Expression of the glycodelin A gene and the detection of its protein in tissues and serum of ovarian carcinoma patients

Anticancer Research

Volumn 27, Issue 4 A, 2007, Pages 2023-2025

  Richter, C ^a   Baetje, M ^a   Bischof, A ^a   Makovitzky, J ^a   Richter, D U ^a   Gerber, B ^a   Briese, V ^a  

^a UNIVERSITY OF ROSTOCK   (Germany)

Author keywords

Glycodelin A (GdA); Ovarian carcinoma; Placental protein 14 (PP14)

Indexed keywords

PLACENTA PROTEIN 14;

BLADDER METASTASIS; BREAST CANCER; COLON CARCINOMA; CONFERENCE PAPER; CONTROLLED STUDY; CYST FLUID; ENDOMETRIOSIS; ENZYME IMMUNOASSAY; FEMALE; GENE EXPRESSION; HUMAN; HUMAN TISSUE; IMMUNOHISTOCHEMISTRY; MAJOR CLINICAL STUDY; OVARY CARCINOMA; POLYMERASE CHAIN REACTION; PRIORITY JOURNAL; PROTEIN ANALYSIS; UTERINE CERVIX CANCER; UTERUS CANCER; UTERUS MYOMA;

ENZYME-LINKED IMMUNOSORBENT ASSAY; FEMALE; GENE EXPRESSION; GLYCOPROTEINS; HUMANS; IMMUNOHISTOCHEMISTRY; OVARIAN NEOPLASMS; POLYMERASE CHAIN REACTION; PREGNANCY PROTEINS; RNA, MESSENGER; SENSITIVITY AND SPECIFICITY; TUMOR MARKERS, BIOLOGICAL;

EID: 34250692985     PISSN: 02507005     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Conference Paper

References (12)

1. Bohn H, Kraus W and Winkler W: New soluble placental tissue proteins: their isolation, characterization, localisation and quantification. Immunology of Human Placental Proteins, pp. 67-82, 1982.
2. Dell A, Morris HR, Panico M, Oehninger S, Patankar M, Koistinen R, Seppälä M and Clark GF: Structural analysis of the oligosaccharides associated with glycodelin, a human glycoprotein with potent immunosuppressive and contraceptive activities. J Biol Chem 270: 24116-24126, 1995.
3. Kämäräinen M, Leivo I, Koistinen R, Julkunen M, Karvonen U, Rutanen EM and Seppälä M: Normal human ovary and ovarian tumours express glycodelin, a glycoprotein with immunosuppressive and contraceptive properties. Am J Pathol 148: 1435-1443, 1996.
4. Seppälä M, Taylor RN, Koistinen H, Koistinen R and Milgrom E: Glycodelin: A major lipocalin protein of the reproductive axis with diverse actions in cell recognition and differentiation. Endocr Rev 23: 401-430, 2002.
5. Jukunen M, Koistinen R, Sjoberg J, Rutanen EM, Wahlstrom T and Seppälä M: Secretory endometrium synthesizes placental protein 14. Endocrinol 118: 1782-1786, 1986.
6. Mylonas I, Speer R, Makovitzky J, Richter DU, Briese V, Jeschke U and Friese K: Immunohistochemical analysis of steroid receptors and glycodelin A (PP14) in isolated glandular epithelial cells of normal human endometrium. Histochem Cell Biol 114: 405-411, 2000.
7. Jukunen M: Human deciduas synthesize placental protein 14 (pp14) in vitro. Acta Endocrinol (Copenh) 112: 271-277, 1986.
8. Jeschke U, Karsten U, Reimer, Richter DU, Bergemann C, Briese V, Mylonas I and Friese K: Stimulation of hCG protein and mRNA in first trimester villous cytotrophoblast cells in vitro by glycodelin A. J Perinat Med 33: 212-218, 2005.
9. Pockley AG, Mowles EA, Stoker RJ, Westwood OM, Chapman MG and Bolton AE: Suppression of in vitro lymphocyte reactivity to phytohaemagglutinin by placental protein 14. J Reprod Immunol 13: 31, 1988.
10. Pockley AG and Bolton AE: Placental protein 14 (PP14) inhibits the synthesis of interleukin-2 and the release of soluble interleukin-2 receptors from phytohaemagglutinin-stimulated lymphocytes. Clin Exp Immunol 77: 252, 1989.
11. Pockley AG and Bolton AE: The effect of human placental protein 14 (PP14) on the production of interleukin-1 mitogenically stimulated mononuclear cell cultures. Immunol 69: 277, 1990.
12. Bischof A, Briese V, Richter DU, Bergemann C, Friese K and Jeschke U: Measurement of glycodelin A in fluids of benign ovarian cysts, borderline tumours and malignant ovarian cancer. Anticancer Res 25: 1639-1644, 2005.