MSI/LOH and extron expression of the FHIT gene in gastric carcinoma

Frontiers of Medicine in China

Volumn 1, Issue 1, 2007, Pages 99-103

  Xiao, Yuping ^a   Mao, Lili ^a   Han, Chengbo ^a   Li, Jinyi ^a   Xu, Lei ^a   Xin, Yan ^a  

^a CHINA MEDICAL UNIVERSITY   (China)

Author keywords

Fragile histidine triad protein; Gene expression regulation; Loss of heterozygosity; Microsatellite instabilities; Neoplastic; Stomach

Indexed keywords

EID: 34250710739     PISSN: 16737342     EISSN: 16737458     Source Type: Journal    
DOI: 10.1007/s11684-007-0019-1     Document Type: Article

References (21)

1. Yu Y, Zhang Y C, Zhang W Z, Shen L S, Hertzog P, Wilson T J, Xu D K. Ets1 as a marker of malignant potential in gastric carcinoma. World J Gastroenterol, 2003, 9(10): 2154-2159
2. Ohta M, Inoue H, Cotticelli M G, Kastury K, Baffa R, Palazzo J, Siprashvili Z, Mori M, McCue P, Druck T, Croce C M, Huebner K. The FHIT gene, spanning the Chromosorne 3p14.2 fragile site and renal carcinoma-associated t (3; 8) breakpoint, is abnormal in digestive tract cancer. Cell, 1996, 84(4): 587-594
3. Huiping C, Kristjansdottir S, Bergthorsson J T, Jonasson J G, Magnusson J, Egilsson V, Ingvarsson S. High frequency of LOH, MSI and abnormal expression of FHIT in gastric cancer. Eur J Cancer, 2002, 38(5): 728-735
4. Zhao P, Song X, Nin Y Y, Lu Y L, Li X H. Loss of fragile histidine triad protein in human hepatocellular carcinoma. World J Gastroenterol, 2003, 9(6): 1216-1219
5. Andachi H, Yashima K, Koda M, Kawaguchi K, Kitamura A, Hosoda A, Kishimoto Y, Shiota G, Ito H, Makino M, Kaibara N, Kawasaki H, Murawaki Y. Reduced FHIT expression is associated with mismatch repair deficiency in human advanced colorectal carcinoma. Br J Cancer, 2002, 87(4): 441-445
6. Fouts R L, Sandusky G E, Zhang S, Eckert G J, Koch M O, Ulbright T M, Eble J N, Cheng L. Down-regulation of fragile histidine triad expression in prostate carcinoma. Cancer, 2003, 97(6): 1447-1452
7. Sukosd F, Kuroda N, Beothe T, Kaur A P, Kovacs G. Deletion of chromosome 3p14.2-p25 involving the VHL and FHIT genes in conventional renal cell carcinoma. Cancer Res, 2003, 63(2): 455-457
8. Lan J, Xiong Y Y, Lin Y X, Wang B C, Gong L L, Xu H S, Guo G S. Helicobacter pylori infection generated gastric cancer through p53-Rb tumor-suppressor system mutation and telomerase reactivation. World J Gastroenterol, 2003, 9(1): 54-58
9. Han C B, Zhao Y J, Li F, He Q, Ma J M, Xin Y. Quantitation and detection of deletion in tumor mitochondrial DNA by microarray technique. Chin J Oncol, 2004, 26(1): 10-13
10. Fouts R L, Sandusky G E, Zhang S, Eckert G J, Koch M O, Ulbright T M, Eble J N, Cheng L. Down-regulation of fragile histidine triad expression in prostate carcinoma. Cancer, 2003, 97(6): 1447-1452
11. Quddus M R, Sung C J, Cook S W, Wang C, Steinhoff M M, Hansen K. Loss of FHIT protein in carcinoma of primary and secondary mullerian systems. Histopathology, 2004, 44(1): 87-88
12. Yao C C, Lin C Y, Hu M B. Abnormal expression of fragile histidine triad (FHIT) and mut S homolog 2 (MSH2) proteins in human sporadic colorectal carcinoma and their clinical significance. Ai Zheng, 2004, 23(3): 310-316
13. Ko J Y, Lee T C, Hsiao C F, Lin G L, Yen S H, Chen K Y, Hsiung C A, Chen P J, Hsu M M, Jou Y S. Definition of three minimal deleted regions by comprehensive allelotyping and mutational screening of FHIT, p16 (INK4A), and p19 (ARF) genes in nasopharyngeal carcinoma. Cancer, 2002, 94(7): 1987-1996
14. Noguchi T, Miiller W, Wirtz H C, Willers R, Gabbert H E. FHIT gene in gastric cancer: Association with tumor progression and prognosis. J Pathol, 1999, 188(4): 378-392
15. Fouts R L, Sandusky G E, Zhang S, Eckert G J, Koch M O, Ulbright T M, Eble J N, Cheng L. Down-regulation of fragile histidine triad expression in prostate carcinoma. Cancer, 2003, 97(6): 1447-1452
16. Sukosd F, Kuroda N, Beothe T, Kaur A P, Kovacs G. Deletion of chromosome 3p14.2-p25 involving the VHL and FHIT genes in conventional renal cell carcinoma. Cancer Res, 2003, 63(2): 455-457
17. Huiping C, Kristjansdottir S, Bergthorsson J T, Jonasson J G, Magnusson J, Egilsson V, Ingvarsson S. High frequency of LOH, MSI and abnormal expression of FHIT in gastric cancer. Eur J Cancer, 2002, 38(5): 728-735
18. Ohta M, Inoue H, Cotticelli M G, Kastury K, Baffa R, Palazzo J, Siprashvili Z, Mori M, McCue P, Druck T, Croce C M, Huebner K. The FHIT gene, spanning the chromosome 3p14.2 fragile site and renal carcinoma-associated t (3,8) breakpoint, is abnormal in digestive tract cancers. Cell, 1996, 84(4): 587-597
19. Ko J Y, Lee T C, Hsiao C F, Lin G L, Yen S H, Chen K Y, Hsiung C A, Chen P J, Hsu M M, Jou Y S. Definition of three minimal deleted regions by comprehensive allelotyping and mutational screening of FHIT, p16(INK4A), and p19(ARF) genes in nasopharyngeal carcinoma. Cancer, 2002, 94(7): 1987-1996
20. Wistuba I I, Ashfaq R, Maitra A, Alvarez H, Riquelme E, Gazdar A F. Fragile histidine triad gene abnormalities in the pathogenesis of gallbladder carcinoma. Am J Pathol, 2002, 160(6): 2073-2079
21. Andachi H, Yashima K, Koda M, Kawaguchi K, Kitamura A, Hosoda A, Kishimoto Y, Shiota G, Ito H, Makino M, Kaibara N, Kawasaki H, Murawaki Y. Reduced Fhit expression is associated with mismatch repair deficiency in human advanced colorectal carcinoma. Br J Cancer, 2002, 87(4): 441-445