18F-FLT PET does not discriminate between reactive and metastatic lymph nodes in primary head and neck cancer patients

Journal of Nuclear Medicine

Volumn 48, Issue 5, 2007, Pages 726-735

  Troost, Esther G C ^a   Vogel, Wouter V ^a   Merkx, Matthias A W ^a   Slootweg, Piet J ^a   Marres, Henri A M ^a   Peeters, Wenny J M ^a   Bussink, Johan ^a   Van Der Kogel, Albert J ^a   Oyen, Wim J G ^a   Kaanders, Johannes H A M ^a  

^a RADBOUD UNIVERSITY MEDICAL CENTER   (Netherlands)

Author keywords

18F FLT; Head and neck cancer; PET CT; Staging

Indexed keywords

3' FLUOROTHYMIDINE; 3' FLUOROTHYMIDINE F 18; IDOXURIDINE; KI 67 ANTIGEN; TRACER; UNCLASSIFIED DRUG; 2',3' DIDEOXYNUCLEOSIDE DERIVATIVE; DIAGNOSTIC AGENT; RADIOPHARMACEUTICAL AGENT;

ADULT; AGED; ARTICLE; B LYMPHOCYTE; CANCER STAGING; CELL PROLIFERATION; CLINICAL ARTICLE; COMPUTER ASSISTED EMISSION TOMOGRAPHY; CONTROLLED STUDY; FEMALE; HEAD AND NECK CANCER; HUMAN; LYMPH NODE DISSECTION; LYMPH NODE METASTASIS; MALE; MAXILLARY SINUS; PRIORITY JOURNAL; SENSITIVITY AND SPECIFICITY; SQUAMOUS CELL CARCINOMA; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; DIFFERENTIAL DIAGNOSIS; HEAD AND NECK TUMOR; LYMPH NODE; LYMPHADENECTOMY; METASTASIS; METHODOLOGY; MIDDLE AGED; POSITRON EMISSION TOMOGRAPHY; PROGNOSIS; PSEUDOLYMPHOMA; RANDOMIZED CONTROLLED TRIAL; SCINTISCANNING; TREATMENT OUTCOME; TUMOR RECURRENCE;

ADULT; AGED; AGED, 80 AND OVER; DIAGNOSIS, DIFFERENTIAL; DIDEOXYNUCLEOSIDES; FEMALE; HEAD AND NECK NEOPLASMS; HUMANS; LYMPH NODE EXCISION; LYMPH NODES; LYMPHATIC METASTASIS; MALE; MIDDLE AGED; NEOPLASM RECURRENCE, LOCAL; POSITRON-EMISSION TOMOGRAPHY; PROGNOSIS; PSEUDOLYMPHOMA; RADIOPHARMACEUTICALS; TREATMENT OUTCOME;

EID: 34250654188     PISSN: 01615505     EISSN: None     Source Type: Journal    
DOI: 10.2967/jnumed.106.037473     Document Type: Article

References (42)

1. Brockstein B, Haraf DJ, Rademaker AW, et al. Patterns of failure, prognostic factors and survival in locoregionally advanced head and neck cancer treated with concomitant chemoradiotherapy: a 9-year, 337-patient, multi-institutional experience. Ann Oncol. 2004;15:1179-1186.
2. van den Brekel MW, Castelijns JA, Stel HV, Golding RP, Meyer CJ, Snow GB. Modern imaging techniques and ultrasound-guided aspiration cytology for the assessment of neck node metastases: a prospective comparative study. Eur Arch Otorhinolaryngol. 1993;250:11-17.
3. Wide JM, White DW, Woolgar JA, Brown JS, Vaughan ED, Lewis-Jones HG. Magnetic resonance imaging in the assessment of cervical nodal metastasis in oral squamous cell carcinoma. Clin Radiol. 1999;54:90-94.
4. Takes RP, Righi P, Meeuwis CA, et al. The value of ultrasound with ultrasound-guided fine-needle aspiration biopsy compared to computed tomography in the detection of regional metastases in the clinically negative neck. Int J Radiat Oncol Biol Phys. 1998;40:1027-1032.
5. van den Brekel MW, Castelijns JA, Stel HV, et al. Occult metastatic neck disease: detection with US and US-guided fine-needle aspiration cytology. Radiology. 1991;180:457-461.
6. 18F-FDG PET with conventional imaging modalities (CT, MRI, US) in lymph node staging of head and neck cancer. Eur J Nucl Med. 1998;25:1255-1260.
7. 18FDG PET. AJR. 2005;184:1326-1331.
8. 18F-FDG PET and CT/MRI in oral cavity squamous cell carcinoma: a prospective study of 124 patients with histologic correlation. J Nucl Med. 2005;46:1136-1143.
9. Stuckensen T, Kovacs AF, Adams S, Baum RP. Staging of the neck in patients with oral cavity squamous cell carcinomas: a prospective comparison of PET, ultrasound, CT and MRI. J Craniomaxillofac Surg. 2000;28:319-324.
10. 18F]fluorodeoxyglucose positron emission tomography and computed tomography and magnetic resonance imaging in oral cavity squamous cell carcinoma with palpably negative neck. J Clin Oncol. 2006;24:4371-4376.
11. Wensing BM, Vogel WV, Marres HA, et al. FDG-PET in the clinically negative neck in oral squamous cell carcinoma. Laryngoscope. 2006;116:809-813.
12. Kim JJ, Tannock IF. Repopulation of cancer cells during therapy: an important cause of treatment failure. Nat Rev Cancer. 2005;5:516-525.
13. Petersen C, Zips D, Krause M, et al. Repopulation of FaDu human squamous cell carcinoma during fractionated radiotherapy correlates with reoxygenation. Int J Radiat Oncol Biol Phys. 2001;51:483-493.
14. Taylor JM, Withers HR, Mendenhall WM. Dose-time considerations of head and neck squamous cell carcinomas treated with irradiation. Radiother Oncol. 1990;17:95-102.
15. Withers HR, Taylor JM, Maciejewski B. The hazard of accelerated tumor clonogen repopulation during radiotherapy. Acta Oncol. 1988;27:131-146.
16. Kaanders JH, van der Kogel AJ, Ang KK. Altered fractionation: limited by mucosal reactions? Radiother Oncol. 1999;50:247-260.
17. Bonner JA, Harari PM, Giralt J, et al. Radiotherapy plus cetuximab for squamous-cell carcinoma of the head and neck. N Engl J Med. 2006;354:567-578.
18. Overgaard J, Hansen HS, Specht L, et al. Five compared with six fractions per week of conventional radiotherapy of squamous-cell carcinoma of head and neck: DAHANCA 6 and 7 randomised controlled trial. Lancet. 2003;362:933-940.
19. Shields AF, Grierson JR, Dohmen BM, et al. Imaging proliferation in vivo with [F-18]FLT and positron emission tomography. Nat Med. 1998;4:1334-1336.
20. 18F-FLT): a pilot study. Eur J Surg Oncol. 2006;32:39-43.
21. 18F-FDG. J Nucl Med. 2003;44:1426-1431.
22. Buck AK, Hetzel M, Schirrmeister H, et al. Clinical relevance of imaging proliferative activity in lung nodules. Eur J Nucl Med Mol Imaging. 2005;32:525-533.
23. 18F]fluorothymidinepositron emission tomography for noninvasive assessment of proliferation in pulmonary nodules. Cancer Res. 2002;62:3331-3334.
24. 18F-FDG. J Nucl Med. 2005;46:945-952.
25. 18F]3′-Deoxy-3′- fluorothymidine PET for the diagnosis and grading of brain tumors. Eur J Nucl Med Mol Imaging. 2005;32:653-659.
26. Cobben DC, Koopal S, Tiebosch AT, et al. New diagnostic techniques in staging in the surgical treatment of cutaneous malignant melanoma. Eur J Surg Oncol. 2002;28:692-700.
27. 18F-FDG PET. J Nucl Med. 2004;45:226-231.
28. 18F]FLT PET for diagnosis and staging of thoracic tumours. Eur J Nucl Med Mol Imaging. 2003;30:1407-1412.
29. Francis DL, Freeman A, Visvikis D, et al. In vivo imaging of cellular proliferation in colorectal cancer using positron emission tomography. Gut. 2003;52:1602-1606.
30. 18F]fluorothymidine for imaging of primary breast cancer: a pilot study. Eur J Nucl Med Mol Imaging. 2004;31:720-724.
31. 18F-fluorodeoxyglucose-positron emission tomography. Chest. 2006;129:393-401.
32. 18F]fluorothymidine-positron emission tomography imaging: evaluation of analytical methods. Cancer Res. 2005;65:10104-10112.
33. 18F]fluorothymidine positron emission tomography: the effect of cisplatin on a fibrosarcoma tumor model in vivo. Cancer Res. 2005;65:4202-4210.
34. Muzi M, Vesselle H, Grierson JR, et al. Kinetic analysis of 3′-deoxy-3′-fluorothymidine PET studies: validation studies in patients with lung cancer. J Nucl Med. 2005;46:274-282.
35. 18F]FLT uptake by positron emission tomography with Ki-67 immunohistochemistry and flow cytometry in human lung tumors. Clin Cancer Res. 2002;8:3315-3323.
36. Begg AC, Haustermans K, Hart AA, et al. The value of pretreatment cell kinetic parameters as predictors for radiotherapy outcome in head and neck cancer: a multicenter analysis. Radiother Oncol. 1999;50:13-23.
37. Brown DC, Gatter KC. Ki67 protein: the immaculate deception? Histopathology. 2002;40:2-11.
38. Kelman Z. PCNA: structure, functions and interactions. Oncogene. 1997;14:629-640.
39. Hughes WL, Commerford SL, Gitlin D, et al. Deoxyribonucleic acid metabolism in vivo. I. Cell proliferation and death as measured by incorporation and elimination of iododeoxyuridine. Fed Proc. 1964;23:640-648.
40. 18F]FLT). J Radioanal Nucl Chem. 2000;243:843-846.
41. Vogel WV, Schinagl DAX, van Dalen JA, Kaanders JHAM, Oyen WJG. Validated image fusion of dedicated PET and CT, for external beam radiation therapy in the head and neck area. Q J Nucl Med. In press.
42. Gregoire V, Coche E, Cosnard G, Hamoir M, Reychler H. Selection and delineation of lymph node target volumes in head and neck conformal radiotherapy: proposal for standardizing terminology and procedure based on the surgical experience tables. Radiother Oncol. 2000;56:135-150.