Strongylophorine-26, an inhibitor of cancer cell invasion: SAR revealed by synthesis of analogues

Journal of Natural Products

Volumn 70, Issue 5, 2007, Pages 736-740

  Warabi, Kaoru ^a   Patrick, Brian O ^a   Austin, Pamela ^a   Roskelley, Calvin D ^a   Roberge, Michel ^a   Andersen, Raymond J ^a  

^a UNIVERSITY OF BRITISH COLUMBIA   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

ANTINEOPLASTIC AGENT; BISLACTONE; STRONGYLOPHORINE 26; STRONGYLOPHORINE 8; UNCLASSIFIED DRUG;

ARTICLE; CANCER CELL; CANCER INVASION; CHEMICAL REACTION; CRYSTAL STRUCTURE; CYTOTOXICITY; DRUG STRUCTURE; DRUG SYNTHESIS; HUMAN; PHARMACOPHORE; PROTON NUCLEAR MAGNETIC RESONANCE; STRUCTURE ACTIVITY RELATION; X RAY DIFFRACTION;

ANTINEOPLASTIC AGENTS; DITERPENES; DRUG SCREENING ASSAYS, ANTITUMOR; MOLECULAR STRUCTURE; STEREOISOMERISM; STRUCTURE-ACTIVITY RELATIONSHIP; X-RAY DIFFRACTION;

EID: 34250772400     PISSN: 01633864     EISSN: None     Source Type: Journal    
DOI: 10.1021/np060481l     Document Type: Article

References (9)

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8. Nishizawa, M.; Takenaka, H.; Hayashi, Y. J. Org. Chem. 1986, 51, 806-813.
9. 13C chemical shift values were assigned as follows: C-15 [δ 2.35, dd, J = 2.5, 13 Hz and 2.72, ddd, J = 1.8, 13, 14 Hz (major); 2.35, d, J = 15 Hz and 2.75, m (minor)], C-19 [δ 5.25, d, J = 1.6 Hz; 99.7 (major); 5.23, d, J = 1.9 Hz; 98.6 (minor)], C-21 [δ 5.76, dd, J = 1.8, 1.6 Hz; 122.5 (major); 5.94, brd; 125.6 (minor)], C-27 [δ 3.70, s (major); 3.72, s (minor)].