Why do young women smoke? IV. Role of genetic variation in the dopamine transporter and lifetime traumatic experience

American Journal of Medical Genetics, Part B: Neuropsychiatric Genetics

Volumn 144, Issue 4, 2007, Pages 533-540

  Segman, Ronnen H ^a   Kanyas, Kyra ^a   Karni, Osnat ^a   Lerer, Elad ^b,c   Goltser Dubner, Tanya ^a   Pavlov, Vera ^a   Lerer, Bernard ^a  

^a HADASSAH HEBREW UNIVERSITY MEDICAL CENTER   (Israel)

^b HEBREW UNIVERSITY OF JERUSALEM   (Israel)

^c HERZOG HOSPITAL   (Israel)

Author keywords

Addiction; Cigarettes; Dependence; Dopamine transporter; Gene; Nicotine; Trauma

Indexed keywords

DOPAMINE TRANSPORTER;

ARTICLE; CIGARETTE SMOKING; COLLEGE STUDENT; DAT1 GENE; FEMALE; GENE; GENETIC VARIABILITY; GENOTYPE; HAPLOTYPE; HUMAN; INJURY; MAJOR CLINICAL STUDY; PRIORITY JOURNAL; PSYCHOLOGIC TEST; RISK FACTOR; TOBACCO DEPENDENCE; UNTRANSLATED REGION; VARIABLE NUMBER OF TANDEM REPEAT;

ADULT; DEMOGRAPHY; DOPAMINE PLASMA MEMBRANE TRANSPORT PROTEINS; FEMALE; HAPLOTYPES; HUMANS; LIFE CHANGE EVENTS; LOGISTIC MODELS; POLYMORPHISM, SINGLE NUCLEOTIDE; SMOKING; TOBACCO USE DISORDER;

EID: 34250888776     PISSN: 15524841     EISSN: 1552485X     Source Type: Journal    
DOI: 10.1002/ajmg.b.30507     Document Type: Article

References (60)

1. 12th World Conference on Tobacco or Health. 2003. Tobacco Control Country Profiles, 2nd edition. Atlanta, GA: American Cancer Society, Inc. Available online at www.who.int and www.cancer.org.
2. Al Koudsi N, Tyndale RF. 2005. Genetic influences on smoking: A brief review. Ther Drug Monit 27:704-709.
3. Arinami T, Ishiguro H, Onaivi ES. 2000. Polymorphisms in genes involved in neurotransmission in relation to smoking. Eur J Pharmacol 410:215-226.
4. Beckham JC, Roodman AA, Shipley RH, Hertzberg MA, Cunha GH, Kudler HS, et al. 1995. Smoking in Vietnam combat veterans with post-traumatic stress disorder. J Trauma Stress 8:461-472.
5. Bierut LJ, Rice JP, Edenberg HJ, Goate A, Foroud T, Cloninger CR, et al. 2000. Family-based study of the association of the dopamine D2 receptor gene (DRD2) with habitual smoking. Am J Med Genet 90:299-302.
6. Breslau N, Davis GC, Schultz LR. 2003. Posttraumatic stress disorder and the incidence of nicotine, alcohol and other drug disorders in persons who have experienced trauma. Arch Gen Psychiatry 60:289-294.
7. Cloninger CR, Przybeck TR, Svrakic DM. 1991. The Tridimensional Personality Questionnaire: US normative data. Psychol Rep 69:1047-1057.
8. Comings DE, Ferry L, Bradshaw-Robinson S, Burchette R, Chiu C, Muhleman D. 1996. The dopamine D2 receptor (DRD2) gene: A genetic risk factor in smoking. Pharmacogenetics 6:73-79.
9. Contin M, Martinelli P, Mochi M, Albani F, Riva R, Scaglione C, et al. 2004. Dopamine transporter gene polymorphism, spect imaging, and levodopa response in patients with Parkinson disease. Clin Neuropharmacol 27:111-115.
10. Corrigall WA, Coen KM, Adamson KL. 1994. Self administered nicotine activates the mesolimbic dopamine system through the ventral tegmental area. Brain Res 653:278-284.
11. Fagerstrom KO. 1978. Measuring degree of physical dependence to tobacco smoking with reference to individuation of treatment. Addict Behav 3:235-241.
12. File S, Fluck E, Leahy A. 2001. Nicotine has calming effects on stress-induced mood changes in females, but enhances aggressive mood in males. Int J Neuropsychopharmacol 4:371-376.
13. Fuke S, Suo S, Takahashi N, Koike H, Sasagawa N, Ishiura S. 2001. The VNTR polymorphism of the human dopamine transporter (DAT1) gene affects gene expression. Pharmacogenomics J 1:152-156.
14. Gabriel SB, Schaffner SF, Nguyen H, Moore JM, Roy J, Blumenstiel B, et al. 2002. The structure of haplotype blocks in the human genome. Science 296:2225-2229.
15. Galili-Weisstub E, Levy S, Frisch A, Gross-Tsur V, Michaelovsky E, Kosov A, et al. 2005. Dopamine transporter haplotype and attention-deficit hyperactivity disorder. Mol Psychiatry 10:617-618.
16. Gelernter J, Liu X, Hesselbrock V, Page GP, Goddard A, Zhang H. 2004. Results of a genomewide linkage scan: Support for chromosomes 9 and 11 loci increasing risk for cigarette smoking. Am J Med Genet Part B 128B:94-101.
17. Greenbaum L, Kanyas K, Karni O, Merbl Y, Olender T, Horowitz A, et al. 2006. Why do young women smoke? 1. Direct and interactive effects of environment, psychological characteristics and micotinic cholinergic receptor genes. Mol Psychiatry 11:312-322.
18. Greenwood TA, Kelsoe JR. 2003. Promoter and intronic variants affect the transcriptional regulation of the human dopamine transporter gene. Genomics 82:511-520.
19. Greenwood TA, Alexander M, Keck PE, McElroy S, Sadovnick AD, Remick RA, Kelsoe JR. 2001. Evidence for linkage disequilibrium between the dopamine transporter and bipolar disorder. Am J Med Genet 105:145-151.
20. Greenwood TA, Alexander M, Keck PE, McElroy S, Sadovnick AD, Remick RA, Shaw SH, Kelsoe JR. 2002. Segmental linkage disequilibrium within the dopamine transporter gene. Mol Psychiatry 7:165-173.
21. Greenwood TA, Schork NJ, Eskin E, Kelsoe JR. 2006. Identification of additional variants within the human dopamine transporter gene provides further evidence for an association with bipolar disorder in two independent samples. Mol Psychiatry 11:125-133 115.
22. Grunhage F, Schulze TG, Muller DJ, Lanczik M, Franzek E, Albus M, et al. 2000. Systematic screening for DNA sequence variation in the coding region of the human dopamine transporter gene (DAT1). Mol Psychiatry 5:275-282.
23. Hapke U, Schumann A, Rumpf HJ, John U, Konerding U, Meyer C. 2005. Association of smoking and nicotine dependence with trauma and posttraumatic stress disorder in a general population sample. J Nerv Ment Dis 193:843-846.
24. Heinz A, Goldman D, Jones DW, Palmour R, Hommer D, Gorey JG, Lee KS, Linnoila M, Weinberger DR. 2000. Genotype influences in vivo dopamine transporter availability in human striatum. Neuropsychopharmacology 22:133-139.
25. Hosmer D, Lemeshow S. 2000. Applied logistic regression. 2nd edition. New York: Wiley Interscience.
26. Israel Ministry of Health. 2004. Report on smoking in Israel 2003-2004. Jerusalem: Israel Ministry of Health.
27. Israel Ministry of Health. 2005. Report on Smoking in Israel 2004-2005. Jerusalem: Israel Ministry of Health.
28. Jaccard J. 2001. Interaction effects in logistic regression. California: Sage.
29. Jacobsen LK, Staley JK, Zoghbi SS, Seibyl JP, Kosten TR, Innis RB, Gelernter J. 2000. Prediction of dopamine transporter binding availability by genotype: A preliminary report. Am J Psychiatry 157:1700-1703.
30. Jorm AF, Henderson AS, Jacomb PA, Christensen H, Korten AE, Rodgers B, et al. 2000. Association of smoking and personality with a polymorphism of the dopamine transporter gene: Results from a community survey. Am J Med Genet 96:331-334.
31. Khantzian EJ. 1997. The self-medication hypothesis of substance use disorders: A reconsideration and recent applications. Harv Rev Psychiatry 4:231-244.
32. Kollins SH, McClernon FJ, Fummeler BF. 2005. Association between smoking and attention deficit/hyperactivity disorder symptoms in a population based sample of young adults. Arch Gen Psychiatry 62:1142-1147.
33. Koob GF, Le Moal M. 1997. Drug abuse: Hedonic homeostatic dysregulation. Science 278:52-58.
34. Lerer E, Kanyas K, Karni O, Ebstein RP, Lerer B. 2006. Why do young women smoke? II. Role of traumatic life experience, psychological characteristics and serotonergic genes. Mol Psychiatry 11:771-781.
35. Lerman C, Caporaso NE, Audrain J, Main D, Bowman ED, Lockshin B, et al. 1999. Evidence suggesting the role of specific genetic factors in cigarette smoking. Health Psychol 18:14-20.
36. Li MD, Cheng R, Ma JZ, Swan GE. 2003. A meta-analysis of estimated genetic and environmental effects on smoking behavior in male and female adult twins. Addiction 98:23-31.
37. Ling D, Niu T, Feng Y, Xing H, Xu X. 2004. Association between polymorphism of the dopamine transporter gene and early smoking onset: An interaction risk on nicotine dependence. J Hum Genet 49:35-39.
38. Martinez D, Gelernter J, Abi-Dargham A, van Dyck CH, Kegeles L, Innis RB, et al. 2001. The variable number of tandem repeats polymorphism of the dopamine transporter gene is not associated with significant change in dopamine transporter phenotype in humans. Neuropsychopharmacol 24:553-560.
39. Michelhaugh SK, Fiskerstrand C, Lovejoy E, Bannon MJ, Quinn JP. 2001. The dopamine transporter gene (SLC6A3) variable number of tandem repeats domain enhances transcription in dopamine neurons. J Neurochem 79:1033-1038.
40. Mill J, Asherson P, Browes C, D'Souza U, Craig I. 2002. Expression of the dopamine transporter gene is regulated by the 3′ UTR VNTR: Evidence from brain and lymphocytes using quantitative RT-PCR. Am J Med Genet (Neuropsychiatr Genet) 114:975-979.
41. Miller GM, Madras BK. 2002. Polymorphisms in the 3′-untranslated region of human and monkey dopamine transporter genes affect reporter gene expression. Mol Psychiatry 7:44-55.
42. Noble EP, St Jeor ST, Ritchie T, Syndulko K, St Jeor SC, Fitch RJ, et al. 1994. D2 dopamine receptor gene and cigarette smoking: Areward gene? Med Hypotheses 42:257-260.
43. Parrot A. 1999. Does cigarette smoking cause stress? Am Psychol 817-820.
44. Pomerleau CS, Pomerleau OF, Flessland KA, Basson SM. 1992. Relationship of Tridimensional Personality Questionnaire scores and smoking variables in female and male smokers. J Subst Abuse 4:143-154.
45. Pontieri FE, Tanda G, Orzi F, Di Chiara G. 1996. Effects of nicotine on the nucleus accumbens and similarity to those of addictive drugs. Nature 382:255-257.
46. Sabol SZ, Nelson ML, Fisher C, Gunzerath L, Brody CL, Hu S, et al. 1999. A genetic association for cigarette smoking behavior. Health Psychol 18:7-13.
47. Segman RH, Cooper-Kazaz R, Macciardi F, Goltser T, Halfon Y, Dobroborski T, Shalev AY. 2002. Association between the dopamine transporter gene and posttraumatic stress disorder. Mol Psychiatry 78:903-907.
48. Stephens M, Donnelly P. 2003. A comparison of Bayesian methods for haplotype reconstruction from population genotype data. Am J Hum Genet 73:1162-1169.
49. Stephens M, Smith NJ, Donnelly P. 2001. A new statistical method for haplotype reconstruction from population data. Am J Hum Genet 68:978-989.
50. Stolerman IP, Jarvis MJ. 1995. The scientific case that nicotine is addictive. Psychopharmacology (Berl) 117:2-10.
51. Straub RE, Sullivan PF, Ma Y, Myakishev MV, Harris-Kerr C, Wormley B, et al. 1999. Susceptibility genes for nicotine dependence: A genome scan and followup in an independent sample suggest that regions on chromosomes 2,4, 10,16,17 and 18 merit further study. Mol Psychiatry 4:129-144.
52. Sullivan PF, Kendler KS. 1999. The genetic epidemiology of smoking. Nicotine Tob Res 1: (Suppl 2) S51-S57 discussion; S69-S70.
53. Timberlake DS, Haberstick BC, Lessem JM, Smolen A, Ehringer M, Hewitt JK, Hopfer C. 2006. An association between the DAT1 polymorphism and smoking behavior in young adults from the National Longitudinal Study of Adolescent Health. Health Psychol 25:190-197.
54. Vandenbergh DJ, Thompson MD, Cook EH, Bendahhou E, Nguyen T, Krasowski MD, et al. 2000. Human dopamine transporter gene: Coding region conservation among normal, Tourette's disorder, alcohol dependence and attention-deficit hyperactivity disorder populations. Mol Psychiatry 5:283-292.
55. Vandenbergh DJ, Bennett CJ, Grant MD, Strasser AA, O'Connor R, Stauffer RL, et al. 2002. Smoking status and the human dopamine transporter variable number of tandem repeats (VNTR) polymorphism: Failure to replicate and finding that never smokers may be different. Nicotine Tob Res 4:333-340.
56. Warren CW, Jones NR, Eriksen MP, Asma S. 2006. Global Tobacco Surveillance System (GTSS) collaborative group. Patterns of global tobacco use in young people and implications for future chronic disease burden in adults. Lancet 367:749-753.
57. Wilkinson D, Abraham C. 2004. Constructing an integrated model of the antecedents of adolescent smoking. Br J Health Psychol 9:315-333.
58. Wills TA, Sandy JM, Yaeger AM. 2002. Stress and smoking in adolescence: A test of directional hypotheses. Health Psychol 21:122-130.
59. World Health Organization. 2003. The World Health Report, Neglected Global Epidemics: Three growing threats. Geneva: World Health Organization.
60. Yakir A, Rigbi A, Kanyas K, Pollak Y, Kahana G, Karni O, et al. 2006. Why do young women smoke III. Attention and impulsivity as neurocognitive predisposing factors. Eur Neuropsychopharmocol Nov 29; [Epub ahead of print] doi:10.1016/j.euroneuro.2006.09.004.