Pt(II)-catalyzed synthesis of 1,2-dihydropyridines from aziridinyl propargylic esters

Organic Letters

Volumn 9, Issue 11, 2007, Pages 2167-2170

  Motamed, Massoud ^a   Bunnelle, Eric M ^a   Singaram, Surendra W ^a   Sarpong, Richmond ^a  

^a UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

DIHYDROPYRIDINE DERIVATIVE; PLATINUM;

ARTICLE; CATALYSIS; CHEMICAL STRUCTURE; CHEMISTRY; SYNTHESIS;

CATALYSIS; DIHYDROPYRIDINES; MODELS, MOLECULAR; MOLECULAR STRUCTURE; PLATINUM;

EID: 34250680552     PISSN: 15237060     EISSN: None     Source Type: Journal    
DOI: 10.1021/ol070658i     Document Type: Article

References (27)

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20. See Supporting Information for a detailed description for the synthesis of the substrates.
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23. Mechanistically, this could proceed as illustrated below image presented.
24. Crystallographic data have been deposited in the Cambridge Crystallographic Data Centre (CCDC #637309). Refinement data are provided in the Supporting Information.
25. The possibility of reduced stability of W-alkyl 1,2-dihydropyridines relative to N-tosyl or N-acyl 1,2-dihydropyridines under the reaction conditions may also contribute to the lack of success of this reaction.
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27. Enantiopure la was obtained by preparative chiral column HPLC of the racemate. For more information, see the Supporting Information.