Activity and post antifungal effect of chlorpromazine and trifluopherazine against Aspergillus, Scedosporium and zygomycetes

Mycoses

Volumn 50, Issue 4, 2007, Pages 270-276

  Vitale, Roxana G ^a   Afeltra, Javier ^a   Meis, Jacques F G M ^b   Verweij, Paul E ^a  

^a RADBOUD UNIVERSITY MEDICAL CENTER   (Netherlands)

^b CANISIUS WILHELMINA HOSPITAL   (Netherlands)

Author keywords

Aspergillus; Chlorpromazine; Postantifungal effect; Scedosporium; Trifluopherazine; Zygomycetes

Indexed keywords

CHLORPROMAZINE; TRIFLUOPERAZINE;

ABSIDIA; ANTIBIOTIC SENSITIVITY; ANTIFUNGAL ACTIVITY; ARTICLE; ASPERGILLUS; ASPERGILLUS FUMIGATUS; CONCENTRATION (PARAMETERS); CONTROLLED STUDY; DRUG MECHANISM; NONHUMAN; PRIORITY JOURNAL; RHIZOPUS MICROSPORUS; RHIZOPUS ORYZAE; SCEDOSPORIUM; SCEDOSPORIUM APIOSPERMUM; SCEDOSPORIUM PROLIFICANS; ZYGOMYCETES;

ANTIFUNGAL AGENTS; ASPERGILLUS; CHLORPROMAZINE; MICROBIAL SENSITIVITY TESTS; SCEDOSPORIUM; SPORES, FUNGAL; TIME FACTORS; TRIFLUOPERAZINE; ZYGOMYCOTA;

ASPERGILLUS; FUNGI; PROTOZOA; SCEDOSPORIUM; ZYGOMYCETES;

EID: 34250374437     PISSN: 09337407     EISSN: 14390507     Source Type: Journal    
DOI: 10.1111/j.1439-0507.2007.01371.x     Document Type: Article

References (29)

1. Walsh TJ, Groll AH. Emerging fungal pathogens: evolving challenges to immunocompromised patients for the twenty-first century. Transpl Infect Dis 1999 1 : 247 61.
2. Ingram CW, Sennesh J, Cooper JN, Perfect JR. Disseminated zygomycosis: report of four cases and review. Rev Infect Dis 1989 11 : 741 54.
3. Carrillo AJ, Guarro J. In vitro activities of four novel triazoles against Scedosporium spp. Antimicrob Agents Chemother 2001 45 : 2151 3.
4. Montero A, Cohen JE, Fernandez MA, Mazzolini G, Gomez CR, Perugini J. Cerebral pseudallescheriasis due to Pseudallescheria boydii as the first manifestation of AIDS. Clin Infect Dis 1998 26 : 1476 7.
5. Berenguer J, Rodriguez-Tudela JL, Richard C et al. Deep infections caused by Scedosporium prolificans. A report on 16 cases in Spain and a review of the literature. Scedosporium prolificans Spanish Study Group. Medicine (Baltimore) 1997 76 : 256 65.
6. Boogaerts M, Winston DJ, Bow EJ et al. Intravenous and oral itraconazole versus intravenous amphotericin B deoxycholate as empirical antifungal therapy for persistent fever in neutropenic patients with cancer who are receiving broad-spectrum antibacterial therapy. A randomized, controlled trial. Ann Intern Med 2001 135 : 412 22.
7. Ribes JA, Vanover-Sams CL, Baker DJ. Zygomycetes in human disease. Clin Microbiol Rev 2000 13 : 236 301.
8. Kantesaria P, Marfey P. The effect of chlorpromazine on some properties of DNA in solution. Physiol Chem Phys 1975 7 : 53 67.
9. Levin RM, Weiss B. Selective binding of antipsychotics and other psychoactive agents to the calcium-dependent activator of cyclic nucleotide phosphodiesterase. J Pharmacol Exp Ther 1979 208 : 454 9.
10. Joseph JD, Means AR. Calcium binding is required for calmodulin function in Aspergillus nidulans. Eukaryot Cell 2002 1 : 119 25.
11. Hubbard M, Bradley M, Sullivan P, Shepherd M, Forrester I. Evidence for the occurrence of calmodulin in the yeasts Candida albicans and Saccharomyces cerevisiae. FEBS Lett 1982 137 : 85 88.
12. Moser MJ, Lee SY, Klevit RE, Davis TN. Ca2+ binding to calmodulin and its role in Schizosaccharomyces pombe as revealed by mutagenesis and NMR spectroscopy. J Biol Chem 1995 270 : 20643 52.
13. Amaral L, Kristiansen JE. Phenothiazines: an alternative to conventional therapy for the initial management of suspected multidrug resistant tuberculosis. A call for studies. Int J Antimicrob Agents 2000 14 : 173 6.
14. Amaral L, Kristiansen JE, Viveiros M, Atouguia J. Activity of phenothiazines against antibiotic-resistant Mycobacterium tuberculosis: a review supporting further studies that may elucidate the potential use of thioridazine as anti-tuberculosis therapy. J Antimicrob Chemother 2001 47 : 505 11.
15. Bettencourt MV, Bosne-David S, Amaral L. Comparative in vitro activity of phenothiazines against multidrug-resistant Mycobacterium tuberculosis. Int J Antimicrob Agents 2000 16 : 69 71.
16. Eilam Y, Polacheck I, Ben-Gigi G, Chernichovsky D. Activity of phenothiazines against medically important yeasts. Antimicrob Agents Chemother 1987 31 : 834 6.
17. Sharma S, Kaur H, Khuller GK. Cell cycle effects of the phenothiazines: trifluoperazine and chlorpromazine in Candida albicans. FEMS Microbiol Lett 2001 199 : 185 90.
18. Wang Y, Casadevall A. Susceptibility of melanized and nonmelanized Cryptococcus neoformans to the melanin-binding compounds trifluoperazine and chloroquine. Antimicrob Agents Chemother 1996 40 : 541 5.
19. Wood NC, Nugent KM. Inhibitory effects of chlorpromazine on Candida species. Antimicrob Agents Chemother 1985 27 : 692 4.
20. National Committee for Laboratory Standards. Reference method for broth dilution antifungal susceptibility testing filamentous fungi; approved standard. M-38A. Wayne, PA : National Committee for Clinical Laboratory Standards, 2002.
21. Vitale RG, Mouton JW, Afeltra J, Meis JF, Verweij PE. Method for measuring postantifungal effect in Aspergillus species. Antimicrob Agents Chemother 2002 46 : 1960 5.
22. Forrest IS, Bolt AG, Serra MT. Distribution of chlorpromazine metabolites in selected organs of psychiatric patients chronically dosed up to the time of death. Biochem Pharmacol 1968 17 : 2061 70.
23. Forrest IS, Green DE. Phenothiazines: metabolism and analytical detection. J Forensic Sci 1972 17 : 592 617.
24. Amaral L, Kristiansen J, Lorian V. Synergic effect of chlorpromazine on the activity of some antibiotics. J Antimicrob Chemother 1992 30 : 556 8.
25. Ellepola AN, Samaranayake LP. The in vitro post-antifungal effect of nystatin on Candida species of oral origin. J Oral Pathol Med 1999 28 : 112 6.
26. Ellepola AN, Samaranayake LP. The postantifungal effect (PAFE) of antimycotics on oral C. albicans isolates and its impact on candidal adhesion. Oral Dis 1998 4 : 260 7.
27. Ernst EJ, Klepser ME, Pfaller MA. Postantifungal effects of echinocandin, azole, and polyene antifungal agents against Candida albicans and Cryptococcus neoformans. Antimicrob Agents Chemother 2000 44 : 1108 11.
28. Kristiansen JE. The antimicrobial activity of psychotherapeutic drugs and stereo-isomeric analogues. Dan Med Bull 1990 37 : 165 82.
29. Kolaczkowski M, Michalak K, Motohashi N. Phenothiazines as potent modulators of yeast multidrug resistance. Int J Antimicrob Agents 2003 22 : 279 83.