A phase II study of single-agent oral vinorelbine in patients with pretreated advanced non-small-cell lung cancer

Clinical Lung Cancer

Volumn 8, Issue 6, 2007, Pages 382-385

  Rossi, David ^a   Catalano, Vincenzo ^a   Alessandroni, Paolo ^a   Fedeli, Anna ^a   Fedeli, Stefano Luzi ^a   Giordani, Paolo ^a   Baldelli, Anna Maria ^a   Casadei, Virginia ^a   Ceccolini, Monica ^a   Ugolini, Marcello ^a   Dennetta, Donatella ^a   Catalano, Giuseppina ^b  

^a SAN SALVATORE HOSPITAL   (Italy)

^b NONE

Author keywords

Chemotherapy; Safety; Salvage therapy; Toxicity

Indexed keywords

NAVELBINE; TROPISETRON;

ABDOMINAL PAIN; ADULT; ADVANCED CANCER; AGED; ARTICLE; ASTHENIA; CANCER CHEMOTHERAPY; CANCER GROWTH; CANCER LOCALIZATION; CLINICAL ARTICLE; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; DIARRHEA; DRUG ACTIVITY; DRUG FORMULATION; DRUG TOLERABILITY; FEMALE; HUMAN; LUNG NON SMALL CELL CANCER; MALE; MULTIPLE CYCLE TREATMENT; NEUTROPENIA; PHASE 2 CLINICAL TRIAL; SALVAGE THERAPY;

EID: 34250635053     PISSN: 15257304     EISSN: None     Source Type: Journal    
DOI: 10.3816/CLC.2007.n.019     Document Type: Article

References (17)

1. Schiller JH, Harrington D, Belani CP, et al, Comparison of four chemotherapy regimens for advanced non-small cell lung cancer. N Engl J Med 2002; 346:92-98.
2. Le Chevalier T, Brisgand D, Douillard JY. Randomized study of navelbine and cisplatin versus vindesine and cisplatin versus navelbine alone in advanced non-small cell lung cancer: results of a European multicenter trial including 612 patienrs. J Clin Oncol 1994; 12:360-367.
3. Gridelli C, Gallo C, Shepherd FA, et al. Gemcitabine plus vinorelbine compared with cisplatin plus vinorelbine or cisplatin plus gemcitabine for advanced non-small cell lung cancer: a phase III trial of the Italian GEMVIN investigators and the Narional Cancer Institute of Canada Clinical Trials Group. J Clin Oncol 2003; 21:3025-3034.
4. Kelly K, Crowley J, Bunn PA, et al. Randomized phase III trial of paclitaxel plus carboplatin versus vinorelbine plus cisplatin in the treatment of patients with advanced non-small cell lung cancer: a Southwest Oncology Group trial. J Clin Oncol 2001; 19:3210-3218.
5. Kosmas C, Tsavaris N, Panopoulos C, et al. Gemcitabine and vinorelbine as second-line therapy in non-small cell lung cancer after prior treatment taxane + platinum based regimens. Eur J Cancer 2001; 37:972-978.
6. Leu KM, Kim KM, Larson M, et al. Phase I/II trial of docetaxel and vinorelbine in patients with non-small cell lung cancer previously treated with platinum-based chemotherapy. Lung Cancer 2001; 34:105-113.
7. Fossella FV, De Vore R, Kerr RN, et al. Randomized phase III trial of docetaxel versus vinorelbine or ifosfamide in patients with advanced non-small cell lung cancer previously treated with platinum containing chemotherapy regimens. J Clin Oncol 2000; 18:2354-2362.
8. Pronzato P, Landucci M, Vaira F, et al. Failure of vinorelbine to produce responses in pretreated non-small cell lung cancer patients. Anticancer Res 1994; 14:1413-1416.
9. Rinaldi M, Delia Giulia M, Venturo I, et al. Vinorelbine as single agent in the treatment of advanced non'small-cell lung cancer. Proc Am Soc Clin Oncol 1994; 13:360a (Abstract #1212).
10. Furuse K, Ohta M, Fukuoka M, et al. Early phase II clinical study of KW-2307 in patients with lung cancer. Lung cancer section in KW-2307 Study Group (in Japanese]. Can To Kagaku Ryo 1994; 21:785-793.
11. Santoro A, Maiorino L, Santoro M. Second line chemotherapy wirh vinorelbine in rhe weekly monochemotherapy for the treatment of advanced non-small cell lung cancer. Lung Cancer 1994; 11(suppl 1):130 (Abstract #497).
12. Devlin JG, Langer CJ. Salvage vinorelbine in the 2nd to 4th line setting in advanced non small cell lung cancer (NSCLC): a retrospective review at the Fox Chase Center Cancer Center (FCCC). J Clin Oncol 2006; 24(18 suppl):672s (Abstract #17072).
13. Jassem J, Ramlau R, Karnicka-Mlodkowska H, et al. A multicenter randomized phase II study of oral vs intravenous vinorelbine in advanced non-small-cell lung cancer patients. Ann Oncol 2001; 12:1375-1381.
14. Gridelli C, Manegold C, Mali P, et al. Oral vinorelbine given as monotherapy to advanced, elderly NSCLC patients: a multicenter phase II trial. Eur J Cancer 2004; 40:2424-2431.
15. Miller AB, Hoogstraten B, Staquet M, et al. Reporting results of cancer treatment. Cancer 1981; 47:207-214.
16. Chen YM, Perng RP, Lee CS, et al. Phase II study of gemcitabine and vinorelbine combination chemotherapy in patients with non-small cell lung cancer not responding to previous chemotherapy. Am J Clin Oncol 2003; 26:567-570.
17. Kanard A, Jatoi A, Castillo R, et al. Oral vinorelbine for the treatment of metastatic non-small cell lung cancer in elderly patients: a phase II trial of efficacy and toxicity. Lung Cancer 2004; 43:345-353.