Polycystic ovary syndrome and pregnancy: Is metformin the magic bullet?

Diabetes Spectrum

Volumn 20, Issue 2, 2007, Pages 85-89

  Zisser, Howard Craig ^a  

^a SANSUM DIABETES RESEARCH INSTITUTE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CYANOCOBALAMIN; GLIBENCLAMIDE; INSULIN; METFORMIN; PHENFORMIN;

ABDOMINAL DISTENSION; ABDOMINAL PAIN; BODY SURFACE; CALORIC RESTRICTION; CARCINOGENICITY; CLINICAL FEATURE; CLINICAL TRIAL; COMBINATION CHEMOTHERAPY; CONCEPTION; CONGENITAL MALFORMATION; CONSTIPATION; DIARRHEA; DRUG BLOOD LEVEL; DRUG CONTRAINDICATION; DRUG EFFECT; DRUG MECHANISM; DRUG WITHDRAWAL; DYSPEPSIA; FLATULENCE; GASTROINTESTINAL MOTILITY DISORDER; HEARTBURN; HUMAN; INSULIN SENSITIVITY; KIDNEY BLOOD FLOW; LACTATION; META ANALYSIS; MONOTHERAPY; NON INSULIN DEPENDENT DIABETES MELLITUS; NONHUMAN; OVARY POLYCYSTIC DISEASE; PERINATAL MORTALITY; PREGNANCY; PREGNANCY DIABETES MELLITUS; PREGNANT WOMAN; REVIEW; SYSTEMATIC REVIEW; TASTE DISORDER; WEIGHT REDUCTION;

EID: 34250724525     PISSN: 10409165     EISSN: None     Source Type: Journal    
DOI: 10.2337/diaspect.20.2.85     Document Type: Review

References (36)

1. Kovacs C, Smith J: A Guide to the Polycystic Ovary: Its Effects on Health and Fertility. Castle Hill Barns, U.K., TFM Publishing, 2002
2. Achard C, Theirs J: Le Virilisme pilaire et son association a l'insuffisance glycolytique (diabete des femme a barbe) [Association of hirsutism and diabetes (diabetes of women with a beard)]. Bull Acad Natl Med 86:51-83, 1921
3. Stein IF, Leventhal ML: Amenorrhea associated with bilateral polycystic ovaries. Am J Obstet Gynecol 29:181-191, 1935
4. Cristello F, Cela V, Artini PG, Genazzani AR: Therapeutic strategies for ovulation induction in infertile women with polycystic ovary syndrome. Gynecol Endocrinol 21:340-352, 2005
5. Knochenhauser ES, Key TJ, Kahser-Miller M, Waggoner W, Boots LR, Aziz R: Prevalence of polycystic ovary syndrome in unselected black and white women of the southeastern United States: a prospective study. J Clin Endocrinol Metab 83:3078-3082, 1998
6. Rotterdam ESHRE/ASRM-Sponsored PCOS Consensus Workshop Group: Revised 2003 consensus on diagnostic criteria and long-term health risks related to polycystic ovary syndrome. Fertil Steril 81:19-25, 2004
7. Liu KE, Tataryn IV, Sagle M: Use of metformin for ovulation induction in women who have polycystic ovary syndrome with or without evidence of insulin resistance. J Obstet Gynaecol Can 28:595-599, 2006
8. Dokras A, Bochner M, Hollinrake E, Markham S, VanVoorhis B, Jagasia D: Screening women with polycystic ovary syndrome for metabolic syndrome. Obstet Gynecol 106:131-137, 2005
9. Lo JC, Feigenbaum SL, Escobar GJ, Yang J, Crites YM, Ferrara A: Increased prevalence of gestational diabetes mellitus among women with diagnosed polycystic ovary syndrome: a population-based study. Diabetes Care 29:1915-1917, 2006
10. Balen A: Polycystic ovary syndrome and cancer. Human Reprod Update 7:522-525, 2001
11. Stern J: Pharmacology and mode of action of the hypoglycemic guanidine derivatives. In Oral Hypoglycemic Agents Pharmacology and Therapeutics. Campbell GD, Ed. Academic Press, New York, 1969, p. 193-245
12. Package insert: Metformin hydrochloride. New York, Bristol-Myers Squibb
13. Glueck CJ, Aregawi D, Agloria M, Winiarska M, Sieve L, Wang P: Sustainability of 8% weight loss, reduction of insulin resistance, and amelioration of atherogenic-metabolic risk factors over 4 years by metformin-diet in women with polycystic ovary syndrome. Metabolism 55:1582-1589, 2006
14. Fleming R: The use of insulin sensitizing agents in ovulation induction in women with polycystic ovary syndrome. Hormones (Athens) 5:171-178 2006
15. Laven JS, Imani B, Eijkemans MJ, Fauser BC: New approach to polycystic ovary syndrome and other forms of anovulatory infertility. Obstet Gynecol Surv 57:755-767, 2002
16. Lord JM, Flight IH, Norman RJ: Metformin in polycystic ovary syndrome: systemic review and meta-analysis. BMJ 327:951-953, 2003
17. Glueck CJ, Sieve L, Zhu B, Wang P: Plasminogen activator inhibitor activity, 4G5G polymorphism of the plasminogen activator inhibitor 1 gene, and first-trimester miscarriage in women with polycystic ovary syndrome. Metabolism 55:345-352, 2006
18. Khattab S, Mohsen IA, Foutouh IA, Ramadan A, Moaz M, Al-Inany H: Metformin reduces abortion in pregnant women with polycystic ovary syndrome. Gynecol Endocrinol 22:680-684, 2006
19. Glueck CJ, Phillips H, Cameron D, Sieve-Smith L, Wang P: Continuing metformin throughout pregnancy in women with polycystic ovary syndrome appears to safely reduce first-trimester spontaneous abortion: a pilot study. Fertil Steril 75:46-52, 2001
20. Glueck CJ, Goldenberg N, Wang P, Loftspring M, Sherman A: Metformin during pregnancy reduces insulin, insulin resistance, insulin secretion, weight, testosterone and development of gestational diabetes: prospective longitudinal assessment of women with polycystic ovary syndrome from preconception throughout pregnancy. Hum Reprod 19:510-521, 2004
21. Glueck CJ, Wang P, Kobayashi S, Phillips H, Sieve-Smith L: Metformin therapy throughout pregnancy reduces the development of gestational diabetes in women with polycystic ovary syndrome. Fertil Steril 77:520-525, 2002
22. Glueck CJ, Wang P, Goldenberg N, Sieve-Smith L: Pregnancy outcomes among women with polycystic ovary syndrome treated with metformin. Hum Reprod 17:2858-2864, 2002
23. Brown F, Wyckoff J, Rowan J, Jovanovic L, Sacks D, Briggs G: Metformin in pregnancy: its time has not come yet. Diabetes Care 29:485-486, 2006
24. Sterne J, Lavieuville M: Biguanides in pregnancy (translated). Presentation at symposium on the biguanides. Congres International de Diabetologie de Remini. Rimini, Italy, October 1968
25. Coetzee EJ, Jackson WPU: Gestational diabetes and the use of oral agents: controversies in diabetes and pregnancy. Endocrinol Metab V2:59-76, 1988
26. Gilbert C, Valois M, Koren G: Pregnancy outcome after first-trimester exposure to metformin: a meta-analysis. Fertil Steril 86:658-663, 2006
27. Vanky E, Zahlsen K, Spigset O, Carlsen SM: Placental passage of metformin in women with polycystic ovary syndrome. Fertil Steril 83:1575-1578, 2005
28. Koren G, Gilbert C, Valois M: Metformin use during the first trimester of pregnancy: is it safe? Can Fam Phys 52:171-172, 2006
29. Briggs GG, Ambrose PJ, Nageotte MP, Padilla G, Wan S: Excretion of metformin into breast milk and the effect on nursing infants. Obstet Gynecol 105:1437-1441, 2005
30. Glueck CJ, Salehi M, Sieve L, Wang P: Growth, motor, and social development in breast- and formula-fed infants of metformin-treated women with polycystic ovary syndrome. J Pediatr 148:628-632, 2006
31. Hawthorne G: Metformin use and diabetic pregnancy: has its time come? Diabet Med 23:223-227, 2006
32. Brock B, Smidt K, Ovesen P, Schmitz O, Rungby J: Is metformin therapy for polycystic ovary syndrome safe during pregnancy? Basic Clin Pharmacol Toxicol 96:410-412, 2005
33. Muth S, Norman J, Sattar N, Fleming R: Women with polycystic ovary syndrome (PCOS) often undergo protracted treatment with metformin and are disinclined to stop: indications for a change in licensing arrangements? Hum Reprod 19:2718-2720, 2004
34. Legro RS, Myers ER, Barnhart HX, Carson SA, Diamond MP, Carr BR, Schlaff WD, Coutifaris C, McGovern PG, Cataldo NA, Steinkampf MP, Nestler JE, Gosman G, Guidice LC, Leppert PC; the Reproductive Medicine Network: The Pregnancy in Polycystic Ovary Syndrome Study: baseline characteristics of the randomized cohort including racial effects. Fertil Steril 86:914-933, 2006
35. Simmons D, Walters BN, Rowan JA, McIntyre HD: Metformin therapy and diabetes in pregnancy. Med J Aust 180:462-464, 2004
36. Lord JM, Flight IH, Norman RJ: Metformin in polycystic ovary syndrome: systematic review and meta-analysis. BMJ 327:951-953, 2003