Treatment of focal hyperhidrosis

Journal of Cutaneous Medicine and Surgery

Volumn 11, Issue 2, 2007, Pages 67-77

  Murray, Christian A ^a,b,c   Cohen, Joel L ^a,b,c   Solish, Nowell ^a,b,c  

^a WOMEN S COLLEGE HOSPITAL   (Canada)

^b UNIVERSITY OF COLORADO   (United States)

^c AboutSkin Dermatology and DermSurgery PC   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ALUMINUM CHLORIDE; BOTULINUM TOXIN; BOTULINUM TOXIN A; BOTULINUM TOXIN B; CHOLINERGIC RECEPTOR BLOCKING AGENT; FORMALDEHYDE; GLUTARALDEHYDE; IODINE; LIDOCAINE; PLACEBO; PRILOCAINE; STARCH; MUSCLE RELAXANT AGENT;

APPLICATION SITE IRRITATION; ASTHENIA; AUTONOMIC DYSFUNCTION; BLURRED VISION; CLINICAL TRIAL; CONSTIPATION; COPING BEHAVIOR; CURETTAGE; DIPLOPIA; DISEASE SEVERITY; DOSE RESPONSE; DRUG CONTRAINDICATION; DRUG DOSE COMPARISON; DRUG EFFICACY; DRUG MECHANISM; DRUG MEGADOSE; DRUG SAFETY; DRY THROAT; DYSPHAGIA; EMOTIONAL DISORDER; ENDOSCOPIC SURGERY; EXCISION; FACE HYPERHIDROSIS; FOCAL HYPERHIDROSIS; FREY SYNDROME; HEART ARRHYTHMIA; HORNER SYNDROME; HUMAN; HYPERHIDROSIS; INDIGESTION; INJECTION SITE PAIN; IONTOPHORESIS; LACRIMATION; LIPOSUCTION; PARESTHESIA; PAROTIDECTOMY; PATIENT SATISFACTION; PHYSICAL MEDICINE; PLANTAR HYPERHIDROSIS; PNEUMOTHORAX; PREVALENCE; PRIORITY JOURNAL; PTOSIS; QUALITY OF LIFE; RELAXATION TRAINING; REVIEW; SALIVATION; SIDE EFFECT; SOCIAL ASPECT; SOCIAL PSYCHOLOGY; SWEAT GLAND DISEASE; SWEATING; SYMPATHECTOMY; TACHYCARDIA; URINE RETENTION; XEROSTOMIA; ARTICLE; AXILLA; HAND; INTRADERMAL DRUG ADMINISTRATION; LIPECTOMY; PATHOPHYSIOLOGY;

AXILLA; BOTULINUM TOXIN TYPE A; CHOLINERGIC ANTAGONISTS; HAND; HUMANS; HYPERHIDROSIS; INJECTIONS, INTRADERMAL; IONTOPHORESIS; LIPECTOMY; NEUROMUSCULAR AGENTS; SYMPATHECTOMY;

EID: 34347255719     PISSN: 12034754     EISSN: None     Source Type: Journal    
DOI: 10.2310/7750.2007.00012     Document Type: Review

References (104)

1. Sato K, Kang WH, Saga K, Sato KT. Biology of sweat glands and their disorders. I. Normal sweat gland function. J Am Acad Dermatol 1989;20:537-63.
2. Heckmann M, Ceballos-Baumann AO, Plewig G. Botulinum toxin A for axillary hyperhidrosis (excessive sweating). N Engl J Med 2001;344:488-93.
3. Hornberger J, Grimes K, Naumann M, et al. Recognition, diagnosis, and treatment of primary focal hyperhidrosis. J Am Acad Dermatol 2004;51:274-86.
4. Adar R, Kurchin A, Zweig A, Mozes M. Palmar hyperhidrosis and its surgical treatment: a report of 100 cases. Ann Surg 1977;186: 34-41.
5. Stolman LP. Treatment of hyperhidrosis. Dermatol Clin 1998;16: 863-9.
6. Strutton DR, Kowalski JW, Glaser DA, Stang PE. US prevalence of hyperhidrosis and impact on individuals with axillary hyperhidrosis results from a national survey. J Am Acad Dermatol 2004;
7. Lin TS, Fang HY. Transthoracic endoscopic sympathectomy in the treatment of palmar hyperhidrosis - with emphasis on perioperative management (1,360 case analyses). Surg Neurol 1999;52:453-7.
8. Amir M, Arish A, Weinstein Y, et al. Impairment in quality of life among patients seeking surgery for hyperhidrosis (excessive sweating): preliminary results. Isr J Psychiatry Relat Sci 2000;37: 25-31.
9. Lin TS, Fang HY. Transthoracic endoscopic sympathectomy in the treatment of palmar hyperhidrosis - with emphasis on perioperative management (1,360 case analyses). Surg Neurol 1999;52:453-7.
10. Solish N, Benohanian A, Kowalski JW. Prospective open-label study of botulinum toxin type A in patients with axillary hyperhidrosis: effects on functional impairment and quality of life. Dermatol Surg 2005;31:405-13.
11. Naumann MK, Hamm H, Lowe NJ. Effect of botulinum toxin type A on quality of life measures in patients with excessive axillary sweating: a randomized controlled trial. Br J Dermatol 2002;147:1218-26.
12. Cina CS, Clase CM. The Illness Intrusiveness Rating Scale: a measure of severity in individuals with hyperhidrosis. Qual Life Res 1999;8:693-8.
13. Swartling C, Naver H, Lindberg M. Botulinum A toxin improves life quality in severe primary focal hyperhidrosis. Eur J Neurol 2001;8:247-52.
14. Lerer B, Jacobowitz J, Wahba A. Personality features in essential hyperhidrosis. Int J Psychiatry Med 1980;10:59-67.
15. Kreyden OP, Scheidegger EP. Anatomy of the sweat glands, pharmacology of botulinum toxin, and distinctive syndromes associated with hyperhidrosis. Clin Dermatol 2004;22:40-4.
16. Sato K, Kang WH, Saga K, Sato KT. Biology of sweat glands and their disorders. II. Disorders of sweat gland function. J Am Acad Dermatol 1989;20(5 Pt 1):713-26.
17. Ro KM, Cantor RM, Lange KL, Ahn SS. Palmar hyperhidrosis: evidence of genetic transmission. J Vasc Surg 2002;35:382-6.
18. Uno H. Sympathetic innervation of the sweat glands and piloarrector muscles of macaques and human beings. J Invest Dermatol 1977;69:112-20.
19. Manca D, Valls-Sole J, Callejas MA. Excitability recovery curve of the sympathetic skin response in healthy volunteers and patients with palmar hyperhidrosis. Clin Neurophysiol 2000;111:1767-70.
20. Birner P, Heinzl H, Schindl M, et al. Cardiac autonomic function in patients suffering from primary focal hyperhidrosis. Eur Neurol 2000;44:112-6.
21. Kaya D, Karaca S, Barutcu I, et al. Heart rate variability in patients with essential hyperhidrosis: dynamic influence of sympathetic and parasympathetic maneuvers. Ann Noninvasive Electrocardiol 2005;10:1-6.
22. Boni R, Kreyden OP, Burg G. Revival of the use of botulinum toxin: application in dermatology. Dermatology 2000;200:287-91.
23. Campanati A, Penna L, Guzzo T, et al. Quality-of-life assessment in patients with hyperhidrosis before and after treatment with botulinum toxin: results of an open-label study. Clin Ther 2003; 25:298-308.
24. Weber A, Heger S, Sinkgraven R, et al. Psychosocial aspects of patients with focal hyperhidrosis. Marked reduction of social phobia, anxiety and depression and increased quality of life after treatment with botulinum toxin A. Br J Dermatol 2005;152:342-5.
25. Holzle E, Braun-Falco O. Structural changes in axillary eccrine glands following long-term treatment with aluminium chloride hexahydrate solution. Br J Dermatol 1984;110:399-403.
26. Gordon BI, Maibach HI. Eccrine anhidrosis due to glutaraldehyde, formaldehyde, and iontophoresis. J Invest Dermatol 1969; 53:436-9.
27. Sato K, Dobson RL. Mechanism of the antiperspirant effect of topical glutaraldehyde. Arch Dermatol 1969;100:564-9.
28. Holzle E. Topical pharmacological treatment. Curr Probl Dermatol 2002;30:30-43.
29. Juhlin L, Evers H, Broberg F. Inhibition of hyperhidrosis by topical application of a local anesthetic composition. Acta Derm Venereol 1979;59:556-9.
30. Macmillan FS, Reller HH, Synder FH. The antiperspirant action of topically applied anticholinergics. J Invest Dermatol 1964;43: 363-77.
31. Gren-Jonsson S, Magnusson B. Sensitization to propantheline bromide, trichlorocarbanilide and propylene glycol in an antiperspirant. Contact Dermatitis 1976;2:79-80.
32. Hays LL, Novack AJ, Worsham JC. The Frey syndrome: a simple, effective treatment. Otolaryngol Head Neck Surg 1982;90:419-25.
33. Seukeran DC, Highet AS. The use of topical glycopyrrolate in the treatment of hyperhidrosis. Clin Exp Dermatol 1998;23:204-5.
34. Luh JY, Blackwell TA. Craniofacial hyperhidrosis successfully treated with topical glycopyrrolate. South Med J 2002;95:756-8.
35. Urman JD, Bobrove AM. Diabetic gustatory sweating successfully treated with topical glycopyrrolate: report of a case and review of the literature. Arch Intern Med 1999;159:877-8.
36. Dolianitis C, Scarff CE, Kelly J, Sinclair R. Iontophoresis with glycopyrrolate for the treatment of palmoplantar hyperhidrosis. Australas J Dermatol 2004;45:208-12.
37. Sato K, Timm DE, Sato F, et al. Generation and transit pathway of H+ is critical for inhibition of palmar sweating by iontophoresis in water. J Appl Physiol 1993;75:2258-64.
38. Sloan JB, Soltani K. Iontophoresis in dermatology. A review. J Am Acad Dermatol 1986;15(4 Pt 1):671-84.
39. Levit F. Simple device for treatment of hyperhidrosis by iontophoresis. Arch Dermatol 1968;98:505-7.
40. Reinauer S, Neusser A, Schauf G, Holzle E. Iontophoresis with alternating current and direct current offset (AC/DC iontophoresis): a new approach for the treatment of hyperhidrosis. Br J Dermatol 1993;129:166-9.
41. Karakoc Y, Aydemir EH, Kalkan MT, Unal G. Safe control of palmoplantar hyperhidrosis with direct electrical current. Int J Dermatol 2002;41:602-5.
42. Tkach JR. Indomethacin treatment of generalized hyperhidrosis. J Am Acad Dermatol 1982;6(4 Pt 1):545.
43. Adams BB, Vargus-Adams JN, Franz DN, Kinnett DG. Hyperhidrosis in pediatric spinal cord injury: a case report and gabapentin therapy. J Am Acad Dermatol 2002;46:444-6.
44. Feder R. Clonidine treatment of excessive sweating. J Clin Psychiatry 1995;56:35.
45. Bar LH, Kuypers BR. Behaviour therapy in dermatological practice. Br J Dermatol 1973;88:591-8.
46. Duller P, Gentry WD. Use of biofeedback in treating chronic hyperhidrosis: a preliminary report. Br J Dermatol 1980;103:143-6.
47. Shenefelt PD. Hypnosis in dermatology. Arch Dermatol 2000;136: 393-9.
48. Hurley HJ, Shelley WB. A simple surgical approach to the management of axillary hyperidrosis. JAMA 1963;186:109-12.
49. Wang HJ, Cheng TY, Chen TM. Surgical management of axillary bromidrosis - a modified skoog procedure by an axillary bipedicle flap approach. Plast Reconstr Surg 1996;98:524-9.
50. Wu WH, Ma S, Lin JT, et al. Surgical treatment of axillary osmidrosis: an analysis of 343 cases. Plast Reconstr Surg 1994;94: 288-94.
51. Kim IH, Seo SL, Oh CH. Minimally invasive surgery for axillary osmidrosis: combined operation with CO2 laser and subcutaneous tissue remover. Dermatol Surg 1999;25:875-9.
52. Jemec B. Abrasio axillae in hyperhidrosis. Scand J Plast Reconstr Surg 1975;9:44-6.
53. Tsai RY, Lin JY. Experience of tumescent liposuction in the treatment of osmidrosis. Dermatol Surg 2001;27:446-8.
54. Lee MR, Ryman WJ. Liposuction for axillary hyperhidrosis. Australas J Dermatol 2005;46:76-9.
55. Dondelinger RF, Kurdziel JC. Percutaneous phenol block of the upper thoracic sympathetic chain with computed tomography guidance. A new technique. Acta Radiol 1987;28:511-5.
56. Kao MC, Lin JY, Chen YL, et al. Minimally invasive surgery: video endoscopic thoracic sympathectomy for palmar hyperhidrosis. Ann Acad Med Singapore 1996;25:673-8.
57. Yano M, Kiriyama M, Fukai I, et al. Endoscopic thoracic sympathectomy for palmar hyperhidrosis: efficacy of T2 and T3 ganglion resection. Surgery 2005;138:40-5.
58. Chiou TS. Chronological changes of postsympathectomy compensatory hyperhidrosis and recurrent sweating in patients with palmar hyperhidrosis. J Neurosurg Spine 2005;2:151-4.
59. Sihoe AD, Au SS, Cheung ML, et al. Incidence of chest wall paresthesia after video-assisted thoracic surgery for primary spontaneous pneumothorax. Eur J Cardiothorac Surg 2004;25: 1054-8.
60. Dumont P, Denoyer A, Robin P. Long-term results of thoracoscopic sympathectomy for hyperhidrosis. Ann Thorac Surg 2004; 78:1801-7.
61. Duarte JB, Kux P. Improvements in video-endoscopic sympathicotomy for the treatment of palmar, axillary, facial, and palmar-plantar hyperhidrosis. Eur J Surg Suppl 1998;(580):9-11.
62. Lin TS, Fang HY. Transthoracic endoscopic sympathectomy in the treatment of palmar hyperhidrosis - with emphasis on perioperative management (1,360 case analyses). Surg Neurol 1999;52:453-7.
63. Han PP, Gottfried ON, Kenny KJ, Dickman CA. Biportal thoracoscopic sympathectomy: surgical techniques and clinical results for the treatment of hyperhidrosis. Neurosurgery 2002;50: 306-11.
64. Bechara FG, Sand M, Moussa G, et al. Treatment of unilateral compensatory sweating after endoscopical thoracic sympathectomy for general hyperhidrosis with botulinum toxin A. Dermatol Surg 2006;32:745-8.
65. Rex LO, Drott C, Claes G, et al. The Boras experience of endoscopic thoracic sympathicotomy for palmar, axillary, facial hyperhidrosis and facial blushing. Eur J Surg Suppl 1998;(580): 23-6.
66. Mbache N. A further survey of the action of Clostridium botulinum toxin upon different types of autonomic nerve fibre. J Physiol 1951;113:1-17.
67. Bushara KO, Park DM. Botulinum toxin and sweating. J Neurol Neurosurg Psychiatry 1994;57:1437-8.
68. Bushara KO, Park DM, Jones JC, Schutta HS. Botulinum toxin - a possible new treatment for axillary hyperhidrosis. Clin Exp Dermatol 1996;21:276-8.
69. Odderson IR. Axillary hyperhidrosis: treatment with botulinum toxin A. Arch Phys Med Rehabil 1998;79:350-2.
70. Schnider P, Binder M, Kittler H, et al. A randomized, double-blind, placebo-controlled trial of botulinum A toxin for severe axillary hyperhidrosis. Br J Dermatol 1999;140:677-80.
71. Naumann M, Lowe NJ. Botulinum toxin type A in treatment of bilateral primary axillary hyperhidrosis: randomised, parallel group, double blind, placebo controlled trial. BMJ 2001;323: 596-9.
72. Lowe NJ, Yamauchi PS, Lask GP, et al. Efficacy and safety of botulinum toxin type a in the treatment of palmar hyperhidrosis: a double-blind, randomized, placebo-controlled study. Dermatol Surg 2002;28:822-7.
73. Tan SR, Solish N. Long-term efficacy and quality of life in the treatment of focal hyperhidrosis with botulinum toxin A. Dermatol Surg 2002;28:495-9.
74. Baumann LS, Halem ML. Botulinum toxin-B and the management of hyperhidrosis. Clin Dermatol 2004;22:60-5.
75. Nelson L, Bachoo P, Holmes J. Botulinum toxin type B: a new therapy for axillary hyperhidrosis. Br J Plast Surg 2005;58:228-32.
76. Heckmann M, Plewig G. Low-dose efficacy of botulinum toxin A for axillary hyperhidrosis: a randomized, side-by-side, open-label study. Arch Dermatol 2005;141:1255-9.
77. Wollina U, Konrad H. Botulinum toxin A in anal fissures: a modified technique. J Eur Acad Dermatol Venereol 2002;16:469-71.
78. Glaser DA, Solish N, Naumann MK, et al. Botulinum toxin type-A improves occupational impairment associated with primary axillary hyperhidrosis and results in high levels of satisfaction with treatment. American Academy of Dermatology Meeting, New York City; 2004.
79. Goodman G. Diffusion and short-term efficacy of botulinum toxin A after the addition of hyaluronidase and its possible application for the treatment of axillary hyperhidrosis. Dermatol Surg 2003;29:533-8.
80. Heckmann M, Teichmann B, Pause BM, Plewig G. Amelioration of body odor after intracutaneous axillary injection of botulinum toxin A. Arch Dermatol 2003;139:57-9.
81. Lapiere JC, Hirsh A, Gordon KB, et al. Botulinum toxin type A for the treatment of axillary Hailey-Hailey disease. Dermatol Surg 2000;26:371-4.
82. Schnider P, Binder M, Berger T, Auff E. Botulinum A toxin injection in focal hyperhidrosis. Br J Dermatol 1996;134:1160-1.
83. Schnider P, Binder M, Auff E, et al. Double-blind trial of botulinum A toxin for the treatment of focal hyperhidrosis of the palms. Br J Dermatol 1997;136:548-52.
84. Saadia D, Voustianiouk A, Wang AK, Kaufmann H. Botulinum toxin type A in primary palmar hyperhidrosis: randomized, single-blind, two-dose study. Neurology 2001;57:2095-9.
85. Wollina U, Karamfilov T. Botulinum toxin A for palmar hyperhidrosis. J Eur Acad Dermatol Venereol 2001;15:555-8.
86. Solomon BA, Hayman R. Botulinum toxin type A therapy for palmar and digital hyperhidrosis. J Am Acad Dermatol 2000;42: 1026-9.
87. Swartling C, Farnstrand C, Abt G, et al. Side-effects of intradermal injections of botulinum A toxin in the treatment of palmar hyperhidrosis: a neurophysiological study. Eur J Neurol 2001;8: 451-6.
88. Tugnoli V, Eleopra R, Quatrale R, et al. Botulism-like syndrome after botulinum toxin type A injections for focal hyperhidrosis. Br J Dermatol 2002;147:808-9.
89. Naumann M, Flachenecker P, Brocker EB, et al. Botulinum toxin for palmar hyperhidrosis. Lancet 1997;349(9047):252.
90. Naumann M, Hofmann U, Bergmann I, et al. Focal hyperhidrosis: effective treatment with intracutaneous botulinum toxin. Arch Dermatol 1998;134:301-4.
91. Sevim S, Dogu O, Kaleagasi H. Botulinum toxin-A therapy for palmar and plantar hyperhidrosis. Acta Neurol Belg 2002;102: 167-70.
92. Vadoud-Seyedi J, Simonart T, Heenen M. Treatment of plantar hyperhidrosis with Dermojet injections of botulinum toxin. Dermatology 2000;201:179.
93. Kinkelin I, Hund M, Naumann M, Hamm H. Effective treatment of frontal hyperhidrosis with botulinum toxin A. Br J Dermatol 2000;143:824-7.
94. Tugnoli V, Marchese RR, Eleopra R, et al. The role of gustatory flushing in Frey's syndrome and its treatment with botulinum toxin type A. Clin Auton Res 2002;12:174-8.
95. Naumann M, Zellner M, Toyka KV, Reiners K. Treatment of gustatory sweating with botulinum toxin. Ann Neurol 1997;42: 973-5.
96. Laccourreye O, Akl E, Gutierrez-Fonseca R, et al. Recurrent gustatory sweating (Frey syndrome) after intracutaneous injection of botulinum toxin type A: incidence, management, and outcome. Arch Otolaryngol Head Neck Surg 1999;125:283-6.
97. Klein AW. Complications and adverse reactions with the use of botulinum toxin. Semin Cutan Med Surg 2001;20:109-20.
98. Vartanian AJ, Dayan SH. Facial rejuvenation using botulinum toxin A: review and updates. Facial Plast Surg 2004;20: 11-9.
99. Smith KC, Comite SL, Balasubramanian S, et al. Vibration anesthesia: a noninvasive method of reducing discomfort prior to dermatologic procedures. Dermatol Online J 2004;10(2):1.
100. Melzack R, Wall PD. Pain mechanisms: a new theory. Science 1965;150:971-9.
101. Benohanian A. Surgical pearl: use of needle-free anesthesia in the treatment of palmar hyperhidrosis with botulinum A toxin. J Am Acad Dermatol 2005;52:1073-4.
102. Pearson IC, Cliff S. Botulinum toxin type A treatment for axillary hyperhidrosis: a comparison of intradermal and subcutaneous injection techniques. Br J Dermatol 2004;151 Suppl 68:95.
103. Lam DG, Choudhary S. Use of a grid to simplify botulinum toxin injection for axillary hyperhidrosis. Plast Reconstr Surg 2003;112: 1741-2.
104. Krogstad AL, Skymne A, Pegenius G, et al. No compensatory sweating after botulinum toxin treatment of palmar hyperhidrosis. Br J Dermatol 2005;152:329-33.