Significance of mutations on the structural perturbation of thymidylate synthase: Implications for their involvement in subunit exchange

Protein Science

Volumn 16, Issue 7, 2007, Pages 1439-1448

  Saxl, Ruth L ^a,b   Maley, Gladys F ^a   Hauer, Charles R ^a   Maccoll, Robert ^a   Changchien, Liming ^a   Maley, Frank ^a  

^a WADSWORTH CENTER   (United States)

^b UNIVERSITY OF PITTSBURGH SCHOOL OF MEDICINE   (United States)

Author keywords

Mass spectrometry; Mutations; Peptide identification; Proteolysis; Subunit dissociation; Thymidylate synthase

Indexed keywords

DIMER; MONOMER; MUTANT PROTEIN; PEPTIDE; PROTEIN SUBUNIT; THYMIDYLATE SYNTHASE; TRYPSIN; UREA;

AMINO ACID SEQUENCE; ARTICLE; CONTROLLED STUDY; CRYSTAL STRUCTURE; DILUTION; DISSOCIATION; ESCHERICHIA COLI; MASS SPECTROMETRY; MUTATIONAL ANALYSIS; NONHUMAN; PH; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN CONFORMATION; PROTEIN HYDROLYSIS; PROTEIN QUATERNARY STRUCTURE; ULTRACENTRIFUGE; WILD TYPE;

DIMERIZATION; ENZYME STABILITY; HYDROGEN-ION CONCENTRATION; LIGANDS; MASS SPECTROMETRY; MODELS, MOLECULAR; MUTATION; PROTEIN STRUCTURE, QUATERNARY; PROTEIN STRUCTURE, TERTIARY; PROTEIN SUBUNITS; STRUCTURE-ACTIVITY RELATIONSHIP; THYMIDYLATE SYNTHASE; TRYPSIN; ULTRACENTRIFUGATION; UREA;

ESCHERICHIA COLI;

EID: 34250836508     PISSN: 09618368     EISSN: 1469896X     Source Type: Journal    
DOI: 10.1110/ps.062509807     Document Type: Article

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