Prevalence, virulence profiles, and clinical significance of shiga toxin-negative variants of enterohemorrhagic Escherichia coli O157 infection in humans

Clinical Infectious Diseases

Volumn 45, Issue 1, 2007, Pages 39-45

  Friedrich, Alexander W ^a   Zhang, Wenlan ^a   Bielaszewska, Martina ^a   Mellmann, Alexander ^a   Köck, Robin ^a   Fruth, Angelika ^b   Tschäpe, Helmut ^b   Karch, Helge ^a  

^a UNIVERSITY OF MÜNSTER   (Germany)

^b ROBERT KOCH INSTITUTE   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

SHIGA TOXIN;

ARTICLE; BACTERIAL GENE; BACTERIAL STRAIN; BACTERIAL VIRULENCE; BACTERIUM ISOLATE; DIARRHEA; ENTEROHEMORRHAGIC ESCHERICHIA COLI; ESCHERICHIA COLI O157; FECES ANALYSIS; HEMOLYTIC UREMIC SYNDROME; HUMAN; NONHUMAN; PREVALENCE; PRIORITY JOURNAL; STX GENE;

BACTERIAL TOXINS; DIARRHEA; DISEASE OUTBREAKS; ESCHERICHIA COLI INFECTIONS; ESCHERICHIA COLI O157; FECES; HEMOLYTIC-UREMIC SYNDROME; HUMANS; PREVALENCE; SHIGA TOXIN; VIRULENCE;

EID: 34250807060     PISSN: 10584838     EISSN: None     Source Type: Journal    
DOI: 10.1086/518573     Document Type: Article

References (39)

1. Tarr PI, Gordon CA, Chandler WL. Shiga toxin-producing Escherichia coli and the haemolytic uraemic syndrome. Lancet 2005; 365:1073-86.
2. Karch H, Tarr PI, Bielaszewska M. Enterohaemorrhagic Escherichia coli in human medicine. Int J Med Microbiol 2005; 295:405-18.
3. Sandvig K. Shiga toxins. Toxicon 2001; 39:1629-35.
4. -. J Clin Microbiol 1993; 31:1200-5.
5. Friedrich AW, Bielaszewska M, Zhang W, et al. Escherichia coli harboring Shiga toxin 2 gene variants: frequency and association with clinical symptoms. J Infect Dis 2002; 185:74-84.
6. Gerber A, Karch H, Allerberger F, Verweyen HM, Zimmerhackl LB. Clinical course and the role of Shiga toxin-producing Escherichia coli infection in the hemolytic-uremic syndrome in pediatric patients, 1997-2000, in Germany and Austria: a prospective study. J Infect Dis 2002; 186:493-500.
7. -. J Infect Dis 1999; 179:1274-77.
8. - in mehreren Bundesländern [in German]. Epidemiologisches Bulletin 2002; 15:123.
9. -: Untersuchungsergebnisse und Lehren für die Surveillance. Epidemiologisches Bulletin 2003; 22:171-5.
10. Bielaszewska M, Schmidt H, Karmali MA, et al. Isolation and characterization of sorbitol-fermenting Shiga toxin-producing Escherichia coli O157H- strains in the Czech Republic. J Clin Microbiol 1998; 36:2135-7.
11. - associated with a family outbreak of diarrhoea. Wien Klin Wochenschr 2000; 112:846-50.
12. Orth D, Grif K, Dierich MP, Würzner R. Sorbitol-fermenting Shiga toxin-producing Escherichia coli O157: indications for an animal reservoir. Epidemiol Infect 2006; 134:719-23.
13. Eklund M, Bielaszewska M, Nakari UM, Karch H, Siitonen A. Molecular and phenotypic profiling of sorbitol-fermenting Escherichia coli O157:H- human isolates from Finland. Clin Microbiol Infect 2006; 12:634-41.
14. Allison L. HUS due to a sorbitol-fermenting verotoxigenic E. coli O157 in Scotland. Eurosurveillance Weekly 2002; 6. Available at: http://www.eurosurveillance.org/ew/2002/021031.asp#2. Accessed 14 May 2007.
15. Bettelheim KA, Whipp M, Djordjevic SP, Ramachandran V. First isolation outside Europe of sorbitol-fermenting verocytotoxigenic Escherichia coli (VTEC) belonging to O group O157. J Med Microbiol 2002; 51:713-4.
16. Lee JH, Choi SJ. Isolation and characteristics of sorbitol-fermenting Escherichia coli O157 strains from cattle. Microbes Infect 2006; 8:2021-6.
17. Reid SD, Herbelin CJ, Bumbaugh AC, Selander RK, Whittam TS. Parallel evolution of virulence in pathogenic Escherichia coli. Nature 2000; 406:64-7.
18. -. Int J Med Microbiol 2002; 292:207-14.
19. - and O157:H7: characterization and evolutionary considerations. Infect Immun 2003; 71:3634-8.
20. -. J Clin Microbiol 2004; 42:4697-701.
21. Friedrich W, Köck R, Bielaszewska M, Zhang W, Karch H, Mathys W. Distribution of the urease gene cluster among and urease activities of enterohemorrhagic Escherichia coli O157 isolates from humans. J Clin Microbiol 2005; 43:546-50.
22. Bielaszewska M, Tarr PI, Karch H, Zhang W, Mathys W. Phenotypic and molecular analysis of tellurite resistance among enterohemorrhagic Escherichia coli O157:H7 and sorbitol-fermenting O157:NM clinical isolates. J Clin Microbiol 2005; 43:452-4.
23. Brunder W, Karch H, Schmidt H. Complete sequence of the large virulence plasmid pSFO157 of the sorbitol-fermenting enterohemorrhagic Escherichia coli O157:H- strain 3072/96. Int J Med Microbiol 2006; 296:467-74.
24. Makino K, Yokoyama K, Kubota Y, at al. Complete nucleotide sequence of the prophage VT2-Sakai carrying the verotoxin 2 genes of the enterohemorrhagic Escherichia coli O157:H7 derived from the Sakai outbreak. Genes Genet Syst 1999; 74:227-39.
25. Perna NT, Plunket G, Burland V, et al. Genome sequence of enterohaemorrhagic Escherichia coli O157:H7. Nature 2001; 409:529-33.
26. De Greve H, Qizhi C, Deboeck F, Hernalsteens JP. The Shiga-toxin VT2-encoding bacteriophage è297 integrates at a distinct position in the Escherichia coli genome. Biochim Biophys Acta 2002; 1579:196-202.
27. Shaikh N, Tarr PI. Escherichia coli O157:H7 Shiga toxin-encoding bacteriophages: integrations, excisions, truncations, and evolutionary implications. J Bacteriol 2003; 185:3596-605.
28. Bielaszewska M, Prager R, Zhang W, et al. Chromosomal dynamism in progeny of outbreak-related sorbitol-fermenting enterohemorrhagic Escherichia coli O157:NM. Appl Environ Microbiol 2006; 72:1900-9.
29. Mellmann A, Bielaszewska M, Zimmerhackl LB, et al. Enterohemorrhagic Escherichia coli in human infection: in vivo evolution of a bacterial pathogen. Clin Infect Dis 2005; 41:785-92.
30. Jelacic S, Wobbe CL, Boster DR, et al. ABO and P1 blood group antigen expression and stx genotype and outcome of childhood Escherichia coli O157:H7 infections. J Infect Dis 2002; 185:214-9.
31. - strains that do not produce Shiga toxin: phenotypic and genetic characterization of isolates associated with diarrhea and hemolytic-uremic syndrome. J Clin Microbiol 1999; 37:3491-6.
32. Besser TE, Shaikh N, Holt NJ, et al. Greater diversity of Shiga toxin-encoding bacteriophage insertion sites among Escherichia coli O157:H7 isolates from cattle than in those from humans. Appl Environ Microbiol 2007; 73:671-9.
33. Bielaszewska M, Friedrich AW, Aldick T, Schurk-Bulgrin R, Karch H. Shiga toxin activatable by intestinal mucus in Escherichia coli isolated from humans: predictor for a severe clinical outcome. Clin Infect Dis 2006; 43:1160-7.
34. Bielaszewska M, Zhang W, Tarr PI, Sonntag AK, Karch H. Molecular profiling and phenotype analysis of Escherichia coli O26:H11 and O26:NM: secular and geographic consistency of enterohemorrhagic and enteropathogenic isolates. J Clin Microbiol 2005; 43:4225-8.
35. Wirth T, Falush D, Lan R, et al. Sex and virulence in Escherichia coli: an evolutionary perspective. Mol Microbiol 2006; 60:1136-51.
36. Friedrich AW, Lu S, Bielaszewska M, et al. Cytolethal distending toxin in Escherichia coli O157:H7: spectrum of conservation, structure, and endothelial toxicity. J Clin Microbiol 2006; 44:1844-6.
37. Centers for Disease Control and Prevention (CDC). Importance of culture confirmation of Shiga toxin-producing Escherichia coli infection as illustrated by outbreaks of gastroenteritis - New York and North Carolina, 2005. MMWR Morb Mortal Wkly Rep 2006; 55:1042-5.
38. Trabulsi LR, Keller R, Gomes TAT. Typical and atypical enteropathogenic Escherichia coli. Emerg Infect Dis 2002; 8:508-13.
39. Ake J, Jelacic S, Ciol MA, et al. Relative nephroprotection during Escherichia coli O157:H7 infections: association with intravenous volume expansion. Pediatrics 2005; 115:673-80.