Antimutagenic effect of broccoli flower head by the Ames Salmonella reverse mutation assay

Phytotherapy Research

Volumn 21, Issue 6, 2007, Pages 545-547

  Murugan, S S ^a   Balakrishnamurthy, P ^a   Mathew, Y J ^a  

^a International Institute of Biotechnology and Toxicology   (India)

Author keywords

Ames assay; Antimutagenic effect; Broccoli flower head; Chemical mutagens; Ethanol extract; Phytomolecules

Indexed keywords

ANTIMUTAGENIC AGENT;

AMES TEST; ARTICLE; BACTERIAL STRAIN; BROCCOLI; CYTOTOXICITY; DRUG MECHANISM; FLOWER; NONHUMAN; REVERTANT; SALMONELLA;

ANTIMUTAGENIC AGENTS; BRASSICA; DOSE-RESPONSE RELATIONSHIP, DRUG; MUTAGENICITY TESTS; MUTAGENS; PLANT EXTRACTS; SALMONELLA;

BRASSICA OLERACEA VAR. ITALICA; SALMONELLA;

EID: 34250370769     PISSN: 0951418X     EISSN: 10991573     Source Type: Journal    
DOI: 10.1002/ptr.2104     Document Type: Article

References (13)

1. Ames BN, McCann J, Yamasaki E. 1975. Method for detecting carcinogens and mutagens with the Salmonella/mammalian-microsome mutagenicity test. Mutat Res 31: 347-364.
2. Bradlow HL, Sepkovic DW, Telang NT, Osborne MP. 1999. Multifunctional aspects of the action of indole-3-carbinol as an antitumor agent. Ann N Y Acad Sci 889: 204-213.
3. Broadbent TA, Broadbent HS. 1998. The chemistry and pharmacology of indole-3-carbinol (indole-3-methanol) and 3-methoxymethyl) indole. Curr Med Chem 5: 469-491.
4. Claxton LD, Allen J, Auletta A, Moetelmans K, Nestmann E, Zeiger E. 1987. Guide for the Salmonella typhimurium/mammalian microsome test for the bacterial mutagenicity. Mutat Res 189: 83-91.
5. Fahey JW, Zhang Y, Talalya P. 1997. Broccoli sprouts: An exceptionally rich source of inducers of enzymes that protect against chemical carcinogens. Proc Natl Acad Sci 94: 10367-10372.
6. Maron DM, Ames BN. 1983. Revised method for Salmonella mutagenicity test. Mutat Res 113: 173-215.
7. Martinez A, Cambero II, Ikken Y, Marin ML, Haza AI, Morales P. 1998. Protective effect of broccoli, onion, carrot, and licorice extracts against cytotoxicity of N-nitrosamines evaluated by 3-(4,5-dimethylthiazol-2-yl)-2,5- diphenyltetrazolium bromide assay. J Agric Food Chem 46: 585-589.
8. Meshram GP, Padma Maline R, Kola M Rao. 1992. Mutagenicity of N,N-dimethylurea and methylamine hydrochloride in the Ames Salmonella/microsome test: absence of mutagenic response. Mutat Res 279: 275-279.
9. Shishu, Kaur IP. 2003. Inhibition of mutagenicity of food-derived heterocyclic amines by sulforaphane - a constituent of broccoli. Indian J Exp Biol 41: 216-219.
10. Talalay P, Fahey JW. 2001. Phytochemicals from cruciferous plants protect against cancer by modulating carcinogen metabolism. Am Soc Nutr Sci J Nutr 131: 3027S-3033S.
11. Vainio H, Bianchini F. 2005. Cruciferous vegetables, isothiocyanates and indoles. IARC Handbooks of Cancer Prevention Volume 9. Oxford University Press: Lyon, France.
12. Wettenberg L. 1978. Inhibition of polyaromatic hydrocarbon-induced neoplasia by naturally occurring indoles. Cancer Res 38: 1410-1413.
13. Zeligs M. 1998. Diet and estrogen: the crucifer connection. J Med Food 1: 67-82.