Protein misfolding and aggregation

Biotechnology Progress

Volumn 23, Issue 3, 2007, Pages 548-552

  Murphy, Regina M ^a   Kendrick, Brent S ^b  

^a University of Wisconsin Madison   (United States)

^b AMGEN INC   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

AMINO ACIDS; COMPUTATIONAL METHODS; DISEASES; MATHEMATICAL MODELS;

DEGENERATIVE DISEASES; PROTEIN MISFOLDING;

PROTEIN FOLDING;

PROTEIN;

ARTICLE; BIOLOGICAL MODEL; CHEMICAL STRUCTURE; CHEMISTRY; METABOLISM; PROTEIN DENATURATION; PROTEIN FOLDING; PROTEIN SECONDARY STRUCTURE;

MODELS, BIOLOGICAL; MODELS, MOLECULAR; PROTEIN DENATURATION; PROTEIN FOLDING; PROTEIN STRUCTURE, SECONDARY; PROTEINS;

EID: 34250376918     PISSN: 87567938     EISSN: None     Source Type: Journal    
DOI: 10.1021/bp060374h     Document Type: Article

References (43)

1. Hart, P. J. Pathogenic superoxide dismutase structure, folding, aggregation and turnover. Curr. Opin. Chem. Biol. 2006, 10, 131-138.
2. Chi, E. Y.; Krishnan, S.; Randolph, T. W.; Carpenter, J. F. Physical stability of proteins in aqueous solution: Mechanism and driving forces in nonnative protein aggregation. Pharm. Res. 2003, 20, 1325-1336.
3. Cromwell, M. E. M.; Hilario, E.; Jacobsen, F. Protein aggregation and bioprocessing. Am. Assoc. Pharm. Sci. J. 2006, 8, E572-E579.
4. Rosenberg, A. S. Effects of protein aggregates: An immunologic perspective. Am. Assoc. Pharm. Sci. J. 2006, 8, E501-E507.
5. Chiti, F.; Dobson, C. M. Protein misfolding, functional amyloid, and human disease. Annu. Rev. Biochem. 2006, 75, 333-366.
6. Inouye, H.; Fraser, P. E.; Kirschner, D. A. Structure of beta-crystallite assemblies formed by Alzheimer beta-amyloid protein analogs-Analysis by X-ray diffraction. Biophys. J. 1993, 64, 502-519.
7. Malinchik, S. B.; Inouye, H.; Szumowski, K. E.; Kirschner, D. A. Structural analysis of Alzheimer's beta(1-40) amyloid: Protofilament assembly of tubular fibrils. Biophys. J. 1998, 74, 537-545.
8. Perutz, M. F.; Finch, J. T.; Berriman, J.; Lesk, A, Amyloid fibers are water-filled nanotubes. Proc. Natl. Acad. Sci. U.S.A. 2002, 99, 5591-5595.
9. Sikorski, P.; Atkins, E. New model for crystalline polyglutamine assemblies and their connection with amyloid fibrils. Biomacromolecules 2005, 6, 425-432.
10. Makin, O. S.; Atkins, E.; Sikorski, P.; Johansson, J.; Serpell, L. C. Molecular basis for amyloid fibril formation and stability. Proc. Natl Acad. Sci. U.S.A. 2005, 102, 315-320.
11. Diaz-Avalos, R.; Long, C.; Fontano, E.; Balbirne, M.; Grothe, R.; Eisenberg, D.; Caspar, D. L. D. Cross-beta order and diversity in nanocrystals of an amyloid-forming peptide. J. Mol. Biol. 2003, 330, 1165-1175.
12. Nelson, R.; Eisenberg, D. Recent atomic models of amyloid fibril structure. Curr. Opin. Struct. Biol. 2006, 16, 260-265.
13. Tycko, R. Molecular structure of amyloid fibrils: insights from solid-state NMR. Quart. Rev. Biophys. 2006, 39, 1-55.
14. Benzinger, T. L. S.; Gregory, D. M.; Burkoth, T. S.; Miller-Auer, H.; Lynn, D. G.; Botto, R. E.; Meredith, S. C. Two-dimensional structure of beta-amyloid(10-35) fibrils. Biochemistry 2000, 39, 3491-3499.
15. Petkova, A. T.; Leapman, R. D.; Guo, Z. H.; Yau, W. M.; Mattson, M. P.; Tycko, R. Self-propagating, molecular-level polymorphism in Alzheimer's beta-amyloid fibrils. Science 2005, 307, 262-265.
16. Tobler, S. A.; Holmes, S. A.; Cromwell, B. W.; Fernandez, M. E. M.; Benzyl E. J. alcohol-induced destabilization of interferon-gamma: A study by hydrogen-deuterium isotope exchange. J. Pharm. Sci. 2004, 93, 1605-1617.
17. Myers, S. L.; Thomson, N. H.; Radford, S. E.; Ashcroft, A. E. Investigating the structural properties of amyloid-like fibrils formed in vitro from beta 2-microglobulin using limited proteolysis and electrospray ionisation mass spectrometry. Rapid Commun. Mass Spectrom. 2006, 20, 1628-1636.
18. Jimenez, J. L.; Nettleton, E. J.; Bouchard, M.; Robinson, C. V.; Dobson C. M.; Saibil, H. R. The protofilament structure of insulin amyloid fibrils. Proc. Natl. Acad. Sci. U.S.A. 2002, 99, 9196-9201.
19. Ramzi, A.; Sutter, M.; Hennink, W. E.; Jiskost, W. Static light scattering and small-angle neutron scattering study on aggregated recombinant gelatin in aqueous solution. J. Pharm. Sci. 2006, 95, 1703-1711.
20. Frare, E.; Mossuto, M. F.; de Laureto, P. P.; Dumoulin, M.; Dobson, C. M.; Fontana, A. Identification of the core structure of lysozyme amyloid fibrils by proteolysis. J. Mol. Biol. 2006, 361, 551-561.
21. Yan, Y.-B.; Zhang, J.; He, H.-W.; Zhou, H.-M. Oligomerization and aggregation of bovine pancreatic ribonuclease A: characteristic events observed by FTIR spectroscopy. Biophys. J. 2006, 90, 2525-2533.
22. Williams, A. D.; Shivaprasad, S.; Wetzel, R. Alanine scanning mutagenesis of Abeta(1-40) amyloid fibril stability. J. Mol. Biol. 2006, 357, 1283-1294.
23. Ross, C. A.; Poirier, M. A. Protein aggregation and neurodegenerative disease. Nat. Med. 2004, July (10 Suppl.), S10-S17.
24. Hermeling S.; Schellekens, H.; Maas, C.; Gebbink, M. F. B. G.; Cronimelin, D. I. A.; Jiskoot, W. Antibody response to aggregated human interferon alpha2b in wild-type and transgenic immune tolerant mice depends on type and level of aggregation. J. Pharm. Sci. 2006, 95, 1084-1096.
25. Kelly, J. W. Mechanisms of amyloidogenesis. Nat. Struct. Biol. 2000, 7, 824-826.
26. Lashuel, H. A.; Lai, Z. H.; Kelly, J. W. Characterization of the transthyretin acid denaturation pathways by analytical ultracentrifugation: Implications for wild-type, V30M, and L55P amyloid fibril formation. Biochemistry 1998, 37, 17851-17864.
27. Ahmad, A.; Millett, I. S.; Doniach, S.; Uversky, V. N.; Fink, A. L. Partially folded intermediates in insulin fibrillation. Biochemistry 2003, 42, 11404-11416.
28. Gibson, T. J.; Murphy, R. M. Design of peptidyl compounds that affect beta-amyloid aggregation: Importance of surface tension and contex. Biochemistry 2005, 44, 8898-8907.
29. Kim, J. R.; Gibson, T. J.; Murphy, R. M. Targeted control of kinetics of beta-amyloid self-association by surface tension-modifying peptides. J. Biol. Chem. 2003, 278, 40730-40735.
30. Kim, J. R.; Gibson, T. J.; Murphy, R. M. Predicting solvent and aggregation effects of peptides using group contribution calculations. Biotechnol. Prog. 2006, 22, 605-608.
31. Winzor, C. L.; Winzor, D. J.; Paleg, L. G.; Jones, G. P.; Naidu, B. P. Rationalization of the effects of compatable solutes on protein stability in terms of thermodynamic nonideality. Arch. Biochem. Biophys. 1992, 296, 102-107.
32. Hall, D. R.; Jacobsen, M. P.; Winzor, D. J. Stabilizing effect of sucrose against irreversible denaturation of rabbit muscle lactate dehydrogenase. Biophys. Chem. 1995, 57, 47-54.
33. Kendrick, B. S.; Cleland, J. L.; Lam, X.; Nguyen, T.; Randolph, T. W.; Manning, M. C.; Carpenter, J. F. Aggregation of recombinant human interferon gamma: Kinetics and structural transitions. J. Pharm. Sci. 1998, 87, 1069-1076.
34. Chi, E. Y.; Krishnan, S.; Kendrick, B. S.; Chang, B. S.; Carpenter, J. F.; Randolph, T. W. Roles of conformational stability and colloidal stability in the aggregation of recombinant human granulocyte colony-stimulating factor. Protein Sci. 2003, 12, 903-913.
35. Nettleton, E. J.; Tito, P.; Sunde, M.; Bouchard, M.; Dobson, C. M.; Robinson, C. V. Characterization of the oligomeric states of insulin in self-assembly and amyloid fibril formation by mass spectrometry. Biophys. J. 2000, 79, 1053-1065.
36. Misbehaving Proteins: Protein (Mis)Folding, Aggregation, and Stability; Murphy, R. M., Tsai, A. M., Eds.; Springer: New York, 2006.
37. Ferrone, F. Analysis of protein aggregation kinetics. Methods Enzymol. 1999, 309, 256-274.
38. Zanuy, D.; Gunasekaran, K.; Lesk, A. M.; Nussinov, R. Computational study of the fibril organization of polyglutamine repeats reveals a common motif identified in beta-helices. J. Mol. Biol. 2006, 358, 330-345.
39. Armen, R. S.; Daggett, V. Characterization of two distinct beta-(2)-microglobulin unfolding intermediates that may lead to amyloid fibrils of different morphology. Biochemistry 2005, 44, 16098-16107.
40. Wang, X. L.; Vitalis, A.; Wyczalkowski, M. A.; Pappu, R. V. Characterizing the conformational ensemble of monomelic polyglutamine. Proteins: Struct., Funct., Bioinform. 2006, 63, 297-311.
41. Nguyen, H. D.; Hall, C. K. Kinetics of fibril formation by polyalanine peptides. J. Biol. Chem. 2005, 280, 9074-9082.
42. Fernandez-Escamilla, A. M.; Rousseau, F.; Schymkowitz, J.; Serrano, L. Prediction of sequence-dependent and mutational effects on the aggregation of peptides and proteins. Nat. Biotechnol. 2004, 22, 1302-1306.
43. Tartaglia, G. G.; Cavalli, A.; Pellarin, R.; Caflisch, A. The role of aromaticity, exposed surface, and dipole moment in determining protein aggregatin rates. Protein Sci. 2004, 13, 1939-1941.