-
1
-
-
0029868593
-
The interaction of coumarin antibiotics with fragments of DNA gyrase B protein
-
Gormley N.A., Orphanides G., Meyer A., Cullis P.M., and Maxwell A. The interaction of coumarin antibiotics with fragments of DNA gyrase B protein. Biochemistry 35 (1996) 5083-5092
-
(1996)
Biochemistry
, vol.35
, pp. 5083-5092
-
-
Gormley, N.A.1
Orphanides, G.2
Meyer, A.3
Cullis, P.M.4
Maxwell, A.5
-
2
-
-
0033573856
-
Probing the binding of coumarins and cyclothilidines to DNA gyrase
-
Kampranis S.C., Gormley N.A., Tranter R., Orphanides G., and Maxwell A. Probing the binding of coumarins and cyclothilidines to DNA gyrase. Biochemistry 38 (1999) 1967-1976
-
(1999)
Biochemistry
, vol.38
, pp. 1967-1976
-
-
Kampranis, S.C.1
Gormley, N.A.2
Tranter, R.3
Orphanides, G.4
Maxwell, A.5
-
3
-
-
0012684806
-
The ATP-binding site of type II topoisomerases as a target for antibacterial drugs
-
Maxwell A., and Lawson D.M. The ATP-binding site of type II topoisomerases as a target for antibacterial drugs. Curr. Top. Med. Chem. 3 (2003) 283-303
-
(2003)
Curr. Top. Med. Chem.
, vol.3
, pp. 283-303
-
-
Maxwell, A.1
Lawson, D.M.2
-
4
-
-
0031407768
-
DNA Gyrase, topoisomerase IV, and the 4-quinolones
-
Drlica K., and Zhao X. DNA Gyrase, topoisomerase IV, and the 4-quinolones. Microbiol. Mol. Biol. Rev. 61 (1997) 377-392
-
(1997)
Microbiol. Mol. Biol. Rev.
, vol.61
, pp. 377-392
-
-
Drlica, K.1
Zhao, X.2
-
5
-
-
0029846117
-
ParC subunit of DNA topoisomerase IV of Streptomyces pneumoniae is the primary target of fluoroquinolones and cooperates with DNA gyrase A subunit in forming resistance phenotype
-
Munoz R., and De La Campa A.G. ParC subunit of DNA topoisomerase IV of Streptomyces pneumoniae is the primary target of fluoroquinolones and cooperates with DNA gyrase A subunit in forming resistance phenotype. Antimicrob. Agents Chemother. 40 (1996) 2252-2257
-
(1996)
Antimicrob. Agents Chemother.
, vol.40
, pp. 2252-2257
-
-
Munoz, R.1
De La Campa, A.G.2
-
6
-
-
0028068693
-
Crystallization of inhibitor complexes of an N-terminal 24 kDa fragment of the DNA gyrase B protein
-
Lewis R.J., Singh O.M., Smith C.V., Maxwell A., Skarzynski T., Wonacott A.J., and Wigley D.B. Crystallization of inhibitor complexes of an N-terminal 24 kDa fragment of the DNA gyrase B protein. J. Mol. Biol. 241 (1994) 128-130
-
(1994)
J. Mol. Biol.
, vol.241
, pp. 128-130
-
-
Lewis, R.J.1
Singh, O.M.2
Smith, C.V.3
Maxwell, A.4
Skarzynski, T.5
Wonacott, A.J.6
Wigley, D.B.7
-
7
-
-
0029978822
-
The nature of inhibition of DNA gyrase by the coumarins and the cyclothialidines revealed by X-ray crystallography
-
Lewis R.J., Singh O.M., Smith C.V., Skarzynski T., Maxwell A., Wonacott A.J., and Wigley D.B. The nature of inhibition of DNA gyrase by the coumarins and the cyclothialidines revealed by X-ray crystallography. EMBO J. 15 (1996) 1412-1420
-
(1996)
EMBO J.
, vol.15
, pp. 1412-1420
-
-
Lewis, R.J.1
Singh, O.M.2
Smith, C.V.3
Skarzynski, T.4
Maxwell, A.5
Wonacott, A.J.6
Wigley, D.B.7
-
8
-
-
0030893658
-
The high-resolution crystal structure of a 24-kDa gyrase B fragment from E. coli complexed with one of the most potent coumarin inhibitors, clorobiocin
-
Tsai F.T., Singh O.M., Skarzynski T., Wonacott A.J., Weston S., Tucker A., Pauptit R.A., Breeze A.L., Poyser J.P., O'Brien R., et al. The high-resolution crystal structure of a 24-kDa gyrase B fragment from E. coli complexed with one of the most potent coumarin inhibitors, clorobiocin. Proteins 28 (1997) 41-52
-
(1997)
Proteins
, vol.28
, pp. 41-52
-
-
Tsai, F.T.1
Singh, O.M.2
Skarzynski, T.3
Wonacott, A.J.4
Weston, S.5
Tucker, A.6
Pauptit, R.A.7
Breeze, A.L.8
Poyser, J.P.9
O'Brien, R.10
-
9
-
-
0141734260
-
Studies on coumermycin: a new antibiotic. II. Structure of coumermycin A1
-
Kawaguchi H., Naito T., and Tsukiura H. Studies on coumermycin: a new antibiotic. II. Structure of coumermycin A1. J. Antibiot. (Tokyo) 18 (1965) 11-25
-
(1965)
J. Antibiot. (Tokyo)
, vol.18
, pp. 11-25
-
-
Kawaguchi, H.1
Naito, T.2
Tsukiura, H.3
-
10
-
-
0036953085
-
Molecular cloning and sequence analysis of the clorobiocin biosynthetic gene cluster: new insights into the biosynthesis of aminocoumarin antibiotics
-
Pojer F., Li S.-M., and Heide L. Molecular cloning and sequence analysis of the clorobiocin biosynthetic gene cluster: new insights into the biosynthesis of aminocoumarin antibiotics. Microbiol. 148 (2002) 3901-3911
-
(2002)
Microbiol.
, vol.148
, pp. 3901-3911
-
-
Pojer, F.1
Li, S.-M.2
Heide, L.3
-
11
-
-
0034048695
-
Identification of the novobiocin biosynthetic gene cluster of Streptomyces spheroides NCIB 11891
-
Steffensky M., Muhlenweg A., Wang Z.-X., Li S.-M., and Heide L. Identification of the novobiocin biosynthetic gene cluster of Streptomyces spheroides NCIB 11891. Antimicrob. Agents Chemother. 44 (2000) 1214-1222
-
(2000)
Antimicrob. Agents Chemother.
, vol.44
, pp. 1214-1222
-
-
Steffensky, M.1
Muhlenweg, A.2
Wang, Z.-X.3
Li, S.-M.4
Heide, L.5
-
12
-
-
0033743319
-
Identification of the coumermycin A1 biosynthetic gene cluster of Streptomyces rishiriensis DSM 40489
-
Wang Z.-X., Li S.-M., and Heide L. Identification of the coumermycin A1 biosynthetic gene cluster of Streptomyces rishiriensis DSM 40489. Antimicrob. Agents Chemother. 44 (2000) 3040-3048
-
(2000)
Antimicrob. Agents Chemother.
, vol.44
, pp. 3040-3048
-
-
Wang, Z.-X.1
Li, S.-M.2
Heide, L.3
-
13
-
-
0037350329
-
Clorobiocin biosynthesis in Streptomyces: identification of the halogenase and generation of structural analogs
-
Eustaquio A.S., Gust B., Luft T., Li S.M., Chater K.F., and Heide L. Clorobiocin biosynthesis in Streptomyces: identification of the halogenase and generation of structural analogs. Chem. Biol. 10 (2003) 279-288
-
(2003)
Chem. Biol.
, vol.10
, pp. 279-288
-
-
Eustaquio, A.S.1
Gust, B.2
Luft, T.3
Li, S.M.4
Chater, K.F.5
Heide, L.6
-
14
-
-
33750385204
-
The biosynthetic gene clusters of aminocoumarin antibiotics
-
Li S.M., and Heide L. The biosynthetic gene clusters of aminocoumarin antibiotics. Planta. Med. 72 (2006) 1093-1099
-
(2006)
Planta. Med.
, vol.72
, pp. 1093-1099
-
-
Li, S.M.1
Heide, L.2
-
15
-
-
0036773122
-
Methyltransferase genes in Streptomyces rishiriensis: new coumermycin derivatives from gene-inactivation experiments
-
Li S.M., Westrich L., Schmidt J., Kuhnt C., and Heide L. Methyltransferase genes in Streptomyces rishiriensis: new coumermycin derivatives from gene-inactivation experiments. Microbiol. 148 (2002) 3317-3326
-
(2002)
Microbiol.
, vol.148
, pp. 3317-3326
-
-
Li, S.M.1
Westrich, L.2
Schmidt, J.3
Kuhnt, C.4
Heide, L.5
-
16
-
-
0037418178
-
CloQ, a prenyltransferase involved in clorobiocin biosynthesis
-
Pojer F., Wemakor E., Kammerer B., Chen H., Walsh C.T., Li S.M., and Heide L. CloQ, a prenyltransferase involved in clorobiocin biosynthesis. Proc. Natl. Acad. Sci. USA 100 (2003) 2316-2321
-
(2003)
Proc. Natl. Acad. Sci. USA
, vol.100
, pp. 2316-2321
-
-
Pojer, F.1
Wemakor, E.2
Kammerer, B.3
Chen, H.4
Walsh, C.T.5
Li, S.M.6
Heide, L.7
-
17
-
-
0042469302
-
CloN6, a novel methyltransferase catalysing the methylation of the pyrrole-2-carboxyl moiety of clorobiocin
-
Westrich L., Heide L., and Li S.M. CloN6, a novel methyltransferase catalysing the methylation of the pyrrole-2-carboxyl moiety of clorobiocin. ChemBioChem 4 (2003) 768-773
-
(2003)
ChemBioChem
, vol.4
, pp. 768-773
-
-
Westrich, L.1
Heide, L.2
Li, S.M.3
-
18
-
-
0042925577
-
CloN2, a novel acyltransferase involved in the attachment of the pyrrole-2-carboxyl moiety to the deoxysugar of clorobiocin
-
Xu H., Kahlich R., Kammerer B., Heide L., and Li S.M. CloN2, a novel acyltransferase involved in the attachment of the pyrrole-2-carboxyl moiety to the deoxysugar of clorobiocin. Microbiol. 149 (2003) 2183-2191
-
(2003)
Microbiol.
, vol.149
, pp. 2183-2191
-
-
Xu, H.1
Kahlich, R.2
Kammerer, B.3
Heide, L.4
Li, S.M.5
-
19
-
-
0036434426
-
Genetic analysis of the biosynthesis of the pyrrole and carbamoyl moieties of coumermycin A1 and novobiocin
-
Xu H., Wang Z.X., Schmidt J., Heide L., and Li S.M. Genetic analysis of the biosynthesis of the pyrrole and carbamoyl moieties of coumermycin A1 and novobiocin. Mol. Genet. Genomics 268 (2002) 387-396
-
(2002)
Mol. Genet. Genomics
, vol.268
, pp. 387-396
-
-
Xu, H.1
Wang, Z.X.2
Schmidt, J.3
Heide, L.4
Li, S.M.5
-
20
-
-
33746068735
-
Acyl transfer in clorobiocin biosynthesis: Involvement of several proteins in the transfer of the pyrrole-2-carboxyl moiety to the deoxysugar
-
Freitag A., Wemakor E., Li S.-M., and Heide L. Acyl transfer in clorobiocin biosynthesis: Involvement of several proteins in the transfer of the pyrrole-2-carboxyl moiety to the deoxysugar. ChemBioChem 6 (2005) 2316-2325
-
(2005)
ChemBioChem
, vol.6
, pp. 2316-2325
-
-
Freitag, A.1
Wemakor, E.2
Li, S.-M.3
Heide, L.4
-
21
-
-
8844224923
-
Production of 8′-halogenated and 8′-unsubstituted novobiocin derivatives in genetically engineered streptomyces coelicolor strains
-
Eustaquio A.S., Gust B., Li S.M., Pelzer S., Wohlleben W., Chater K.F., and Heide L. Production of 8′-halogenated and 8′-unsubstituted novobiocin derivatives in genetically engineered streptomyces coelicolor strains. Chem. Biol. 11 (2004) 1561-1572
-
(2004)
Chem. Biol.
, vol.11
, pp. 1561-1572
-
-
Eustaquio, A.S.1
Gust, B.2
Li, S.M.3
Pelzer, S.4
Wohlleben, W.5
Chater, K.F.6
Heide, L.7
-
22
-
-
1842865010
-
New aminocoumarin antibiotics from a cloQ-defective mutant of the clorobiocin producer Streptomyces roseochromogenes DS12.976
-
Freitag A., Galm U., Li S.M., and Heide L. New aminocoumarin antibiotics from a cloQ-defective mutant of the clorobiocin producer Streptomyces roseochromogenes DS12.976. J. Antibiot. (Tokyo) 57 (2004) 205-209
-
(2004)
J. Antibiot. (Tokyo)
, vol.57
, pp. 205-209
-
-
Freitag, A.1
Galm, U.2
Li, S.M.3
Heide, L.4
-
23
-
-
33749434635
-
Metabolic engineering of the heterologous production of clorobiocin derivatives and elloramycin in Streptomyces coelicolor M512
-
Freitag A., Mendez C., Salas J.A., Kammerer B., Li S.M., and Heide L. Metabolic engineering of the heterologous production of clorobiocin derivatives and elloramycin in Streptomyces coelicolor M512. Metab. Eng. 8 (2006) 653-661
-
(2006)
Metab. Eng.
, vol.8
, pp. 653-661
-
-
Freitag, A.1
Mendez, C.2
Salas, J.A.3
Kammerer, B.4
Li, S.M.5
Heide, L.6
-
24
-
-
23644445499
-
Metabolic engineering of aminocoumarins: inactivation of the methyltransferase gene cloP and generation of new clorobiocin derivatives in a heterologous host
-
Freitag A., Rapp H., Heide L., and Li S.M. Metabolic engineering of aminocoumarins: inactivation of the methyltransferase gene cloP and generation of new clorobiocin derivatives in a heterologous host. ChemBioChem 6 (2005) 1411-1418
-
(2005)
ChemBioChem
, vol.6
, pp. 1411-1418
-
-
Freitag, A.1
Rapp, H.2
Heide, L.3
Li, S.M.4
-
25
-
-
1542350250
-
In vitro and in vivo production of new aminocoumarins by a combined biochemical, genetic, and synthetic approach
-
Galm U., Dessoy M.A., Schmidt J., Wessjohann L.A., and Heide L. In vitro and in vivo production of new aminocoumarins by a combined biochemical, genetic, and synthetic approach. Chem. Biol. 11 (2004) 173-183
-
(2004)
Chem. Biol.
, vol.11
, pp. 173-183
-
-
Galm, U.1
Dessoy, M.A.2
Schmidt, J.3
Wessjohann, L.A.4
Heide, L.5
-
26
-
-
14544267242
-
New aminocoumarin antibiotics from genetically engineered Streptomyces strains
-
Li S.M., and Heide L. New aminocoumarin antibiotics from genetically engineered Streptomyces strains. Curr. Med. Chem. 12 (2005) 419-427
-
(2005)
Curr. Med. Chem.
, vol.12
, pp. 419-427
-
-
Li, S.M.1
Heide, L.2
-
27
-
-
2642518095
-
New aminocoumarin antibiotics formed by a combined mutational and chemoenzymatic approach utilizing the carbamoyltransferase NovN
-
Xu H., Heide L., and Li S.-M. New aminocoumarin antibiotics formed by a combined mutational and chemoenzymatic approach utilizing the carbamoyltransferase NovN. Chem. Biol. 11 (2004) 655-662
-
(2004)
Chem. Biol.
, vol.11
, pp. 655-662
-
-
Xu, H.1
Heide, L.2
Li, S.-M.3
-
28
-
-
14344261742
-
Characterization of the formation of the pyrrole moiety during clorobiocin and coumermycin A1 biosynthesis
-
Garneau S., Dorrestein P.C., Kelleher N.L., and Walsh C.T. Characterization of the formation of the pyrrole moiety during clorobiocin and coumermycin A1 biosynthesis. Biochemistry 44 (2005) 2770-2780
-
(2005)
Biochemistry
, vol.44
, pp. 2770-2780
-
-
Garneau, S.1
Dorrestein, P.C.2
Kelleher, N.L.3
Walsh, C.T.4
-
29
-
-
33746061680
-
Installation of the pyrrolyl-2-carboxyl pharmacophore by CouN1 and CouN7 in the late biosynthetic steps of the aminocoumarin antibiotics clorobiocin and coumermycin A1
-
Garneau-Tsodikova S., Stapon A., Kahne D., and Walsh C.T. Installation of the pyrrolyl-2-carboxyl pharmacophore by CouN1 and CouN7 in the late biosynthetic steps of the aminocoumarin antibiotics clorobiocin and coumermycin A1. Biochemistry 45 (2006) 8568-8578
-
(2006)
Biochemistry
, vol.45
, pp. 8568-8578
-
-
Garneau-Tsodikova, S.1
Stapon, A.2
Kahne, D.3
Walsh, C.T.4
-
30
-
-
0020360025
-
Effect of novobiocin, coumermycin A1, clorobiocin, and their analogs on Escherichia coli DNA gyrase and bacterial growth
-
Hooper D.C., Wolfson J.S., McHugh G.L., Winters M.B., and Swartz M.N. Effect of novobiocin, coumermycin A1, clorobiocin, and their analogs on Escherichia coli DNA gyrase and bacterial growth. Antimicrob. Agents Chemother. 22 (1982) 662-671
-
(1982)
Antimicrob. Agents Chemother.
, vol.22
, pp. 662-671
-
-
Hooper, D.C.1
Wolfson, J.S.2
McHugh, G.L.3
Winters, M.B.4
Swartz, M.N.5
-
31
-
-
77349086625
-
Characterization of NovP and NovN: completion of novobiocin biosynthesis by sequential tailoring of the noviosyl ring
-
Freel Meyers C.L., Oberthür M., Xu H., Heide L., Kahne D., and Walsh C.T. Characterization of NovP and NovN: completion of novobiocin biosynthesis by sequential tailoring of the noviosyl ring. Angew. Chem. Int. Ed. Engl. 43 (2004) 67-70
-
(2004)
Angew. Chem. Int. Ed. Engl.
, vol.43
, pp. 67-70
-
-
Freel Meyers, C.L.1
Oberthür, M.2
Xu, H.3
Heide, L.4
Kahne, D.5
Walsh, C.T.6
-
32
-
-
9744235772
-
Assembly of dimeric variants of coumermycins by tandem action of the four biosynthetic enzymes CouL, CouM, CouP, and NovN
-
Freel Meyers C.L., Oberthur M., Heide L., Kahne D., and Walsh C.T. Assembly of dimeric variants of coumermycins by tandem action of the four biosynthetic enzymes CouL, CouM, CouP, and NovN. Biochemistry 43 (2004) 15022-15036
-
(2004)
Biochemistry
, vol.43
, pp. 15022-15036
-
-
Freel Meyers, C.L.1
Oberthur, M.2
Heide, L.3
Kahne, D.4
Walsh, C.T.5
-
33
-
-
24144485937
-
Cryptic chlorination by a non-haem iron enzyme during cyclopropyl amino acid biosynthesis
-
Vaillancourt F.H., Yeh E., Vosburg D.A., O'Connor S.E., and Walsh C.T. Cryptic chlorination by a non-haem iron enzyme during cyclopropyl amino acid biosynthesis. Nature 436 (2005) 1191-1194
-
(2005)
Nature
, vol.436
, pp. 1191-1194
-
-
Vaillancourt, F.H.1
Yeh, E.2
Vosburg, D.A.3
O'Connor, S.E.4
Walsh, C.T.5
-
34
-
-
0345020337
-
SyrC, an enzyme involved in syringomycin biosynthesis, shows thioesterasic activity
-
Rudolf T.J.B.K., Mansfield J.W., Stead D., Vivian A., and Von Kietzell J. (Eds), Kluwer Academic Publishers, Dordrecht, The Netherlands
-
Grgurina I., Gross D.C., Delligiovas I., and Zhang J.H. SyrC, an enzyme involved in syringomycin biosynthesis, shows thioesterasic activity. In: Rudolf T.J.B.K., Mansfield J.W., Stead D., Vivian A., and Von Kietzell J. (Eds). Pseudomonas syringae Pathovars and Related Pathogens (1997), Kluwer Academic Publishers, Dordrecht, The Netherlands 192-197
-
(1997)
Pseudomonas syringae Pathovars and Related Pathogens
, pp. 192-197
-
-
Grgurina, I.1
Gross, D.C.2
Delligiovas, I.3
Zhang, J.H.4
-
35
-
-
34250357946
-
CmaE: a transferase shuttling aminoacyl groups between carrier protein domains in the coronamic acid biosynthetic pathway
-
in press
-
Strieter E.R., Vaillancourt F.H., and Walsh C.T. CmaE: a transferase shuttling aminoacyl groups between carrier protein domains in the coronamic acid biosynthetic pathway. Biochemistry (2007) in press
-
(2007)
Biochemistry
-
-
Strieter, E.R.1
Vaillancourt, F.H.2
Walsh, C.T.3
-
36
-
-
33846312155
-
Characterization of SyrC, an aminoacyltransferase shuttling threonyl and chlorothreonyl residues in the syringomycin biosynthetic assembly line
-
Singh G.M., Vaillancourt F.H., Yin J., and Walsh C.T. Characterization of SyrC, an aminoacyltransferase shuttling threonyl and chlorothreonyl residues in the syringomycin biosynthetic assembly line. Chem. Biol. 14 (2007) 31-40
-
(2007)
Chem. Biol.
, vol.14
, pp. 31-40
-
-
Singh, G.M.1
Vaillancourt, F.H.2
Yin, J.3
Walsh, C.T.4
-
37
-
-
0032501971
-
Characterization of Sfp, a Bacillus subtilis phosphopantetheinyl transferase for peptidyl carrier protein domains in peptide synthetases
-
Quadri L.E.N., Weinreb P.H., Lei M., Nakano M.M., Zuber P., and Walsh C.T. Characterization of Sfp, a Bacillus subtilis phosphopantetheinyl transferase for peptidyl carrier protein domains in peptide synthetases. Biochemistry 37 (1998) 1585-1595
-
(1998)
Biochemistry
, vol.37
, pp. 1585-1595
-
-
Quadri, L.E.N.1
Weinreb, P.H.2
Lei, M.3
Nakano, M.M.4
Zuber, P.5
Walsh, C.T.6
-
38
-
-
33744994317
-
Platensimycin is a selective FabF inhibitor with potent antibiotic properties
-
Wang J., Soisson S.M., Young K., Shoop W., Kodali S., Galgoci A., Painter R., Parthasarathy G., Tang Y.S., Cummings R., et al. Platensimycin is a selective FabF inhibitor with potent antibiotic properties. Nature 441 (2006) 358-361
-
(2006)
Nature
, vol.441
, pp. 358-361
-
-
Wang, J.1
Soisson, S.M.2
Young, K.3
Shoop, W.4
Kodali, S.5
Galgoci, A.6
Painter, R.7
Parthasarathy, G.8
Tang, Y.S.9
Cummings, R.10
-
39
-
-
29244459093
-
Natural products to drugs: daptomycin and related lipopeptide antibiotics
-
Baltz R.H., Miao V., and Wrigley S.K. Natural products to drugs: daptomycin and related lipopeptide antibiotics. Nat. Prod. Rep. 22 (2005) 717-741
-
(2005)
Nat. Prod. Rep.
, vol.22
, pp. 717-741
-
-
Baltz, R.H.1
Miao, V.2
Wrigley, S.K.3
-
40
-
-
33645730786
-
The efficacy and safety of daptomycin: first in a new class of antibiotics for Gram-positive bacteria
-
Rybak M.J. The efficacy and safety of daptomycin: first in a new class of antibiotics for Gram-positive bacteria. Clin. Microbiol. Infect. 12 Suppl 1 (2006) 24-32
-
(2006)
Clin. Microbiol. Infect.
, vol.12
, Issue.SUPPL. 1
, pp. 24-32
-
-
Rybak, M.J.1
-
41
-
-
27144460621
-
Dysregulation of bacterial proteolytic machinery by a new class of antibiotics
-
Brotz-Oesterhelt H., Beyer D., Kroll H.P., Endermann R., Ladel C., Schroeder W., Hinzen B., Raddatz S., Paulsen H., Henninger K., et al. Dysregulation of bacterial proteolytic machinery by a new class of antibiotics. Nat. Med. 11 (2005) 1082-1087
-
(2005)
Nat. Med.
, vol.11
, pp. 1082-1087
-
-
Brotz-Oesterhelt, H.1
Beyer, D.2
Kroll, H.P.3
Endermann, R.4
Ladel, C.5
Schroeder, W.6
Hinzen, B.7
Raddatz, S.8
Paulsen, H.9
Henninger, K.10
-
42
-
-
21344461453
-
Mannopeptimycins, a novel class of glycopeptide antibiotics active against Gram-positive bacteria
-
He H. Mannopeptimycins, a novel class of glycopeptide antibiotics active against Gram-positive bacteria. Appl. Microbiol. Biotechnol. 67 (2005) 444-452
-
(2005)
Appl. Microbiol. Biotechnol.
, vol.67
, pp. 444-452
-
-
He, H.1
-
43
-
-
0035036477
-
Coumarin formation in novobiocin biosynthesis: beta-hydroxylation of the aminoacyl enzyme tyrosyl-S-NovH by a cytochrome P450 NovI
-
Chen H., and Walsh C.T. Coumarin formation in novobiocin biosynthesis: beta-hydroxylation of the aminoacyl enzyme tyrosyl-S-NovH by a cytochrome P450 NovI. Chem. Biol. 8 (2001) 301-312
-
(2001)
Chem. Biol.
, vol.8
, pp. 301-312
-
-
Chen, H.1
Walsh, C.T.2
-
44
-
-
0344885564
-
Initial characterization of novobiocic acid noviosyl transferase activity of NovM in biosynthesis of the antibiotic novobiocin
-
Freel Meyers C.L., Oberthur M., Anderson J.W., Kahne D., and Walsh C.T. Initial characterization of novobiocic acid noviosyl transferase activity of NovM in biosynthesis of the antibiotic novobiocin. Biochemistry 42 (2003) 4179-4189
-
(2003)
Biochemistry
, vol.42
, pp. 4179-4189
-
-
Freel Meyers, C.L.1
Oberthur, M.2
Anderson, J.W.3
Kahne, D.4
Walsh, C.T.5
-
45
-
-
25444475215
-
NovJ/NovK catalyze benzylic oxidation of a beta-hydroxyl tyrosyl-S-pantetheinyl enzyme during aminocoumarin ring formation in novobiocin biosynthesis
-
Pacholec M., Hillson N.J., and Walsh C.T. NovJ/NovK catalyze benzylic oxidation of a beta-hydroxyl tyrosyl-S-pantetheinyl enzyme during aminocoumarin ring formation in novobiocin biosynthesis. Biochemistry 44 (2005) 12819-12826
-
(2005)
Biochemistry
, vol.44
, pp. 12819-12826
-
-
Pacholec, M.1
Hillson, N.J.2
Walsh, C.T.3
-
46
-
-
27744564434
-
CouO and NovO: C-methyltransferases for tailoring the aminocoumarin scaffold in coumermycin and novobiocin antibiotic biosynthesis
-
Pacholec M., Tao J., and Walsh C.T. CouO and NovO: C-methyltransferases for tailoring the aminocoumarin scaffold in coumermycin and novobiocin antibiotic biosynthesis. Biochemistry 44 (2005) 14969-14976
-
(2005)
Biochemistry
, vol.44
, pp. 14969-14976
-
-
Pacholec, M.1
Tao, J.2
Walsh, C.T.3
-
47
-
-
3042791444
-
Mass spectrometric characterization of a three-enzyme tandem reaction for assembly and modification of the novobiocin skeleton
-
Pi N., Meyers C.L., Pacholec M., Walsh C.T., and Leary J.A. Mass spectrometric characterization of a three-enzyme tandem reaction for assembly and modification of the novobiocin skeleton. Proc. Natl. Acad. Sci. USA 101 (2004) 10036-10041
-
(2004)
Proc. Natl. Acad. Sci. USA
, vol.101
, pp. 10036-10041
-
-
Pi, N.1
Meyers, C.L.2
Pacholec, M.3
Walsh, C.T.4
Leary, J.A.5
-
48
-
-
0141632774
-
Synthesis of proposed oxidation-cyclization-methylation intermediates of the coumarin antibiotic biosynthetic pathway
-
Tao J., Hu S., Pacholec M., and Walsh C.T. Synthesis of proposed oxidation-cyclization-methylation intermediates of the coumarin antibiotic biosynthetic pathway. Org. Lett. 5 (2003) 3233-3236
-
(2003)
Org. Lett.
, vol.5
, pp. 3233-3236
-
-
Tao, J.1
Hu, S.2
Pacholec, M.3
Walsh, C.T.4
-
49
-
-
1642461379
-
Antimicrobial and DNA gyrase-inhibitory activities of novel clorobiocin derivatives produced by mutasynthesis
-
Galm U., Heller S., Shapiro S., Page M., Li S.-M., and Heide L. Antimicrobial and DNA gyrase-inhibitory activities of novel clorobiocin derivatives produced by mutasynthesis. Antimicrob. Agents Chemother. 48 (2004) 1307-1312
-
(2004)
Antimicrob. Agents Chemother.
, vol.48
, pp. 1307-1312
-
-
Galm, U.1
Heller, S.2
Shapiro, S.3
Page, M.4
Li, S.-M.5
Heide, L.6
-
50
-
-
0036315519
-
Cloning and analysis of the simocyclinone biosynthetic gene cluster of Streptomyces antibioticus Tü 6040
-
Galm U., Schimana J., Fiedler H.P., Schmidt J., Li S.-M., and Heide L. Cloning and analysis of the simocyclinone biosynthetic gene cluster of Streptomyces antibioticus Tü 6040. Arch. Microbiol. 178 (2002) 102-114
-
(2002)
Arch. Microbiol.
, vol.178
, pp. 102-114
-
-
Galm, U.1
Schimana, J.2
Fiedler, H.P.3
Schmidt, J.4
Li, S.-M.5
Heide, L.6
-
51
-
-
0041732088
-
CloR, a bifunctional non-heme iron oxygenase involved in clorobiocin biosynthesis
-
Pojer F., Kahlich R., Kammerer B., Li S.M., and Heide L. CloR, a bifunctional non-heme iron oxygenase involved in clorobiocin biosynthesis. J. Biol. Chem. 278 (2003) 30661-30668
-
(2003)
J. Biol. Chem.
, vol.278
, pp. 30661-30668
-
-
Pojer, F.1
Kahlich, R.2
Kammerer, B.3
Li, S.M.4
Heide, L.5
-
52
-
-
0344442901
-
An unusual amide synthetase (CouL) from the coumermycin A1 biosynthetic gene cluster from Streptomyces rishiriensis DSM 40489
-
Schmutz E., Steffensky M., Schmidt J., Porzel A., Li S.M., and Heide L. An unusual amide synthetase (CouL) from the coumermycin A1 biosynthetic gene cluster from Streptomyces rishiriensis DSM 40489. Eur. J. Biochem. 270 (2003) 4413-4419
-
(2003)
Eur. J. Biochem.
, vol.270
, pp. 4413-4419
-
-
Schmutz, E.1
Steffensky, M.2
Schmidt, J.3
Porzel, A.4
Li, S.M.5
Heide, L.6
-
53
-
-
33748302743
-
Exploiting the reversibility of natural product glycosyltransferase-catalyzed reactions
-
Zhang C., Griffith B.R., Fu Q., Albermann C., Fu X., Lee I.K., Li L., and Thorson J.S. Exploiting the reversibility of natural product glycosyltransferase-catalyzed reactions. Science 313 (2006) 1291-1294
-
(2006)
Science
, vol.313
, pp. 1291-1294
-
-
Zhang, C.1
Griffith, B.R.2
Fu, Q.3
Albermann, C.4
Fu, X.5
Lee, I.K.6
Li, L.7
Thorson, J.S.8
-
54
-
-
0004136246
-
-
Cold Spring Harbor Press, Plainview, NY
-
Sambrook J., Fritsch E.F., and Maniatis T. Molecular Cloning: A Laboratory Manual. Second Edition (1989), Cold Spring Harbor Press, Plainview, NY
-
(1989)
Molecular Cloning: A Laboratory Manual. Second Edition
-
-
Sambrook, J.1
Fritsch, E.F.2
Maniatis, T.3
-
55
-
-
0024520745
-
Site-directed mutagenesis by overlap extension using the polymerase chain reaction
-
Ho S.N., Hunt H.D., Horton R.M., Pullen J.K., and Pease L.R. Site-directed mutagenesis by overlap extension using the polymerase chain reaction. Gene 77 (1989) 51-59
-
(1989)
Gene
, vol.77
, pp. 51-59
-
-
Ho, S.N.1
Hunt, H.D.2
Horton, R.M.3
Pullen, J.K.4
Pease, L.R.5
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