Anxiety-like and exploratory behaviors of isolation-reared mice in the staircase test

Journal of Pharmacological Sciences

Volumn 104, Issue 2, 2007, Pages 153-158

  Ago, Yukio ^a   Takahashi, Keiko ^a   Nakamura, Shigeo ^a   Hashimoto, Hitoshi ^a,b   Baba, Akemichi ^a   Matsuda, Toshio ^a,b  

^a OSAKA UNIVERSITY   (Japan)

^b OSAKA UNIVERSITY GRADUATE SCHOOL OF MEDICINE   (Japan)

Author keywords

Anxiety; Exploratory behavior; Isolation rearing; Locomotor activity; Staircase test (ddY strain mice)

Indexed keywords

ANXIOLYTIC AGENT; BENZODIAZEPINE RECEPTOR BLOCKING AGENT; DIAZEPAM; METHAMPHETAMINE; N METHYL BETA CARBOLINE 3 CARBOXAMIDE; PHENOBARBITAL;

ANIMAL EXPERIMENT; ANXIETY; ARTICLE; CLIMBING; CONTROLLED STUDY; EXPERIMENTAL TEST; EXPLORATORY BEHAVIOR; HYPERACTIVITY; LOCOMOTION; MALE; MICROANALYSIS; MOUSE; MOUSE STRAIN; NONHUMAN; OUTBRED STRAIN; REARING; SOCIAL ISOLATION;

EID: 34250822217     PISSN: 13478613     EISSN: 13478648     Source Type: Journal    
DOI: 10.1254/jphs.FP0070325     Document Type: Article

References (36)

1. Sahakian BJ, Robbins TW, Morgan M, Iversen SD. The effects of psychomotor stimulants on stereotypy and locomotor activity in socially-deprived and control rats. Brain Res. 1974;84:195-205.
2. Garzon J, Del Rio J. Hyperactivity induced in rats by long-term isolation: further studies on a new animal model for the detection of antidepressants. Eur J Pharmacol. 1981;74:278-294.
3. Lapiz MD, Mateo Y, Parker T, Marsden C. Effects of noradrenaline depletion in the brain on response on novelty in isolation-reared rats. Psychopharmacology (Berl). 2000;152:312-320.
4. Wongwitdecha N, Marsden CA. Social isolation increases aggressive behaviour and alters the effects of diazepam in the rat social interaction test. Behav Brain Res. 1996;75:27-32.
5. 1A receptor activation in isolated mice. Eur J Pharmacol. 2001;432:163-166.
6. Geyer MA, Wilkinson LS, Humby T, Robbins TW. Isolation rearing of rats produces a deficit in prepulse inhibition of acoustic startle similar to that in schizophrenia. Biol Psychiat. 1993;34:361-372.
7. Bristow LJ, Landon L, Saywell KL, Tricklebank MD. The glycine/NMDA receptor antagonist, L-701,324 reverses isolation-induced deficits in prepulse inhibition in the rat. Psychopharmacology (Berl). 1995;118:230-232.
8. 1A receptor agonist MKC-242 reverses isolation rearing-induced deficits of prepulse inhibition in mice. Psychopharmacology (Berl). 2003;170:73-79.
9. Hall FS, Huang S, Fong GW, Sundstrom JM, Pert A. Differential basis of strain and rearing effects on open-field behavior in Fawn Hooded and Wistar rats. Physiol Behav. 2000;71:525-532.
10. 1A receptor activation on the anxiogenic effects induced by isolation in the elevated plus-maze test. Physiol Behav. 1993;54:573-578.
11. A receptor function in rat brain. J Neurochem. 2000;75:732-740.
12. Lodge DJ, Lawrence AJ. The effect of isolation rearing on volitional ethanol consumption and central CCK/dopamine systems in Fawn Hooded rats. Behav Brain Res. 2003;141:113-122.
13. Hellemans KGC, Benge LC, Olmstead MC. Adolescent enrichment partially reverses the social isolation syndrome. Brain Res Dev Brain Res. 2004;150:103-115.
14. Weiss IC, Pryce CR, Jongen-Rêlo AL, Nanz-Bohr NI, Feldon J. Effect of social isolation on stress-related behavioural and neuroendocrine state in the rat. Behav Brain Res. 2004;152:279-295.
15. Vale AL, Montgomery AMJ. Social interaction: responses to chlordiazepoxide and the loss of isolation-reared effects with paired-housing. Psychopharmacology (Berl). 1997;133:127-132.
16. Thorsell A, Slawecki CJ, El Khoury A, Mathe AA, Ehlers CL. The effects of social isolation on neuropeptide Y levels, exploratory and anxiety-related behaviors in rats. Pharmacol Biochem Behav. 2006;83:28-34.
17. 2 receptor gene antagonises behavioural changes induced by social isolation in female, but not in male mice. Behav Brain Res. 2004;155:1-11.
18. Guo M, Wu CF, Liu W, Yang JY, Chen D. Sex difference in psychological behavior changes induced by long-term social isolation in mice. Prog Neuropsychopharmacol Biol Psychiat. 2004;28:115-121.
19. Võikar V, Polus A, Vasar E, Rauvala H. Long-term individual housing in C57BL/6J and DBA/2 mice: assessment of behavioral consequences. Genes Brain Behav. 2005;4:240-252.
20. Pollard GT, Howard JL. The staircase test: some evidence of nonspecificity for anxiolytics. Psychopharmacology (Berl). 1986;89:14-19.
21. Simiand J, Keane PE, Morre M. The staircase test in mice: a simple and efficient procedure for primary screening of anxiolytic agents. Psychopharmacology (Berl). 1984;84:48-53.
22. Pick CG, Peter Y, Terkel J, Gavish M, Weizman R. Effect of the neuroactive steroid α-THDOC on staircase test behavior in mice. Psychopharmacology (Berl). 1996;128:61-66.
23. Weizman R, Paz L, Backer MM, Amiri Z, Modai I, Pick CG. Mouse strains differ in their sensitivity to alprazolam effect in the staircase test. Brain Res. 1999;839:58-65.
24. Weizman R, Paz L, Peter Y, Pick CG. Mice performance on the staircase test following acute ethanol administration. Pharmacol Biochem Behav. 2001;68:491-495.
25. Milman A, Weizman R, Rigai T, Rice KC, Pick CG. Behavioral effects of opioid subtypes compared with benzodiazepines in the staircase paradigm. Behav Brain Res. 2006;170:141-147.
26. Lister RG. The use of a plus-maze to measure anxiety in the mouse. Psychopharmacology (Berl). 1987;92:180-185.
27. Thiébot MH, Soubrié P, Sanger D. Anxiogenic properties of β-CCE and FG 7142: a review of promises and pitfalls. Psychopharmacology (Berl). 1988;94:452-463.
28. Takeda H, Tsuji M, Matsumiya T. Changes in head-dipping behavior in the hole-board test reflect the anxiogenic and /or anxiolytic state in mice. Eur J Pharmacol. 1998;350:21-29.
29. 1A receptor-mediated dopamine release in vivo in the frontal cortex of mice. J Neurochem. 2002;83:353-359.
30. Stéru L, Thierry B, Chermat R, Millet B, Simon P, Porsolt RD. Comparing benzodiazepines using the staircase test in mice. Psychopharmacology (Berl). 1987;92:106-109.
31. Lepicard EM, Joubert C, Hagneau I, Perez-Diaz F, Chapouthier G. Differences in anxiety-related behavior and response to diazepam in BALB/cByJ and C57BL/6J strains of mice. Pharmacol Biochem Behav. 2000;67:739-748.
32. Griebel G, Sanger DJ, Perrault G. Further evidence for differences between non-selective and BZ-1 (ω1) selective, benzodiazepine receptor ligands in murine models of "state" and "trait" anxiety. Neuropharmacology. 1996;35:1081-1091.
33. 1A receptor knockout mice on a 129/Sv background. Eur J Pharmacol. 2002;447:67-74.
34. 1A receptor agonist MKC-242 increases the exploratory activity of mice in the elevated plus-maze. Eur J Pharmacol. 2003;458:141-144.
35. Emmanouil DE, Quock RM. Effects of benzodiazepine agonist, inverse agonist and antagonist drugs in the mouse staircase test. Psychopharmacology (Berl). 1990;102:95-97.
36. Belzung C, Misslin R, Vogel E. The benzodiazepine receptor inverse agonists β-CCM and RO 15-3505 both reverse the anxiolytic effects of ethanol in mice. Life Sci. 1988;42:1765-1772.