Highly regioselective hydrolysis of substituted 2-benzylidene-1,3-propylene diacetates using porcine pancreas lipase

Chemistry Letters

Volumn 36, Issue 6, 2007, Pages 814-815

  Miura, Tsuyoshi ^a   Kawashima, Yuya ^a   Umetsu, Satoe ^a   Kanamori, Daisuke ^a   Tsuyama, Nanae ^a   Jyo, Yuki ^a   Murakami, Yasuoki ^a   Imai, Nobuyuki ^a  

^a CHIBA INSTITUTE OF SCIENCE   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

EID: 34347235069     PISSN: 03667022     EISSN: None     Source Type: Journal    
DOI: 10.1246/cl.2007.814     Document Type: Article

References (6)

1. T. Miura, Y. Kawashima, M. Takahashi, Y. Murakami, N. Imai, Synth. Commun. 2007, 37, in press. Porcine pancreas lipase (PPL) Type II is commercially available from Sigma.
2. a) T. Hisano, K. Onodera, Y. Toyabe, N. Mase, H. Yoda, K. Takabe, Tetrahedron Lett. 2005, 46, 6293, and the references cited therein.
3. b) K. Takabe, N. Mase, T. Hisano, H. Yoda, Tetrahedron Lett. 2003, 44, 3267.
4. 4Na, 259.0941; found, 259.0913.
5. 4. The mixture was filtered, and the filtrate was evaporated. The crude product was chromatographed on silica gel with a 2:3 mixture of AcOEt and hexane to afford 101 mg (98% yield) of 2a.
6. G. W. Daub, J. P. Edwards, C. R. Okada, J. W. Allen, C. T. Maxey, M. S. Wells, A. S. Goldstein, M. J. Dibley, C. J. Wang, D. P. Ostercamp, S. Chung, P. S. Cunningham, M. A. Berliner, J. Org. Chem. 1997, 62, 1976.