Altered cholinergic metabolism and muscarinic receptor linked second messenger pathways after chronic exposure to dichlorvos in rat brain

Toxicology and Industrial Health

Volumn 23, Issue 1, 2007, Pages 25-37

  Raheja, Geetu ^a   Dip Gill, Kiran ^a  

^a POSTGRADUATE INSTITUTE OF MEDICAL EDUCATION AND RESEARCH   (India)

Author keywords

AChE; cholinergic metabolism; dichlorvos; muscarinic receptors; OP neurotoxicity; second messenger systems

Indexed keywords

ACETYLCHOLINE; ACETYLCHOLINESTERASE; ADENYLATE CYCLASE; CHOLINE; CHOLINE ACETYLTRANSFERASE; CYCLIC AMP; DICHLORVOS; MUSCARINIC RECEPTOR; ORGANOPHOSPHATE;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; BINDING AFFINITY; BRAIN; BRAIN REGION; BRAIN STEM; CEREBELLUM; CHOLINERGIC SYSTEM; CONTROLLED STUDY; DIETARY INTAKE; ENZYME ACTIVITY; LONG TERM EXPOSURE; MALE; METABOLIC DISORDER; NEUROTOXICITY; NONHUMAN; PROTEIN BINDING; RAT; WEIGHT GAIN;

ACETYLCHOLINESTERASE; ADMINISTRATION, ORAL; ANIMALS; BRAIN; BRAIN STEM; CEREBELLUM; CHOLINE O-ACETYLTRANSFERASE; DICHLORVOS; DISSECTION; INSECTICIDES; MALE; RATS; RATS, WISTAR; RECEPTORS, MUSCARINIC; SECOND MESSENGER SYSTEMS; SYNAPTOSOMES; TELENCEPHALON; WEIGHT GAIN;

ANIMALIA; RATTUS; RATTUS NORVEGICUS;

EID: 34250771627     PISSN: 07482337     EISSN: None     Source Type: Journal    
DOI: 10.1177/0748233707072490     Document Type: Article

References (60)

1. Allgaier, C., Choi, B.K. and Hertting, G. 1993: Muscarinic receptors regulating electrically evoked release of acetylcholine in hippocampus are linked to pertussis toxin-sensitive G-proteins but not to adenylate cyclase. J Neurochem 61, 1043—49.
2. Aoyagi, T., Wada, T., Kojima, F., Nagai, M., Harada, S., Takeuchi, T. and Hirokawa, K. 1990: Increase in aminobutyrate aminotransferase and cholineracetyltransferase in cerebrum of aged rats. Chem Pharm Bull 38, 1750—52.
3. Bakry, N.M.S., El-Rashidy, A.H., Eldefrawi, A.T. and Eldefrawi, M.E. 1988: Direct actions of organophosphorus anticholinesterase on nicotinic and muscarinic acetylcholine receptors. J Biochem Toxicol 3, 235—39.
4. Balduini, W., Cimino, M., Reno, F., Marini, P., Princivalle, A. and Cattabeni, F. 1993: Effects of postnatal or adult chronic acetyl cholinesterase inhibition on muscarinic receptors, phosphoinositide turnonver and M1 mRNA expression. Eur J Pharmacol 248, 281—88.
5. Bignami, G., Rosik, N., Michalek, H., Milosevic, M. and Gatti, G.I. 1975: Behavioural toxicity of anticholinesterase agents: Methodological, neurochemical and neuropsychological aspects. In L aties, V. ed. Behavioural toxicity. Plenum Press: 155—215.
6. Bonner, T.I. 1989: The molecular basis of muscarinic receptor diversity. Trends Neurosci 12, 148—51.
7. Burchfiel, J.L., Duffy, F.H. and Sim, V.M. 1976: Persistent effects of sarin and dieldrin upon the primate electroencephalogram. Toxicol Appl Pharmacol 35, 265—379.
8. Carod-Artal, F.J. and Speck-Martins, C. 1999: Late onset polyneuropathy due to exposure to organophosphates. Rev Neurol 29, 123—37.
9. Costa, L., Schwab, B.W. and Murphy, S.D. 1982: Differential alterations of cholinergic muscarinic receptors during chronic and acute tolerance to organophosphorus insecticides. Biochem Pharmacol 31, 3407—13.
10. Desi, I. and Nagymajtenyi, I. 1999: Electrophysiological biomarkers of an organophosphate pesticide, dichlorvos. Toxicol Lett 107, 55—64.
11. Eldefrawi, A.T., Jett, D. and Eldefrawi, M.E. 1992: Direct actions of organophosphate anticholinesterases on muscarinic receptors, In Chambers J.E., Levi, P.E. eds. Organophospates: Chemistry, fate and effects. Academic Press, 257—70.
12. Ellman, G.L., Courtney, K.D., Anders, V. Jr and Featherstone, R.M. 1961: A rapid, new and calorimetric determination of acetylcholinesterase activity. Biochem Pharmacol 7, 88—95.
13. Elnatan, A. and Mitchelson, F. 1994: A simple and rapid HPLC assay for quantitating cyclic AMP accumulation in intact cell preparations. J Pharmacol Toxicol Met 31, 47—51.
14. Eskenazi, B., Bradman, A. and Castorina, R. 1999: Exposures of children to OP pesticides and their potential adverse health effects. Environ Health Perspect 107, 409—19.
15. Fonnum, F. 1966: A radiochemical method for the estimation of choline acetyltransferase. Biochem J 100, 479—84.
16. Glowinski, J. and Iversen, L.L. 1966: Regional studies of catecholamines in the rat brain. J Neurochem 13, 655—69.
17. Gray, E.G. and Whittaker, V.P. 1962: The isolation of nerve endings from brain: An electron microscopic study of cell fragments derived by homogenization and centrifugation. J Anat 96, 79—88.
18. Guler, K., Tascioglu, C. and Ozbey, N. 1996: Organophosphate poisoning: Israel. J Med Sci 32, 791—95.
19. Hertz, L. 1969: The biochemistry of brain tissue. In Bitter, E.E. and Bitter, N. eds. The biological basis of medicine. Academic Press, 3—37.
20. Horowitz, S.H., Stark, E. and Marshall, A. 1999: Multidrug modality assessment of peripheral nerve function in organophosphate pesticide applications. J Occup Environ Med 41, 405—408.
21. Huff, R.A. and Abou-Donia, M.B. 1995: In vitro effect of chlorpyrifos oxon on muscarinic receptors and adenylate cyclase. Neurotoxicol 16, 281—90.
22. Huff, R.A., Corcoran, J.J., Anderson, J.K. and Abou-Donia, M.B. 1994: Chlorpyrifos oxon binds directly to muscarinic receptors and inhibits cAMP accumulation in rat striatum. J Pharmacol Exp Ther 269, 329—35.
23. Jokanovic, M., Kosanovic, M. and Maksimovic, M. 1996: Interaction of organophosphorus compounds with carboxyle sterases in the rate. Archives of Toxicology 70(7): 444—50.
24. Jones, D.H. and Matus, A.I. 1974: Isolation of synaptic plasma membranes from brain by combined floatation density gradient centrifugation. Biochem Biophys Acta 356, 276—87.
25. Julka, D., Sandhir, R. and Gill, K.D. 1995: Altered cholinergic metabolism in rat CNS following aluminium exposure: Implications on learning performance. J Neurochem 65, 2157—64.
26. Kaufer, D., Friedman, A., Seidman, S. and Soreq, H. 1999: Anticholinesterases induce multigenic transcriptional feedback response suppressing cholinergic neurotransmission. Chem Biol Interact 119—120, 349—60.
27. Khym, J.X. 1975: An analytical system for rapid separation of tissue nucleotides at low pressure on conventional anion exchangers. Clin Chem 21, 1245—52.
28. Kobayashi, H., Yuyama, A. and Chiba, K.I. 1986: Cholinergic system of brain tissue in rats poisoned with the organophosphate O,O-dimethyl O-(2,2-dichlorovinyl) phosphate. Toxicol Appl Pharmacol 82, 32—39.
29. Kwong, T.C. 2002: Organophosphate pesticides: biochemistry and clinical toxicology. Ther Drug Monit 24, 144—49.
30. Lambert, D.G., Burford, N.T. and Nahorski, S.R. 1992: Muscarinic receptor subtypes: Inositol phosphates and intracellular calcium. Biochem Soc Trans 20, 130—35.
31. Liu, J., Chakraborti, T. and Pope, C. 2002: In vitro effects of organophosphorus anticholinesterases on muscarinic receptor-mediated inhibition of acetylcholine release in rat striatum. Toxicol Appl Pharmacol 178, 102—108.
32. Lotti, M. 1995: Cholinesterase exhibition: complexities in interpretations. Clin Chem 41, 1814—18.
33. Lowry, O.H., Rosebrough, N.J., Farr, A.L. and Randall, R.J. 1951: Protein measurement with the folin-phenol reagent. J Biol Chem 193, 265—75.
34. Marchi, M., Ruelle, A., Andriolli, G.C. and Raiteri, M. 1990: Pirenzipine-insensitive muscarinic autoreceptors regulate acetylcholine release in human neocortex. Brain Res 520, 347—50.
35. Maroni, M., Colosio, C., Ferioli, A. and Fait, A. 2000: Biological monitoring of pesticide exposure: a review. Introduction. Toxicol 143, 111—18.
36. McKinney, M., Anderson, D., Forray, C. and El-Fakahany, E.E. 1989: Characterization of the striatal M2 muscarinic receptor mediating inhibition of cyclic AMP using selective antagonists: A comparison with brainstem M2 receptor. J Pharmacol Expt Ther 250, 265—72.
37. Milby, T. 1971: Prevention and management of organophosphate poisoning. J Am Med Assoc 216, 2131—33.
38. Nicklas, W.J., Purzkin, S. and Berl, S. 1973: Effect of vinblastine and colchicines on uptake and release of putative neurotransmitters by synaptosomes and on brain actinomycin-like protein. J Neurochem 20, 109—22.
39. Plotkin, D.A. and Jarvik, L.F. 1986: Cholinergic dysfunction in Alzheimer's disease: cause or effect? Prog. Brain Res 65, 91—102.
40. Prendergast, M.A., Terry, A.V. Jr and Buccafusco, J.J. 1997: Chronic, low-level exposure to diisopropylfluorophosphate causes protracted impairment of spatial navigation learning. Psychopharmacology 129, 183—91.
41. Rouse, S.T., Edmunds, S.M., Gilmor, M.L. and Levey A.I. 2000: Localization of M(2) muscarinic acetylcholine receptor protein in cholingeneric and non-cholinegic terminals in rat hippocampus. Neuroscience Letters 284(3): 182—6.
42. Russell, R.W., Carson, V.G., Booth, R.A. and Jenden, D.J. 1981: Mechanisms of tolerance to the anticholinesterase, DFP: acetylcholine levels and dynamics in the rat brain. Psychopharmacology 20, 1197—201.
43. Russell, R.W., Carson, V.G., Jope, R.S., Booth, R.A. and Macri, J. 1979: Development of behavioural tolerance: A search for subcellular mechanism. Psychopharmacology 66, 155—58.
44. Russell, R.W., Booth, R.A., Lauretz, S.D., Smith, C.A. and Jenden, D.J. 1986: Behavioural, neurochemical and psychological effects of repeated exposures to subsynaptomatic levels of anticholinesterase, soman. Neurobehav Toxicol Teratol 8, 675—85.
45. Rydel, R.E. and Green, L. 1988: cAMP analogs promote survival and neurite outgrowth in cultures of rat sympathetic and sensory neurons independently of nerve growth factors. Proc Natl Acad Sci USA 85, 1257—61.
46. Salomon, Y., Londos, C. and Rodbell, M. 1974: A highly sensitive adenylate cyclase assay. Anal Biochem 58, 541—48.
47. Sarin, S. and Gill, K.D. 1998: Dichlorvos induced alterations in glucose homeostasis: possible implications on the state of neuronal function in rats. Mol Cell Biochem 199, 87—92.
48. Sarin, S. and Gill, K.D. 2000: Biochemical characterization of dichloruos-induced delayed neurotoxicity in rat. IUBMB Life 49(2): 125—30.
49. Savage, E.P., Keefe, T.J., Mounce, L.M., Heaton, R.K., Lewis, J.A. and Brucar, P.J. 1988: Chronic neurological sequelae of acute organophosphate pesticide poisoning. Arch Environ Health 43, 38—45.
50. Scaps, P., Demuynck, S., Descamps, M. and Dhainert, A. 1997: Effect of organophosphate and carbonate pesticides on acetyl cholinesterase and cholineacetyltransferase activities of the poilychaete nervis diversicolor. Arch Environ Contam Toxicol 33, 203—208.
51. Silveira, C.L.P., Eldefrawi, A.T. and Eldefrawi, M.E. 1990: Putative M2 muscarinic receptors of rat heart have high affinity for organophosphorus anticholinesterase. Toxicol Appl Pharmacol 103, 474—81.
52. Steenland, K. 1996: Chronic neurological effects of organophosphate pesticides. Br Med J 312, 1312—13.
53. Sultatos, L.G. 1994: Mammalian toxicology of organophosphorus pesticides. J Toxicol Environ Health 43, 271—89.
54. Szerb, J.C. 1977: Characterization of presynaptic muscarinic receptors in central cholinergic neurons. In Jenden, D.J. ed. Cholinergic mechanisms and psychopharmacology Plenum Press, 49—60.
55. Volpe, L.S., Biagioni, T.M. and Marquis, J.K. 1985: In vitro modulation of bovine caudate muscarinic receptor number by organophosphates and carbamates. Toxicol Appl Pharmacol 78, 226—34.
56. Ward, T.R. and Mundy, W.R. 1996: Organophosphorus compounds preferentially affect second messenger systems coupled to M2/M4 receptors in rat frontal cortex. Brain Res Bull 39, 49—55.
57. Weiler, M.H. 1989: Characterization of muscarinic receptors modulating acetylcholine release in the rat neostriatum. Experientia Suppl 57, 204—11.
58. Woodruff, T.J., Kyle, A.D. and Bois, F.V. 1994: Evaluating health risks from occupational exposure to pesticides and the regulatory response. Environ Health Perspec 102, 1088—96.
59. Yamamura, H.I. and Snyder, S.H. 1974: Muscarinic cholinergic binding in rat brain. Proc Natl Acad Sci USA 71, 1725—29.
60. Zheng, Q., Olivier, K., Wan, Y.K., and Pope, C.N. 2000: Comparative cholinergic neurotoxicity of oral chlorpygrifos exposures in preweanling and adult rats. Toxicological Sciences 55(1): 124—32.