-
1
-
-
0000972524
-
Mechanism of calcification: Inhibitory role of pyrophosphate
-
Fleisch H, Bisaz S: Mechanism of calcification: inhibitory role of pyrophosphate. Nature 1962, 195:911.
-
(1962)
Nature
, vol.195
, pp. 911
-
-
Fleisch, H.1
Bisaz, S.2
-
2
-
-
0034813884
-
Inorganic pyrophosphate generation and disposition in pathophysiology
-
Terkeltaub RA: Inorganic pyrophosphate generation and disposition in pathophysiology. Am J Physiol Cell Physiol 2001, 281:0-01.
-
(2001)
Am J Physiol Cell Physiol
, vol.281
, pp. 0-01
-
-
Terkeltaub, R.A.1
-
3
-
-
18244392685
-
Unique coexpression in osteoblasts of broadly expressed genes accounts for the spatial restriction of ECM mineralization to bone
-
Fascinating study demonstrating that Pi rather than Ca is the key regulator of mineralization, and that the basic requirements determining tissue specificity are the presence of alkaline phosphatase and fibrillary collagen
-
Murshed M, Harmey D, Millan JL, et al.: Unique coexpression in osteoblasts of broadly expressed genes accounts for the spatial restriction of ECM mineralization to bone. Genes Dev 2005, 19:1093-1104. Fascinating study demonstrating that Pi rather than Ca is the key regulator of mineralization, and that the basic requirements determining tissue specificity are the presence of alkaline phosphatase and fibrillary collagen.
-
(2005)
Genes Dev
, vol.19
, pp. 1093-1104
-
-
Murshed, M.1
Harmey, D.2
Millan, J.L.3
-
4
-
-
73649189184
-
Chondrocalcinosis articularis
-
Zitnan D, Sitaj S: Chondrocalcinosis articularis. Ann Rheum Dis 1963, 22:142-152.
-
(1963)
Ann Rheum Dis
, vol.22
, pp. 142-152
-
-
Zitnan, D.1
Sitaj, S.2
-
6
-
-
0015978036
-
A hereditary type of idiopathic articular chondrocalcinosis. Survey of a pedigree
-
Van der Korst JK, Gerards J, Driessens FM: A hereditary type of idiopathic articular chondrocalcinosis. Survey of a pedigree. Am J Med Genet 1974, 56:307-314.
-
(1974)
Am J Med Genet
, vol.56
, pp. 307-314
-
-
Van der Korst, J.K.1
Gerards, J.2
Driessens, F.M.3
-
7
-
-
0016960768
-
Articular chondrocalcinosis in the Chiloe Islanders
-
Reginato A: Articular chondrocalcinosis in the Chiloe Islanders. Arthritis Rheum 1976, 19(Suppl 3):395-404.
-
(1976)
Arthritis Rheum
, vol.19
, Issue.SUPPL. 3
, pp. 395-404
-
-
Reginato, A.1
-
9
-
-
0020043463
-
Pyrophosphate arthropathy in two Swedish families
-
Bjelle A, Edvinson U, Hagstam A: Pyrophosphate arthropathy in two Swedish families. Arthritis Rheum 1982, 25:66-74.
-
(1982)
Arthritis Rheum
, vol.25
, pp. 66-74
-
-
Bjelle, A.1
Edvinson, U.2
Hagstam, A.3
-
11
-
-
0025367086
-
Familial articular chondrocalcinosis in Spain
-
Balsa A, Martin-Mola E, Gonzalez T, et al.: Familial articular chondrocalcinosis in Spain. Ann Rheum Dis 1990, 49:531-535.
-
(1990)
Ann Rheum Dis
, vol.49
, pp. 531-535
-
-
Balsa, A.1
Martin-Mola, E.2
Gonzalez, T.3
-
12
-
-
0025369715
-
Hereditary chondrocalcinosis in an Ashkenazi Jewish family
-
Eshel G, Gulik A, Halperin N, et al.: Hereditary chondrocalcinosis in an Ashkenazi Jewish family. Ann Rheum Dis 1990, 49:528-530.
-
(1990)
Ann Rheum Dis
, vol.49
, pp. 528-530
-
-
Eshel, G.1
Gulik, A.2
Halperin, N.3
-
13
-
-
0025831446
-
Familial chondrocalcinosis due to calcium pyrophosphate dihydrate crystal deposition in English Families
-
Doherty M, Hamilton E, Henderson J, et al.: Familial chondrocalcinosis due to calcium pyrophosphate dihydrate crystal deposition in English Families. Br J Rheum 1991, 30:10-15.
-
(1991)
Br J Rheum
, vol.30
, pp. 10-15
-
-
Doherty, M.1
Hamilton, E.2
Henderson, J.3
-
14
-
-
0026595114
-
Hereditary chondrocalcinosis in a Tunisian family
-
Hamza M, Meddeb N, Bardin T: Hereditary chondrocalcinosis in a Tunisian family. Clin Exp Rheum 1992, 10:43-49.
-
(1992)
Clin Exp Rheum
, vol.10
, pp. 43-49
-
-
Hamza, M.1
Meddeb, N.2
Bardin, T.3
-
15
-
-
0033962991
-
Familial osteoarthritis and Milwaukee shoulder associated with calcium pyrophosphate and apatite crystal deposition
-
Pons-Estel BA, Gimenez C, Sacnun M, et al.: Familial osteoarthritis and Milwaukee shoulder associated with calcium pyrophosphate and apatite crystal deposition. J Rheumatol 1999, 27:471-480.
-
(1999)
J Rheumatol
, vol.27
, pp. 471-480
-
-
Pons-Estel, B.A.1
Gimenez, C.2
Sacnun, M.3
-
16
-
-
33646366643
-
-
Bruges-Armas J, Couto AR, Timms A, et al.: Ectopic calcification among families in the Azores: clinical and radiological manifestations in families with diffuse idiopathic skeletal hyperostosis and chondrocalcinosis. Arthritis Rheum 2006, 54:1340-1349. Report of a novel group of families with coinheritance with a monogenic pattern of DISH and CC, suggesting that the conditions have shared genetic features.
-
Bruges-Armas J, Couto AR, Timms A, et al.: Ectopic calcification among families in the Azores: clinical and radiological manifestations in families with diffuse idiopathic skeletal hyperostosis and chondrocalcinosis. Arthritis Rheum 2006, 54:1340-1349. Report of a novel group of families with coinheritance with a monogenic pattern of DISH and CC, suggesting that the conditions have shared genetic features.
-
-
-
-
17
-
-
0018901025
-
Familial chondrocalcinosis. Prevalence in Northern Spain and clinical features in five pedigrees
-
Rodriguez-Valverde V, Tinture T, Zuniga M, et al.: Familial chondrocalcinosis. Prevalence in Northern Spain and clinical features in five pedigrees. Arthritis Rheum 1980, 23:471-478.
-
(1980)
Arthritis Rheum
, vol.23
, pp. 471-478
-
-
Rodriguez-Valverde, V.1
Tinture, T.2
Zuniga, M.3
-
18
-
-
0022480872
-
Familial chondrocalcinosis in the Spanish population
-
Fernandez-Dapica MP, Gomez-Reino JJ: Familial chondrocalcinosis in the Spanish population. J Rheumatol 1986, 13:631-633.
-
(1986)
J Rheumatol
, vol.13
, pp. 631-633
-
-
Fernandez-Dapica, M.P.1
Gomez-Reino, J.J.2
-
19
-
-
34250734227
-
Calcium pyrophosphate deposition disease in a kindred of Spanish-Mapuche ancestry
-
Reginato A, Orces C, Ronda, et al.: Calcium pyrophosphate deposition disease in a kindred of Spanish-Mapuche ancestry. Arthritis Rheum 1995, 38:S246.
-
(1995)
Arthritis Rheum
, vol.38
-
-
Reginato, A.1
Orces, C.2
Ronda3
-
20
-
-
3242677836
-
Relative risk of knee chondrocalcinosis in siblings of index cases with pyrophosphate arthropathy
-
Zhang W, Neame R, Doherty S, Doherty M: Relative risk of knee chondrocalcinosis in siblings of index cases with pyrophosphate arthropathy. Ann Rheum Dis 2004, 63:969-973.
-
(2004)
Ann Rheum Dis
, vol.63
, pp. 969-973
-
-
Zhang, W.1
Neame, R.2
Doherty, S.3
Doherty, M.4
-
21
-
-
0028920216
-
Linkage of early-onset osteoarthritis and chondrocalcinosis to human chromosome 8q
-
Baldwin CT, Farrer LA, Adair R, et al.: Linkage of early-onset osteoarthritis and chondrocalcinosis to human chromosome 8q. Am J Hum Genet 1995, 56:692-697.
-
(1995)
Am J Hum Genet
, vol.56
, pp. 692-697
-
-
Baldwin, C.T.1
Farrer, L.A.2
Adair, R.3
-
22
-
-
0029020994
-
Localisation of a gene for chondrocalcinosis to chromosome 5p
-
Hughes AE, McGibbon D, Woodward E, et al.: Localisation of a gene for chondrocalcinosis to chromosome 5p. Hum Mol Genet 1995, 4:1225-1228.
-
(1995)
Hum Mol Genet
, vol.4
, pp. 1225-1228
-
-
Hughes, A.E.1
McGibbon, D.2
Woodward, E.3
-
23
-
-
0033364524
-
Refinement of the chromosome 5p locus for familial calcium pyrophosphate dihydrate deposition disease
-
Andrew LJ, Brancolini V, Serrano de la Pena L, et al.: Refinement of the chromosome 5p locus for familial calcium pyrophosphate dihydrate deposition disease. Am J Hum Genet 1999, 64:136-145.
-
(1999)
Am J Hum Genet
, vol.64
, pp. 136-145
-
-
Andrew, L.J.1
Brancolini, V.2
Serrano de la Pena, L.3
-
24
-
-
0034647482
-
Role of the mouse ank gene in control of tissue calcification and arthritis
-
Ho AM, Johnson MD, Kingsley DM: Role of the mouse ank gene in control of tissue calcification and arthritis. Science 2000, 289:265-289.
-
(2000)
Science
, vol.289
, pp. 265-289
-
-
Ho, A.M.1
Johnson, M.D.2
Kingsley, D.M.3
-
25
-
-
0036319008
-
Genetic studies of disorders of calcium crystal deposition
-
Timms AE, Zhang Y, Russel RG, Brown MA: Genetic studies of disorders of calcium crystal deposition. Rheumatol 2002, 41:725-729.
-
(2002)
Rheumatol
, vol.41
, pp. 725-729
-
-
Timms, A.E.1
Zhang, Y.2
Russel, R.G.3
Brown, M.A.4
-
26
-
-
18144445478
-
Autosomal dominant familial calcium pyrophosphate dihydrate deposition disease is caused by mutation in the transmembrane protein ANKH
-
Williams CJ, Zhang Y, Timms A, et al.: Autosomal dominant familial calcium pyrophosphate dihydrate deposition disease is caused by mutation in the transmembrane protein ANKH. Am J Hum Genet 2002, 71:985-991.
-
(2002)
Am J Hum Genet
, vol.71
, pp. 985-991
-
-
Williams, C.J.1
Zhang, Y.2
Timms, A.3
-
28
-
-
0141788321
-
Mutations in the amino terminus of ANKH in two US families with calcium pyrophosphate dihydrate crystal deposition disease
-
Williams CJ, Pendleton A, Bonavita G, et al.: Mutations in the amino terminus of ANKH in two US families with calcium pyrophosphate dihydrate crystal deposition disease. Arthritis Rheum 2003, 48:2627-2631.
-
(2003)
Arthritis Rheum
, vol.48
, pp. 2627-2631
-
-
Williams, C.J.1
Pendleton, A.2
Bonavita, G.3
-
29
-
-
17244367679
-
-
Zhang Y, Johnson K, Russell RG, et al.: Association of sporadic chondrocalcinosis with a -4-basepair G-to-A transition in the 5′-untranslated region of ANKH that promotes enhanced expression of ANKH protein and excess generation of extracellular inorganic pyrophosphate. Arthritis Rheum 2005, 52:1110-1117. Demonstrates a role for a novel polymorphism of ANKH in severe sporadic CC. Mutations associated with CPPD CC shown to be gain of expression, though functional consequences differed between different mutations.
-
Zhang Y, Johnson K, Russell RG, et al.: Association of sporadic chondrocalcinosis with a -4-basepair G-to-A transition in the 5′-untranslated region of ANKH that promotes enhanced expression of ANKH protein and excess generation of extracellular inorganic pyrophosphate. Arthritis Rheum 2005, 52:1110-1117. Demonstrates a role for a novel polymorphism of ANKH in severe "sporadic" CC. Mutations associated with CPPD CC shown to be "gain of expression," though functional consequences differed between different mutations.
-
-
-
-
30
-
-
0034987026
-
Autosomal dominant craniometaphyseal dysplasia is caused by mutations in the transmembrane protein ANK
-
Reichenberger E, Tiziani V, Watanabe S, et al.: Autosomal dominant craniometaphyseal dysplasia is caused by mutations in the transmembrane protein ANK. Am J Hum Genet 2001, 68:1321-1326.
-
(2001)
Am J Hum Genet
, vol.68
, pp. 1321-1326
-
-
Reichenberger, E.1
Tiziani, V.2
Watanabe, S.3
-
31
-
-
0035041718
-
Heterozygous mutations in ANKH, the human ortholog of the mouse progressive ankylosis gene, result in craniometaphyseal dysplasia
-
Nurnberg P, Thiele H, Chandler D, et al.: Heterozygous mutations in ANKH, the human ortholog of the mouse progressive ankylosis gene, result in craniometaphyseal dysplasia. Nature Genet 2001, 28:37-41.
-
(2001)
Nature Genet
, vol.28
, pp. 37-41
-
-
Nurnberg, P.1
Thiele, H.2
Chandler, D.3
-
32
-
-
33845229878
-
Biochemical and genetic analysis of ANK in arthritis and bone disease
-
Am J Hum Genet, but that CPPD-associated mutations did not significantly effect PPi transport
-
Gurley KA, Reimer RJ, Kingsley DM: Biochemical and genetic analysis of ANK in arthritis and bone disease. Am J Hum Genet 2006, 79:1017-1029. Superb series of experiments in transgenic mice and in vitro systems indicating that hydroxyapatite-associated ANKH mutations cause reduced export of PPi from cells, but that CPPD-associated mutations did not significantly effect PPi transport.
-
(2006)
Superb series of experiments in transgenic mice and in vitro systems indicating that hydroxyapatite-associated ANKH mutations cause reduced export of PPi from cells
, vol.79
, pp. 1017-1029
-
-
Gurley, K.A.1
Reimer, R.J.2
Kingsley, D.M.3
-
33
-
-
34247550930
-
-
Zaka R, Stokes D, Dion AS, et al.: P5L mutation in Ank results in an increase in extracellular inorganic pyrophosphate during proliferation and nonmineralizing hypertrophy in stably transduced ATDC5 cells. Arthritis Res Ther 2006, 8:R164. Stable transfectants of the CPPD-associated P5L Ank mutant demonstrated gain-of-function with respect to increasing extracellular PPi levels, but this effect was modified by varying levels of alkaline phosphatase expression during differentiation.
-
Zaka R, Stokes D, Dion AS, et al.: P5L mutation in Ank results in an increase in extracellular inorganic pyrophosphate during proliferation and nonmineralizing hypertrophy in stably transduced ATDC5 cells. Arthritis Res Ther 2006, 8:R164. Stable transfectants of the CPPD-associated P5L Ank mutant demonstrated gain-of-function with respect to increasing extracellular PPi levels, but this effect was modified by varying levels of alkaline phosphatase expression during differentiation.
-
-
-
-
34
-
-
0025788687
-
Stimulation of cartilage inorganic pyrophosphate elaboration by ascorbate
-
Ryan LM, Kurup I, Cheung HS: Stimulation of cartilage inorganic pyrophosphate elaboration by ascorbate. Matrix 1991, 11:276-281.
-
(1991)
Matrix
, vol.11
, pp. 276-281
-
-
Ryan, L.M.1
Kurup, I.2
Cheung, H.S.3
-
35
-
-
5344279183
-
-
McKee S, Pendleton A, Dixey J, et al: Autosomal dominant early childhood seizures associated with chondrocalcinosis and a mutation in the ANKH gene. Epilepsia 2004, 45:1258-1260. Further characterisation of British family with seizures and CC, carrying -11C>T mutation in ANKH. Raises the hypothesis that ANKH mutations may play a role in other forms of epilepsy.
-
McKee S, Pendleton A, Dixey J, et al: Autosomal dominant early childhood seizures associated with chondrocalcinosis and a mutation in the ANKH gene. Epilepsia 2004, 45:1258-1260. Further characterisation of British family with seizures and CC, carrying -11C>T mutation in ANKH. Raises the hypothesis that ANKH mutations may play a role in other forms of epilepsy.
-
-
-
-
36
-
-
33745728421
-
Strong association between polymorphisms in ANKH locus and skeletal size traits
-
Association reported between vertebral column length and biacromial breadth (adjusted for height) with ANKH variation. Group has previously reported in a different population association with ANKH variants and hand bone size. Warrants follow-up in a substantial cohort
-
Malkin I, Ermakov S, Kobyliansky E, Livshits G: Strong association between polymorphisms in ANKH locus and skeletal size traits. Hum Genet 2006, 120:42-51. Association reported between vertebral column length and biacromial breadth (adjusted for height) with ANKH variation. Group has previously reported in a different population association with ANKH variants and hand bone size. Warrants follow-up in a substantial cohort.
-
(2006)
Hum Genet
, vol.120
, pp. 42-51
-
-
Malkin, I.1
Ermakov, S.2
Kobyliansky, E.3
Livshits, G.4
-
37
-
-
34250767495
-
Osteoprotegerin plasma levels are strongly associated with polymorphisms in human homologue of the mouse progressive ankylosis (ANKH) gene
-
Epub ahead of print. Strong association reported between osteoprotegerin levels and ANKH variation. Small sample size and no confirmation dataset
-
Vistoropsky Y, Malkin I, Kobyliansky E, Livshits G: Osteoprotegerin plasma levels are strongly associated with polymorphisms in human homologue of the mouse progressive ankylosis (ANKH) gene. Ann Hum Genet 2006, Epub ahead of print. Strong association reported between osteoprotegerin levels and ANKH variation. Small sample size and no confirmation dataset.
-
(2006)
Ann Hum Genet
-
-
Vistoropsky, Y.1
Malkin, I.2
Kobyliansky, E.3
Livshits, G.4
-
38
-
-
0037333553
-
Novel genetic markers in the 5′-flanking region of ANKH are associated with ankylosing spondylitis
-
Tsui FW, Tsui HW, Cheng EY, et al.: Novel genetic markers in the 5′-flanking region of ANKH are associated with ankylosing spondylitis. Arthritis Rheum 2003, 48:791-797.
-
(2003)
Arthritis Rheum
, vol.48
, pp. 791-797
-
-
Tsui, F.W.1
Tsui, H.W.2
Cheng, E.Y.3
-
39
-
-
0142135638
-
Investigation of the role of ANKH in ankylosing spondylitis
-
Timms AE, Zhang Y, Bradbury L, et al.: Investigation of the role of ANKH in ankylosing spondylitis. Arthritis Rheum 2003, 48:2898-2902.
-
(2003)
Arthritis Rheum
, vol.48
, pp. 2898-2902
-
-
Timms, A.E.1
Zhang, Y.2
Bradbury, L.3
-
40
-
-
0032806520
-
Association of the human NPPS gene with ossification of the posterior longitudinal ligament of the spine (OPLL)
-
Nakamura I, Ikegawa S, Okawa A, et al.: Association of the human NPPS gene with ossification of the posterior longitudinal ligament of the spine (OPLL). Hum Genet 1999, 104:492-497.
-
(1999)
Hum Genet
, vol.104
, pp. 492-497
-
-
Nakamura, I.1
Ikegawa, S.2
Okawa, A.3
-
41
-
-
0042166167
-
Mutations in ENPP1 are associated with "idiopathic" infantile arterial calcification
-
Rutsch F, Ruf N, Vaingankar S, et al.: Mutations in ENPP1 are associated with "idiopathic" infantile arterial calcification. Nature Genet 2003, 34:379-381.
-
(2003)
Nature Genet
, vol.34
, pp. 379-381
-
-
Rutsch, F.1
Ruf, N.2
Vaingankar, S.3
-
42
-
-
0031859977
-
Mutation in Npps in a mouse model of ossification of the posterior longitudinal ligament of the spine
-
Okawa A, Nakamura I, Goto S, et al.: Mutation in Npps in a mouse model of ossification of the posterior longitudinal ligament of the spine. Nat Genet 1998, 19:271-273.
-
(1998)
Nat Genet
, vol.19
, pp. 271-273
-
-
Okawa, A.1
Nakamura, I.2
Goto, S.3
-
43
-
-
0042166167
-
Mutations in ENPP1 are associated with "idiopathic" infantile arterial calcification
-
Rutsch F, Ruf N, Vaingankar S, et al.: Mutations in ENPP1 are associated with "idiopathic" infantile arterial calcification. Nat Genet 2003, 34:379-381.
-
(2003)
Nat Genet
, vol.34
, pp. 379-381
-
-
Rutsch, F.1
Ruf, N.2
Vaingankar, S.3
-
44
-
-
79959420693
-
Investigation of the role of ENPP1 and TNAP genes in chondrocalcinosis
-
Epub ahead of print. No major effect of polymorphisms of ENPP1 and TNAP observed on CPPD CC. Small to moderate effects were not excluded
-
Zhang Y, Brown MA, Peach C, et al.: Investigation of the role of ENPP1 and TNAP genes in chondrocalcinosis. Rheumatology (Oxford) 2006, Epub ahead of print. No major effect of polymorphisms of ENPP1 and TNAP observed on CPPD CC. Small to moderate effects were not excluded.
-
(2006)
Rheumatology (Oxford)
-
-
Zhang, Y.1
Brown, M.A.2
Peach, C.3
-
45
-
-
13144249219
-
Identification of fifteen novel mutations in the tissue-nonspecific alkaline phosphatase (TNSALP) gene in European patients with severe hypophosphatasia
-
Mornet E, Taillandier A, Peyramaure S, et al.: Identification of fifteen novel mutations in the tissue-nonspecific alkaline phosphatase (TNSALP) gene in European patients with severe hypophosphatasia. Eur J Hum Genet 1998, 6:308-314.
-
(1998)
Eur J Hum Genet
, vol.6
, pp. 308-314
-
-
Mornet, E.1
Taillandier, A.2
Peyramaure, S.3
-
46
-
-
0037047051
-
Tissue-non-specific alkaline phosphatase and plasma cell membrane glycoprotein-1 are central antagonistic regulators of bone mineralization
-
Hessle L, Johnson KA, Anderson HC, et al.: Tissue-non-specific alkaline phosphatase and plasma cell membrane glycoprotein-1 are central antagonistic regulators of bone mineralization. PNAS 2002, 99:9445-9449.
-
(2002)
PNAS
, vol.99
, pp. 9445-9449
-
-
Hessle, L.1
Johnson, K.A.2
Anderson, H.C.3
-
47
-
-
0023915526
-
Calcium pyrophosphate crystal deposition: The effect of soluble iron in a kinetic study using a gelatin matrix model
-
Mandel GS, Halverson PB, Mandel NS: Calcium pyrophosphate crystal deposition: the effect of soluble iron in a kinetic study using a gelatin matrix model. Scanning Microsc 1988, 2:1177-1188.
-
(1988)
Scanning Microsc
, vol.2
, pp. 1177-1188
-
-
Mandel, G.S.1
Halverson, P.B.2
Mandel, N.S.3
-
48
-
-
0023847660
-
Ferrous [Fe++] but non ferric [Fe] ions inhibit de novo formation of calcium pyrophosphate dihydrate crystals: Possible relationships to chondrocalcinosis and hemochromatosis
-
Cheng PT, Pritzker KP: Ferrous [Fe++] but non ferric [Fe] ions inhibit de novo formation of calcium pyrophosphate dihydrate crystals: possible relationships to chondrocalcinosis and hemochromatosis. J Rheumatol 1988, 15:321-324.
-
(1988)
J Rheumatol
, vol.15
, pp. 321-324
-
-
Cheng, P.T.1
Pritzker, K.P.2
-
49
-
-
0019497564
-
Clearance of calcium pyrophosphate dihydrate crystals in vivo. III. Effects of synovial hemosiderosis
-
McCarty DJ, Palmer DW, Garancis JC: Clearance of calcium pyrophosphate dihydrate crystals in vivo. III. Effects of synovial hemosiderosis. Arthritis Rheum 1981, 24:706-710.
-
(1981)
Arthritis Rheum
, vol.24
, pp. 706-710
-
-
McCarty, D.J.1
Palmer, D.W.2
Garancis, J.C.3
-
50
-
-
33845631059
-
-
Urakawa I, Yamazaki Y, Shimada T, et al.: Klotho converts canonical FGF receptor into a specific receptor for FGF23. Nature 2006, 444:770-774. Ground-breaking paper demonstrating that Klotho interacts with FGF-23, leading to loss of FGF-23 function. Klotho mice develop premature ageing, osteoporosis, and atherosclerosis. This paper will launch a thousand studies.
-
Urakawa I, Yamazaki Y, Shimada T, et al.: Klotho converts canonical FGF receptor into a specific receptor for FGF23. Nature 2006, 444:770-774. Ground-breaking paper demonstrating that Klotho interacts with FGF-23, leading to loss of FGF-23 function. Klotho mice develop premature ageing, osteoporosis, and atherosclerosis. This paper will launch a thousand studies.
-
-
-
|