Role for glutathione peroxidase-4 in brain development and neuronal apoptosis: Specific induction of enzyme expression in reactive astrocytes following brain injury

Free Radical Biology and Medicine

Volumn 43, Issue 2, 2007, Pages 191-201

  Savaskan, Nicolai E ^a   Borchert, Astrid ^b   Bräuer, Anja U ^b   Kuhn, Hartmut ^b  

^a NETHERLANDS CANCER INSTITUTE   (Netherlands)

^b CHARITÉ UNIVERSITÄTSMEDIZIN BERLIN   (Germany)

Author keywords

Apoptosis; Astrocytes; Caspase 3; Eicosanoids; Embryogenesis; Oxidative stress; Selenium

Indexed keywords

CASPASE 3; GLUTATHIONE PEROXIDASE; GLUTATHIONE PEROXIDASE 4; ISOPROTEIN; MESSENGER RNA; PHOSPHATIDYLINOSITOL 4,5 BISPHOSPHATE; SELENIUM; SMALL INTERFERING RNA; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; APOPTOSIS; ARTICLE; ASTROCYTE; BRAIN CORTEX; BRAIN DEVELOPMENT; BRAIN INJURY; CEREBELLUM; CONTROLLED STUDY; EMBRYO DEVELOPMENT; ENZYME ACTIVATION; FEMALE; GLIA CELL; HIPPOCAMPUS; IMMUNOHISTOCHEMISTRY; IN SITU HYBRIDIZATION; MALE; NERVE CELL; NONHUMAN; NUCLEOTIDE SEQUENCE; OXIDATIVE STRESS; PRIORITY JOURNAL; PROTEIN EXPRESSION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION;

ANIMALS; APOPTOSIS; ASTROCYTES; BRAIN; BRAIN INJURIES; DISEASE MODELS, ANIMAL; ENZYME INDUCTION; GENE EXPRESSION REGULATION, ENZYMOLOGIC; GLUTATHIONE PEROXIDASE; IMMUNOHISTOCHEMISTRY; MALE; NEURONS; RATS; RATS, SPRAGUE-DAWLEY; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION;

MUS;

EID: 34250847109     PISSN: 08915849     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.freeradbiomed.2007.03.033     Document Type: Article

References (39)

1. Brigelius-Flohe R. Tissue-specific functions of individual glutathione peroxidases. Free Radic. Biol. Med. 27 (1999) 951-965
2. Imai H., and Nakagawa Y. Biological significance of phospholipid hydroperoxide glutathione peroxidase (PHGPx, GPx4) in mammalian cells. Free Radic. Biol. Med. 34 (2003) 145-169
3. Thomas J.P., Maiorino M., Ursini F., and Girotti A.W. Protective action of phospholipid hydroperoxide glutathione peroxidase against membrane-damaging lipid peroxidation. In situ reduction of phospholipid and cholesterol hydroperoxides. J. Biol. Chem. 265 (1990) 454-461
4. Sattler W., Maiorino M., and Stocker R. Reduction of HDL- and LDL-associated cholesterylester and phospholipid hydroperoxides by phospholipid hydroperoxide glutathione peroxidase and Ebselen (PZ 51). Arch. Biochem. Biophys. 309 (1994) 214-221
5. Ursini F., Heim S., Kiess M., Maiorino M., Roveri A., Wissing J., and Flohe L. Dual function of the selenoprotein PHGPx during sperm maturation. Science 285 (1999) 1393-1396
6. Nomura K., Imai H., Koumura T., Arai M., and Nakagawa Y. Mitochondrial phospholipid hydroperoxide glutathione peroxidase suppresses apoptosis mediated by a mitochondrial death pathway. J. Biol. Chem. 274 (1999) 29294-29302
7. Yant L.J., Ran Q., Rao L., van Remmen H., Shibatani T., Belter J.G., Motta L., Richardson A., and Prolla T.A. The selenoprotein GPX4 is essential for mouse development and protects from radiation and oxidative damage insults. Free Radic. Biol. Med. 34 (2003) 496-502
8. Imai H., Hirao F., Sakamoto T., Sekine K., Mizukura Y., Saito M., Kitamoto T., Hayasaka M., Hanaoka K., and Nakagawa Y. Early embryonic lethality caused by targeted disruption of the mouse PHGPx gene. Biochem. Biophys. Res. Commun. 305 (2003) 278-286
9. Kelner M.J., and Montoya M.A. Structural organization of the human selenium-dependent phospholipid hydroperoxide glutathione peroxidase gene (GPX4): chromosomal localization to 19p13.3. Biochem. Biophys. Res. Commun. 249 (1998) 53-55
10. Maiorino M., Bosello V., Ursini F., Foresta C., Garolla A., Scapin M., Sztajer H., and Flohe L. Genetic variations of gpx-4 and male infertility in humans. Biol. Reprod. 68 (2003) 1134-1141
11. Roveri A., Maiorino M., and Ursini F. Enzymatic and immunological measurements of soluble and membrane-bound phospholipid-hydroperoxide glutathione peroxidase. Methods Enzymol. 233 (1994) 202-212
12. Maiorino M., Gregolin C., and Ursini F. Phospholipid hydroperoxide glutathione peroxidase. Methods Enzymol. 186 (1990) 448-457
13. Zhang L.P., Maiorino M., Roveri A., and Ursini F. Phospholipid hydroperoxide glutathione peroxidase: specific activity in tissues of rats of different age and comparison with other glutathione peroxidases. Biochim. Biophys. Acta 1006 (1989) 140-143
14. Panfili E., Sandri G., and Ernster L. Distribution of glutathione peroxidases and glutathione reductase in rat brain mitochondria. FEBS Lett. 290 (1991) 35-37
15. Schweizer U., Bräuer A., Köhrle J., Nitsch R., and Savaskan E. Selenium and brain function: a poorly recognized liaison. Brain Res. 45 (2004) 164-178
16. Ran Q., Liang H., Gu M., Qi W., Walter C.A., Roberts II J.L., Herman B., Richardson A., and van Remmen H. Transgenic mice overexpressing glutathione peroxidase 4 are protected against oxidative stress-induced apoptosis. J. Biol. Chem. 279 (2004) 55137-55146
17. Ran Q., Gu M., van Remmen H., Strong R., Roberts J.L., and Richardson A. Glutathione peroxidase 4 protects cortical neurons from oxidative injury and amyloid toxicity. J. Neurosci. Res. 84 (2006) 202-208
18. Kang J.K., Sul D., Kang J.K., Nam S.Y., Kim H.J., and Lee E. Effects of lead exposure of phospholipid hydroperoxidase glutathione peroxidase mRNA in rat brain. Toxicol. Sci. 82 (2004) 136-228
19. Borchert A., Wang C.C., Ufer C., Schiebel H., Savaskan N.E., and Kuhn H. The role of phospholipid hydroperoxide glutathione peroxidase (GPx4) isoforms in murine embryogenesis. J. Biol. Chem. 281 (2006) 9655-9664
20. Paxinos G., Watson C., Pennisi M., and Topple A. Bregma, lambda and the interaural midpoint in stereotaxic surgery with rats of different sex, strain and weight. J. Neurosci. Methods 13 (1985) 139-143
21. Halstead J.R., van Rheenen J., Snel M.H., Meeuws S., Mohammed S., D'Santos C.S., Heck A.J., Jalink K., and Divecha N. A role for PtdIns(4,5)P2 and PIP5Kalpha in regulating stress-induced apoptosis. Curr. Biol. 16 (2006) 1850-1856
22. von Gertten C., Flores-Morales A., Holmin S., Mathiesen T., and Nordqvist A.C. Genomic responses in rat cerebral cortex after traumatic brain injury. BMC Neurosci. 6 (2005) 69
23. Deller T., and Frotscher M. Lesion-induced plasticity of central neurons: sprouting of single fibres in the rat hippocampus after unilateral entorhinal cortex lesion. Prog. Neurobiol. 53 (1997) 687-727
24. Savaskan N.E., and Nitsch R. Molecules involved in reactive sprouting in the hippocampus. Rev. Neurosci. 12 (2001) 195-215
25. Guyton K.Z., Liu Y., Gorospe M., Xu Q., and Holbrook N.J. Activation of mitogen-activated protein kinase by H2O2. J. Biol. Chem. 271 (1996) 4138-4142
26. Ursini F., Maiorino M., Valente M., Ferri L., and Gregolin C. Purification from pig liver of a protein which protects liposomes and biomembranes from peroxidative degradation and exhibits glutathione peroxidase activity on phosphatidylcholine hydroperoxides. Biochim. Biophys. Acta 710 (1982) 197-211
27. Imai H., and Nakagawa Y. Biological significance of phospholipid hydroperoxide glutathione peroxidase (PHGPx, GPx4) in mammalian cells. Free Radic. Biol. Med. 34 (2003) 145-169
28. Shidoji Y., Okamoto K., Muto Y., Komura S., Ohishi N., and Yagi K. Prevention of geranylgeranoic acid-induced apoptosis by phospholipid hydroperoxide glutathione peroxidase gene. J. Cell. Biochem. 97 (2006) 178-187
29. Borchert A., Savaskan N.E., and Kuhn H. Regulation of expression of the phospholipid hydroperoxide/sperm nucleus glutathione peroxidase gene. Tissue-specific expression pattern and identification of functional cis- and trans-regulatory elements. J. Biol. Chem. 278 (2003) 2571-2580
30. Maiorino M., Scapin M., Ursini F., Biasolo M., Bosello V., and Flohe L. Distinct promoters determine alternative transcription of gpx-4 into phospholipid-hydroperoxide glutathione peroxidase variants. J. Biol. Chem. 278 (2003) 34286-34290
31. Brigelius-Flohe R., Aumann K.D., Blocker H., Gross G., Kiess M., Kloppel K.D., Maiorino M., Roveri A., Schuckelt R., Ursini F., Wingender E., and Flohé L. Phospholipid-hydroperoxide glutathione peroxidase. Genomic DNA, cDNA, and deduced amino acid sequence. J. Biol. Chem. 269 (1994) 7342-7348
32. Borchert A., Schnurr K., Thiele B., and Kühn H. Cloning of the mouse phospholipid glutathione peroxidase gene. FEBS Lett. 446 (1999) 223-227
33. Kelner M.J., and Montoya M.A. Structural organization of the human selenium-dependent phospholipid hydroperoxide glutathione peroxidase gene (GPX4): chromosomal localization to 19p13.3. Biochem. Biophys. Res. Commun. 249 (1998) 53-55
34. Huang H.S., Jiunn C., and Chang W.C. The CCAAT-box binding factor NF-Y is required for the expression of the phospholipid hydroperoxide glutathione peroxidase in human epidermoid carcinoma A431 cells. FEBS Lett. 455 (1999) 111-116
35. Ufer C., Borchert A., and Kuhn H. Functional characterization of cis- and trans-regulatory elements involved in expression of phospholipid hydroperoxide glutathione peroxidase. Nucleic Acids Res. 31 (2003) 4293-4303
36. Tramer F., Vetere A., Martinelli M., Paroni F., Marsich E., Boitani C., Sandri G., and Panfili E. cAMP-response element modulator-tau activates a distinct promoter element for the expression of the phospholipid hydroperoxide/sperm nucleus glutathione peroxidase gene. Biochem. J. 383 (2004) 179-185
37. Schnabel D., Salas-Vidal E., Narvaez V., Sanchez-Carbente-Mdel R., Hernandez-Garcia D., Cuervo R., and Covarrubias L. Expression and regulation of antioxidant enzymes in the developing limb support a function of ROS in interdigital cell death. Dev. Biol. 291 (2006) 291-299
38. Eyupoglu I.Y., Savaskan N.E., Brauer A.U., Nitsch R., and Heimrich B. Identification of neuronal cell death in a model of degeneration in the hippocampus. Brain Res. Protoc. 11 (2003) 1-8
39. Kovac A.D., Kwidzinski E., Heimrich B., Bittigau P., Deller T., Nitsch R., and Bechmann I. Entorhinal cortex lesion in the mouse induces transsynaptic death of perforant path target neurons. Brain Pathol. 14 (2004) 249-257