Inhibitory role of magnolol on proliferative capacity and matrix metalloproteinase-9 expression in TNF-α-induced vascular smooth muscle cells

International Immunopharmacology

Volumn 7, Issue 8, 2007, Pages 1083-1091

  Kim, Hong Man ^a   Bae, Sung Jin ^b   Kim, Dong Wook ^c   Kim, Bo Kyung ^d   Lee, Soo Bok ^e   Lee, Ung Soo ^f   Kim, Cheorl Ho ^g   Moon, Sung Kwon ^f  

^a Seoul National University   (South Korea)

^b Dongguk University   (South Korea)

^c Mokpo National University   (South Korea)

^d Konkuk University School of Medicine   (South Korea)

^e Yonsei University   (South Korea)

^f Chungju National University   (South Korea)

^g Sungkyunkwan University   (South Korea)

Author keywords

AP 1; Atherosclerosis; G1 cell cycle arrest; Magnolol; MMP 9; NF B; TNF ; Vascular smooth muscle cell

Indexed keywords

CYCLIN DEPENDENT KINASE INHIBITOR 1; DNA; GELATINASE B; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; MAGNOLOL; MITOGEN ACTIVATED PROTEIN KINASE 1; MITOGEN ACTIVATED PROTEIN KINASE 3; TRANSCRIPTION FACTOR AP 1; TUMOR NECROSIS FACTOR ALPHA;

ARTICLE; ATHEROGENESIS; ATHEROSCLEROSIS; CELL CYCLE; CELL GROWTH; CELL PROLIFERATION; CONTROLLED STUDY; DOSE TIME EFFECT RELATION; DRUG EFFECT; GENE EXPRESSION; GROWTH INHIBITION; HUMAN; HUMAN CELL; MAGNOLIACEAE; NUCLEOTIDE SEQUENCE; PHYTOCHEMISTRY; POLYMERASE CHAIN REACTION; PRIORITY JOURNAL; VASCULAR SMOOTH MUSCLE;

BIPHENYL COMPOUNDS; CELL PROLIFERATION; CELLS, CULTURED; CYCLIN-DEPENDENT KINASE 4; CYCLIN-DEPENDENT KINASE INHIBITOR P21; CYCLIN-DEPENDENT KINASES; DOSE-RESPONSE RELATIONSHIP, DRUG; G1 PHASE; GENE EXPRESSION; HUMANS; IMMUNOBLOTTING; LIGNANS; MAGNOLIA; MATRIX METALLOPROTEINASE 2; MATRIX METALLOPROTEINASE 9; MUSCLE, SMOOTH, VASCULAR; MYOCYTES, SMOOTH MUSCLE; NF-KAPPA B; PLANT EXTRACTS; TRANSCRIPTION FACTOR AP-1; TUMOR NECROSIS FACTOR-ALPHA; UP-REGULATION;

EID: 34250377341     PISSN: 15675769     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.intimp.2007.04.004     Document Type: Article

References (36)

1. Ross R. The pathogenesis of atherosclerosis: a perspective for the 1990s. Nature 362 (1993) 801-809
2. Abedi H., and Zachary I. Signalling mechanisms in the regulation of vascular cell migration. Cardiovasc Res 30 (1995) 544-556
3. Jovinge S., Hultgardh-Nilsson A., Regnstrom J., and Nilsson J. TNF-α activates smooth muscle cell migration in culture and is expressed in the balloon-injured rat aorta. Arterioscler Thromb Vasc Biol 17 (1997) 490-497
4. Tipping PG., and Hancock W.W. Production of tumor necrosis factor and interleukin-1 by macrophages from human atherosclerotic plaques. Am J Pathol 142 (1993) 1721-1728
5. Clausell N., De Lima V.C., and Molossi S. Expression of tumor necrosis factor á and accumulation of fibronectin in coronary artery restenotic lesions retrieved by atherectomy. Br Heart J 73 (1995) 534-539
6. Hoefer I.E., van Royen N., Rectenwald J.E., Bray E.J., Abouhamze Z., Moldawer L.L., et al. Direct evidence for tumor necrosis factor-alpha signaling in arteriogenesis. Circulation 105 14 (2002) 1639-1641
7. Goetze S., Xi X.P., and Kawano Y. TNF-α-induced migration of vascular smooth muscle cells is MAPK-dependent. Hypertension 33 (1999) 183-189
8. Goetze U., Kintscher K., Kaneshiro W.P., Meehan A., Collins E., Fleck W.A., et al. TNF-á induces expression of transcription factors c-fos Egr-1 and Ets-1 in vascular lesions through extracellular signal-regulated kinases 1/2. Atherosclerosis 159 (2001) 93-101
9. Hunter T., and Pines J. Cyclins and cancer. II: cyclin D and CDK inhibitors come of age. Cell 79 4 (1994) 573-582
10. Morgan D.O. Principles of CDK regulation. Nature 374 6518 (1995) 131-134
11. Sherr C.J., and Roberts J.M. Inhibitors of mammalian G1 cyclin-dependent kinases. Genes Dev 9 10 (1995) 1149-1163
12. Sherr C.J. G1 phase progression: cycling on cue. Cell 79 (1994) 551-555
13. Sherr C.J. Cancer cell cycles. Science 274 (1996) 1672-1677
14. Collins K., Jacks T., and Pavletich N.P. The cell cycle and cancer. Proc Natl Acad Sci U S A 94 (1997) 2776-2778
15. Jacks T., and Weinberg R.A. Cell-cycle control and its watchman. Nature 381 (1996) 643-644
16. Xiong Y., Hannon G.J., Zhang H., Casso D., Kobayashi R., and Beach D. p21 is a universal inhibitor of cyclin kinases. Nature 366 (1993) 701-704
17. Toyoshima H., and Hunter T. p27, a novel inhibitor of G1 cyclin-cdk protein kinase activity, is related to p21. Cell 78 (1994) 67-74
18. Ross R. Atherosclerosis-an inflammatory disease. N Eng J Med 340 (1999) 115-126
19. Newby A.C., and Zaltsman A.B. Molecular mechanisms in intimal hyperplasia. J Pathol 190 (2000) 300-309
20. Cho A., and Reidy M.A. Matrix metalloproteinase-9 is necessary for the regulation of smooth muscle cell replication and migration after arterial injury. Circ Res 91 (2002) 845-851
21. Galis Z.S., Johnson C., Godin D., Magid R., Shipley J.M., Senior R.M., et al. Targeted disruption of the matrix metalloproteinase-9 gene impairs smooth muscle cell migration and geometrical arterial remodeling. Circ Res 91 (2002) 852-859
22. Cho A., Graves J., and Reidy M.A. Mitogen-activated protein kinases mediate matrix metalloproteinase-9 expression in vascular smooth muscle cells. Arterioscler Thromb Vasc Biol 20 (2000) 2527-2532
23. Moon S.K., Cha B.Y., and Kim C.H. ERK1/2 mediates TNF-alpha-induced matrix metalloproteinase-9 expression in human vascular smooth muscle cells via the regulation of NF-kappaB and AP-1: involvement of the ras dependent pathway. J Cell Physiol 198 (2004) 417-427
24. Liou K.T., Shen Y.C., Chen C.F., Tsao C.M., and Tsai S.K. The anti-inflammatory effect of honokiol on neutrophils: mechanisms in the inhibition of reactive oxygen species production. Eur J Pharmacol 475 (2003) 19-27
25. Teng C.M., Chen C.C., Ko F.N., Lee LG., Huang T.F., Chen Y.P., et al. Two antiplatelet agents from Magnolia officinalis. Thromb Res 50 (1988) 757-765
26. Lo Y.C., Teng C.M., Chen C.F., Chen C.C., and Hong C.Y. Magnolol and honokiol isolated from Magnolia officinalis protect rat heart mitochondria against lipid peroxidation. Biochem Pharmacol 47 (1994) 549-553
27. Lin S.Y., Liu J.D., Chang H.C., Yeh S.D., Lin C.H., and Lee W.S. Magnolol suppresses proliferation of cultured human colon and liver cancer cells by inhibiting DNA synthesis and activating apoptosis. J Cell Biochem 84 3 (2002) 532-544
28. Fong W.F., Tse A.K., Poon K.H., and Wang C. Magnolol and honokiol enhance HL-60 human leukemia cell differentiation induced by 1,25-dihydroxyvitamin D3 and retinoic acid. Int J Biochem Cell Biol 37 2 (2005) 427-441
29. Chen J.H., Wu C.C., Hsiao G., and Yen M.H. Magnolol induces apoptosis in vascular smooth muscle. Naunyn Schmiedebergs Arch Pharmacol 398 2 (2003) 127-133
30. Chen Y.H., Lin S.J., Chen J.W., Ku H.H., and Chen Y.L. Magnolol attenuates VCAM-1 expression in vitro in TNF-alpha-treated human aortic endothelial cells and in vivo in the aorta of cholesterol-fed rabbits. Br J Pharmacol 135 1 (2002) 37-47
31. Nagase H., Ikeda K., and Sakai Y. Inhibitory effect of magnolol and honokiol from Magnolia obovata on human fibrosarcoma HT-1080. Invasiveness in vitro. Planta Med 67 8 (2001) 705-708
32. Chen Y.L., Lin K.F., Shiao M.S., Chen Y.T., Hong C.Y., and Lin S.J. Magnolol, a potent antioxidant from Magnolia officinalis, attenuates intimal thickening and MCP-1 expression after balloon injury of the aorta in cholesterol-fed rabbits. Basic Res Cardiol 96 4 (2001) 353-363
33. Moon S.K., Cho G.O., Jung S.Y., Gal S.W., Kwon T.K., Lee Y.C., et al. Quercetin exerts multiple inhibitory effects on vascular smooth muscle cells: role of ERK1/2, cell-cycle regulation, and matrix metalloproteinase-9. Biochem Biophys Res Commun 301 (2003) 1069-1078
34. Wu C.H., Chen C.W., Chen H.C., Chang W.C., Shu M.J., and Hung J.S. Elucidating the inhibitory mechanisms of magnolol on rat smooth muscle cell proliferation. J Pharmacol Sci 99 4 (2005) 392-399
35. Huang S.H., Shen W.J., Yeo H.L., and Wang S.M. Signaling pathway of magnolol-stimulated lipolysis in sterol ester-loaded 3T3-L1 Preadipocyes. J Cell Biochem 91 5 (2004) 1021-1029
36. Hsu Y.F., Lee T.S., Lin S.Y., Hsu S.P., Juan S.H., Hsu Y.H., et al. Involvement of Ras/Raf-1/ERK actions in the mognolol-induced upregulation of p21 and cell-cycle arrest in colon cancer cells. Mol Carcinog 46 4 (2007) 275-283