Correlation between protein accumulation profiles and conventional toxicological findings using a model antiandrogenic compound, flutamide

Toxicological Sciences

Volumn 97, Issue 1, 2007, Pages 81-93

  Friry Santini, Claire ^a,b   Rouquié, David ^a   Kennel, Philippe ^a   Tinwell, Helen ^a   Benahmed, Mohamed ^b   Bars, Rémi ^a  

^a BAYER AG   (Germany)

^b UNIVERSITÉ LYON 1   (France)

Author keywords

Antiandrogen; Flutamide; Proteomics; Testis; Two dimensional gel electrophoresis

Indexed keywords

ANDROGEN; ANTIANDROGEN; APOLIPOPROTEIN E; FLUTAMIDE; LUTEINIZING HORMONE; PROTEIN; TESTOSTERONE; BIOLOGICAL MARKER;

AMINO ACID SEQUENCE; ANIMAL TISSUE; ARTICLE; CANCER; CELL CYCLE; CELL HYPERPLASIA; CONTROLLED STUDY; GRAVIMETRY; HISTOPATHOLOGY; LEYDIG CELL; LUTEINIZING HORMONE BLOOD LEVEL; MALE; NONHUMAN; PHENOTYPE; SPERMATOGENESIS; SPRAGUE DAWLEY RAT; STEROIDOGENESIS; TESTOSTERONE BLOOD LEVEL; TWO DIMENSIONAL GEL ELECTROPHORESIS; ANIMAL; BLOOD; COMPARATIVE STUDY; DOSE RESPONSE; DRUG EFFECT; ELECTROSPRAY MASS SPECTROMETRY; EVALUATION; GENE REGULATORY NETWORK; GENETICS; HYPERPLASIA; MALE GENITAL SYSTEM; MASS SPECTROMETRY; METABOLISM; METHODOLOGY; ORGAN SIZE; PATHOLOGY; PROTEOMICS; RAT; TANDEM MASS SPECTROMETRY; TESTIS; TOXICITY TESTING;

RATTUS; RODENTIA;

ANDROGEN ANTAGONISTS; ANIMALS; BIOLOGICAL MARKERS; DOSE-RESPONSE RELATIONSHIP, DRUG; ELECTROPHORESIS, GEL, TWO-DIMENSIONAL; FLUTAMIDE; GENE REGULATORY NETWORKS; GENITALIA, MALE; HYPERPLASIA; LEYDIG CELLS; LUTEINIZING HORMONE; MALE; ORGAN SIZE; PROTEINS; PROTEOMICS; RATS; RATS, SPRAGUE-DAWLEY; SPECTROMETRY, MASS, ELECTROSPRAY IONIZATION; SPECTROMETRY, MASS, MATRIX-ASSISTED LASER DESORPTION-IONIZATION; TANDEM MASS SPECTROMETRY; TESTIS; TESTOSTERONE; TOXICITY TESTS;

EID: 34347228727     PISSN: 10966080     EISSN: 10960929     Source Type: Journal    
DOI: 10.1093/toxsci/kfm022     Document Type: Article

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