Subclinical peritubular capillaritis at 3 months is associated with chronic rejection at 1 year

Transplantation

Volumn 83, Issue 11, 2007, Pages 1416-1422

  Lerut, Evelyne ^a   Naesens, Maarten ^a   Kuypers, Dirk R ^a   Vanrenterghem, Yves ^a   Van Damme, Boudewijn ^a  

^a UNIVERSITY HOSPITALS LEUVEN   (Belgium)

Author keywords

C4d; Chronic antibody mediated rejection; Electron microscopy; Peritubular capillary; Protocol biopsy

Indexed keywords

COMPLEMENT COMPONENT C4D; LEUKOCYTE ANTIBODY;

ADULT; AGED; ARTICLE; BASEMENT MEMBRANE; CAPILLARITIS; CAPILLARY; CHRONIC GRAFT REJECTION; CONTROLLED STUDY; FEMALE; GLOMERULOPATHY; GRAFT RECIPIENT; HISTOLOGY; HUMAN; INTIMA; KIDNEY ALLOGRAFT; KIDNEY BIOPSY; KIDNEY FIBROSIS; MAJOR CLINICAL STUDY; MALE; PRIORITY JOURNAL; SENSITIVITY AND SPECIFICITY;

ACUTE DISEASE; ADULT; AGED; ANTIBODIES; BASEMENT MEMBRANE; CAPILLARIES; CHRONIC DISEASE; FEMALE; FIBROSIS; GRAFT REJECTION; HUMANS; KIDNEY; KIDNEY TRANSPLANTATION; KIDNEY TUBULES; MALE; MIDDLE AGED; TIME FACTORS; VASCULITIS;

EID: 34250621322     PISSN: 00411337     EISSN: None     Source Type: Journal    
DOI: 10.1097/01.tp.0000266676.10550.70     Document Type: Article

References (22)

1. Solez K, Colvin RB, Racusen LC, et al. Banff '05 meeting report: Differential diagnosis of chronic allograft injury and elimination of chronic allograft nephropathy ('CAN'). Am J Transplant 2007; 7: 518.
2. Aita K, Yamaguchi Y, Horita S, et al. Peritubular capillaritis in early renal allograft is associated with the development of chronic rejection and chronic allograft nephropathy. Clin Transplant 2005; 19 Suppl 14: 20.
3. Racusen LC, Solez K, Colvin RB, et al. The Banff 97 working classification of renal allograft pathology. Kidney Int 1999; 55: 713.
4. Isoniemi H, Taskinen E, Hayry P. Histological chronic allograft damage index accurately predicts chronic renal allograft rejection. Transplantation 1994; 58: 1195.
5. Yilmaz S, Tomlanovich S, Mathew T, et al. Protocol core needle biopsy and histologic Chronic Allograft Damage Index (CADI) as surrogate end point for long-term graft survival in multicenter studies. J Am Soc Nephrol 2003; 14: 773.
6. Nankivell BJ, Fenton-Lee CA, Kuypers DR, et al. Effect of histological damage on long-term kidney transplant outcome. Transplantation 2001; 71: 515.
7. Seron D, Moreso F, Bover J, et al. Early protocol renal allograft biopsies and graft outcome. Kidney Int 1997; 51: 310.
8. Nicholson ML, McCulloch TA, Harper SJ, et al. Early measurement of interstitial fibrosis predicts long-term renal function and graft survival in renal transplantation. Br J Surg 1996; 83: 1082.
9. Nankivell BJ, Borrows RJ, Fung CL, O'Connell PJ, Chapman JR, Allen RD. Delta analysis of posttransplantation tubulointerstitial damage. Transplantation 2004; 78: 434.
10. Nankivell BJ, Borrows RJ, Fung CL, O'Connell PJ, Allen RD, Chapman JR. Natural history, risk factors, and impact of subclinical rejection in kidney transplantation. Transplantation 2004; 78: 242.
11. Rush D, Nickerson P, Gough J, et al. Beneficial effects of treatment of early subclinical rejection: A randomized study. J Am Soc Nephrol 1998; 9: 2129.
12. Moreso F, Ibernon M, Goma M, et al. Subclinical rejection associated with chronic allograft nephropathy in protocol biopsies as a risk factor for late graft loss. Am J Transplant 2006; 6: 747.
13. Legendre C, Thervet E, Skhiri H, et al. Histologic features of chronic allograft nephropathy revealed by protocol biopsies in kidney transplant recipients. Transplantation 1998; 65: 1506.
14. Koo DD, Roberts IS, Quiroga I, et al. C4d deposition in early renal allograft protocol biopsies. Transplantation 2004; 7: 398.
15. Sund S, Hovig T, Reisaeter AV, Scott H, Bentdal O, Mollnes TE. Complement activation in early protocol kidney graft biopsies after living-donor transplantation. Transplantation 2003; 75: 1204.
16. Mengel M, Bogers J, Bosmans JL, et al. Incidence of C4d stain in protocol biopsies from renal allografts: Results from a multicenter trial. Am J Transplant 2005; 5: 1050.
17. Racusen LC, Colvin RB, Solez K, et al. Antibody-mediated rejection criteria - an addition to the Banff 97 classification of renal allograft rejection. Am J Transplant 2003; 3: 708.
18. Racusen LC, Halloran PF, Solez K. Banff 2003 meeting report: New diagnostic insights and standards. Am J Transplant 2004; 4: 1562.
19. Ivanyi B, Fahmy H, Brown H, Szenohradszky P, Halloran PF, Solez K. Peritubular capillaries in chronic renal allograft rejection: a quantitative ultrastructural study. Hum Pathol 2000; 31: 1129.
20. Colvin RB, Smith RN. Antibody-mediated organ-allograft rejection. Nat Rev Immunol 2005; 5: 807.
21. Uehara S, Chase CM, Cornell LD, Madsen JC, Russell PS, Colvin RB. Chronic cardiac transplant arteriopathy in mice: Relationship of alloantibody, C4d deposition and neointimal fibrosis. Am J Transpl 2007; 7: 57.
22. Rush D. Protocol biopsies should be part of the routine management of kidney transplant recipients. Pro. Am J Kidney Dis 2002; 40: 671.