Thalassemia: Macroscopic and radiological study of a case

International Journal of Osteoarchaeology

Volumn 17, Issue 3, 2007, Pages 269-285

  Lagia, Anna ^a,d   Eliopoulos, C ^b   Manolis, S ^c  

^a UNIVERSITY OF CHICAGO   (United States)

^b UNIVERSITY OF SHEFFIELD   (United Kingdom)

^c UNIVERSITY OF ATHENS   (Greece)

^d NONE   (Germany)

Author keywords

Differential diagnosis; Skeletal characteristics; Thalassemias

Indexed keywords

EID: 34250797431     PISSN: 1047482X     EISSN: 10991212     Source Type: Journal    
DOI: 10.1002/oa.881     Document Type: Article

References (82)

1. Agelarakis A. 2000. Aspects of demography and paleopathology among the Hellenistic Abderetes in Thrace, Greece. Eulimene 1: 13-24.
2. Agelarakis A. 2002. Investigations of physical anthropology and paleopathology of the ancient necropolis of Thassos. In Excavating Classical Culture: Recent Archaeological Discoveries in Greece, Stamatopoulou M, Yeroulanou M (eds). BAR International Series 1031: Oxford; 12-19.
3. Angastiniotis M, Modell B. 1998. Global epidemiology of hemoglobin disorders. Annals of the New York Academy of Sciences 850: 251-269.
4. Angel JL. 1945. Skeletal material from Attica. Hesperia 14: 279-363.
5. Angel JL. 1959. Early Helladic skulls from Aghios Kosmas. In Agbios Kosmas: An Early Bronze Age Settlement and Cemetety in Attica, Mylonas GE (ed.). Princeton University Press: Princeton; 169-179.
6. Angel JL. 1960. Paleodemography and disease in bronze age Greece (abs). American Journal of Physical Antbropology 18: 351-352.
7. Angel JL. 1964. Osteoporosis: Thalassemia? American Journal of Physical Anthropology 22: 369-374.
8. Angel JL. 1966. Porotic hyperostosis, anemias, malarias, and marshes in the Prehistoric eastern Mediterranean. Science 153: 760-762.
9. Angel JL. 1967. Porotic hyperostosis or osteoporosis symmetrica. In Diseases in Antiquity, Brothwell DR, Sandison AT (eds). Charles C. Thomas: Springfield, IL; 378-389.
10. Angel JL. 1969. Paleodemography and evolution. American Journal of Physical Anthropology 31: 343-354.
11. Angel JL. 1971a. Early Neolithic skeletons from Catal Huyük: demography and pathology. Anatolian Studies 21: 77-98.
12. Angel JL. 1971b. Lerna. The People. Results of the Excavation Conducted by the American School of Classical Studies at Athens. Princeton University Press: Princeton.
13. Angel JL. 1973. Human skeletons from grave circles at Mycenae. In Grave Circle B from Mycenae, Mylonas GE (ed.). En Athenais Archaeologike Etaireia 73: Athens; 379-397.
14. Angel JL. 1978. Porotic hyperostosis in the Eastern Mediterranean. Medical College of Virginia Quarterly 14: 10-16.
15. Angel JL. 1984. Health as a crucial factor in the changes from hunting to developed farming in the eastern Mediterranean. In Paleopathology at the Origins of Agriculture, Cohen MN, Armelagos GJ (eds). Academic Press: New York; 51-73.
16. Angel JL, Kelley JO, Parrington M, Pinter S. 1987. Life stresses of the free black community as represented by the First African Baptist Church, Philadelphia, 1823-1841. American Journal of Physical Anthropology 74: 213-229.
17. Asbell MB. 1964. Orthodontic aspects of Cooley's anemia. Annals of the New York Academy of Sciences 119: 662-663.
18. Baker DH. 1964. Roentgen manifestations of Cooley's anemia. Annals of the New York Academy of Sciences 119: 641-661.
19. Boonpucknavig S, Chiewsilp P, Isarangkura P, O'Charoen R, Akkawat R. 1987. Immunologic reactivity in thalassemia. Birth Defects Original Article Series 23: 565-569.
20. Borgna-Pignatti C, De Stefano P, Zonta L, Vullo C, De Sanctis V, Melevendi C, Naselli A, Masera G, Terzoli S, Gabutti V, Piga A. 1985. Growth and sexual maturation in thalassemia major. Journal of Paediatrics 106: 150-155.
21. Bucci E, LoMuzio L, Mignogna MD, Caparrotti MA. 1990. β-thalassemia ed implicazioni odontostomatologische. Nota 1. Considerazioni cliniche. (Betathalassemia and its orodental implications. I. The clinical considerations). Minerva Stomatologica 39: 1-8.
22. Caffey J. 1937. The skeletal changes in the chronic hemolytic anemias (erythroblastic anemia, sickle cell anemia and chronic hemolytic icterus). American Journal of Roentgenology and Radium Therapy 37: 293-324.
23. Caffey J. 1951. Cooley's erythroblastic anemia. Some skeletal findings in adolescents and young adults. American Journal of Roentgenology Radium Therapy and Nuclear Medicine 65: 547-560.
24. Caffey J. 1957. Cooley's anemia: A review of the roentgenographic findings in the skeleton: Hickey lecture. American Journal of Roentgenology, Radium Therapy and Nuclear Medicine 78: 381-391.
25. Cassady JR, Berdon WE, Baker DH. 1967. The "typical" spine changes in sickle cell anemia in a patient with thalassemia major (Cooley's anemia). Radiology 89: 1065-1068.
26. Christenson RA, Pootrakul P, Burnell JM, Teubner EJ, Finch CA, Baylink DJ. 1988. Patients with thalassemia develop osteoporosis, osteomalacia and hypoparathyroidism, all of which are corrected by transfusion. Birth, Defects Original Article Series 23: 409-416.
27. Cockshutt-Smith CM. 1986. Nutritional status of late prehistoric and early historic Amerindians: Evidence from the American Southwest and Plains. MA thesis, George Washington University.
28. Cooley TB, Lee P. 1925. A series of cases of splenomegaly in children with anemia and peculiar bone changes. Transactions of the American Pediatric Society 37: 29-30.
29. Cooley TB, Witwer ER, Lee P. 1927. Anemia in children with splenomegaly and peculiar changes in the bones. Report of cases. American Journal of Diseases of Children 34: 347-363.
30. Daly D. 1987. "Hair-on-end" pattern in the skull. Seminars in Roentgenology 22: 144-145.
31. Edelstein G, Kyriakos M. 1984. Focal hemopoietic hyperplasia of the rib-a form of pseudotumor. Skeletal Radiology 11: 108-118.
32. Finsterbush A, Ferber I, Mogle P. 1985. Lower limb pain in thalassemia. Journal of Rheumatology 12: 529-532.
33. Fox-Leonard SC. 1997. Comparative health from paleopathological analysis of The human skeletal remains dating to the Hellenistic and Roman periods, from Paphos, Cyprus and Corinth, Greece. PhD dissertation, University of Arizona.
34. Galanello R, Cao A. 1998. Relationship between genotype and phenotype. Thalassemia intermedia. Annals of the New York Academy of Sciences 850: 325-333.
35. Greenfield GB. 1990. Radiology of Bone Diseases. JB Lippincott Co: Philadelphia.
36. Hershkovitz I, Rothschild BM, Latimer B, Dutour O, Leonetti G, Greenwald CM, Rothschild C, Jellema LM. 1997. Recognition of sickle cell anemia in skeletal remains of children. American Journal of Physical Anthropology 104: 213-226.
37. Hes J, Van der Waal I, de Man K. 1990. Bimaxillary hyperplasia: the facial expression of homozygous beta-thalassemia. Oral Surgery, Oral Medicine, Oral Pathology 69: 185-190.
38. Ho PJ, Hall GW, Luo LY, Weatherall DJ, Thein SL. 1998. Beta-thalassaemia intermedia: is it possible consistently to predict phenotype from genotype? British Journal of Haematology 100: 70-78.
39. Hooton EA. 1930. The Indians of Pecos Pueblo: A Study of their Skeletal Remains. Yale University Press: New Haven, CT.
40. Jacobsen TW, Cullen T. 1992. The work of J.L. Angel in the Eastern Mediterranean. In A Life in Science: Papers in Honor of J. Lawrence Angel, Buikstra JE (ed.). Centre for American Archaeology, Scientific Papers 6: 38-51.
41. Kaplan RI, Werther R, Castano F. 1964, Dental and oral findings in Cooley's anemia: a study of fifty cases. Annals of the New York Academy of Sciences 119: 664-666.
42. Kattamis C, Liakopoulou T, Kattamis A. 1990. Growth and development in children with thalassaemia major. Acta Paediatrica Scandinavica. Supplement 366: 111-117.
43. Lagia A. 1993. Differential diagnosis of the three main types of anemia (thalassemia, sickle cell anemia, iron deficiency anemia) from the skeleton based on macroscopic and radiographic skeletal characteristics. MSc thesis, University of Bradford, UK.
44. Lawson JP, Ablow RC, Pearson HA. 1981a. The ribs in thalassemia: I. The relationship to therapy. Pediatric Radiology 140: 663-672.
45. Lawson JP, Ablow RC, Pearson HA. 1981b. The ribs in thalassemia: II. The pathogenesis of the changes. Pediatric Radiology 140: 673-679.
46. Lawson JP, Ablow RC, Pearson HA. 1983. Premature fusion of the proximal humeral epiphyses in thalassemia. American Journal of Roentgenology 140: 239-244.
47. Lawson JP, Ablow RC, Pearson HA. 1984. Calvarial and phalangeal vascular impressions in thalassemia. American Journal of Roentgenology 143: 641-645.
48. Liston MA. 1993. The human skeletal remains from Kavousi, Crete: A bioarchaeological analysis. PhD dissertation, University of Tennessee.
49. Loukopoulos D. 1991. Thalassemia: genotypes and phenotypes. Annals of Haematology 62: 85-94.
50. Loukopoulos D. 1996. Current status of thalassemia and the sickle cell syndromes in Greece. Seminars in Hematology 33: 76-86.
51. Magro S, Puzzionia P, Consarino C, Galati MC, Morgione S, Porcelli D, Grimaldi S, Tancre D, Arcuri V, De Santis V, Alberti A. 1990. Hypothyroidism in patients with thalassemia syndromes. Acta Haematologica 84: 72-76.
52. Moore S. 1929. Bone changes in sickle cell anemia with a note on similar changes in skulls of ancient Mayan Indians. Journal of the Missouri State Medical Association 26: 561-564.
53. Moseley JE. 1963. Bone Changes in Haematologic Disorders (Roentgen Aspects). Grune and Stratton: New York.
54. Moseley JE. 1965. The paleopathological riddle of "symmetrical osteoporosis". American Journal of Roentgenology, Radium Therapy and Nuclear Medicine 95: 135-142.
55. Moseley JE. 1971. Hematologic disorders. In Radiology of the Skull and the Brain, Newton TH, Potts DG (eds). CV Mosby Co.: St Louis; 697-715.
56. Moseley JE. 1974. Skeletal changes in the anemias. Seminars in Roentgenology 9: 169-184.
57. O'Hara EA. 1967. Roentgenographic osseous manifestations of the anemias and the leukemias. Clinical Orthopaedics and Related Research 52: 63-82.
58. Olivieri NF. 1998. Thalassemia: clinical management. Baillieres Clinical Haematology 11: 147-162.
59. Ortner DJ, Putschar WGJ. 1981. Identification of Pathological Conditions in Human Skeletal Remains. Smithsonian Institution Press: Washington, DC.
60. Papathanasiou A. 2001. A Bioarchaeological Analysis of Neolithic Alepotrypa Cave, Greece. BAR International Series 961: Oxford.
61. Parano E, Pavone V, Di Gregorio F, Pavone P, Trifiletti RR. 1999. Extraordinary intrathecal bone reaction in (-thalassemia intermedia. Lancet 354: 922.
62. Pike S. 1997. The Wiener Laboratory. Paleopathology Newsletter 100: 8-9.
63. Poyton HG, Davey KW. 1968. Thalassemia: changes visible in radiographs used in dentistry. Oral Surgery, Oral Medicine and Oral Pathology 25: 564-576.
64. Pusaksrikit S, Isarangkura P, Hathirat P. 1988. Occlusion of the teeth in thalassemic patients. Birth Defects Original Article Series 23: 429-433.
65. Ratip S, Modell B. 1996. Psychological and sociological aspects of the thalassemias. Seminars in Hematology 33: 53-65.
66. Resnick D, Niwayama G. 1988. Diagnosis of Bone and Joint Disorders. WB Saunders Co: Philadelphia.
67. Roberts C, Bourbou C, Lagia A, Triantaphyllou S, Tsaliki A. 2005. Health and disease in Greece: Past, present and future. In Health in Antiquity, King H (ed.). Routledge: New York, 32-57.
68. Sahni A, Thapa BR, Gulati S, Mehta S. 1991. Skeletal manifestations in beta-thalassemia intermedia. Journal of the Association of Physicians of India 39: 288-290.
69. Singcharoen T, Piyachon C, Kulapongs P. 1987. Radiographic abnormalities of ribs in beta-thalassemic children. Birth Defects Original Article Series 23: 417-420.
70. Steinbock RT. 1976. Paleopathological Diagnosis and Interpretation. Charles C. Thomas: Springfield.
71. Stuart-Macadam P. 1987a. A radiographic study of porotic hyperostosis. American Journal of Physical Anthropology 74: 511-520.
72. Stuart-Macadam P. 1987b. Porotic hyperostosis: new evidence to support the anemia theory. American Journal of Physical Anthropology 74: 521-526.
73. Thein SL. 2004. Genetic insights into the clinical severity of beta thalassaemia. British Journal of Haematology 124: 264-274.
74. Triantaphyllou S. 2001. A Bioarchaeological Approach to Prehistoric Cemetery Populations from Central and Western Greek Macedonia. BAR International Series 976: Oxford.
75. Vogt EC, Diamond LK. 1930. Congenital anemias, roentgenographically considered. American Journal of Roentgenology and Radium Therapy 23: 625-627.
76. Von Endt DW, Ortner DJ. 1982. Amino acid analysis of bone from a possible case of prehistoric iron deficiency anemia from the American Southwest. American Journal of Physical Anthropology 59: 377-385.
77. Wapler U, Crubézy E, Schultz M. 2004. Is cribra orbitalia synonymous with anemia? Analysis and interpretation of cranial pathology, in Sudan. American Journal of Physical Anthropology 123: 333-339.
78. Weatherall DJ. 1980. Toward an understanding of the molecular basis of some common inherited anemias: the story of thalassemia. In Blood, Pure and Eloquent, Wintrobe MM (ed.). McGraw-Hill Book Co.: New York; 373-414.
79. Weatherall DJ, Clegg JB. 1999. Genetic disorders of hemoglobin. Seminars in Hematology 36: 24-37.
80. Welcker H. 1888. Cribra orbitalia, ein ethnologischdiagnostisches Merkmal am Schädel mehrerer Menschenrassen. Archiv für Anthropologie 17: 1-18.
81. Whiple GH, Bradford WL. 1935. Mediterranean disease-thalassemia (erythroblastic anemia of Cooley). Journal of Pediatrics 9: 279-311.
82. Zimmerman MR, Kelley MA. 1982. Atlas of Human Paleopathology. Praeger Publishers: New York.