Genetic and environmental sources of variation in heart rate response to infused nicotine in twins

Cancer Epidemiology Biomarkers and Prevention

Volumn 16, Issue 6, 2007, Pages 1057-1064

  Swan, Gary E ^a   Lessov Schlaggar, Christina N ^a   Krasnow, Ruth E ^a   Wilhelmsen, Kirk C ^b   Jacob III, Peyton ^c   Benowitz, Neal L ^c  

^a SRI INTERNATIONAL   (United States)

^b UNIVERSITY OF NORTH CAROLINA   (United States)

^c UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

NICOTINE;

ADULT; AGED; ARTICLE; BODY MASS; CENTRAL NERVOUS SYSTEM; CONTROLLED STUDY; DIZYGOTIC TWINS; FEMALE; HEART RATE; HEART RATE VARIABILITY; HEREDITY; HUMAN; INFUSION; MALE; MEASUREMENT; METABOLIC CLEARANCE RATE; MONITOR; MONOZYGOTIC TWINS; PRIORITY JOURNAL; SMOKING; TOBACCO DEPENDENCE;

ADULT; AGE FACTORS; BODY MASS INDEX; FEMALE; HEART RATE; HUMANS; MALE; NICOTINE; NICOTINIC AGONISTS; PHENOTYPE; SMOKING; TOBACCO USE DISORDER; TWINS, DIZYGOTIC; TWINS, MONOZYGOTIC;

EID: 34250878528     PISSN: 10559965     EISSN: None     Source Type: Journal    
DOI: 10.1158/1055-9965.EPI-06-1093     Document Type: Article

References (41)

1. Benowitz NL, Hansson A, Jacob P III. Cardiovascular effects of nasal and transdermal nicotine and cigarette smoking. Hypertension 2002;39:1107-12.
2. Mehta MC, Jain AC, Mehta A, Billie M. Cardiac arrhythmias following intravenous nicotine: experimental study in dogs. J Cardiovasc Pharmacol Ther 1997;2:291-8.
3. Grassi G, Seravalle G, Calhoun DA, et al. Mechanisms responsible for sympathetic activation by cigarette smoking in humans. Circulation 1994;90:248-53.
4. Moolchan ET, Hudson DL, Schroeder JR, Sehnert SS. Heart rate and blood pressure responses to tobacco smoking among African-American adolescents. J Natl Med Assoc 2004;96:767-71.
5. Niaura R, Shadel WG, Goldstein MG, Hutchinson KE, Abrams DB. Individual differences in responses to the first cigarette following overnight abstinence in regular smokers. Nicotine Tob Res 2001;3:37-44.
6. Garrett BE, Griffiths RR. Intravenous nicotine and caffeine: subjective and physiological effects in cocaine abusers. J Pharmacol Exp Ther 2001;296:486-94.
7. Molander L, Hansson A, Lunell E. Pharmacokinetics of nicotine in healthy elderly people. Clin Pharmacol Ther 2001;69:57-65.
8. Soria R, Stapleton JM, Gilson SF, Sampson-Cone A, Henningfield JE, London ED. Subjective and cardiovascular effects of intravenous nicotine in smokers and nonsmokers. Psychopharmacology (Berl) 1996;128:221-6.
9. Benowitz NL, Jacob P III. Intravenous nicotine replacement suppresses nicotine intake from cigarette smoking. J Pharmacol Exp Ther 1990;254:1000-5.
10. Robertson DR, Waller DG, Renwick AG, George CF. Age-related changes in the pharmacokinetics and pharmacodynamics of nifedipine. Br J Clin Pharmacol 1988;25:297-305.
11. Rose JE, Behm FM, Westman EC, Johnson M. Dissociating nicotine and nonnicotine components of cigarette smoking. Pharmacol Biochem Behav 2000;67:71-81.
12. Tseng CJ, Appalsamy M, Robertson D, Mosqueda-Garcia R. Effects of nicotine on brain stem mechanisms of cardiovascular control. J Pharmacol Exp Ther 1993;265:1511-8.
13. Gottesman II, Gould TD. The endophenotype concept in psychiatry: etymology and strategic intentions. Am J Psychiatry 2003;160:636-45.
14. Snieder H, Harshfield GA, Barbeau P, Pollock DM, Pollock JS, Treiber FA. Dissecting the genetic architecture of the cardiovascular and renal stress response. Biol Psychol 2002;61:73-95.
15. Dubreuil E, Ditto B, Dionne G, et al. Familiality of heart rate and cardiac-related autonomic activity in five-month-old twins: the Quebec newborn twins study. Psychophysiology 2003;40:849-62.
16. McCaffery JM, Bleil M, Pogue-Geile MF, Ferrell RE, Manuck SB. Allelic variation in the serotonin transporter gene-linked polymorphic region (5-HTTLPR) and cardiovascular reactivity in young adult male and female twins of European-American descent. Psychosom Med 2003;65:721-8.
17. McCaffery JM, Pogue-Geile MF, Ferrell RE, Petro N, Manuck SB. Variability within alpha- and beta-adrenoreceptor genes as a predictor of cardiovascular function at rest and in response to mental challenge. J Hypertens 2002;20:1105-14.
18. Li GH, Faulhaber HD, Rosenthal M, et al. Beta-2 adrenergic receptor gene variations and blood pressure under stress in normal twins. Psychophysiology 2001;38:485-9.
19. Snieder H, Dong Y, Barbeau P, et al. Beta2-adrenergic receptor gene and resting hemodynamics in European and African American youth. Am J Hypertens 2002;15:973-9.
20. William RB, Marchuk DA, Gadde KM, et al. Central nervous system serotonin function and cardiovascular responses to stress. Psychosom Med 2001;63:300-5.
21. Zhang L, Rao F, Wessel J, et al. Functional allelic heterogeneity and pleiotropy of a repeat polymorphism in tyrosine hydroxylase: prediction of catecholamines and response to stress in twins. Physiol Genomics 2004;19:277-91.
22. Swan GE, Benowitz NL, Jacob P III, et al. Pharmacogenetics of nicotine metabolism in twins: methods and procedures. Twin Res 2004;7:435-48.
23. Swan GE, Benowitz NL, Lessov CN, Jacob P III, Tyndale RF, Wilhelmsen K. Nicotine metabolism: the impact of CYP2A6 on estimates of additive genetic influence. Pharmacogenomics 2005;15:115-25.
24. Benowitz NL, Lessov CN, Swan GE, Jacob P III. Female sex and oral contraceptive use accelerate nicotine metabolism. Clin Pharmacol Ther 2006;79:480-8.
25. Benowitz NL, Swan GE, Jacob P III, Lessov-Schlaggar CN, Tyndale RF. CYP2A6 genotype and the metabolism and disposition kinetics of nicotine. Clin Pharmacol Ther 2006;80:457-67.
26. Al Koudsi N, Mwenifumbo JC, Sellers EM, Benowitz NL, Swan GE, Tyndale RF. Characterization of the novel CYP2A6*21 allele using in vivo nicotine kinetics. Eur J Clin Pharmacol 2006;62:481-4.
27. Cederlof R, Friberg L, Jonsson E, Kaij L. Studies on similarity diagnosis in twins with the aid of mailed questionnaires. Acta Genet Stat Med 1961;11:338-62.
28. Pomerleau CS, Garcia AW, Pomerleau OF, Cameron OG. The effects of menstrual phase and nicotine abstinence on nicotine intake and on biochemical and subjective measures in women smokers: a preliminary report. Psychoneuroendocrinology 1992;17:627-38.
29. Jacob P III, Benowitz NL, Shulgin A. Synthesis of optically pure deuterium labeled nicotine, nornicotine and cotinine. J Labeled Comp Radiopharm 1988;25:1117-28.
30. Jacob P III, Yu L, Wilson M, Benowitz NL. Selected ion monitoring method for determination of nicotine, cotinine and deuterium-labeled analogs: absence of an isotope effect in the clearance of (S)-nicotine-3′,3′-d2 in humans. Biol Mass Spectrom 1991;20:247-52.
31. Benowitz NL, Jacob P III. Metabolism of nicotine to cotinine studied by a dual stable isotope method. Clin Pharmacol Ther 1994;56:483-93.
32. Perez-Stable EL, Herrera B, Jacob P III, Benowitz NL. Nicotine metabolism and intake in black and white smokers. JAMA 1998;280:152-6.
33. Weber JL, May PE. Abundant class of human DNA polymorphisms which can be typed using the polymerase chain reaction. Am J Hum Genet 1989;44:388-96.
34. SAS Institute. (2002-2003). Cary (NC): SAS Institute Inc.
35. Porchet HC, Benowitz NL, Sheiner LB. Pharmacodynamic model of tolerance: application to nicotine. J Pharmacol Exp Ther 1988;244:231-6.
36. Neale MC, Boker SM, Xie G, Maes HH. Mx: statistical modeling. 6th ed. Department of Psychiatry, Virginia Commonwealth University, Box 980126, Richmond, VA, 2002.
37. Benowitz NL. Drug therapy. Pharmacologic aspects of cigarette smoking and nicotine addiction. N Engl J Med 1988;319:1318-30.
38. Benowitz NL, Jacob P III, Jones RT, Rosenberg J. Interindividual variability in the metabolism and cardiovascular effects of nicotine in man. J Pharmacol Exp Ther 1982;221:368-72.
39. Steptoe A, Wardle J. Cardiovascular stress responsivity, body mass and abdominal adiposity. Int J Obes Lond 2005;29:1329-37.
40. Swan GE, Ward MM, Jack LM, Javitz HS. Cardiovascular reactivity as a predictor of relapse in male and female smokers. Health Psychol 1993;12:451-8.
41. Benowitz NL, Kuyt F, Jacob P III. Influence of nicotine on cardiovascular and hormonal effects of cigarette smoking. Clin Pharmacol Ther 1984;36:74-81.