Sertoliform endometrioid carcinoma of the endometrium with dual immunophenotypes for epithelial membrane antigen and inhibin α: Case report and literature review

International Journal of Gynecological Pathology

Volumn 26, Issue 3, 2007, Pages 291-297

  Liang, Sharon X ^a   Patel, Kausha ^a   Pearl, Michael ^b   Liu, Jingxuan ^a   Zheng, Wenxin ^c   Tornos, Carmen ^a  

^a STONY BROOK UNIVERSITY   (United States)

^b STONY BROOK UNIVERSITY   (United States)

^c UNIVERSITY OF ARIZONA COLLEGE OF MEDICINE   (United States)

Author keywords

EMA; Endometrium; Immunohistochemistry; Inhibin ; Ovary; Sertoliform endometrioid carcinoma

Indexed keywords

CD99 ANTIGEN; COMMON ACUTE LYMPHOBLASTIC LEUKEMIA ANTIGEN; DESMIN; EPITHELIAL MEMBRANE ANTIGEN; ESTROGEN RECEPTOR; INHIBIN A; PROGESTERONE RECEPTOR; SMOOTH MUSCLE ACTIN; TUMOR MARKER; VIMENTIN;

AFRICAN AMERICAN; AGED; ARTICLE; BLEEDING; CANCER GRADING; CANCER RADIOTHERAPY; CASE REPORT; ENDOMETRIOID CARCINOMA; ENDOMETRIUM CARCINOMA; FEMALE; FOLLOW UP; GRANULOSA CELL TUMOR; HISTOPATHOLOGY; HUMAN; HYSTERECTOMY; IMMUNOHISTOCHEMISTRY; IMMUNOPHENOTYPING; IMMUNOREACTIVITY; MENOPAUSAL SYNDROME; MICROSCOPY; POSTOPERATIVE CARE; PRIORITY JOURNAL; SALPINGOOOPHORECTOMY; SERTOLI CELL TUMOR; SEX CORD TUMOR; TUMOR CELL;

AGED; CA-15-3 ANTIGEN; CARCINOMA, ENDOMETRIOID; ENDOMETRIAL NEOPLASMS; FEMALE; HUMANS; IMMUNOPHENOTYPING; INHIBINS; SERTOLI CELL TUMOR;

EID: 34250836984     PISSN: 02771691     EISSN: None     Source Type: Journal    
DOI: 10.1097/01.pgp.0000236948.67087.56     Document Type: Article

References (27)

1. Roth LM, Liban E, Czernobilsky B. Ovarian endometrioid tumors mimicking Sertoli and Sertoli-Leydig cell tumors: sertoliform variant of endometrioid carcinoma. Cancer 1982;50:1322-31.
2. Young RH, Prat J, Scully RE. Ovarian endometrioid carcinomas resembling sex cord-stromal tumors. A clinicopathological analysis of 13 cases. Am J Surg Pathol 1982;6:513-22.
3. Aguirre P, Thor AD, Scully RE. Ovarian endometrioid carcinomas resembling sex cord-stromal tumors. An immunohistochemical study. Int J Gynecol Pathol 1989;8:364-73.
4. Guerrieri C, Franlund B, Malmstrom H, et al. Ovarian endometrioid carcinomas simulating sex cord-stromal tumors: a study using inhibin and cytokeratin 7. Int J Gynecol Pathol 1998;17:l266-71.
5. Ordi J, Schammel DP, Rasekh L, et al. Sertoliform endometrioid carcinomas of the ovary: a clinicopathologic and immunohistochemical study of 13 cases. Mod Pathol 1999;12:933-40.
6. Pelkey TJ, Frierson HF Jr, Mills SE, et al. The diagnostic utility of inhibin staining in ovarian neoplasms. Int J Gynecol Pathol 1998;17:97-105.
7. Rishi M, Howard LN, Bratthauer GL, et al. Use of monoclonal antibody against human inhibin as a marker for sex cord-stromal tumors of the ovary. Am J Surg Pathol 1997;21:583-9.
8. Zhao C, Vang R, Bratthauer GL, et al. Comparative analysis of alternate immunohistochemical (IHC) markers for the distinction of ovarian Sertoli cell tumors from endometrioid tumors and carcinoid tumors: a study of 160 cases. United States and Canadian Academy of Pathology Annual Meeting; 2006; Atlanta, GA. Abstract 947.
9. Matias-Guiu X, Pons C, Prat J. Mullerian inhibiting substance, alpha-inhibin, and CD99 expression in sex cord-stromal tumors and endometrioid ovarian carcinomas resembling sex cord-stromal tumors. Hum Pathol 1998;29:840-9.
10. Matadial L, Escoffery CT, Bowen-Chatoor JS. Sertoliform variant of endometrioid carcinoma of the ovary. West Indian Med J 1995;44:72-3.
11. Remadi S, Ismail A, Tawil A, et al. Ovarian sertoliform endometrioid carcinoma. Virchows Arch 1995;426:533-6.
12. Fox H, Brander WL. A sertoliform endometrioid adenocarcinoma of the endometrium. Histopathology 1988;13:584-6.
13. Usadi RS, Bentley RC. Endometrioid carcinoma of the endometrium with sertoliform differentiation. Int J Gynecol Pathol 1995;14:360-4.
14. Eichhorn JH, Young RH, Clement PB. Sertoliform endometrial adenocarcinoma: a study of four cases. Int J Gynecol Pathol 1996;15:119-26.
15. Murray SK, Clement PB, Young RH. Endometrioid carcinomas of the uterine corpus with sex cord-like formations, hyalinization, and other unusual morphologic features: a report of 31 cases of a neoplasm that may be confused with carcinosarcoma and other uterine neoplasms. Am J Surg Pathol 2005;29:157-66.
16. Flemming P, Wellmann A, Maschek H, et al. Monoclonal antibodies against inhibin represent key markers of adult granulosa cell tumors of the ovary even in their metastases. Am J Surg Pathol 1995;19:927-33.
17. McCluggage WG, Maxwell P. Adenocarcinoma of various sites may exhibit immunoreactivity with anti-inhibin antibodies. Histopathology 1999;35:216-20.
18. Irving JA, Carinelli S, Prat J. Uterine tumors resembling ovarian sex cord tumors are polyphenotypic neoplasms with true sex cord differentiation. Mod Pathol 2006;19:17-24.
19. Clement PB, Scully RE. Endometrial stromal sarcomas of the uterus with extensive endometrioid glandular differentiation: a report of three cases that caused problems in differential diagnosis. Int J Gynecol Pathol 1992;11:163-73.
20. Horn LC, Stegner HE. Uterine stromal tumor with ovarian sex cord differentiation. Pathologe 1995;16:421-5.
21. Lillemoe TJ, Perrone T, Norris HJ, et al. Myogeneous phenotype of epithelial-like areas in endometrial stromal sarcomas. Arch Pathol Lab Med 1991;4:215-9.
22. Oliva E, Clement PB, Young RH. Endometrial stromal tumors: an update on a group of tumors with a protean phenotype. Adv Anat Pathol 2000;7:257-81.
23. Clement PB, Scully RE. Uterine tumors resembling ovarian sexcord tumors: a clinicopathologic analysis of fourteen cases. Am J Clin Pathol 1976;66:512-25.
24. Czernobilsky B, Mamet Y, David MB, et al. Uterine retiform Sertoli-Leydig cell tumor: report of a case providing additional evidence that uterine tumors resembling ovarian sex cord tumors have a histologic and immunohistochemical phenotype of genuine sex cord tumors. Int J Gynecol Pathol 2005;24:335-40.
25. Krishnamurthy S, Jungbluth AA, Busam KJ, et al. Uterine tumors resembling ovarian sex-cord tumors have an immunophenotype consistent with true sex-cord differentiation. Am J Surg Pathol 1998;22:1078-82.
26. Leval LD, Waltregny D, Dupuis LM, et al. Uterine tumors resembling ovarian sex-cord tumors: a study of 14 cases showing a diverse phenotypic profile. United States and Canadian Academy of Pathology Annual Meeting; 2006; Atlanta, GA. Abstract 812.
27. Fujibayashi M, Aiba M, Iizuka E, et al. Granulosa cell tumor-like variant of endometrioid carcinoma of the ovary exhibiting nuclear clearing with biotin activity: a subtype showing close macroscopic, cytologic, and histologic similarity to adult granulosa cell tumor. Arch Pathol Lab Med 2005;129:1288-94.