In vitro anti-proliferation/cytotoxic activity of epingaione and its derivatives on the human SH-SY5Y neuroblastoma and TE-671 sarcoma cells

West Indian Medical Journal

Volumn 56, Issue 1, 2007, Pages 5-10

  Williams, Lawrence A D ^a,e   Conrad, J ^a   Vogler, B ^b   Rosner H ^a   Porter, R B R ^c   Setzer, W ^b   Barton, E N ^c   Levy, H G ^d   Mika, S ^a   Klaiber, I ^a   Nkurunziza, J P ^a   Kraus, W ^a  

^a UNIVERSITY OF HOHENHEIM   (Germany)

^b University of Alabama in Huntsville   (United States)

^c UNIVERSITY OF THE WEST INDIES   (Jamaica)

^d PG Pharma   (United States)

^e Scientific Research Council of Jamaica   (Jamaica)

Author keywords

[No Author keywords available]

Indexed keywords

5' ETHOXY 5 METHYL 5 (4 METHYL 2 OXO PENTYL) 2,3,4,5 TETRAHYDRO 5'H [2,3']BIFURANYL 2' ONE; ALCOHOL; ANTINEOPLASTIC AGENT; BIOLOGICAL MARKER; EPINGAIONE; HERBACEOUS AGENT; PACLITAXEL; PROTODIOCIN; UNCLASSIFIED DRUG;

ARTICLE; BONTIA DAPHNOIDES; CELL CYCLE ARREST; CELL CYCLE M PHASE; CONCENTRATION RESPONSE; CONTROLLED STUDY; CYTOTOXICITY; DRUG ISOLATION; DRUG STRUCTURE; IN VITRO STUDY; MYOPORACEAE; NEUROBLASTOMA CELL; NONHUMAN; PLANT LEAF; PLANT STEM; SARCOMA CELL; STRUCTURE ANALYSIS;

CELL LINE, TUMOR; CELL PROLIFERATION; CELL SURVIVAL; DRUG SCREENING ASSAYS, ANTITUMOR; FURANS; HUMANS; MYOPORACEAE; NEUROBLASTOMA; PENTANONES; PHYTOTHERAPY; PLANT EXTRACTS; PLANT LEAVES; PLANT STEMS; SARCOMA;

EID: 34347205614     PISSN: 00433144     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (9)

1. Ayensu ES. Medicinal plants of the West Indies. Reference Publication, Inc, Algonac, Michigan, USA, 1981.
2. Chinnock RJ, Ghinsalberti EL, Jefferies PR. (-)-Epingaione from Bontia daphnoides. Phytochemistry 1987; 26: 1202-3.
3. Williams LAD, Caleb-Williams, LS. Insecticidally active sesquiterpene furan from Bontia daphnoides. Philippine J Sci 1997; 126: 155-62.
4. Williams LAD, Gardner MT, Singh PDA, The TL, Fletcher CK, Caleb-Williams LS et al. Mode of action studies of the acaricidal agent; epingaione. Journal of Invertebrate Reproduction and Development. 1997; 31: 231-6.
5. Williams DH, Stone MJ, Hauck PP, Rahman SK. Why are secondary metabolites (Natural Products) biosynthesized ? J Nat Prod 1989; 52: 1189-208.
6. Rosner H, Williams LAD, Jung A, Kraus W. Disassembly of microtubules and inhibition of neurite outgrowth, neuroblastoma cell proliferation, and MAP Kinase tyrosine dephosphorylation by dibenzyl trisulphide. Biochim Biophys Acta 2001; 1540: 166-77.
7. Williams LAD, Rosner H, Conrad J, Moller W, Beifuss U, Chiba K et al. Selected secondary metabolites from the Phytolaccaceae and their biological/pharmaceutical significance, Research Signpost, In: Recent Research Development in Phytochemistry 2002; 6: 13-68.
8. Hamilton WD, Park RJ, Perry GJ, Sutherland MD. (-)-Epingaione, (-)-dehydrogaine and (-)-desisopropylngainoe, toxic furanoid sesquiterpenoid ketones from Myoporum deserti. Aust J Chem 1973; 26: 375-87.
9. Williams LAD, Rosner H, Moller W, Conrad J, Nkurunziza JP, Kraus W. In vitro anti-proliferaion/cytotoxic activity of sixty natural products on the human SH-SY5Y neuroblastoma cells with specific reference to dibenzyl trisulphide. West Indian Med J 2004; 53: 208-19.