Successful treatment of cancer-associated retinopathy with alemtuzumab

Journal of Neuro-Oncology

Volumn 83, Issue 3, 2007, Pages 295-302

  Espandar, Ladan ^a   O'Brien, Susan ^a   Thirkill, Charles ^b   Lubecki, Linda A ^a   Esmaeli, Bita ^a  

^a UNIVERSITY OF TEXAS   (United States)

^b UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

Alemtuzumab; Cancer associated retinopathy; Paraneoplastic syndrome

Indexed keywords

ALEMTUZUMAB; ANTINEOPLASTIC AGENT; CYCLOSPORIN; FLUDARABINE; PREDNISONE;

AGED; ARTICLE; BONE MARROW BIOPSY; BREAST CANCER; CANCER CHEMOTHERAPY; CASE REPORT; CHILL; CHRONIC LYMPHATIC LEUKEMIA; CLINICAL FEATURE; DRUG DOSE REDUCTION; DRUG MEGADOSE; DRUG RESPONSE; ECHOGRAPHY; ELECTROENCEPHALOGRAPHY; ELECTRORETINOGRAPHY; FATIGUE; FEMALE; FOLLOW UP; HUMAN; MAGNETIC RESONANCE ANGIOGRAPHY; MULTIPLE CYCLE TREATMENT; NAUSEA; NUCLEAR MAGNETIC RESONANCE IMAGING; OPTIC NERVE DISEASE; OPTIC NEURITIS; PARTIAL MASTECTOMY; PLASMAPHERESIS; RETINOPATHY; SEROLOGY; TREATMENT OUTCOME; VISION; VISUAL ACUITY; VISUAL FIELD; VISUAL SYSTEM EXAMINATION;

AGED; ANTIBODIES, MONOCLONAL; ANTIBODIES, NEOPLASM; ANTINEOPLASTIC AGENTS; ELECTRORETINOGRAPHY; FEMALE; HUMANS; NEOPLASMS; OPTIC NERVE DISEASES; PARANEOPLASTIC SYNDROMES; REMISSION INDUCTION; RETINAL DISEASES; VISUAL FIELDS;

EID: 34250724422     PISSN: 0167594X     EISSN: 15737373     Source Type: Journal    
DOI: 10.1007/s11060-006-9326-7     Document Type: Article

References (29)

1. Jacobson DM (1998) Paraneoplastic diseases of neuro-ophthalmologic interest. In: Miller NR, Newman N (eds) Walsh & Hoyts clinical neuro-ophthalmology, 5th edn. Williams and Wilkins, Baltimore, pp 2497-2551
2. Adamus G, Guy J, Schmied JL et al (1993) Role of anti-recoverin autoantibodies in cancer-associated retinopathy. Invest Ophthalmol Vis Sci 34:2626-2633
3. Thirkill CE, Tait RC, Tyler NK et al (1992) The cancer-associated retinopathy antigen is a recoverin-like protein. Invest Ophthalmol Vis Sci 33:2768-2772
4. Malik S, Furlan AJ, Sweeney PJ, Kosmorsky GS, Wong M (1992) Optic neuropathy: A rare paraneoplastic syndrome. J Clin Neuroophthalmol 12:137-141
5. Keltner JL, Thirkill CE (1998) Cancer-associated retinopathy vs recoverin-associated retinopathy. Am J Ophthalmol 126:296-302
6. Luiz JE, Lee AG, Keltner JL, Thirkill CE, Lai EC (1998) Paraneoplastic optic neuropathy and autoantibody production in small-cell carcinoma of the lung. J Neuroophthalmol 18:178-181
7. de la Sayette V, Bertran F, Honnorat J, Schaeffer S, Iglesias S, Defer G (1998) Paraneoplastic cerebellar syndrome and optic neuritis with anti-CV2 antibodies: Clinical response to excision of the primary tumor. Arch Neurol 55:405-408
8. Thambisetty MR, Scherzer CR, Yu Z, Lennon VA, Newman NJ (2001) Paraneoplastic optic neuropathy and cerebellar ataxia with small cell carcinoma of the lung. J Neuroophthalmol 21:164-167
9. Browning AC, Amoaku WM, Vernon SA et al (2004) Cachexia and poor night vision. Lancet 363:1305
10. Cancer-associated retinopathy (CAR syndrome) with antibodies reacting with retinal, optic nerve, and cancer cells. (1989) N Engl J Med 321:1589-1594
11. Hohwy T, Bang K, Steiniche T, Peterslund NA, d'Amore F (2004) Alemtuzumab-induced remission of both severe paraneoplastic pemphigus and leukaemic bone marrow infiltration in a case of treatment-resistant B-cell chronic lymphocytic leukaemia. Eur J Haematol 73:206-209
12. Full prescribing information (PI) for Campath®. www.campath.com
13. Golay J, Cortiana C, Manganini M et al (2006) The sensitivity of acute lymphoblastic leukemia cells carrying the t(12;21) translocation to campath-1H-mediated cell lysis. Haematologica 91:322-330
14. Ravandi F, Kantarjian H, Jones D, Dearden C, Keating M, O'Brien S (2005) Mature T-cell leukemias. Cancer 104:1808-1818
15. Busca A, Locatelli F, Lovisone E et al (2005) Treatment of severe refractory acute graft-versus-host disease of the gastrointestinal tract with campath-1H. Biol Blood Marrow Transplant 11:734-736
16. Wertheim MS, Ross AH, Tole DM. The use of Campath in severe peripheral ulcerative keratitis associated with Wegener's granulomatosis. Eye Advance. Online publication, 7 April 2006; doi:10.1038/sj.eye.6702330
17. Coles AJ, Cox A, Le Page E et al (2006) The window of therapeutic opportunity in multiple sclerosis: Evidence from monoclonal antibody therapy. J Neurol 253:98-108
18. Chalandon Y, Roosnek E, Mermillod B, Waelchli L, Helg C, Chapuis B (2006) Can only partial T-cell depletion of the graft before hematopoietic stem cell transplantation mitigate graft-versus-host disease while preserving a graft-versus-leukemia reaction? A prospective phase II study. Biol Blood Marrow Transplant 12:102-110
19. Keltner JL, Thirkill CE, Tyler NK et al (1992) Management and monitoring of cancer-associated retinopathy. Arch Ophthalmol 110:48-53
20. Jacobson DM, Thirkill CE, Tipping SJ (1990) A clinical triad to diagnose paraneoplastic retinopathy. Ann Neurol 28:162-167
21. Kashiwabara K, Nakamura H, Kishi K et al (1999) Cancer-associated retinopathy during treatment for small-cell lung carcinoma. Intern Med 38:597-601
22. Thirkill CE, Roth AM, Keltner JL (1987) Cancer-associated retinopathy. Arch Ophthalmol 105:372-375
23. Keltner JL, Thirkill CE, Tyler NK et al (1992) Management and monitoring of cancer-associated retinopathy. Arch Ophthalmol 110:48-53
24. Yoon YH, Cho EH, Sohn J, Thirkill CE (1999) An unusual type of cancer-associated retinopathy in a patient with ovarian cancer. Korean J Ophthalmol 13:43-48
25. Murphy MA, Thirkill CE, Hart WM (1996) Paraneoplastic retinopathy: A novel autoantibody reaction associated with small cell lung carcinoma. J Neuroophthalmol 17:77-83
26. Salgia R, Hedges TR, Rizk M et al (1998) Cancer-associated retinopathy in a patient with non-small-cell lung carcinoma. Lung Cancer 22:149-152
27. Thirkill CE, FitzGerald P, Sergott RC et al (1989) Cancer-associated retinopathy (CAR syndrome) with antibodies reacting with retinal, optic-nerve, and cancer cells. N Engl J Med 321:1589-1594
28. Guy J, Aptsiauri N (1999) Treatment of paraneoplastic visual loss with intravenous immunoglobulin: Report of 3 cases. Arch Ophthalmol 117:471-477
29. Brink H, Deutman A, Beex L (1997) Unusual retinal pigment epitheliopathy and choroidopathy in carcinomatosis: A rare case of cancer-associated retinopathy. Graefes Arch Clin Exp Ophthalmol 236:75