Large-scale biotechnological production of the antileukemic marine natural product sorbicillactone A

Marine Drugs

Volumn 5, Issue 2, 2007, Pages 23-30

  Bringmann, Gerhard ^a   Gulder, Tobias A M ^a   Lang, Gerhard ^a,b   Schmitt, Stefanie ^a   Stöhr, Rüdiger ^b   Wiese, Jutta ^b   Nagel, Kerstin ^b   Imhoff, Johannes F ^b  

^a UNIVERSITY OF WÜRZBURG   (Germany)

^b GEOMAR HELMHOLTZ CENTRE FOR OCEAN RESEARCH KIEL   (Germany)

Author keywords

Anti leukemic activity; BIOTECmarin; Large scale production; Sorbicillactone A

Indexed keywords

ANTILEUKEMIC AGENT; SORBICILLACTONE A; UNCLASSIFIED DRUG;

ANTINEOPLASTIC ACTIVITY; ARTICLE; BIOTECHNOLOGICAL PRODUCTION; DRUG SCREENING; DRUG SYNTHESIS; NONHUMAN; STRUCTURE ACTIVITY RELATION;

EID: 34347235529     PISSN: None     EISSN: 16603397     Source Type: Journal    
DOI: 10.3390/md502023     Document Type: Article

References (9)

1. Bringmann, G.; Lang, G.; Mühlbacher, J.; Schaumann, K.; Steffens, S.; Rytik, P.G.; Hentschel, U.; Morschhäuser, J.; Brun, R. In Sponges (Porifera), Müller, W.E.G., Ed.; Springer: Berlin, 2003; Vol. 1, pp 231-253.
2. Bringmann, G.; Lang, G.; Gulder, T.A.M., Hideyuki, H.; Mühlbacher, J.; Maksimenka, K.; Steffens, S.; Schaumann, K.; Stöhr, R.; Wiese, J.; Imhoff, J.F.; Perović-Ottstadt, S.; Boreiko, O.; Müller, W.E.G. The first sorbicillinoid alkaloids, the antileukemic sorbicillactones A and B, from a sponge derived Penicillium chrysogenum strain. Tetrahedron 2005, 61, 7252-7265.
3. Bringmann, G.; Lang, G.; Mühlbacher, J.; Schaumann, K.; Steffens, S.; Müller, W.E.G. Sorbicillactone A derivatives for the treatment of tumor and viral diseases. International Patent Application WO 2004/026854 (1.4.2004).
4. Bringmann, G.; Lang, G.; Gulder, T.A.M.; Schaumann, K.; Müller, W.E.G.; Perović-Ottstadt, S.; Stöhr, R.; Wiese, J.; Schmaljohan, R.; Imhoff, J.F. Method for producing sorbicillactone A. International Patent Application WO 2005/072711 (11.8.2005).
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6. For more information on FCPC from KROMATON TECHNOLOGIES, see www.kromaton.com
7. Ito, Y. High Speed Countercurrent Chromatography. Crit. Rev. Anal. Chem. 1986, 17, 65-143.
8. The amount of extract purified per run was easily scaled up in a linear manner by using a 1-1 rotor in the same FCPC system.
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