Thyrotropin Releasing Hormone (TRH) may preserve pancreatic islet cell function: Potential role in the treatment of diabetes mellitus

Acta Biomedica

Volumn 78, Issue SUPPL. 1, 2007, Pages 216-221

  Luo, L G ^a   Jackson, Ivor ^b  

^a ROGER WILLIAMS MEDICAL CENTER   (United States)

^b BROWN UNIVERSITY   (United States)

Author keywords

Diabetes mellitus; Insulin; Islets of Langerhans; Pancreas; Stem cells; Streptozotocin; Thyrotropin Releasing Hormone (TRH)

Indexed keywords

INSULIN; PROTIRELIN; STREPTOZOCIN;

ANIMAL; ARTICLE; DIABETES MELLITUS; DRUG EFFECT; DRUG SCREENING; EXPERIMENTAL DIABETES MELLITUS; FORECASTING; GENE EXPRESSION REGULATION; GLUCOSE BLOOD LEVEL; HOMEOSTASIS; HUMAN; HYPERGLYCEMIA; INSULINOMA; METABOLISM; MOUSE; MOUSE MUTANT; PANCREAS ISLET; PANCREAS TUMOR; PATHOLOGY; PATHOPHYSIOLOGY; PHYSIOLOGY; RABBIT; RAT; SECRETION; STEM CELL; TUMOR CELL LINE;

ANIMALS; BLOOD GLUCOSE; CELL LINE, TUMOR; DIABETES MELLITUS; DIABETES MELLITUS, EXPERIMENTAL; DRUG EVALUATION, PRECLINICAL; FORECASTING; GENE EXPRESSION REGULATION; HOMEOSTASIS; HUMANS; HYPERGLYCEMIA; INSULIN; INSULINOMA; ISLETS OF LANGERHANS; MICE; MICE, KNOCKOUT; PANCREATIC NEOPLASMS; RABBITS; RATS; STEM CELLS; STREPTOZOCIN; THYROTROPIN-RELEASING HORMONE;

EID: 34347265797     PISSN: 03924203     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (31)

1. Engler D, Chad D, Jackson IM. Thyrotropin-releasing hormone in the pancreas and brain of the rat is regulated by central noradrenergic and dopaminergic pathways. J Clin Invest 1982; 69: 1310-20.
2. Reichlin S, Saperstein R, Jackson IM, Boyd AE, 3rd, Patel Y. Hypothalamic hormones. Annu Rev Physiol 1976; 38: 389-424.
3. Wu P, Jackson IM. Identification, characterization and localization of thyrotropin-releasing hormone precursor peptides in perinatal rat pancreas. Regul Pept 1988; 22: 347-60.
4. Basmaciogullari A, Cras-Meneur C, Czernichow P, Scharfmann R. Pancreatic pattern of expression of thyrotropin-releasing hormone during rat embryonic development. J Endocrinol 2000; 166: 481-8.
5. Yamagishi K. Pancreatic exocrine and endocrine functions stimulated with secretin and thyrotropin-releasing hormone in patients with hyperparathyroidism. Nippon Geka Gakkai Zasshi 1992; 93: 494-504.
6. Yamada M, Saga Y, Shibusawa N, et al. Tertiary hypothyroidism and hyperglycemia in mice with targeted disruption of the thyrotropin-releasing hormone gene. Proc Natl Acad Sci USA 1997; 94: 10862-7.
7. Fragner P, Ladram A, Aratan de Leon S. Triiodothyronine down-regulates thyrotropin-releasing hormone (TRH) synthesis and decreases pTRH-(160-169) and insulin releases from fetal rat islets in culture. Endocrinology 1999; 140: 4113-9.
8. Yamaoka T, Itakura M. Development of pancreatic islets (review). Int J Mol Med 1999; 3: 247-61.
9. Koenig ML, Sgarlat CM, Yourick DL, Long JB, Meyerhoff JL. In vitro neuroprotection against glutamateinduced toxicity by pGlu-Glu-Pro-NH(2) (EEP). Peptides 2001; 22: 2091-7.
10. Behrmann DL, Bresnahan JC, Beattie MS. Modeling of acute spinal cord injury in the rat: neuroprotection and enhanced recovery with methylprednisolone, U-74006F and YM-14673. Exp Neurol 1994; 126: 61-75.
11. Stanley SA, Small CJ, Murphy KG, et al. Actions of cocaine-and amphetamine-regulated transcript (CART) peptide on regulation of appetite and hypothalamo-pituitary axes in vitro and in vivo in male rats. Brain Res 2001; 893: 186-94.
12. de Gortari P, Mendez M, Rodriguez-Keller I, Perez-Martinez L, Joseph-Bravo P. Acute ethanol administration induces changes in TRH and proenkephalin expression in hypothalamic and limbic regions of rat brain. Neurochem Int 2000; 37: 483-96.
13. Amir S, Jackson IM. Immunological blockade of endogenous thyrotropin-releasing hormone impairs recovery from hyperglycemia in mice. Brain Res 1988; 462: 160-2.
14. Chen Y, Uemura K, Yoshioka S, et al. Centrally administered TRH-induced insulin secretion is impaired in the Otsuka-Long-Evans-Tokushima Fatty rats, a model of spontaneous non-insulin-dependent diabetes mellitus. J Auton Nerv Syst 1998; 71: 10-7.
15. Rondeel JM, de Greef WJ, Heide R, Visser TJ. Hypothalamo-hypophysial-thyroid axis in streptozotocin-induced diabetes. Endocrinology 1992; 130: 216-20.
16. Ishiguro T, Iguchi A, Kunoh Y, et al. Relative contribution of nervous system and hormones to hyperglycemia induced by thyrotropin-releasing hormone in fed rats. Neuroendocrinology 1991; 54: 1-6.
17. Amir S. Thyrotropin-releasing hormone (TRH) blocks glucagon-induced hyperglycemia in mice: dissociation of the antihyperglycemic and pituitary actions of TRH. Brain Res 1988; 455: 201-3.
18. Qian XJ. [The effects of thyrotropin releasing hormone (TRH) on the digestive activity (author's transl)]. Sheng Li Ke Xue Jin Zhan 1981; 12: 171-4.
19. Maltese JY, Giraud P, Kowalski C, et al. Ontogenetic expression of peptidyl-glycine alpha-amidating monooxygenase mRNA in the rat pancreas. Biochem Biophys Res Commun 1989; 158: 244-50.
20. Vara E, Idahl LA, Lindstrom P, Sehlin J, Tamarit-Rodriguez J. Insulin, glucagon, somatostatin, and thyrotropin-releasing hormone content and secretion by perifused fetal rat islets during culture. Acta Endocrinol (Copenh) 1990; 123: 353-8.
21. Glasbrenner B, Malfertheiner P, Duntas L, Buchler M, Bereiter T, Ditschuneit H. Effects of TRH on pancreatic growth and secretion in rats. Pancreas 1990; 5: 37-41.
22. Strbak V, Ouafik LH, Resetkova E, et al. Thyrotropin releasing hormone in the pancreas of newborn rats from streptozotocin-treated mothers. Life Sci 1989; 44: 779-87.
23. Yamada M, Shibusawa N, Hashida T, et al. Expression of thyrotropin-releasing hormone (TRH) receptor subtype 1 in mouse pancreatic islets and HIT-T15, an insulin-secreting clonal beta cell line. Life Sci 2000; 66: 1119-25.
24. Alhan E, Kucuktulu U, Ercin C, Efe H, Al S. The effects of calcium channel blocker and thyrotropin releasing hormone on acute necrotizing pancreatitis in rats. Res Exp Med (Berl) 1999; 199: 51-8.
25. Luo LG, Yano N. Expression of thyrotropin-releasing hormone receptor in immortalized beta-cell lines and rat pancreas. J Endocrinol 2004; 181: 401-12.
26. Doong ML, Yang H: Intravenous glucose infusion decreases intracisternal thyrotropin-releasing hormone induced vagal stimulation of gastric acid secretion in anesthetized rats. Neurosci Lett 2003; 340: 49-52.
27. Pizzi M, Boroni F, Benarese M, Moraitis C, Memo M, Spano P. Neuroprotective effect of thyrotropin-releasing hormone against excitatory amino acid-induced cell death in hippocampal slices. Eur J Pharmacol 1999; 370: 133-7.
28. Yano N, Luo L. Effect of thyrotropin releasing hormone (TRH) on gene expressions in rat pancreas: approach by microarray hybridization. JOP 2004; 5: 193-204.
29. Li Y, Hansotia T, Yusta B, Ris F, Halban PA, Drucker DJ. Glucagon-like peptide-1 receptor signaling modulates beta cell apoptosis. J Biol Chem 2003; 278: 471-8.
30. Luo LG, Yano N, Jackson IM. Thyrotropin Releasing Hormone (TRH) reverses hyperglycemia: a novel role for TRH on glucose homeostasis. The Endocrine Society's 86th Annual Meeting; New Orleans, Louisana June 16-19, 2004, 141 (Abstract).
31. Luo L-G. Thyrotropin Releasing Hormone (TRH) reversed streptozotocin (STZ) destroyed beta cells initiating adult pancreatic cell regeneration from stem cells. 2nd Annual Meeting International Society For Stem Cell Research (ISSCR) 2004; 183: 417 (Abstract).