Pyrroloquinoline quinone biogenesis: Characterization of PqqC and its H84N and H84A active site variants

Biochemistry

Volumn 46, Issue 24, 2007, Pages 7174-7186

  Magnusson, Olafur Th ^a,b   Rosefigura, Jordan M ^a   Toyama, Hirohide ^c,d   Schwarzenbacher, Robert ^e   Klinman, Judith P ^a  

^a UNIVERSITY OF CALIFORNIA   (United States)

^b DECODE GENETICS   (Iceland)

^c YAMAGUCHI UNIVERSITY   (Japan)

^d UNIVERSITY OF THE RYUKYUS   (Japan)

^e UNIVERSITY OF SALZBURG   (Austria)

Author keywords

[No Author keywords available]

Indexed keywords

COFACTOR; PROTON DONOR; PYRROLOQUINOLINE QUINONE; QUINOL;

AMINO ACIDS; BACTERIA; BIOSYNTHESIS; ENZYME KINETICS; MOLECULAR INTERACTIONS; NEGATIVE IONS;

VITAMINS;

3A (2 AMINO 2 CARBOXYETHYL) 4,5 DIOXO 4,5,6,7,8,9 HEXAHYDROQUINOLINE 7,9 DICARBOXYLIC ACID; ALANINE; ALCOHOL DEHYDROGENASE; ASPARAGINE; BACTERIAL PROTEIN; HISTIDINE; PROTEIN PQQC; PYRROLOQUINOLINEQUINONE; QUINOLINE DERIVATIVE; UNCLASSIFIED DRUG;

AMINO ACID SUBSTITUTION; ARTICLE; BACTERIAL GENE; CATALYSIS; CONTROLLED STUDY; CRYSTAL STRUCTURE; ENZYME ACTIVE SITE; ENZYME ANALYSIS; ENZYME KINETICS; KLEBSIELLA PNEUMONIAE; MOLECULAR INTERACTION; MUTATION; NONHUMAN; OXIDATION REDUCTION REACTION; PQQA GENE; PQQB GENE; PQQC GENE; PQQD GENE; PQQE GENE; PQQF GENE; PRIORITY JOURNAL; PROTEIN PROTEIN INTERACTION; REACTION ANALYSIS; RING CLOSING METATHESIS;

AMINO ACID SUBSTITUTION; BACTERIAL PROTEINS; BASE SEQUENCE; BINDING SITES; DNA PRIMERS; DNA, BACTERIAL; GENES, BACTERIAL; KINETICS; KLEBSIELLA PNEUMONIAE; MODELS, CHEMICAL; MODELS, MOLECULAR; MUTAGENESIS, SITE-DIRECTED; PQQ COFACTOR; RECOMBINANT PROTEINS; VARIATION (GENETICS);

BACTERIA (MICROORGANISMS); KLEBSIELLA PNEUMONIAE;

EID: 34250850181     PISSN: 00062960     EISSN: None     Source Type: Journal    
DOI: 10.1021/bi700162n     Document Type: Article

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