Biotransformation of 6-methoxy-3-(3′,4′,5′-trimethoxy- benzoyl)-1H-indole (BPR0L075), a novel antimicrotubule agent, by mouse, rat, dog, and human liver microsomes

Drug Metabolism and Disposition

Volumn 35, Issue 7, 2007, Pages 1042-1049

  Yao, Hsien Tsung ^a   Wu, Yu Shan ^a   Chang, Yi Wei ^a   Hsieh, Hsing Pang ^a   Chen, Wei Cheng ^a   Lan, Shih Jung ^a   Chen, Chiung Tong ^a   Chao, Yu Sheng ^a   Chang, Ling ^a   Sun, Hsu Yi ^a   Yeh, Teng Kuang ^a  

^a NATIONAL HEALTH RESEARCH INSTITUTES   (Taiwan)

Author keywords

[No Author keywords available]

Indexed keywords

5 HYDROXYL 6 METHOXY 3 (3',4',5' TRIMETHOXYBENZOYL)INDOLE; 6 ETHOXY 3 (3',4',5' TRIMETHOXYBENZOYL) 7 AZAINDOLE; 6 METHOXY 3 (3' HYDROXY 4',5' METHOXYBENZOYL)INDOLE; 6 METHOXY 3 (3',4',5' TRIMETHOXYBENZOYL) 1H INDOLE; 6 METHOXY 3 (4' HYDROXY 3',5' METHOXYBENZOYL)INDOLE; 7 HYDROXYL 6 METHOXY 3 (3',4',5' TRIMETHOXYBENZOYL)INDOLE; BPROL 075; BPROL 082; BPROL 187; CYTOCHROME P450; CYTOCHROME P450 1A2; CYTOCHROME P450 2C19; CYTOCHROME P450 2C9; CYTOCHROME P450 2D6; CYTOCHROME P450 2E1; CYTOCHROME P450 3A4; INDOLE DERIVATIVE; ISOENZYME; O DEMETHYLASE; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; ARTICLE; CATALYSIS; CONTROLLED STUDY; DEMETHYLATION; DRUG CLEARANCE; DRUG HYDROXYLATION; DRUG METABOLISM; DRUG TRANSFORMATION; FEMALE; HUMAN; HUMAN CELL; INCUBATION TIME; ISOENZYME ANALYSIS; LIQUID CHROMATOGRAPHY; LIVER MICROSOME; MALE; MOUSE; NONHUMAN; PRIORITY JOURNAL; RAT; STANDARD; TANDEM MASS SPECTROMETRY;

ANIMALS; BIOTRANSFORMATION; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; CYTOCHROME P-450 CYP1A2; CYTOCHROME P-450 CYP2D6; CYTOCHROME P-450 ENZYME SYSTEM; DEALKYLATION; DOGS; FEMALE; HUMANS; HYDROXYLATION; INDOLES; MALE; MICE; MICROSOMES, LIVER; MOLECULAR STRUCTURE; NADP; RATS; RECOMBINANT PROTEINS; REFERENCE STANDARDS; SPECIES SPECIFICITY; TANDEM MASS SPECTROMETRY; TUBULIN MODULATORS;

CANIS FAMILIARIS; HEXAPODA; RATTUS;

EID: 34250779934     PISSN: 00909556     EISSN: 1521009X     Source Type: Journal    
DOI: 10.1124/dmd.106.014597     Document Type: Article

References (4)

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