Pathophysiology and clinical manifestations of osteoporosis

Clinical Cornerstone

Volumn 8, Issue 1, 2006, Pages 19-27

  Becker, Carolyn ^a  

^a Och Spine at New York Presbyterian Hospitals   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ARTICLE; BONE DISEASE; BONE STRENGTH; CLINICAL FEATURE; FRAGILITY FRACTURE; HUMAN; OSTEOPOROSIS; PATHOGENESIS; PATHOPHYSIOLOGY; PHYSICIAN; PRIMARY MEDICAL CARE; PSYCHOLOGICAL ASPECT; RISK FACTOR;

AGED; BONE AND BONES; FEMALE; FRACTURES, SPONTANEOUS; HUMANS; MALE; MIDDLE AGED; OSTEOPOROSIS; OSTEOPOROSIS, POSTMENOPAUSAL;

EID: 34250728104     PISSN: 10983597     EISSN: None     Source Type: Journal    
DOI: 10.1016/S1098-3597(06)80062-1     Document Type: Article

References (55)

1. Albright F., Bloomberg E., and Smith P.H. Postmenopausal osteoporosis. Trans Assoc Am Physicians 55 (1940) 298-305
2. Raisz L. Pathogenesis of osteoporosis: Concepts, conflicts, and prospects. J Clin Invest 115 (2005) 3318-3325
3. NIH Consensus Development Panel on Osteoporosis Prevention, Diagnosis, and Therapy. Osteoporosis prevention, diagnosis, and therapy. JAMA 285 (2001) 785-795
4. Felsenberg D., and Boonen S. The bone quality framework: Determinants of bone strength and their interrelationships, and implications for osteoporosis management. Clin Ther 27 (2005) 1-11
5. Seeman E., and Delmas P.D. Bone quality-the material and structural basis of bone strength and fragility. N Engl J Med 354 (2006) 2250-2261
6. Mora S., and Gilsanz V. Establishment of peak bone mass. Endocrinol Metab Clin North Am 32 (2003) 39-63
7. Walker M.D., Babbar R., Opotowsky A.R., et al. A referent bone mineral density database for Chinese American women. Osteoporos Int 17 (2006) 878-887
8. Seeman E. Sexual dimorphism in skeletal size, density, and strength. J Clin Endocrinol Metab 86 (2001) 4576-4584
9. Sambrook P.N., Kelly P.J., Morrison N.A., et al. Scientific review. Genetics of osteoporosis. Br J Rheumatol 33 (1994) 1007-1011
10. Howard G.M., Nguyen T.V., Harris M., et al. Genetic and environmental contributions to the association between quantitative ultrasound and bone mineral density mea surements: A twin study. J Bone Miner Res 13 (1998) 1318-1327
11. Stewart A., Kumar V., and Reid D.M. Long-term fracture prediction by DXA and QUS-a 10-year prospective study. J Bone Miner Res 21 (2006) 413-418
12. Pantsulaia I., Trofimov S., Kobyliansky E., and Livshits G. Contribution of the familial and genetic factors on monocyte chemoattractant protein-1 variation in healthy human pedigrees. Cytokine 32 (2005) 117-123
13. Khosla S., Riggs B.L., Atkinson E.J., et al. Effects of sex and age on bone microstructure at the ultradistal radius: A population-based noninvasive in vivo assessment. J Bone Miner Res 21 (2006) 124-131
14. Roodman G.D. Mechanisms of bone metastasis. N Engl J Med 350 (2004) 1655-1664
15. Khosla S. Minireview: The OPG/RANKL/RÀNK system. Endocrinology 142 (2001) 5050-5055
16. McClung M.R., Leweicki E.M., Cohen S.B., et al. Denosumab in postmenopausal women with low bone mineral density. N Engl J Med 354 (2006) 821-831
17. Garnero P., Somay-Rendu E., Chapuy M.C., and Delmas P.D. Increased bone turnover in late postmenopausal women is a major determinant of osteoporosis. J Bone Miner Res 11 (1996) 337-349
18. Parfitt A.M., Villanueva A.R., Foldes J., and Rao D.S. Relations between histologic indices of bone formation: Implications for the pathogenesis of spinal osteoporosis. J Bone Miner Res 10 (1995) 466-473
19. Ebeling P.R., Atley L.M., Guthrie J.R., et al. Bone turnover markers and bone density across the menopausal transition. J Clin Endocrinol Metab 81 (1996) 3366-3371
20. Riggs B.L., Khosla S., and Melton III L.J. Sex steroids and the construction and conservation of the adult skeleton. Endocr Rev 23 (2002) 279-302
21. Goderie-Plomp H.W., van der Klift M., de Ronde W., et al. Endogenous sex hormones, sex hormone-binding globulin, and the risk of incident vertebral fractures in elderly men and women: The Rotterdam Study. J Clin Endocrinol Metab 89 (2004) 3261-3269
22. Van Pottelbergh I., Goemaere S., and Kaufman J.M. Bio-available estradiol and an aromatase gene polymorphism are determinants of bone mineral density changes in men over 70 years of age. J Clin Endocrinol Metab 88 (2003) 3075-3081
23. Weitzmann M.N., and Pacific R. Estrogen deficiency and bone loss: An inflammatory tale. J Clin Invest 116 (2006) 1186-1194
24. Weitzmann M.N., and Paccfifii R. The role of T lymphocytes in bone metabolism. Immunol Rev 208 (2005) 154-168
25. Weitzmann M.N., Roggia C., Toraldo G., et al. Increased production of IL-7 uncouples bone formation from bone resorption during estrogen deficiency. J Clin Invest 110 (2002) 1643-1650
26. Gilbert L., He X., Farmer P., et al. Inhibition of osteoblast differentiation by tumor necrosis factor-alpha. Endocrinology 141 (2000) 3956-3964
27. Cenci S., Weitzmann M.N., Roggia C., et al. Estrogen deficiency induces bone loss by enhancing T-cell production of TNF-α. J Clin Invest 106 (2000) 1229-1237
28. Lips P. Vitamin D deficiency and secondary hyperparathyroidism in the elderly: Consequences for bone loss and fractures and therapeutic implications. Endocr Rev 22 (2001) 477-501
29. Becker C., Crow S., Toman J., et al. Characteristics of elderly patients admitted to an urban tertiary care hospital with osteoporotic fractures: Correlations with risk factors, fracture type, gender and ethnicity. Osteoporos Int 17 (2006) 410-416
30. Boonen S., Bischoff-Ferrari H.A., Cooper C., et al. Addressing the musculoskeletal components of fracture risk with calcium and vitamin D: A review of the evidence. Calcif Tissue Int 78 (2006) 257-270
31. Bischoff-Ferrari H.A., Dawson-Hughes B., Willett W.C., et al. Effect of vitamin D on falls: A meta-analysis. JAMA 291 (2004) 1999-2006
32. Sambrook P.N., Chen J.S., March L.M., et al. Serum parathyroid hormone predicts time to fall independent of vitamin D status in a frail elderly population. J Clin Endocrinol Metab 89 (2004) 1572-1576
33. Bischoff-Ferrari H.A., Orav E.J., and Dawson-Hughes B. Effect of cholecalciferol plus calcium on falling in ambulatory older men and women: A 3-year randomized controlled trial. Arch Intern Med 166 (2006) 424-430
34. Bischoff H.A., Stahelin H.B., Dick W., et al. Effects of vitamin D and calcium supplementation on falls: A randomized controlled trial. J Bone Miner Res 18 (2003) 343-351
35. Grant A.M., Avenell A., Campbell M.K., et al. Oral vitamin D3 and calcium for secondary prevention of low-trauma fractures in elderly people (Randomised Evaluation of Calcium Or vitamin D, RECORD): A randomised placebocontrolled trial. Lancet 365 (2005) 1621-1628
36. Jackson R.D., LaCroix A.Z., Gass M., et al. Calcium plus vitamin D supplementation and the risk of fractures. N Engl J Med 354 (2006) 669-683
37. Lips P. Which circulating level of 25-hydroxyvitamin D is appropriate?. J Steroid Biochem Mol Biol 89-90 (2004) 611-614
38. Pasco J.A., Henry M.J., Kotowica M.A., et al. Seasonal periodicity of serum vitamin D and parathyroid hormone, bone resorption, and fractures: The Geelong Osteoporosis Study. J Bone Miner Res 19 (2004) 752-758
39. Available at:. National Osteoporosis Foundation. Physician's guide to prevention and treatment of osteoporosis. Accessed October 1 (2006). http://www.nof.org/_vti_bin/shtml.dll/physguide/index.htm
40. National Osteoporosis Foundation. America's Bone Health: The State of Osteoporosis and Low Bone Mass in Our Nation (2002), National Osteoporosis Foundation, Washington, DC
41. US Dept of Health and Human Services. Bone Health and Osteoporosis: A Report of the Surgeon General (2004), US Dept of Health and Human Services, Public Health Service, Office of the Surgeon General, Rockville, MD
42. Cummings S.R., and Melton III L.J. Epidemiology and outcomes of osteoporotic fractures. Lancet 359 (2002) 1761-1767
43. National Institutes of Health. Osteoporosis prevention, diagnosis, and therapy. NIH Consens Statement 17 (2000) 1-45
44. Empana J.P., Dargent-Molina P., Breart G., and EPIDOS Group. Effect of hip fracture on mortality in elderly women: The EPIDOS prospective study. J Am Geriatr Soc 52 (2004) 685-690
45. Ensrud E., Thompson D.E., Cauley J.A., et al., Fracture Intervention Trial Research Group. Prevalent vertebral deformities predict mortality and hospitalization in older women with low bone mass. J Am Geriatr Soc 48 (2000) 241-249
46. Kado D.M., Browner W.S., Palermo L., et al., Study of Osteoporotic Fractures Research Group. Vertebral fractures and mortality in older women: A prospective study. Arch Intern Med 159 (1999) 1215-1220
47. Nevitt M.C., Ettinger B., Black D.M., et al. The association of radiographically detected vertebral fractures with back pain and function: A prospective study. Ann Intern Med 128 (1998) 793-800
48. Johnell O., Kanis J.A., Oden A., et al. Mortality after osteoporotic fractures. Osteoporos Int 15 (2004) 38-42
49. Miyakoshi M., Itoi E., Kobayashi M., and Kodama H. Impact of postural deformities and spinal mobility on quality of life in postmenopausal osteoporosis. Osteoporos Int 14 (2003) 1007-1012
50. Lindsay R., Silverman S.L., Cooper C., et al. Risk of new vertebral fracture in the year following a fracture. JAMA 285 (2001) 320-323
51. Lombardi I., Oliveira L.M., Mayer A.F., et al. Evaluation of pulmonary function and quality of life in women with osteoporosis. Osteoporos Int 16 (2005) 1247-1253
52. Lane N.E. Epidemiology, etiology and diagnosis of osteoporosis. Am J Obstet Gynecol 194 Suppl 1 (2006) S3-S11
53. Gold D.T. The nonskeletal consequences of osteoporotic fractures. Psychologic and social outcomes. Rheum Dis Clin North Am 27 (2001) 255-262
54. Adachi J.D., Ioannidis G., Olszynski W.P., et al. The impact of incident vertebral and non-vertebral fractures on health related quality of life in postmenopausal women. BMC Musculoskelet Disord 3 (2002) 11
55. Johnell O., and Kanis J. Epidemiology of osteoporotic fractures. Osteoporos Int 16 Suppl 2 (2005) S3-S7