Risk of recurrent emergency department visits or hospitalizations in children with asthma receiving nebulized budesonide inhalation suspension compared with other asthma medications

Current Medical Research and Opinion

Volumn 23, Issue 6, 2007, Pages 1319-1328

  McLaughlin, Trent ^a,d   Leibman, Christopher ^b,d   Patel, Pankaj ^b,e   Camargo Jr , Carlos A ^c  

^a Wolters Kluwer   (United States)

^b ASTRAZENECA   (United Kingdom)

^c MASSACHUSETTS GENERAL HOSPITAL   (United States)

^d ELAN PHARMACEUTICALS   (United States)

^e TAP PHARMACEUTICAL PRODUCTS INC   (United States)

Author keywords

Asthma; Child; Cohort studies; Emergency service; Hospitalization; Nebulized budesonide inhalation suspension

Indexed keywords

BECLOMETASONE; BETA 2 ADRENERGIC RECEPTOR STIMULATING AGENT; BETAMETHASONE; BUDESONIDE; CORTICOSTEROID; CROMOGLYCATE DISODIUM; DEXAMETHASONE; FLUNISOLIDE; FLUTICASONE PROPIONATE; FLUTICASONE PROPIONATE PLUS SALMETEROL; FORMOTEROL; HYDROCORTISONE; ISOPRENALINE; LEUKOTRIENE RECEPTOR BLOCKING AGENT; LEVALBUTEROL; MOMETASONE FUROATE; MONTELUKAST; NEDOCROMIL; PIRBUTEROL; PREDNISOLONE; PREDNISONE; ROTADISK; SALBUTAMOL; TERBUTALINE; TRIAMCINOLONE ACETONIDE; TURBUHALER; UNCLASSIFIED DRUG; ZAFIRLUKAST; ZILEUTON;

ASTHMA; CHILD; CONFERENCE PAPER; CONFIDENCE INTERVAL; CONSULTATION; DATA BASE; DRUG EFFECT; DRUG EFFICACY; EMERGENCY WARD; FEMALE; HOSPITALIZATION; HUMAN; LONGITUDINAL STUDY; MAJOR CLINICAL STUDY; MALE; MANAGED CARE ORGANIZATION; NEBULIZATION; PRESCRIPTION; RECURRENCE RISK; RECURRENT DISEASE; RETROSPECTIVE STUDY; SUSPENSION; UNITED STATES;

ADMINISTRATION, INHALATION; ANTI-ASTHMATIC AGENTS; ANTI-INFLAMMATORY AGENTS; ASTHMA; BUDESONIDE; CHILD; CHILD, PRESCHOOL; COHORT STUDIES; EMERGENCY SERVICE, HOSPITAL; FEMALE; FOLLOW-UP STUDIES; HOSPITALIZATION; HUMANS; LONGITUDINAL STUDIES; MALE; NEBULIZERS AND VAPORIZERS; RECURRENCE; RETROSPECTIVE STUDIES; RISK FACTORS;

EID: 34347225103     PISSN: 03007995     EISSN: None     Source Type: Journal    
DOI: 10.1185/030079907X188170     Document Type: Conference Paper

References (34)

1. Asthma prevalence, health care use and mortality. National Center for Health Statistics, 2002. Available from http://www.cdc.gov/nchs/products/pubs/ pubd/hestats/asthma/asthma.htm [Last accessed April 11, 2007]
2. Emerman CL, Cydulka RK, Crain EF, et al. Prospective multicenter study of relapse after treatment for acute asthma among children presenting to the emergency department. J Pediatr 2001;138:318-24
3. Stevens MW, Gorelick MH. Short-term outcomes after acute treatment of pediatric asthma. Pediatrics 2001;107:1357-62
4. Bloomberg GR, Trinkaus KM, Fisher EB, Jr., et al. Hospital readmissions for childhood asthma: a 10-year metropolitan study. Am J Respir Crit Care Med 2003;167:1068-76
5. Mitchell EA, Bland JM, Thompson JM. Risk factors for readmission to hospital for asthma in childhood. Thorax 1994;49:33-36
6. Schaubel D, Johansen H, Mao Y, et al. Risk of preschool asthma: incidence, hospitalization, recurrence, and readmission probability. J Asthma 1996;33:97-103
7. Weiss KB, Gergen PJ, Hodgson TA. An economic evaluation of asthma in the United States. N Engl J Med 1992;326:862-66
8. National Asthma Education and Prevention Program. Expert Panel Report: guidelines for the diagnosis and management of asthma update on selected topics - 2002. J Allergy Clin Immunol 2002;110:S141-219
9. Donahue JG, Weiss ST, Livingston JM, et al. Inhaled steroids and the risk of hospitalization for asthma. JAMA 1997;277:887-91
10. Sin DD, Man SF. Low-dose inhaled corticosteroid therapy and risk of emergency department visits for asthma. Arch Intern Med 2002;162:1591-95
11. Stempel DA, Pinto L, Stanford RH. The risk of hospitalization in patients with asthma switched from an inhaled corticosteroid to a leukotriene receptor antagonist. J Allergy Clin Immunol 2002;110:39-41
12. Suissa S, Ernst P. Inhaled corticosteroids: impact on asthma morbidity and mortality. J Allergy Clin Immunol 2001;107:937-44
13. Berger WE, Shapiro GG. The use of inhaled corticosteroids for persistent asthma in infants and young children. Ann Allergy Asthma Immunol 2004;92:387-400
14. Szefler SJ, Eigen H. Budesonide inhalation suspension: a nebulized corticosteroid for persistent asthma. J Allergy Clin Immunol 2002;109:730-42
15. Kofman C, Berlinski A, Zaragoza S, et al. Aerosol therapy for pediatric outpatients. RT: The Journal for Respiratory Care Practitioners 2004. Available from http://www.rtmagazine.com/issues/articles/2004-03_05.asp [Last accessed April 18, 2007]
16. NAEPP. National Asthma Education and Prevention Program Expert Panel Report 2. Guidelines for the diagnosis and management of asthma. Rockville, MD: National Institutes of Health/National Heart, Lung, and Blood Institute; 1997. Publication no. 97-4051
17. Scarfone RJ, Zorc JJ, Angsuco CJ. Emergency physicians' prescribing of asthma controller medications. Pediatrics 2006;117:821-7
18. Rachelefsky G. Treating exacerbations of asthma in children: the role of systemic corticosteroids. Pediatrics 2003;112:382-97
19. Adams RJ, Fuhlbrigge A, Finkelstein JA, et al. Impact of inhaled antiinflammatory therapy on hospitalization and emergency department visits for children with asthma. Pediatrics 2001;107:706-11
20. Long-term effects of budesonide or nedocromil in children with asthma. The Childhood Asthma Management Program Research Group. N Engl J Med 2000;343:1054-63
21. Leflein JG, Szefler SJ, Murphy KR, et al. Nebulized budesonide inhalation suspension compared with cromolyn sodium nebulizer solution for asthma in young children: results of a randomized outcomes trial. Pediatrics 2002;109:866-72
22. Bisca N, Cernatescu I, Dragomir D, et al. Comparison of the efficacy and safety of beclometasone dipropionate suspension for nebulization and beclometasone dipropionate via a metered-dose inhaler in paediatric patients with moderate to severe exacerbation of asthma. Respir Med 2003;97(Suppl B):S15-20
23. Benson K, Hartz AJ. A comparison of observational studies and randomized, controlled trials. N Engl J Med 2000;342:1878-86
24. Britton A, McKee M, Black N, et al. Choosing between randomised and non-randomised studies: a systematic review. Health Technol Assess 1998;2:1-124
25. Concato J, Shah N, Horwitz RI. Randomized, controlled trials, observational studies, and the hierarchy of research designs. N Engl J Med 2000;342:1887-92
26. Storms W. Clinical trials: are these your patients? J Allergy Clin Immunol 2003;112:S107-11
27. Feinstein AR. Epidemiologic analyses of causation: the unlearned scientific lessons of randomized trials. J Clin Epidemiol 1989;42:481-489; discussion 499-502
28. Michels KB, Braunwald E. Estimating treatment effects from observational data: dissonant and resonant notes from the SYMPHONY trials. JAMA 2002;287:3130-32
29. Pocock SJ, Elbourne DR. Randomized trials or observational tribulations? N Engl J Med 2000;342:1907-9
30. Calmes D, Leake BD, Carlisle DM. Adverse asthma outcomes among children hospitalized with asthma in California. Pediatrics 1998;101:845-50
31. Kaugars AS, Klinnert MD, Bender BG. Family influences on pediatric asthma. J Pediatr Psychol 2004;29:475-91
32. Camargo C, Jr, Ramachandran S, Ryskina K, et al. Recurrent asthma exacerbations in children enrolled in a state Medicaid plan: comparative analysis of common therapies. Am J Health-System Pharm 2007 [in press]
33. Blaiss MS. Allergic rhinitis and impairment issues in schoolchildren: a consensus report. Curr Med Res Opin 2004;20:1937-52
34. Lozano P, Fishman P, VonKorff M, et al. Health care utilization and cost among children with asthma who were enrolled in a health maintenance organization. Pediatrics 1997;99:757-64