Methicillin-resistant Staphylococcus aureus in a Canadian intensive care unit: Delays in initiating effective therapy due to the low prevalence of infection

Canadian Journal of Infectious Diseases and Medical Microbiology

Volumn 18, Issue 2, 2007, Pages 139-143

  Sligl, Wendy ^a   Taylor, Geoffrey ^a   Gibney, R T Noel ^a   Rennie, Robert ^b   Chui, Linda ^a  

^a UNIVERSITY OF ALBERTA   (Canada)

^b Hospital Provincial Laboratory   (Canada)

Author keywords

Critical care; Intensive care; Methicillin resistance; MRSA; Nosocomial infection; Staphylococcus aureus

Indexed keywords

ANTIINFECTIVE AGENT;

ADULT; AGED; ARTICLE; BACTERIAL STRAIN; CANADA; COHORT ANALYSIS; CONTROLLED STUDY; FEMALE; HOSPITAL ADMISSION; HUMAN; INTENSIVE CARE UNIT; LENGTH OF STAY; MAJOR CLINICAL STUDY; MALE; METHICILLIN RESISTANT STAPHYLOCOCCUS AUREUS; MOLECULAR CLONING; MORTALITY; PREVALENCE; RESPIRATORY FAILURE; RETROSPECTIVE STUDY; SEPTIC SHOCK; STAPHYLOCOCCUS INFECTION; TREATMENT OUTCOME; UNIVERSITY HOSPITAL;

EID: 34250359782     PISSN: 17129532     EISSN: None     Source Type: Journal    
DOI: 10.1155/2007/120987     Document Type: Article

References (33)

1. Seal JB, Moreira B, Bethel CD, Daum RS. Antimicrobial resistance in Staphylococcus aureus at the University of Chicago Hospitals: A 15-year longitudinal assessment in a large university-based hospital. Infect Control Hosp Epidemiol 2003;24:403-8.
2. Diekema DJ, Pfaller MA, Schmitz FJ, et al; SENTRY Partcipants Group. Survey of infections due to Staphylococcus species: Frequency of occurrence and antimicrobial susceptibility of isolates collected in the United States, Canada, Latin America, Europe, and the Western Pacific region for the SENTRY Antimicrobial Surveillance Program, 1997-1999. Clin Infect Dis 2001;32(Suppl 2):S114-32.
3. Vincent JL, Bihari DJ, Suter PM, et al. The prevalence of nosocomial infection in intensive care units in Europe. Results of the European Prevalence of Infection in Intensive Care (EPIC) Study. EPIC International Advisory Committee. JAMA 1995;274:639-44.
4. National Nosocomial Infections Surveillance (NNIS) System Report, Data Summary from January 1992-June 2001, issued August 2001. Am J Infect Control 2001;29:404-21.
5. Berthelot P, Grattard F, Fascia P, et al. Implication of a healthcare worker with chronic skin disease in the transmission of an epidemic strain of methicillin-resistant Staphylococcus aureus in a pediatric intensive care unit. Infect Control Hosp Epidemiol 2003;24:299-300.
6. Gastmeier P, Sohr D, Geffers C, Nassauer A, Dettenkofer M, Ruden H. Occurrence of methicillin-resistant Staphylococcus aureus infections in German intensive care units. Infection 2002;30:198-202.
7. Saiman L, Cronquist A, Wu F, et al. An outbreak of methicillin-resistant Staphylococcus aureus in a neonatal intensive care unit. Infect Control Hosp Epidemiol 2003;24:317-21.
8. Cosgrove SE, Qi Y, Kaye KS, Harbarth S, Karchmer AW, Carmeli Y. The impact of methicillin resistance in Staphylococcus aureus bacteremia on patient outcomes: Mortality, length of stay, and hospital charges. Infect Control Hosp Epidemiol 2005;26:166-74.
9. Niederman MS. Impact of antibiotic resistance on clinical outcomes and the cost of care. Crit Care Med 2001;29(Suppl 4):N114-20.
10. Shorr AF, Combes A, Kollef MH, Chastre J. Methicillin-resistant Staphylococcus aureus prolongs intensive care unit stay in ventilator-associated pneumonia, despite initially appropriate antibiotic therapy. Crit Care Med 2006;34:700-6.
11. Miller LG, Perdreau-Remington F, Rieg G, et al. Necrotizing fasciitis caused by community-associated methicillin-resistant Staphylococcus aureus in Los Angeles. N Engl J Med 2005;352:1445-53.
12. Boussaud V, Parrot A, Mayaud C, et al. Life-threatening hemoptysis in adults with community-acquired pneumonia due to Panton-Valentine leukocidin-secreting Staphylococcus aureus. Intensive Care Med 2003;29:1840-3.
13. van der Flier M, van Dijk NB, Fluit AC, Fleer A, Wolfs TF, van Gestel JP. [Fatal pneumonia in an adolescent due to community-acquired methicillin-resistant Staphylococcus aureus positive for Panton-Valentine- leukocidin]. Ned Tijdschr Geneeskd 2003;147:1076-9.
14. Garner JS, Jarvis WR, Emori TG, Horan TC, Hughes JM. CDC definitions for nosocomial infections. Am J Infect Control 1988;16:128-40. (Erratum in 1988;16:177).
15. Performance Standards for Antimicrobial Susceptibility Testing: Seventeen Informational Supplement. Clinical and Laboratory Standards Institute. M100-S17. 2007;27(1).
16. Mulvey MR, Chui L, Ismail J, et al; Canadian Committee for the Standardization of Molecular Methods. Development of a Canadian standardized protocol for subtyping methicillin-resistant Staphylococcus aureus using pulsed-field gel electrophoresis. J Clin Microbiol 2001;39:3481-5.
17. Tenover FC, Arbeit RD, Goering RV, et al. Interpreting chromosomal DNA restriction patterns produced by pulsed-field gel electrophoresis: Criteria for bacterial strain typing. J Clin Microbiol 1995;33:2233-9.
18. Simor AE, Ofner-Agostini M, Bryce E, McGeer A, Paton S, Mulvey MR; Canadian Hospital Epidemiology Committee and Canadian Nosocomial Infection Surveillance Program, Health Canada. Laboratory characterization of methicillin-resistant Staphylococcus aureus in Canadian hospitals: Results of 5 years of National Surveillance, 1995-1999. J Infect Dis 2002;186:652-60.
19. Roberts RB, Tennenberg AM, Eisner W, et al. Outbreak in a New York City teaching hospital burn center caused by the Iberian epidemic clone of MRSA. Microb Drug Resist 1998;4:175-83.
20. Murchan S, Kaufmann ME, Deplano A, et al. Harmonization of pulsed-field gel electrophoresis protocols for epidemiological typing of strains of methicillin-resistant Staphylococcus aureus: A single approach developed by consensus in 10 European laboratories and its application for tracing the spread of related strains. J Clin Microbiol 2003;41:1574-85.
21. McDougal LK, Steward CD, Killgore GE, Chaitram JM, McAllister SK, Tenover FC. Pulsed-field gel electrophoresis typing of oxacillin-resistant Staphylococcus aureus isolates from the United States: Establishing a national database. J Clin Microbiol 2003;41:5113-20.
22. Meyer E, Schwab F, Gastmeier P, Jonas D, Rueden H, Daschner FD. Methicillin-resistant Staphylococcus aureus in German intensive care units during 2000-2003: Data from Project SARI (Surveillance of Antimicrobial Use and Antimicrobial Resistance in Intensive Cate Units). Infect Control Hosp Epidemiol 2006;27:146-54.
23. Styers D, Sheehan DJ, Hogan P, Sahm DF. Laboratory-based surveillance of current antimicrobial resistance patterns and trends among Staphylococcus aureus: 2005 status in the United States. Ann Clin Microbiol Antimicrob 2006;5:2.
24. DeRyke CA, Lodise TP Jr, Rybak MJ, McKinnon PS. Epidemiology, treatment, and outcomes of nosocomial bacteremic Staphylococcus aureus pneumonia. Chest 2005;128:1414-22.
25. Zoutman DE, Ford BD. The relationship between hospital infection surveillance and control activities and antibiotic-resistant pathogen rates. Am J Infect Control 2005;33:1-5.
26. Montesinos I, Salido E, Delgado T, Lecuona M, Sierra A. Epidemiology of methicillin-resistant Staphylococcus aureus at a university hospital in the Canary Islands. Infect Control Hosp Epidemiol 2003;24:667-72.
27. Theaker C, Ormond-Walshe S, Azadian B, Soni N. MRSA in the critically ill. J Hosp Infect 2001;48:98-102.
28. Ibelings MM, Bruining HA. Methicillin-resistant Staphylococcus aureus: Acquisition and risk of death in patients in the intensive care unit. Eur J Surg 1998;164:411-8.
29. Kumar A, Roberts D, Wood KE, et al. Duration of hypotension before initiation of effective antimicrobial therapy is the critical determinant of survival in human septic shock. Crit Care Med 2006;34:1589-96.
30. Kumar A, Haery C, Paladugu B, et al. The duration of hypotension before the initiation of antibiotic treatment is a critical determinant of survival in a murine model of Escherichia coli septic shock: Association with serum lactate and inflammatory cytokine levels. J Infect Dis 2006;193:251-8.
31. Kollef MH, Ward S, Sherman G, et al. Inadequate treatment of nosocomial infections is associated with certain empitic antibiotic choices. Crit Care Med 2000;28:3456-64.
32. King MD, Humphrey BJ, Wang YF, Kourbatova EV, Ray SM, Blumberg HM. Emergence of community-acquired methicillin-resistant Staphylococcus aureus USA 300 clone as the predominant cause of skin and soft-tissue infections. Ann Intern Med 2006;144:309-17.
33. Gosbell IB. Epidemiology, clinical features and management of infections due to community methicillin-resistant Staphylococcus aureus (cMRSA). Intern Med J 2005;35(Suppl 2):S120-35.