Overexpression of SERTAD3, a putative oncogene located within the 19q13 amplicon, induces E2F activity and promotes tumor growth

Oncogene

Volumn 26, Issue 29, 2007, Pages 4319-4328

  Darwish, H ^a   Cho, J M ^a   Loignon, M ^a   Alaoui Jamali, M A ^a  

^a MCGILL UNIVERSITY   (Canada)

Author keywords

19q13; Cell cycle; E2F; Oncogenesis; SERTAD

Indexed keywords

DACTINOMYCIN; LUCIFERASE; MESSENGER RNA; SMALL INTERFERING RNA; TRANSCRIPTION FACTOR E2F;

AMPLICON; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CANCER CELL CULTURE; CELL CYCLE; CELL PROLIFERATION; CELL STRAIN MCF 7; CELL TRANSFORMATION; CHROMOSOME 19Q; CHROMOSOME ABERRATION; CONTROLLED STUDY; ENZYME ASSAY; FIBROBLAST CULTURE; FLOW CYTOMETRY; GENE OVEREXPRESSION; GENETIC TRANSCRIPTION; GENETIC TRANSFECTION; HUMAN; HUMAN CELL; MOUSE; NONHUMAN; NUCLEOTIDE SEQUENCE; NUDE MOUSE; ONCOGENE; ONCOGENE SERTAD3; PRIORITY JOURNAL; TUMOR GROWTH; WESTERN BLOTTING;

AMINO ACID SEQUENCE; ANIMALS; CELL LINE; CELL LINE, TUMOR; CHROMOSOMES, HUMAN, PAIR 19; E2F TRANSCRIPTION FACTORS; GENE AMPLIFICATION; GENE EXPRESSION REGULATION, NEOPLASTIC; HUMANS; MICE; MOLECULAR SEQUENCE DATA; NEOPLASMS, EXPERIMENTAL; NIH 3T3 CELLS; ONCOGENE PROTEINS; SEQUENCE HOMOLOGY, AMINO ACID; TRANS-ACTIVATORS;

MUS;

EID: 34250795652     PISSN: 09509232     EISSN: 14765594     Source Type: Journal    
DOI: 10.1038/sj.onc.1210195     Document Type: Article

References (37)

1. Abdullah JM, Jing X, Spassov DS, Nachtman RG, Jurecic R. (2001). Cloning and characterization of Hepp, a novel gene expressed preferentially in hematopoietic progenitors and mature blood cells. Blood Cells Mol Dis 27: 667-676.
2. Alarcon-Vargas D, Ronai Z. (2004). c-Jun-NH2 kinase (JNK) contributes to the regulation of c-Myc protein stability. J Biol Chem 279: 5008-5016.
3. Alitalo K, Schwab M, Lin CC, Varmus HE, Bishop JM. (1983). Homogeneously staining chromosomal regions contain amplified copies of an abundantly expressed cellular oncogene (c-myc) in malignant neuroendocrine cells from a human colon carcinoma. Proc Natl Acad Sci USA 80: 1707-1711.
4. Barker PE. (1982). Double minutes in human tumor cells. Cytogenetics 5: 81-94.
5. Beghini A, Magnani I, Roversi G, Piepoli T, Di Terlizzi S, Moroni RF et al. (2003). The neural progenitor-restricted isoform of the MARK4 gene in 19q13.2 is upregulated in human gliomas and overexpressed in a subset of glioblastoma cell lines. Oncogene 22: 2581-2591.
6. Bicher A, Ault K, Kimmelman A, Gershenson D, Reed E, Liang B. (1997). Loss of heterozygosity in human ovarian cancer on chromosome 19q. Gynecol Oncol 66: 36-40.
7. Bienz M. (2006). The PHD finger, a nuclear protein-interaction domain. Trends Biochem Sci 31: 35-40.
8. Calgaro S, Boube M, Cribbs DL, Bourbon H-M. (2002). The Drosophila gene taranis encodes a novel trithorax group member potentially linked to the cell cycle regulatory apparatus. Genetics 160: 547-560.
9. Cho JM, Song DJ, Bergeron J, Benlimame N, Wold MS, Alaoui-Jamali MA. (2000). SERTAD3, a novel transcriptional co-activator, binds the second subunit of replication protein A. Nucleic Acids Res 28: 3478-3485.
10. Curtis LJ, Li Y, Gerbault-Seureau M, Kuick R, Dutrillaux AM, Goubin G. (1998). Amplification of DNA sequences from chromosome 19q13.1 in human pancreatic cell lines. Genomics 53: 42-55.
11. Gupta S, Takhar PP, Degenkolbe R, Koh CH, Zimmermann H, Yang CM. (2003). The human papillomavirus type 11 and 16 E6 proteins modulate the cell-cycle regulator and transcription cofactor TRIP-Br1. Virology 317: 155-164.
12. Hiemstra JL, Schneider SS, Brodeur GM. (1994). Highresolution mapping of the N-myc amplicon core domain in neuroblastomas. Prog Clin Biol Res 385: 51-57.
13. Hoglund M, Gorunova L, Andren-Sandberg A, Dawiskiba S, Mitelman F, Johansson B. (1998). Cytogenetic and fluorescence in situ hybridization analyses of chromosome 19 aberrations in pancreatic carcinomas: frequent loss of 19p13.3 and gain of 19q131-13.2. Genes Chromosomes Cancer 21: 8-16.
14. Hsu SI, Yang CM, Sim KG, Hentschel DM, O'Leary E, Bonventre JV. (2001). TRIP-Br: a novel family of PHD zinc finger- and bromodomain-interacting proteins that regulate the transcriptional activity of E2F-1/DP-1. EMBO J 20: 2273-2285.
15. Lengauer C, Kinzler KW, Vogelstein B. (1998). Genetic instabilities in human cancers. Nature 396: 643-649.
16. Loignon M, Drobetsky EA. (2002). The initiation of UV-induced G(1) arrest in human cells is independent of the p53/p21/pRb pathway but can be attenuated through expression of the HPV E7 oncoprotein. Carcinogenesis 23: 35-45.
17. Luoh SW. (2002). Amplification and expression of genes from the 17q11 approximately q12 amplicon in breast cancer cells. Cancer Genet Cytogenet 136: 43-47.
18. Marchio A, Meddeb M, Pineau P, Danglot G, Tiollais P, Bernheim A et al. (1997). Recurrent chromosomal abnormalities in hepatocellular carcinoma detected by comparative genomic hybridization. Genes Chromosomes Cancer 18: 59-65.
19. Miwa W, Yasuda J, Murakami Y, Yashima K, Sugano K, Sekine T et al. (1996). Isolation of DNA sequences amplified at chromosome 19q13.1-q13.2 including the AKT2 locus in human pancreatic cancer. Biochem Biophys Res Commun 225: 968-974.
20. Morgenstern JP, Land H. (1990). Advanced mammalian gene transfer: high titre retroviral vectors with multiple drug selection markers and a complementary helper-free packaging cell line. Nucleic Acids Res 18: 3587-3596.
21. Muleris M, Almeida A, Gerbault-Seureau M, Malfoy B, Dutrillaux B. (1995). Identification of amplified DNA sequences in breast cancer and their organization within homogeneously staining regions. Genes Chromosomes Cancer 14: 155-163.
22. Oliner JD, Kinzler KW, Meltzer PS, George DL, Vogelstein B. (1992). Amplification of a gene encoding a p53-associated protein in human sarcomas. Nature 358: 80-83.
23. Ormandy CJ, Musgrove EA, Hui R, Daly RJ, Sutherland RL. (2003). Cyclin D1, EMS1 and 11q13 amplification in breast cancer. Breast Cancer Res Treat 78: 323-335.
24. Petersen I, Langreck H, Wolf G, Schwendel A, Psille R, Vogt P et al. (1997). Small-cell lung cancer is characterized by a high incidence of deletions on chromosomes 3p, 4q, 5q, 10q, 13q and 17p. Br J Cancer 75: 79-86.
25. Reifenberger G, Liu L, Ichimura K, Schmidt EE, Collins VP. (1993). Amplification and overexpression of the MDM2 gene in a subset of human malignant gliomas without p53 mutations. Cancer Res 53: 2736-2739.
26. Ross JS, Fletcher JA. (1999). The HER-2/neu oncogene: prognostic factor, predictive factor, and target for therapy. Semin Cancer Biol 9: 125-138.
27. Schneider SS, Hiemstra JL, Zehnbauer BA, Taillon-Miller P, Le Paslier DL, Vogelstein B et al. (1992). Isolation and structural analysis of a 12-megabase N-myc amplicon from a human neuroblastoma. Mol Cell Biol 12: 5563-5570.
28. Shiloh Y, Korf B, Kohl NE, Sakai K, Brodeur GM, Harris P et al. (1986). Amplification and rearrangement of DNA sequences from the chromosomal region 2p24 in human neuroblastomas. Cancer Res 46: 5297-5301.
29. Sieber OM, Heinimann K, Tomlinson IP. (2003). Genomic instability - the engine of tumorigenesis? Nat Rev Cancer 3: 701-708.
30. Singh P, Wong SH, Hong W. (1994). Overexpression of E2F-1 in rat embryo fibroblasts leads to neoplastic transformation. EMBO J 13: 3329-3338.
31. Sugimoto M, Nakamura T, Ohtani N, Hampson L, Hampson IN, Shimamoto A et al. (1999). Regulation of CDK4 activity by a novel CDK4-binding protein, p34(SEI-1). Genes Dev 13: 3027-3033.
32. Tang TC, Sham JS, Xie D, Fang Y, Huo KK, Wu QL et al. (2002). Identification of a candidate oncogene SEI-1 within a minimally amplified region at 19q13.1 in ovarian cancer cell lines. Cancer Res 62: 7157-7161.
33. Thompson FH, Nelson MA, Trent JM, Guan XY, Liu Y, Yang JM et al. (1996). Amplification of 19q13.1-q13.2 sequences in ovarian cancer. G-band, FISH, and molecular studies. Cancer Genet Cytogenet 87: 55-62.
34. Wang ZJ, Churchman M, Campbell IG, Xu WH, Yan ZY, McCluggage WG et al. (1999). Allele loss and mutation screen at the Peutz-Jeghers (LKB1) locus (19p13.3) in sporadic ovarian tumors. Br J Cancer 80: 70-72.
35. Yang XH, Sladek TL. (1995). Overexpression of the E2F-1 transcription factor gene mediates cell transformation. Gene Exp 4: 195-204.
36. Yen L, Benlimame N, Nie Z, Xiao D, Wang T, Al Moustafa A et al. (2002). Differential regulation of tumor angiogenesis by distinct ErbB homo- and heterodimers. Mol Biol Cell 13: 4029-4044.
37. Zaharieva BM, Simon R, Diener PA, Ackermann D, Maurer R, Alund G et al. (2003). High-throughput tissue microarray analysis of 11q13 gene amplification (CCND1, FGF3, FGF4, EMS1) in urinary bladder cancer. J Pathol 201: 603-608.