Roche elecsys proclactin II assay: Reactivity with macroprolactin compared with eight commercial assay for prolactin and determination of monomeric prolactin by precipitation with polyethylene glycol

Clinical Laboratory

Volumn 53, Issue 5-6, 2007, Pages 301-307

  Fahie Wilson, Michael ^a   Bieglmayer, Christian ^b   Kratzsch, Jürgen ^c   Nusbaumer, Charly ^d   Roth, Heinz Jürgen ^e   Zaninotto, Martina ^f   Plebani, Mario ^f   Hubbuch, Arnulf ^g   Schneider, Erich ^g  

^a SOUTHEND HOSPITAL   (United Kingdom)

^b UNIVERSITY OF VIENNA   (Austria)

^c UNIVERSITY HOSPITAL LEIPZIG   (Germany)

^d UNIVERSITY HOSPITAL BASEL   (Switzerland)

^e Limbach Laboratory   (Germany)

^f UNIVERSITY HOSPITAL OF PADOVA   (Italy)

^g ROCHE DIAGNOSTICS GMBH   (Germany)

Author keywords

ADVIA Centaur; Assay comparison; Macroprolactin; Monomeric prolactin; NEQAS; PEG; Polyethylene glycol precipitation; Prolactin; Reference interval; Roche Elecsys

Indexed keywords

MACROGOL; PROLACTIN; DIAGNOSTIC AGENT; MACROGOL DERIVATIVE; PROLACTIN, POLYMERIC; UNCLASSIFIED DRUG;

ARTICLE; CONTROLLED STUDY; DIAGNOSTIC ACCURACY; DIAGNOSTIC VALUE; FEMALE; HORMONE BLOOD LEVEL; HORMONE DETERMINATION; HUMAN; HUMAN CELL; HYPERPROLACTINEMIA; IMMUNOASSAY; INTERMETHOD COMPARISON; MALE; PRECIPITATION; REFERENCE VALUE; ANALYTICAL EQUIPMENT; BLOOD; CLINICAL CHEMISTRY; INSTRUMENTATION; METABOLISM; METHODOLOGY; REPRODUCIBILITY; STANDARD;

CLINICAL CHEMISTRY TESTS; HUMANS; HYPERPROLACTINEMIA; POLYETHYLENE GLYCOLS; PRECIPITATION; PROLACTIN; REAGENT KITS, DIAGNOSTIC; REFERENCE VALUES; REPRODUCIBILITY OF RESULTS;

EID: 34250828430     PISSN: 14336510     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (13)

1. Fahie-Wilson, John R, Ellis AR. Macroprolactin; high molecular mass forms of circulating prolactin. Ann Clin Biochem 2005; 42:175-92
2. Gibney J, Smith TP, McKenna TJ. Clinical relevance of macroprolactin. Clin Endocrinol 2005; 62, 633-43
3. Suliman AM, Smith TP, Gibney J, McKenna TJ. Frequent misdiagnosis & mismanagement of hyperprolactinaemic patients before the introduction of macroprolactin screening: application of a new strict laboratory definition of macroprolactinaemia. Clin Chem 2003;49:1504-9
4. John R, McDowell IFW, Scanlon MF, Ellis AR. Macroprolactin reactivities in prolactin assays: an issue for clinical laboratories & equipment manufacturers [Letter]. Clin Chem 2000;46:884-5
5. Fahie-Wilson MN. In hyperprolactinaemia, testing for macroprolactin is essential. Clin Chem 2003;49:1434-6
6. Fahie-Wilson MN, Brunsden P, Surrey J, Everitt A. Macroprolactin and the Roche Elecsys Prolactin Assay: characteristics of the reaction and detection by precipitation with polyethylene glycol. Clin Chem 2000;46:1993-5
7. Sturgeon CM, Ellis AR, Al-Sadie R, Logan M, Costa M. United Kingdom National External Quality Assessment Scheme for peptide hormones annual review 2004. UK NEQAS, Department of Clinical Biochemistry, Royal Infirmary of Edinburgh, Edinburgh EH16 4SA, UK
8. Bablok W et al. A General Regression Procedure for Method Transformation. J Clin Chem Clin Biochem 1988;26:783-90
9. Ellis AR, Fahie-Wilson M, Axcell M, Sands K, Hill RP. Macroprolactin(s): composition and reactivity in immunosassays and laboratory interpretation of results of an unusual patient serum. Ann Clin Biochem 2006;43:57-62
10. Beltran L, Ahlquist J, Ellis A, Fahie-Wilson M. The contribution of big prolactin to macroprolactinaemia detected by the polyethylene glycol precipitation test and gel filtration chromatography [Abstract T9]. Ann Clin Biochem 2006;43 (Supplement):34.
11. Sapin R, Gasser F, Grucker D. Free prolactin determinations in hyperprolactinemic men with suspicion of macroprolactinaemia. Clin Chim Acta 2002;316:33-41
12. Kavanagh L, McKenna TJ, Fahie-Wilson MN, Gibney J, Smith TP. Specificity and clinical utility of methods for the detection of macroprolactin. Clin Chem 2006;52:1366-72
13. Jeffcoate SL, Bacon RRA, Beastall GH, Diver MJ, Franks S, Seth J. Assays for prolactin: guidelines for the provision of a clinical biochemistry service. Ann Clin Biochem 1986;23:638-51