1025:430-438
85. Ministry of Health, Labor and Welfare. Annual number of suicide by suicide method and sex. Vital Statistics of Japan, Special Report, 2004. Available at: http://wwwdbtk.mhlw.go.jp/toukei/data/012/2004/toukeihyou/0004877/ t0105626/s22_001.html. Accessed Feb 2, 2006
86. Cooper PN, Milroy CM. The coroner's system and under-reporting of suicide. Med Sci Law 1995;35:319-326
87. Kessing LV, Hansen HV, Demyttenaere K, et al. Depressive and bipolar disorders: patients' attitudes and beliefs towards depression and antidepressants. Psychol Med 2005;35:1205-1213
88. Brown C, Battista DR, Bruehlman R, et al. Beliefs about antidepressant medications in primary care patients: relationship to self-reported adherence. Med Care 2005;43:1203-1207