Simultaneous assay of metformin and glibenclamide in human plasma based on extraction-less sample preparation procedure and LC/(APCI)MS

Journal of Chromatography B: Analytical Technologies in the Biomedical and Life Sciences

Volumn 854, Issue 1-2, 2007, Pages 211-218

  Georgita, Cristina ^a   Albu, Florin ^a   David, Victor ^b   Medvedovici, Andrei ^a,b  

^a LaborMed Pharma SA   (Romania)

^b UNIVERSITY OF BUCHAREST   (Romania)

Author keywords

Anti diabetic combination; APCI; Bioequivalence; Extraction less sample preparation; Glibenclamide; Human plasma; Metformin; Method validation; MS detection; Pharmacokinetic parameters; Simultaneous assay

Indexed keywords

ASSAYS; BODY FLUIDS; CHROMATOGRAPHIC ANALYSIS; LIQUID CHROMATOGRAPHY; MASS SPECTROMETRY; PHARMACOKINETICS; PRECIPITATION (CHEMICAL); PROTEINS;

ANTI-DIABETIC COMBINATION; BIOEQUIVALENCE; EXTRACTION-LESS SAMPLE PREPARATION; GLIBENCLAMIDE; HUMAN PLASMA; METFORMIN; METHOD VALIDATION; MS DETECTION; PHARMACOKINETIC PARAMETERS; SIMULTANEOUS ASSAY;

ANTIBIOTICS;

GLIBENCLAMIDE; METFORMIN;

ADULT; ANALYTIC METHOD; ARTICLE; BIOEQUIVALENCE; BLOOD SAMPLING; CONTROLLED STUDY; FEMALE; HUMAN; ION TRAP MASS SPECTROMETRY; MALE; MASS SPECTROMETRY; PRIORITY JOURNAL;

ADULT; CHROMATOGRAPHY, LIQUID; FEMALE; GLYBURIDE; HUMANS; HYPOGLYCEMIC AGENTS; MALE; MASS SPECTROMETRY; METFORMIN; SENSITIVITY AND SPECIFICITY; THERAPEUTIC EQUIVALENCY;

EID: 34250743581     PISSN: 15700232     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jchromb.2007.04.032     Document Type: Article

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