Normotonic cell shrinkage induced by Na+ deprivation results in apoptotic cell death in human epithelial HeLa cells

Journal of Physiological Sciences

Volumn 56, Issue 5, 2006, Pages 335-339

  Nukui, Miho ^a   Shimizu, Takahiro ^a   Okada, Yasunobu ^a,b  

^a GRADUATE UNIVERSITY FOR ADVANCED STUDIES   (Japan)

^b NATIONAL INSTITUTE FOR PHYSIOLOGICAL SCIENCES   (Japan)

Author keywords

Apoptosis; Apoptotic volume decrease; Na+ efflux; Normotonic cell shrinkage

Indexed keywords

CASPASE 3; LACTATE DEHYDROGENASE; RINGER SOLUTION; SODIUM; SODIUM CALCIUM EXCHANGE PROTEIN; SODIUM POTASSIUM CHLORIDE COTRANSPORTER; SODIUM PROTON EXCHANGE PROTEIN;

APOPTOSIS; ARTICLE; CELL DEATH; CELL VIABILITY; CELL VOLUME; CONTROLLED STUDY; CYTOLYSIS; ENZYME ACTIVATION; EPITHELIUM CELL; FEMALE; HELA CELL; HUMAN; HUMAN CELL; PROTEIN SECRETION; SODIUM DEFICIENCY; SODIUM TRANSPORT; CELL SIZE; DRUG EFFECT; METABOLISM;

APOPTOSIS; CELL SIZE; HELA CELLS; HUMANS; SODIUM; SODIUM-CALCIUM EXCHANGER; SODIUM-HYDROGEN ANTIPORTER; SODIUM-POTASSIUM-CHLORIDE SYMPORTERS;

EID: 34347212526     PISSN: 18806546     EISSN: None     Source Type: Journal    
DOI: 10.2170/physiolsci.RP009606     Document Type: Article

References (19)

1. Wyllie AH, Kerr JF, Currie AR. Cell death: the significance of apoptosis. Int Rev Cytol. 1980;68:251-306.
2. Maeno E, Ishizaki Y, Kanaseki T, Hazama A, Okada Y. Normotonic cell shrinkage due to disordered volume regulation is an early prerequisite to apoptosis. Proc Natl Acad Sci USA. 2000;97:9487-92.
3. Okada Y, Maeno E, Shimizu T, Dezaki K, Wang J, Morishima S. Receptormediated control of regulatory volume decrease (RVD) and apoptotic volume decrease (AVD). J Physiol (Lond). 2001;532:3-16.
4. Gomez-Angelats M, Cidlowski JA. Cell volume control and signal transduction in apoptosis. Toxicol Pathol. 2002;30:541-51.
5. - conditions in human lymphoid and epithelial cells. Acta Physiol. 2006;187:217-22.
6. Shimizu T, Yoshitomi K, Nakamura M, Imai M. Site and mechanism of action of trichlormethiazide in rabbit distal nephron segments perfused in vitro. J Clin Invest. 1988;82:721-30.
7. Gamba G, Miyanoshita A, Lombardi M, Lytton J, Lee WS, Hediger MA, Hebert SC. Molecular cloning, primary structure, and characterization of two members of the mammalian electroneutral sodium-(potassium)-chloride cotransporter family expressed in kidney. J Biol Chem. 1994;269:17713-22.
8. Wehner F, Shimizu T, Sabirov R, Okada Y. Hypertonic activation of a non-selective cation conductance in HeLa cells and its contribution to cell volume regulation. FEBS Lett. 2003;551:20-4.
9. + influx is required for volume loss during programmed cell death. J Biol Chem. 2003;278:39176-84.
10. McCarthy JV, Cotter TG. Cell shrinkage and apoptosis: a role for potassium and sodium ion efflux. Cell Death Differ. 1997;4:756-70.
11. McConkey DJ, Orrenius S. The role of calcium in the regulation of apoptosis. Biochem Biophys Res Commun. 1997;239:357-66.
12. Gulbins E, Jekle A, Ferlinz K, Grassme H, Lang F. Physiology of apoptosis. Am J Physiol Renal Physiol. 2000;279:F605-15.
13. +-ATPase. Proc Natl Acad Sci USA. 1995;92:5965-8.
14. Matsuyama S, Llopis J, Deveraux QL, Tsien RY, Reed JC. Changes in intramitochondrial and cytosolic pH: early events that modulate caspase activation during apoptosis. Nat Cell Biol. 2000;2:318-25.
15. Offen D, Ziv I, Gorodin S, Barzilai A, Malik Z, Melamed E. Dopamine-induced programmed cell death in mouse thymocytes. Biochim Biophys Acta. 1995;1268:171-7.
16. Fernandez-Segura E, Canizares FJ, Cubero MA, Warley A, Campos A. Changes in elemental content during apoptotic cell death studied by electron probe X-ray microanalysis. Exp Cell Res. 1999;253:454-62.
17. Skepper JN, Karydis I, Garnett MR, Hegyi L, Hardwick SJ, Warley A, Mitchinson MJ, Cary NR. Changes in elemental concentrations are associated with early stages of apoptosis in human monocyte-macrophages exposed to oxidized low-density lipoprotein: an X-ray microanalytical study. J Pathol. 1999;188:100-6.
18. Bortner CD, Gomez-Angelats M, Cidlowski JA. Plasma membrane depolarization without repolarization is an early molecular event in anti-Fas-induced apoptosis. J Biol Chem. 2001;276:4304-14.
19. Bortner CD, Cidlowski JA. Absence of volume regulatory mechanisms contributes to the rapid activation of apoptosis in thymocytes. Am J Physiol. 1996;271:C950-61.