Teratogenicity of lamotrigine

Canadian Family Physician

Volumn 53, Issue 6, 2007, Pages 1007-1009

  Shor, Sarit ^a   Koren, Gideon ^a,b   Nulman, Irena ^a,b  

^a HOSPITAL FOR SICK CHILDREN   (Canada)

^b Motherisk Program   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

LAMOTRIGINE; VALPROIC ACID;

CASE REPORT; EPILEPSY; FEMALE; FETUS MALFORMATION; GESTATIONAL AGE; HUMAN; MALFORMATION SYNDROME; MONOTHERAPY; PATIENT SAFETY; PREGNANCY; RISK ASSESSMENT; RISK FACTOR; SHORT SURVEY; TERATOGENICITY;

ABNORMALITIES, DRUG-INDUCED; ANTICONVULSANTS; CLEFT PALATE; DRUG EVALUATION; EPILEPSY; FEMALE; HUMANS; PREGNANCY; PREGNANCY COMPLICATIONS; RISK; TRIAZINES;

EID: 34250715419     PISSN: 0008350X     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Short Survey

References (9)

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2. Dansky LV, Andermann E, Andermann F. Marriage and fertility in epileptic patients. Epilepsia 1980;21(3):261-71.
3. Morrow J, Russell A, Guthrie E, Parsons L, Robertson I, Waddell R, et al. Malformation risks of antiepileptic drugs in pregnancy: a prospective study from the UK Epilepsy and Pregnancy Register. J Neurol Neurosurg Psychiatry 2006;77(2):193-8.
4. Vajda FJ, Hitchcock A, Graham J, Solinas C, O'Brien TJ, Lander CM, et al. Foetal malformations and seizure control: 52 months data of the Australian Pregnancy Registry. Eur J of Neurol 2006;13(6):645-54.
5. GlaxoSmithKline. The lamotrigine pregnancy registry [Interim Report]. Wilmington, NC: Kendle International Inc; 2007.
6. Wide K, Winbladh B, Kallen B. Major malformations in infants exposed to antiepileptic drugs in utero, with emphasis on carbamazepine and valproic acid: a nation-wide, population-based register study. Acta Paediatr 2004;93(2):174-6.
7. Holmes LB, Wyszynski DF, Baldwin EJ, Habecker E, Glassman LH, Smith CR. Increased risk for non-syndromic cleft palate among infants exposed to lamotrigine during pregnancy [Abstract]. Birth Defects Res A Clin Mol Teratol 2006;76(5)318.
8. Meador KJ, Baker GA, Finnell RH, Kalayjian LA, Liporace JD, Loring DW, et al. In utero antiepileptic drug exposure: fetal death and malformations. Neurology 2006;67(3):407-12.
9. Dillon JA. Health Canada endorsed important safety information on LAMICTAL® (lamotrigine) tablets [Report]. Mississauga, Ont: GlaxoSmithKline; August 1, 2006. Available from: http://www.gsk.ca/en/ health_info/LAMICTAL_DHCPL_ENG_FNL.pdf. Accessed 2007 Mar 7.